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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THBS2
Full Name:
Thrombospondin-2
Alias:
tsp2
Type:
Extracellular region protein
Mass (Da):
129991
Number AA:
1172
UniProt ID:
P35442
International Prot ID:
IPI00018769
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0031093
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008201
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
A
G
H
Q
D
K
D
T
T
F
D
L
F
S
I
Site 2
T26
G
H
Q
D
K
D
T
T
F
D
L
F
S
I
S
Site 3
S31
D
T
T
F
D
L
F
S
I
S
N
I
N
R
K
Site 4
S33
T
F
D
L
F
S
I
S
N
I
N
R
K
T
I
Site 5
T39
I
S
N
I
N
R
K
T
I
G
A
K
Q
F
R
Site 6
Y55
P
D
P
G
V
P
A
Y
R
F
V
R
F
D
Y
Site 7
Y62
Y
R
F
V
R
F
D
Y
I
P
P
V
N
A
D
Site 8
S72
P
V
N
A
D
D
L
S
K
I
T
K
I
M
R
Site 9
S96
Q
L
K
Q
D
G
K
S
R
G
T
L
L
A
L
Site 10
T99
Q
D
G
K
S
R
G
T
L
L
A
L
E
G
P
Site 11
S109
A
L
E
G
P
G
L
S
Q
R
Q
F
E
I
V
Site 12
T123
V
S
N
G
P
A
D
T
L
D
L
T
Y
W
I
Site 13
T127
P
A
D
T
L
D
L
T
Y
W
I
D
G
T
R
Site 14
Y128
A
D
T
L
D
L
T
Y
W
I
D
G
T
R
H
Site 15
T133
L
T
Y
W
I
D
G
T
R
H
V
V
S
L
E
Site 16
S147
E
D
V
G
L
A
D
S
Q
W
K
N
V
T
V
Site 17
T153
D
S
Q
W
K
N
V
T
V
Q
V
A
G
E
T
Site 18
Y180
F
A
L
D
E
P
F
Y
E
H
L
Q
A
E
K
Site 19
S188
E
H
L
Q
A
E
K
S
R
M
Y
V
A
K
G
Site 20
Y191
Q
A
E
K
S
R
M
Y
V
A
K
G
S
A
R
Site 21
S196
R
M
Y
V
A
K
G
S
A
R
E
S
H
F
R
Site 22
S200
A
K
G
S
A
R
E
S
H
F
R
G
L
L
Q
Site 23
S222
N
S
V
E
D
I
L
S
K
K
G
C
Q
Q
G
Site 24
S238
G
A
E
I
N
A
I
S
E
N
T
E
T
L
R
Site 25
T243
A
I
S
E
N
T
E
T
L
R
L
G
P
H
V
Site 26
T251
L
R
L
G
P
H
V
T
T
E
Y
V
G
P
S
Site 27
T252
R
L
G
P
H
V
T
T
E
Y
V
G
P
S
S
Site 28
Y254
G
P
H
V
T
T
E
Y
V
G
P
S
S
E
R
Site 29
S259
T
E
Y
V
G
P
S
S
E
R
R
P
E
V
C
Site 30
S269
R
P
E
V
C
E
R
S
C
E
E
L
G
N
M
Site 31
S291
H
V
L
V
N
Q
L
S
E
N
L
K
R
V
S
Site 32
S298
S
E
N
L
K
R
V
S
N
D
N
Q
F
L
W
Site 33
T314
L
I
G
G
P
P
K
T
R
N
M
S
A
C
W
Site 34
S318
P
P
K
T
R
N
M
S
A
C
W
Q
D
G
R
Site 35
T332
R
F
F
A
E
N
E
T
W
V
V
D
S
C
T
Site 36
S362
C
P
P
A
T
C
A
S
P
S
F
V
E
G
E
Site 37
T401
S
V
T
C
G
S
G
T
Q
Q
R
G
R
S
C
Site 38
S407
G
T
Q
Q
R
G
R
S
C
D
V
T
S
N
T
Site 39
T411
R
G
R
S
C
D
V
T
S
N
T
C
L
G
P
Site 40
S412
G
R
S
C
D
V
T
S
N
T
C
L
G
P
S
Site 41
T414
S
C
D
V
T
S
N
T
C
L
G
P
S
I
Q
Site 42
S426
S
I
Q
T
R
A
C
S
L
S
K
C
D
T
R
Site 43
S428
Q
T
R
A
C
S
L
S
K
C
D
T
R
I
R
Site 44
T432
C
S
L
S
K
C
D
T
R
I
R
Q
D
G
G
Site 45
S466
T
R
I
R
L
C
N
S
P
V
P
Q
M
G
G
Site 46
S479
G
G
K
N
C
K
G
S
G
R
E
T
K
A
C
Site 47
T483
C
K
G
S
G
R
E
T
K
A
C
Q
G
A
P
Site 48
T518
A
G
G
I
R
E
R
T
R
V
C
N
S
P
E
Site 49
S523
E
R
T
R
V
C
N
S
P
E
P
Q
Y
G
G
Site 50
S566
F
P
G
A
Q
C
S
S
F
P
D
G
S
W
S
Site 51
S571
C
S
S
F
P
D
G
S
W
S
C
G
S
C
P
Site 52
S573
S
F
P
D
G
S
W
S
C
G
S
C
P
V
G
Site 53
Y626
C
L
P
C
P
P
R
Y
R
G
N
Q
P
V
G
Site 54
T641
V
G
L
E
A
A
K
T
E
K
Q
V
C
E
P
Site 55
Y667
H
K
H
A
E
C
I
Y
L
G
H
F
S
D
P
Site 56
Y676
G
H
F
S
D
P
M
Y
K
C
E
C
Q
T
G
Site 57
Y684
K
C
E
C
Q
T
G
Y
A
G
D
G
L
I
C
Site 58
S695
G
L
I
C
G
E
D
S
D
L
D
G
W
P
N
Site 59
S726
N
C
P
H
L
P
N
S
G
Q
E
D
F
D
K
Site 60
T750
D
D
D
N
D
G
V
T
D
E
K
D
N
C
Q
Site 61
Y767
F
N
P
R
Q
A
D
Y
D
K
D
E
V
G
D
Site 62
T790
H
N
P
A
Q
I
D
T
D
N
N
G
E
G
D
Site 63
S800
N
G
E
G
D
A
C
S
V
D
I
D
G
D
D
Site 64
Y817
N
E
R
D
N
C
P
Y
V
Y
N
T
D
Q
R
Site 65
Y819
R
D
N
C
P
Y
V
Y
N
T
D
Q
R
D
T
Site 66
T826
Y
N
T
D
Q
R
D
T
D
G
D
G
V
G
D
Site 67
T847
L
V
H
N
P
D
Q
T
D
V
D
N
D
L
V
Site 68
T991
Q
G
K
E
L
V
Q
T
A
N
S
D
P
G
I
Site 69
S1011
E
F
G
S
V
D
F
S
G
T
F
Y
V
N
T
Site 70
T1013
G
S
V
D
F
S
G
T
F
Y
V
N
T
D
R
Site 71
Y1015
V
D
F
S
G
T
F
Y
V
N
T
D
R
D
D
Site 72
T1018
S
G
T
F
Y
V
N
T
D
R
D
D
D
Y
A
Site 73
Y1024
N
T
D
R
D
D
D
Y
A
G
F
V
F
G
Y
Site 74
Y1031
Y
A
G
F
V
F
G
Y
Q
S
S
S
R
F
Y
Site 75
Y1038
Y
Q
S
S
S
R
F
Y
V
V
M
W
K
Q
V
Site 76
T1055
T
Y
W
E
D
Q
P
T
R
A
Y
G
Y
S
G
Site 77
Y1058
E
D
Q
P
T
R
A
Y
G
Y
S
G
V
S
L
Site 78
S1070
V
S
L
K
V
V
N
S
T
T
G
T
G
E
H
Site 79
T1088
A
L
W
H
T
G
N
T
P
G
Q
V
R
T
L
Site 80
Y1107
R
N
I
G
W
K
D
Y
T
A
Y
R
W
H
L
Site 81
T1115
T
A
Y
R
W
H
L
T
H
R
P
K
T
G
Y
Site 82
T1120
H
L
T
H
R
P
K
T
G
Y
I
R
V
L
V
Site 83
Y1122
T
H
R
P
K
T
G
Y
I
R
V
L
V
H
E
Site 84
S1137
G
K
Q
V
M
A
D
S
G
P
I
Y
D
Q
T
Site 85
Y1141
M
A
D
S
G
P
I
Y
D
Q
T
Y
A
G
G
Site 86
T1144
S
G
P
I
Y
D
Q
T
Y
A
G
G
R
L
G
Site 87
Y1145
G
P
I
Y
D
Q
T
Y
A
G
G
R
L
G
L
Site 88
Y1161
V
F
S
Q
E
M
V
Y
F
S
D
L
K
Y
E
Site 89
Y1167
V
Y
F
S
D
L
K
Y
E
C
R
D
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation