PhosphoNET

           
Protein Info 
   
Short Name:  ADM
Full Name:  ADM
Alias:  ADML; adrenomedullin; AM
Type:  Secreted protein
Mass (Da):  20420
Number AA:  185
UniProt ID:  P35318
International Prot ID:  IPI00017968
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005615  GO:0005625 Uniprot OncoNet
Molecular Function:  GO:0005179     PhosphoSite+ KinaseNET
Biological Process:  GO:0007186  GO:0008015  GO:0006171 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S28TARLDVASEFRKKWN
Site 2S40KWNKWALSRGKRELR
Site 3S49GKRELRMSSSYPTGL
Site 4S50KRELRMSSSYPTGLA
Site 5S51RELRMSSSYPTGLAD
Site 6Y52ELRMSSSYPTGLADV
Site 7S77PQDMKGASRSPEDSS
Site 8S79DMKGASRSPEDSSPD
Site 9S83ASRSPEDSSPDAARI
Site 10S84SRSPEDSSPDAARIR
Site 11S98RVKRYRQSMNNFQGL
Site 12T116GCRFGTCTVQKLAHQ
Site 13Y125QKLAHQIYQFTDKDK
Site 14S139KDNVAPRSKISPQGY
Site 15S142VAPRSKISPQGYGRR
Site 16Y146SKISPQGYGRRRRRS
Site 17S153YGRRRRRSLPEAGPG
Site 18T162PEAGPGRTLVSSKPQ
Site 19S165GPGRTLVSSKPQAHG
Site 20S166PGRTLVSSKPQAHGA
Site 21S178HGAPAPPSGSAPHFL
Site 22S180APAPPSGSAPHFL__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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