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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCGF2
Full Name:
Polycomb group RING finger protein 2
Alias:
DNA-binding protein Mel-18; MEL18; MEL-18; RING finger protein 110; RNF110; Zinc finger protein 144; ZNF144
Type:
Nucleus protein
Mass (Da):
37788
Number AA:
344
UniProt ID:
P35227
International Prot ID:
IPI00017302
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y46
C
K
T
C
I
V
R
Y
L
E
T
N
K
Y
C
Site 2
Y52
R
Y
L
E
T
N
K
Y
C
P
M
C
D
V
Q
Site 3
T63
C
D
V
Q
V
H
K
T
R
P
L
L
S
I
R
Site 4
S68
H
K
T
R
P
L
L
S
I
R
S
D
K
T
L
Site 5
S71
R
P
L
L
S
I
R
S
D
K
T
L
Q
D
I
Site 6
T74
L
S
I
R
S
D
K
T
L
Q
D
I
V
Y
K
Site 7
Y98
M
K
R
R
R
D
F
Y
A
A
Y
P
L
T
E
Site 8
Y101
R
R
D
F
Y
A
A
Y
P
L
T
E
V
P
N
Site 9
T104
F
Y
A
A
Y
P
L
T
E
V
P
N
G
S
N
Site 10
S110
L
T
E
V
P
N
G
S
N
E
D
R
G
E
V
Site 11
S126
E
Q
E
K
G
A
L
S
D
D
E
I
V
S
L
Site 12
S132
L
S
D
D
E
I
V
S
L
S
I
E
F
Y
E
Site 13
S134
D
D
E
I
V
S
L
S
I
E
F
Y
E
G
A
Site 14
Y138
V
S
L
S
I
E
F
Y
E
G
A
R
D
R
D
Site 15
T161
G
D
G
D
K
E
K
T
G
V
R
F
L
R
C
Site 16
S189
R
N
K
M
D
V
P
S
K
Y
K
V
E
V
L
Site 17
Y191
K
M
D
V
P
S
K
Y
K
V
E
V
L
Y
E
Site 18
Y197
K
Y
K
V
E
V
L
Y
E
D
E
P
L
K
E
Site 19
Y205
E
D
E
P
L
K
E
Y
Y
T
L
M
D
I
A
Site 20
Y206
D
E
P
L
K
E
Y
Y
T
L
M
D
I
A
Y
Site 21
T207
E
P
L
K
E
Y
Y
T
L
M
D
I
A
Y
I
Site 22
Y213
Y
T
L
M
D
I
A
Y
I
Y
P
W
R
R
N
Site 23
Y215
L
M
D
I
A
Y
I
Y
P
W
R
R
N
G
P
Site 24
Y227
N
G
P
L
P
L
K
Y
R
V
Q
P
A
C
K
Site 25
T237
Q
P
A
C
K
R
L
T
L
A
T
V
P
T
P
Site 26
T240
C
K
R
L
T
L
A
T
V
P
T
P
S
E
G
Site 27
T243
L
T
L
A
T
V
P
T
P
S
E
G
T
N
T
Site 28
S245
L
A
T
V
P
T
P
S
E
G
T
N
T
S
G
Site 29
T250
T
P
S
E
G
T
N
T
S
G
A
S
E
C
E
Site 30
S251
P
S
E
G
T
N
T
S
G
A
S
E
C
E
S
Site 31
S254
G
T
N
T
S
G
A
S
E
C
E
S
V
S
D
Site 32
S258
S
G
A
S
E
C
E
S
V
S
D
K
A
P
S
Site 33
S260
A
S
E
C
E
S
V
S
D
K
A
P
S
P
A
Site 34
S265
S
V
S
D
K
A
P
S
P
A
T
L
P
A
T
Site 35
T268
D
K
A
P
S
P
A
T
L
P
A
T
S
S
S
Site 36
T272
S
P
A
T
L
P
A
T
S
S
S
L
P
S
P
Site 37
S273
P
A
T
L
P
A
T
S
S
S
L
P
S
P
A
Site 38
S274
A
T
L
P
A
T
S
S
S
L
P
S
P
A
T
Site 39
S275
T
L
P
A
T
S
S
S
L
P
S
P
A
T
P
Site 40
S278
A
T
S
S
S
L
P
S
P
A
T
P
S
H
G
Site 41
T281
S
S
L
P
S
P
A
T
P
S
H
G
S
P
S
Site 42
S283
L
P
S
P
A
T
P
S
H
G
S
P
S
S
H
Site 43
S286
P
A
T
P
S
H
G
S
P
S
S
H
G
P
P
Site 44
S288
T
P
S
H
G
S
P
S
S
H
G
P
P
A
T
Site 45
S289
P
S
H
G
S
P
S
S
H
G
P
P
A
T
H
Site 46
T295
S
S
H
G
P
P
A
T
H
P
T
S
P
T
P
Site 47
S299
P
P
A
T
H
P
T
S
P
T
P
P
S
T
A
Site 48
T301
A
T
H
P
T
S
P
T
P
P
S
T
A
S
G
Site 49
S304
P
T
S
P
T
P
P
S
T
A
S
G
A
T
T
Site 50
T305
T
S
P
T
P
P
S
T
A
S
G
A
T
T
A
Site 51
S307
P
T
P
P
S
T
A
S
G
A
T
T
A
A
N
Site 52
T311
S
T
A
S
G
A
T
T
A
A
N
G
G
S
L
Site 53
T323
G
S
L
N
C
L
Q
T
P
S
S
T
S
R
G
Site 54
S325
L
N
C
L
Q
T
P
S
S
T
S
R
G
R
K
Site 55
S326
N
C
L
Q
T
P
S
S
T
S
R
G
R
K
M
Site 56
T334
T
S
R
G
R
K
M
T
V
N
G
A
P
V
P
Site 57
T344
G
A
P
V
P
P
L
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation