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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPHX2
Full Name:
Epoxide hydrolase 2
Alias:
CEH; Cytosolic epoxide hydrolase; EC 3.3.2.10; Epoxide hydratase; Epoxide hydrolase 2, cytoplasmic; HYES; SEH; Soluble epoxide hydrolase
Type:
Lipid Metabolism - arachidonic acid; EC 3.3.2.10; Hydrolase
Mass (Da):
62616
Number AA:
555
UniProt ID:
P34913
International Prot ID:
IPI00942976
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005777
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0004301
GO:0000287
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0019439
GO:0006874
GO:0017144
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T51
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
Site 2
S75
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
Site 3
T77
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
Site 4
S87
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
Site 5
S97
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
Site 6
T118
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
Site 7
Y166
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
Site 8
T172
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
Site 9
S178
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
Site 10
T208
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
Site 11
S231
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
Site 12
S235
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
Site 13
S238
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
Site 14
Y241
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
Site 15
T243
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
Site 16
Y276
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
Site 17
S300
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Site 18
Y308
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
Site 19
S370
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
Site 20
S374
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
Site 21
Y383
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
Site 22
Y386
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
Site 23
S402
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
Site 24
T404
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
Site 25
S407
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
Site 26
S412
F
K
S
L
F
R
A
S
D
E
S
V
L
S
M
Site 27
S415
L
F
R
A
S
D
E
S
V
L
S
M
H
K
V
Site 28
S418
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
Site 29
S432
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
Site 30
S437
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
Site 31
S439
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
Site 32
T443
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
Site 33
Y450
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
Site 34
S457
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
Site 35
S544
I
L
I
K
W
L
D
S
D
A
R
N
P
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation