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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHMT2
Full Name:
Serine hydroxymethyltransferase, mitochondrial
Alias:
GLYA; Glycine hydroxymethyltransferase; GLYM; Serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase, mitochondrial; SHMT
Type:
Other Amino Acids Metabolism - cyanoamino acid; Methyltransferase; Energy Metabolism - methane; Cofactor and Vitamin Metabolism - one carbon pool by folate; Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.2.1; Mitochondrial
Mass (Da):
55993
Number AA:
504
UniProt ID:
P34897
International Prot ID:
IPI00002520
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042645
Uniprot
OncoNet
Molecular Function:
GO:0004372
GO:0005515
GO:0030170
PhosphoSite+
KinaseNET
Biological Process:
GO:0006563
GO:0006544
GO:0006730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y3
_
_
_
_
_
M
L
Y
F
S
L
F
W
A
A
Site 2
T44
G
E
A
N
R
G
W
T
G
Q
E
S
L
S
D
Site 3
S48
R
G
W
T
G
Q
E
S
L
S
D
S
D
P
E
Site 4
S50
W
T
G
Q
E
S
L
S
D
S
D
P
E
M
W
Site 5
S52
G
Q
E
S
L
S
D
S
D
P
E
M
W
E
L
Site 6
S76
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
Site 7
S90
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
Site 8
Y96
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
Site 9
S97
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Site 10
Y100
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
Site 11
Y105
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
Site 12
Y106
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
Site 13
S142
G
V
N
V
Q
P
Y
S
G
S
P
A
N
L
A
Site 14
S144
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
Site 15
T173
L
P
D
G
G
H
L
T
H
G
Y
M
S
D
V
Site 16
Y176
G
G
H
L
T
H
G
Y
M
S
D
V
K
R
I
Site 17
S178
H
L
T
H
G
Y
M
S
D
V
K
R
I
S
A
Site 18
S192
A
T
S
I
F
F
E
S
M
P
Y
K
L
N
P
Site 19
Y195
I
F
F
E
S
M
P
Y
K
L
N
P
K
T
G
Site 20
T201
P
Y
K
L
N
P
K
T
G
L
I
D
Y
N
Q
Site 21
Y206
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
Site 22
T212
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
Site 23
T225
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
I
Site 24
Y228
I
I
A
G
T
S
A
Y
A
R
L
I
D
Y
A
Site 25
Y234
A
Y
A
R
L
I
D
Y
A
R
M
R
E
V
C
Site 26
T281
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
Site 27
S287
K
T
L
R
G
A
R
S
G
L
I
F
Y
R
K
Site 28
T303
V
K
A
V
D
P
K
T
G
R
E
I
P
Y
T
Site 29
T310
T
G
R
E
I
P
Y
T
F
E
D
R
I
N
F
Site 30
T344
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
Site 31
Y350
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
Site 32
S351
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
Site 33
Y370
D
A
L
L
E
R
G
Y
S
L
V
S
G
G
T
Site 34
S371
A
L
L
E
R
G
Y
S
L
V
S
G
G
T
D
Site 35
S417
N
T
C
P
G
D
R
S
A
I
T
P
G
G
L
Site 36
T420
P
G
D
R
S
A
I
T
P
G
G
L
R
L
G
Site 37
T432
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
Site 38
S460
N
I
G
L
E
V
K
S
K
T
A
K
L
Q
D
Site 39
S470
A
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
Site 40
S476
K
S
F
L
L
K
D
S
E
T
S
Q
R
L
A
Site 41
T478
F
L
L
K
D
S
E
T
S
Q
R
L
A
N
L
Site 42
S479
L
L
K
D
S
E
T
S
Q
R
L
A
N
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation