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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHMT1
Full Name:
Serine hydroxymethyltransferase, cytosolic
Alias:
14 kDa protein; CSHMT; Cytoplasmic serine hydroxymethyltransferase; GLYC; MGC15229; MGC24556; Serine hydroxymethyltransferase 1 (soluble); Serine methylase; SHMT
Type:
Lyase; Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; Energy Metabolism - methane; EC 2.1.2.1; Other Amino Acids Metabolism - cyanoamino acid; Methyltransferase; Mitochondrial
Mass (Da):
53083
Number AA:
483
UniProt ID:
P34896
International Prot ID:
IPI00002519
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004372
GO:0042803
GO:0030170
PhosphoSite+
KinaseNET
Biological Process:
GO:0006565
GO:0046655
GO:0006730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
H
K
D
A
D
L
W
S
S
H
D
K
M
L
A
Site 2
S17
K
D
A
D
L
W
S
S
H
D
K
M
L
A
Q
Site 3
S29
L
A
Q
P
L
K
D
S
D
V
E
V
Y
N
I
Site 4
Y34
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
Site 5
S41
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
Site 6
Y73
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
Site 7
S74
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Site 8
Y77
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
Site 9
Y82
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
Site 10
Y83
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
D
Site 11
Y104
Q
K
R
A
L
Q
A
Y
K
L
D
P
Q
C
W
Site 12
Y118
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
Site 13
S119
G
V
N
V
Q
P
Y
S
G
S
P
A
N
F
A
Site 14
S121
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
Site 15
T150
L
P
D
G
G
H
L
T
H
G
F
M
T
D
K
Site 16
S161
M
T
D
K
K
K
I
S
A
T
S
I
F
F
E
Site 17
S164
K
K
K
I
S
A
T
S
I
F
F
E
S
M
P
Site 18
Y172
I
F
F
E
S
M
P
Y
K
V
N
P
D
T
G
Site 19
Y180
K
V
N
P
D
T
G
Y
I
N
Y
D
Q
L
E
Site 20
Y183
P
D
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
Site 21
Y205
I
I
A
G
T
S
C
Y
S
R
N
L
E
Y
A
Site 22
Y224
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
Site 23
T258
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
Site 24
S275
F
Y
R
K
G
V
K
S
V
D
P
K
T
G
K
Site 25
T280
V
K
S
V
D
P
K
T
G
K
E
I
L
Y
N
Site 26
Y286
K
T
G
K
E
I
L
Y
N
L
E
S
L
I
N
Site 27
Y327
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
Site 28
S365
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
Site 29
S394
N
T
C
P
G
D
R
S
A
L
R
P
S
G
L
Site 30
S399
D
R
S
A
L
R
P
S
G
L
R
L
G
T
P
Site 31
T405
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
Site 32
T409
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
Site 33
T432
I
H
R
G
I
E
L
T
L
Q
I
Q
S
D
T
Site 34
T439
T
L
Q
I
Q
S
D
T
G
V
R
A
T
L
K
Site 35
T444
S
D
T
G
V
R
A
T
L
K
E
F
K
E
R
Site 36
Y457
E
R
L
A
G
D
K
Y
Q
A
A
V
Q
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation