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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GUCY1A2
Full Name:
Guanylate cyclase soluble subunit alpha-2
Alias:
Type:
Mass (Da):
81750
Number AA:
732
UniProt ID:
P33402
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
R
R
K
I
S
S
E
S
F
S
S
L
Site 2
S8
M
S
R
R
K
I
S
S
E
S
F
S
S
L
G
Site 3
S10
R
R
K
I
S
S
E
S
F
S
S
L
G
S
D
Site 4
S12
K
I
S
S
E
S
F
S
S
L
G
S
D
Y
L
Site 5
S13
I
S
S
E
S
F
S
S
L
G
S
D
Y
L
E
Site 6
S16
E
S
F
S
S
L
G
S
D
Y
L
E
T
S
P
Site 7
Y18
F
S
S
L
G
S
D
Y
L
E
T
S
P
E
E
Site 8
S22
G
S
D
Y
L
E
T
S
P
E
E
E
G
E
C
Site 9
S32
E
E
G
E
C
P
L
S
R
L
C
W
N
G
S
Site 10
S39
S
R
L
C
W
N
G
S
R
S
P
P
G
P
L
Site 11
S41
L
C
W
N
G
S
R
S
P
P
G
P
L
E
P
Site 12
S89
R
R
R
V
N
L
D
S
L
G
E
S
I
S
R
Site 13
S93
N
L
D
S
L
G
E
S
I
S
R
L
T
A
P
Site 14
S95
D
S
L
G
E
S
I
S
R
L
T
A
P
S
P
Site 15
T98
G
E
S
I
S
R
L
T
A
P
S
P
Q
T
I
Site 16
S101
I
S
R
L
T
A
P
S
P
Q
T
I
Q
Q
T
Site 17
T108
S
P
Q
T
I
Q
Q
T
L
K
R
T
L
Q
Y
Site 18
Y116
L
K
R
T
L
Q
Y
Y
E
H
Q
V
I
G
Y
Site 19
Y139
N
I
S
N
R
C
S
Y
A
D
H
S
N
K
E
Site 20
S143
R
C
S
Y
A
D
H
S
N
K
E
E
I
E
D
Site 21
S152
K
E
E
I
E
D
V
S
G
I
L
Q
C
T
A
Site 22
T212
A
L
L
E
H
I
R
T
S
F
G
K
Q
A
T
Site 23
S213
L
L
E
H
I
R
T
S
F
G
K
Q
A
T
L
Site 24
T219
T
S
F
G
K
Q
A
T
L
E
S
P
S
F
L
Site 25
S222
G
K
Q
A
T
L
E
S
P
S
F
L
C
K
E
Site 26
S224
Q
A
T
L
E
S
P
S
F
L
C
K
E
L
P
Site 27
S278
V
A
N
E
K
L
C
S
D
V
S
N
P
G
N
Site 28
S281
E
K
L
C
S
D
V
S
N
P
G
N
C
S
C
Site 29
S310
K
N
L
P
Q
G
T
S
Q
V
P
A
D
L
R
Site 30
T354
R
K
Q
L
R
C
D
T
H
K
V
L
K
F
E
Site 31
T390
S
T
P
F
V
I
R
T
K
P
E
A
S
G
S
Site 32
S397
T
K
P
E
A
S
G
S
E
N
K
D
K
V
M
Site 33
S441
M
G
R
G
L
H
L
S
D
I
P
I
H
D
A
Site 34
T475
R
M
D
K
L
K
A
T
L
E
R
T
H
Q
A
Site 35
T490
L
E
E
E
K
K
K
T
V
D
L
L
Y
S
I
Site 36
Y550
I
S
M
L
N
E
L
Y
T
R
F
D
H
Q
C
Site 37
S582
A
A
G
L
H
R
K
S
L
C
H
A
K
P
I
Site 38
T605
E
L
S
E
E
V
L
T
P
D
G
R
P
I
Q
Site 39
S619
Q
M
R
I
G
I
H
S
G
S
V
L
A
G
V
Site 40
S621
R
I
G
I
H
S
G
S
V
L
A
G
V
V
G
Site 41
S645
G
N
N
V
T
L
A
S
K
F
E
S
G
S
H
Site 42
S649
T
L
A
S
K
F
E
S
G
S
H
P
R
R
I
Site 43
S651
A
S
K
F
E
S
G
S
H
P
R
R
I
N
V
Site 44
S659
H
P
R
R
I
N
V
S
P
T
T
Y
Q
L
L
Site 45
Y663
I
N
V
S
P
T
T
Y
Q
L
L
K
R
E
E
Site 46
S671
Q
L
L
K
R
E
E
S
F
T
F
I
P
R
S
Site 47
T673
L
K
R
E
E
S
F
T
F
I
P
R
S
R
E
Site 48
S678
S
F
T
F
I
P
R
S
R
E
E
L
P
D
N
Site 49
T701
C
Y
F
L
E
V
R
T
G
P
K
P
P
K
P
Site 50
S709
G
P
K
P
P
K
P
S
L
S
S
S
R
I
K
Site 51
S711
K
P
P
K
P
S
L
S
S
S
R
I
K
K
V
Site 52
S712
P
P
K
P
S
L
S
S
S
R
I
K
K
V
S
Site 53
S713
P
K
P
S
L
S
S
S
R
I
K
K
V
S
Y
Site 54
S719
S
S
R
I
K
K
V
S
Y
N
I
G
T
M
F
Site 55
Y720
S
R
I
K
K
V
S
Y
N
I
G
T
M
F
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation