PhosphoNET

           
Protein Info 
   
Short Name:  CYP2C19
Full Name:  Cytochrome P450 2C19
Alias:  CP239; CP2CJ; CPCJ; CYP 2C; CYP2C; CYPIIC17; CYPIIC19; EC 1.14.13.48; EC 1.14.13.49; EC 1.14.13.80; EC 1.14.14.1; Mephenytoin 4-hydroxylase; P450-11A; P450-254C; P450C2C; P450IIC19; S-mephenytoin 4-hydroxylase
Type:  Oxidoreductase, Lipid Metabolism group, Linoleic acid metabolism family, Arachidonic acid metabolism family, Biosynthesis of Secondary Metabolites group, Monoterpenoid biosynthesis family
Mass (Da):  55931
Number AA:  490
UniProt ID:  P33261
International Prot ID:  IPI00013323
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005789  GO:0019898  GO:0005792 Uniprot OncoNet
Molecular Function:  GO:0018675  GO:0018676  GO:0033767 PhosphoSite+ KinaseNET
Biological Process:  GO:0017144  GO:0016098  GO:0055114 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S12VVLVLCLSCLLLLSI
Site 2S23LLSIWRQSSGRGKLP
Site 3S24LSIWRQSSGRGKLPP
Site 4T34GKLPPGPTPLPVIGN
Site 5S51QIDIKDVSKSLTNLS
Site 6S53DIKDVSKSLTNLSKI
Site 7T55KDVSKSLTNLSKIYG
Site 8S58SKSLTNLSKIYGPVF
Site 9Y61LTNLSKIYGPVFTLY
Site 10S95IDLGEEFSGRGHFPL
Site 11S115RGFGIVFSNGKRWKE
Site 12S127WKEIRRFSLMTLRNF
Site 13S140NFGMGKRSIEDRVQE
Site 14T159LVEELRKTKASPCDP
Site 15S162ELRKTKASPCDPTFI
Site 16Y189IFQKRFDYKDQQFLN
Site 17Y225NFPTIIDYFPGTHNK
Site 18T229IIDYFPGTHNKLLKN
Site 19S242KNLAFMESDILEKVK
Site 20T304AGTETTSTTLRYALL
Site 21S336RVVGRNRSPCMQDRG
Site 22Y347QDRGHMPYTDAVVHE
Site 23T348DRGHMPYTDAVVHEV
Site 24T371TSLPHAVTCDVKFRN
Site 25Y379CDVKFRNYLIPKGTT
Site 26S393TILTSLTSVLHDNKE
Site 27Y424GNFKKSNYFMPFSAG
Site 28S460LQNFNLKSLIDPKDL
Site 29T469IDPKDLDTTPVVNGF
Site 30T470DPKDLDTTPVVNGFA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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