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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP2C18
Full Name:
Cytochrome P450 2C18
Alias:
CP255; CP2CI; CPCI; CYP2C; CYP2C17; CYPIIC18; Cytochrome P450, family 2, subfamily C, polypeptide 18; P450-6B/29C; P450IIC17
Type:
Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - arachidonic acid; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - metabolism by cytochrome P450
Mass (Da):
55711
Number AA:
490
UniProt ID:
P33260
International Prot ID:
IPI00289647
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0070330
GO:0009055
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
L
S
L
W
R
Q
S
S
G
R
G
R
L
P
Site 2
S24
L
S
L
W
R
Q
S
S
G
R
G
R
L
P
S
Site 3
S31
S
G
R
G
R
L
P
S
G
P
T
P
L
P
I
Site 4
T34
G
R
L
P
S
G
P
T
P
L
P
I
I
G
N
Site 5
S51
Q
L
D
V
K
D
M
S
K
S
L
T
N
F
S
Site 6
S53
D
V
K
D
M
S
K
S
L
T
N
F
S
K
V
Site 7
T55
K
D
M
S
K
S
L
T
N
F
S
K
V
Y
G
Site 8
S58
S
K
S
L
T
N
F
S
K
V
Y
G
P
V
F
Site 9
Y61
L
T
N
F
S
K
V
Y
G
P
V
F
T
V
Y
Site 10
S95
I
D
H
G
E
E
F
S
G
R
G
S
F
P
V
Site 11
S99
E
E
F
S
G
R
G
S
F
P
V
A
E
K
V
Site 12
S115
K
G
L
G
I
L
F
S
N
G
K
R
W
K
E
Site 13
S140
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
Site 14
T159
L
V
E
E
L
R
K
T
N
A
S
P
C
D
P
Site 15
S162
E
L
R
K
T
N
A
S
P
C
D
P
T
F
I
Site 16
Y189
I
F
H
D
R
F
D
Y
K
D
Q
R
F
L
N
Site 17
S209
N
E
N
L
R
I
L
S
S
P
W
I
Q
V
C
Site 18
S210
E
N
L
R
I
L
S
S
P
W
I
Q
V
C
N
Site 19
Y225
N
F
P
A
L
I
D
Y
L
P
G
S
H
N
K
Site 20
S229
L
I
D
Y
L
P
G
S
H
N
K
I
A
E
N
Site 21
S242
E
N
F
A
Y
I
K
S
Y
V
L
E
R
I
K
Site 22
Y243
N
F
A
Y
I
K
S
Y
V
L
E
R
I
K
E
Site 23
S254
R
I
K
E
H
Q
E
S
L
D
M
N
S
A
R
Site 24
S259
Q
E
S
L
D
M
N
S
A
R
D
F
I
D
C
Site 25
T299
T
D
M
F
G
A
G
T
E
T
T
S
T
T
L
Site 26
S303
G
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
Site 27
T304
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
Site 28
T305
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
Site 29
Y316
G
L
L
L
L
L
K
Y
P
E
V
T
A
K
V
Site 30
S336
C
V
V
G
R
N
R
S
P
C
M
Q
D
R
S
Site 31
Y347
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
Site 32
T348
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Site 33
Y358
V
V
H
E
I
Q
R
Y
I
D
L
L
P
T
N
Site 34
Y379
C
D
V
K
F
K
N
Y
L
I
P
K
G
T
T
Site 35
S416
P
G
H
F
L
D
K
S
G
N
F
K
K
S
D
Site 36
S422
K
S
G
N
F
K
K
S
D
Y
F
M
P
F
S
Site 37
Y424
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
Site 38
S460
L
Q
N
F
N
L
K
S
Q
V
D
P
K
D
I
Site 39
T470
D
P
K
D
I
D
I
T
P
I
A
N
A
F
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation