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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIF5B
Full Name:
Kinesin-1 heavy chain
Alias:
Kinesin family member 5B; Kinesin heavy chain; KINH; KNS; KNS1; Ubiquitous kinesin heavy chain; UKHC; U-KHC
Type:
Microtubule binding protein; Motor protein
Mass (Da):
109685
Number AA:
963
UniProt ID:
P33176
International Prot ID:
IPI00012837
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005871
GO:0005874
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008017
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0047496
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
R
F
R
P
L
N
E
S
E
V
N
R
G
D
K
Site 2
Y29
E
V
N
R
G
D
K
Y
I
A
K
F
Q
G
E
Site 3
T38
A
K
F
Q
G
E
D
T
V
V
I
A
S
K
P
Site 4
S54
A
F
D
R
V
F
Q
S
S
T
S
Q
E
Q
V
Site 5
S55
F
D
R
V
F
Q
S
S
T
S
Q
E
Q
V
Y
Site 6
S57
R
V
F
Q
S
S
T
S
Q
E
Q
V
Y
N
D
Site 7
Y84
Y
N
G
T
I
F
A
Y
G
Q
T
S
S
G
K
Site 8
T92
G
Q
T
S
S
G
K
T
H
T
M
E
G
K
L
Site 9
T94
T
S
S
G
K
T
H
T
M
E
G
K
L
H
D
Site 10
Y134
E
F
H
I
K
V
S
Y
F
E
I
Y
L
D
K
Site 11
Y138
K
V
S
Y
F
E
I
Y
L
D
K
I
R
D
L
Site 12
S149
I
R
D
L
L
D
V
S
K
T
N
L
S
V
H
Site 13
T151
D
L
L
D
V
S
K
T
N
L
S
V
H
E
D
Site 14
S154
D
V
S
K
T
N
L
S
V
H
E
D
K
N
R
Site 15
Y164
E
D
K
N
R
V
P
Y
V
K
G
C
T
E
R
Site 16
S175
C
T
E
R
F
V
C
S
P
D
E
V
M
D
T
Site 17
T182
S
P
D
E
V
M
D
T
I
D
E
G
K
S
N
Site 18
S188
D
T
I
D
E
G
K
S
N
R
H
V
A
V
T
Site 19
T195
S
N
R
H
V
A
V
T
N
M
N
E
H
S
S
Site 20
S201
V
T
N
M
N
E
H
S
S
R
S
H
S
I
F
Site 21
S202
T
N
M
N
E
H
S
S
R
S
H
S
I
F
L
Site 22
S204
M
N
E
H
S
S
R
S
H
S
I
F
L
I
N
Site 23
S206
E
H
S
S
R
S
H
S
I
F
L
I
N
V
K
Site 24
T219
V
K
Q
E
N
T
Q
T
E
Q
K
L
S
G
K
Site 25
S224
T
Q
T
E
Q
K
L
S
G
K
L
Y
L
V
D
Site 26
S235
Y
L
V
D
L
A
G
S
E
K
V
S
K
T
G
Site 27
S239
L
A
G
S
E
K
V
S
K
T
G
A
E
G
A
Site 28
S257
E
A
K
N
I
N
K
S
L
S
A
L
G
N
V
Site 29
S259
K
N
I
N
K
S
L
S
A
L
G
N
V
I
S
Site 30
Y274
A
L
A
E
G
S
T
Y
V
P
Y
R
D
S
K
Site 31
Y277
E
G
S
T
Y
V
P
Y
R
D
S
K
M
T
R
Site 32
S280
T
Y
V
P
Y
R
D
S
K
M
T
R
I
L
Q
Site 33
T283
P
Y
R
D
S
K
M
T
R
I
L
Q
D
S
L
Site 34
S289
M
T
R
I
L
Q
D
S
L
G
G
N
C
R
T
Site 35
S303
T
T
I
V
I
C
C
S
P
S
S
Y
N
E
S
Site 36
S305
I
V
I
C
C
S
P
S
S
Y
N
E
S
E
T
Site 37
S306
V
I
C
C
S
P
S
S
Y
N
E
S
E
T
K
Site 38
S310
S
P
S
S
Y
N
E
S
E
T
K
S
T
L
L
Site 39
T312
S
S
Y
N
E
S
E
T
K
S
T
L
L
F
G
Site 40
S314
Y
N
E
S
E
T
K
S
T
L
L
F
G
Q
R
Site 41
T315
N
E
S
E
T
K
S
T
L
L
F
G
Q
R
A
Site 42
Y344
A
E
Q
W
K
K
K
Y
E
K
E
K
E
K
N
Site 43
T357
K
N
K
I
L
R
N
T
I
Q
W
L
E
N
E
Site 44
T397
F
T
V
D
K
D
I
T
L
T
N
D
K
P
A
Site 45
T405
L
T
N
D
K
P
A
T
A
I
G
V
I
G
N
Site 46
T414
I
G
V
I
G
N
F
T
D
A
E
R
R
K
C
Site 47
T451
Q
L
V
E
K
L
K
T
Q
M
L
D
Q
E
E
Site 48
S462
D
Q
E
E
L
L
A
S
T
R
R
D
Q
D
N
Site 49
S484
L
Q
A
E
N
D
A
S
K
E
E
V
K
E
V
Site 50
S506
A
V
N
Y
D
Q
K
S
Q
E
V
E
D
K
T
Site 51
T513
S
Q
E
V
E
D
K
T
K
E
Y
E
L
L
S
Site 52
Y516
V
E
D
K
T
K
E
Y
E
L
L
S
D
E
L
Site 53
S520
T
K
E
Y
E
L
L
S
D
E
L
N
Q
K
S
Site 54
S527
S
D
E
L
N
Q
K
S
A
T
L
A
S
I
D
Site 55
S532
Q
K
S
A
T
L
A
S
I
D
A
E
L
Q
K
Site 56
S557
R
A
A
E
M
M
A
S
L
L
K
D
L
A
E
Site 57
Y593
E
F
T
V
A
R
L
Y
I
S
K
M
K
S
E
Site 58
S595
T
V
A
R
L
Y
I
S
K
M
K
S
E
V
K
Site 59
S599
L
Y
I
S
K
M
K
S
E
V
K
T
M
V
K
Site 60
T603
K
M
K
S
E
V
K
T
M
V
K
R
C
K
Q
Site 61
S613
K
R
C
K
Q
L
E
S
T
Q
T
E
S
N
K
Site 62
T614
R
C
K
Q
L
E
S
T
Q
T
E
S
N
K
K
Site 63
T616
K
Q
L
E
S
T
Q
T
E
S
N
K
K
M
E
Site 64
S637
A
A
C
Q
L
R
I
S
Q
H
E
A
K
I
K
Site 65
S645
Q
H
E
A
K
I
K
S
L
T
E
Y
L
Q
N
Site 66
Y649
K
I
K
S
L
T
E
Y
L
Q
N
V
E
Q
K
Site 67
S663
K
K
R
Q
L
E
E
S
V
D
A
L
S
E
E
Site 68
S668
E
E
S
V
D
A
L
S
E
E
L
V
Q
L
R
Site 69
S707
A
V
E
Q
Q
I
Q
S
H
R
E
T
H
Q
K
Site 70
T711
Q
I
Q
S
H
R
E
T
H
Q
K
Q
I
S
S
Site 71
S717
E
T
H
Q
K
Q
I
S
S
L
R
D
E
V
E
Site 72
S718
T
H
Q
K
Q
I
S
S
L
R
D
E
V
E
A
Site 73
T769
S
R
K
L
H
E
L
T
V
M
Q
D
R
R
E
Site 74
T788
D
L
K
G
L
E
E
T
V
A
K
E
L
Q
T
Site 75
T809
L
F
V
Q
D
L
A
T
R
V
K
K
S
A
E
Site 76
S814
L
A
T
R
V
K
K
S
A
E
I
D
S
D
D
Site 77
S819
K
K
S
A
E
I
D
S
D
D
T
G
G
S
A
Site 78
T822
A
E
I
D
S
D
D
T
G
G
S
A
A
Q
K
Site 79
S825
D
S
D
D
T
G
G
S
A
A
Q
K
Q
K
I
Site 80
S833
A
A
Q
K
Q
K
I
S
F
L
E
N
N
L
E
Site 81
T870
L
E
K
R
L
R
A
T
A
E
R
V
K
A
L
Site 82
Y895
A
S
R
D
R
K
R
Y
Q
Q
E
V
D
R
I
Site 83
S908
R
I
K
E
A
V
R
S
K
N
M
A
R
R
G
Site 84
S917
N
M
A
R
R
G
H
S
A
Q
I
A
K
P
I
Site 85
S933
P
G
Q
H
P
A
A
S
P
T
H
P
S
A
I
Site 86
T935
Q
H
P
A
A
S
P
T
H
P
S
A
I
R
G
Site 87
S938
A
A
S
P
T
H
P
S
A
I
R
G
G
G
A
Site 88
S950
G
G
A
F
V
Q
N
S
Q
P
V
A
V
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation