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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACSL1
Full Name:
Long-chain-fatty-acid--CoA ligase 1
Alias:
ACS1; Acyl-CoA synthetase long-chain family member 1; EC 6.2.1.3; FACL1; FACL2; LACS; LACS 1; LACS 2; LACS1; LACS2; Lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 1; Long-chain acyl-CoA synthetase 2; Long-chain fatty acid CoA ligase 2; Long-chain fatty-acid-coenzyme A ligase 1; Long-chain-fatty-acid-CoA ligase 1; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2
Type:
EC 6.2.1.3; Lipid Metabolism - fatty acid; Ligase
Mass (Da):
77943
Number AA:
698
UniProt ID:
P33121
International Prot ID:
IPI00012728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004467
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007586
GO:0006631
GO:0046320
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
Q
A
H
E
L
F
R
Y
F
R
M
P
E
L
V
Site 2
Y21
E
L
V
D
F
R
Q
Y
V
R
T
L
P
T
N
Site 3
T24
D
F
R
Q
Y
V
R
T
L
P
T
N
T
L
M
Site 4
Y44
A
A
L
T
T
F
W
Y
A
T
R
P
K
P
L
Site 5
S58
L
K
P
P
C
D
L
S
M
Q
S
V
E
V
A
Site 6
S67
Q
S
V
E
V
A
G
S
G
G
A
R
R
S
A
Site 7
S73
G
S
G
G
A
R
R
S
A
L
L
D
S
D
E
Site 8
S78
R
R
S
A
L
L
D
S
D
E
P
L
V
Y
F
Site 9
Y84
D
S
D
E
P
L
V
Y
F
Y
D
D
V
T
T
Site 10
Y86
D
E
P
L
V
Y
F
Y
D
D
V
T
T
L
Y
Site 11
Y93
Y
D
D
V
T
T
L
Y
E
G
F
Q
R
G
I
Site 12
S103
F
Q
R
G
I
Q
V
S
N
N
G
P
C
L
G
Site 13
Y118
S
R
K
P
D
Q
P
Y
E
W
L
S
Y
K
Q
Site 14
S122
D
Q
P
Y
E
W
L
S
Y
K
Q
V
A
E
L
Site 15
Y123
Q
P
Y
E
W
L
S
Y
K
Q
V
A
E
L
S
Site 16
T144
L
I
Q
K
G
F
K
T
A
P
D
Q
F
I
G
Site 17
Y188
L
G
N
E
A
I
T
Y
I
V
N
K
A
E
L
Site 18
T289
N
P
K
G
A
M
V
T
H
R
N
I
V
S
D
Site 19
T307
F
V
K
A
T
E
N
T
V
N
P
C
P
D
D
Site 20
T384
I
F
G
Q
A
N
T
T
L
K
R
W
L
L
D
Site 21
S394
R
W
L
L
D
F
A
S
K
R
K
E
A
E
L
Site 22
S410
S
G
I
I
R
N
N
S
L
W
D
R
L
I
F
Site 23
S423
I
F
H
K
V
Q
S
S
L
G
G
R
V
R
L
Site 24
Y455
A
A
L
G
C
Q
F
Y
E
G
Y
G
Q
T
E
Site 25
T476
L
T
M
P
G
D
W
T
A
G
H
V
G
A
P
Site 26
Y499
V
D
V
E
E
M
N
Y
M
A
A
E
G
E
G
Site 27
Y567
F
K
L
A
Q
G
E
Y
I
A
P
E
K
I
E
Site 28
Y577
P
E
K
I
E
N
I
Y
M
R
S
E
P
V
A
Site 29
S610
P
D
V
E
T
L
C
S
W
A
Q
K
R
G
F
Site 30
S620
Q
K
R
G
F
E
G
S
F
E
E
L
C
R
N
Site 31
S645
M
V
R
L
G
K
D
S
G
L
K
P
F
E
Q
Site 32
T671
S
I
D
N
G
L
L
T
P
T
M
K
A
K
R
Site 33
Y684
K
R
P
E
L
R
N
Y
F
R
S
Q
I
D
D
Site 34
S687
E
L
R
N
Y
F
R
S
Q
I
D
D
L
Y
S
Site 35
Y693
R
S
Q
I
D
D
L
Y
S
T
I
K
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation