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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTH
Full Name:
Cystathionine gamma-lyase
Alias:
CGL; Cystathionase (cystathionine gamma-lyase); EC 4.4.1.1; MGC9471
Type:
Enzyme - Trans-sulfuration
Mass (Da):
44508
Number AA:
405
UniProt ID:
P32929
International Prot ID:
IPI00031557
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004123
GO:0030170
PhosphoSite+
KinaseNET
Biological Process:
GO:0019344
GO:0070814
GO:0051289
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
Q
E
K
D
A
S
S
Q
G
F
L
P
H
Site 2
S8
M
Q
E
K
D
A
S
S
Q
G
F
L
P
H
F
Site 3
S34
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
Site 4
T46
P
P
I
S
L
S
T
T
F
K
Q
G
A
P
G
Site 5
S56
Q
G
A
P
G
Q
H
S
G
F
E
Y
S
R
S
Site 6
Y60
G
Q
H
S
G
F
E
Y
S
R
S
G
N
P
T
Site 7
S61
Q
H
S
G
F
E
Y
S
R
S
G
N
P
T
R
Site 8
S63
S
G
F
E
Y
S
R
S
G
N
P
T
R
N
C
Site 9
T67
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
Site 10
Y114
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
Site 11
T117
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
Site 12
Y120
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
Site 13
S126
R
Y
F
R
Q
V
A
S
E
F
G
L
K
I
S
Site 14
T158
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
Site 15
S192
V
V
D
N
T
F
M
S
P
Y
F
Q
R
P
L
Site 16
Y194
D
N
T
F
M
S
P
Y
F
Q
R
P
L
A
L
Site 17
Y208
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
Site 18
Y213
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
Site 19
S231
L
V
S
V
N
C
E
S
L
H
N
R
L
R
F
Site 20
S242
R
L
R
F
L
Q
N
S
L
G
A
V
P
S
P
Site 21
Y253
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
Site 22
T261
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
Site 23
S282
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
Site 24
Y291
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Site 25
S296
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
Site 26
S377
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
Site 27
S401
L
K
A
A
H
P
P
S
G
S
H
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation