KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HPD
Full Name:
4-hydroxyphenylpyruvate dioxygenase
Alias:
4-hydroxyphenylpyruvic acid oxidase; EC 1.13.11.27; HPPD; PPD
Type:
Enzyme - Oxidoreductase, Amino Acid Metabolism: Phenylalanine,Tyrosine and Histidine
Mass (Da):
44934
Number AA:
393
UniProt ID:
P32754
International Prot ID:
IPI00218297
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003868
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0006559
GO:0055114
GO:0006572
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
T
T
Y
S
D
K
G
A
K
P
Site 2
S34
G
N
A
K
Q
A
A
S
F
Y
C
S
K
M
G
Site 3
Y36
A
K
Q
A
A
S
F
Y
C
S
K
M
G
F
E
Site 4
S38
Q
A
A
S
F
Y
C
S
K
M
G
F
E
P
L
Site 5
Y47
M
G
F
E
P
L
A
Y
R
G
L
E
T
G
S
Site 6
S54
Y
R
G
L
E
T
G
S
R
E
V
V
S
H
V
Site 7
S59
T
G
S
R
E
V
V
S
H
V
I
K
Q
G
K
Site 8
Y105
F
E
V
E
D
C
D
Y
I
V
Q
K
A
R
E
Site 9
T145
T
Y
G
D
T
T
H
T
L
V
E
K
M
N
Y
Site 10
S195
Q
P
D
Q
E
M
V
S
A
S
E
W
Y
L
K
Site 11
S197
D
Q
E
M
V
S
A
S
E
W
Y
L
K
N
L
Site 12
S211
L
Q
F
H
R
F
W
S
V
D
D
T
Q
V
H
Site 13
T219
V
D
D
T
Q
V
H
T
E
Y
S
S
L
R
S
Site 14
Y221
D
T
Q
V
H
T
E
Y
S
S
L
R
S
I
V
Site 15
S222
T
Q
V
H
T
E
Y
S
S
L
R
S
I
V
V
Site 16
S223
Q
V
H
T
E
Y
S
S
L
R
S
I
V
V
A
Site 17
S226
T
E
Y
S
S
L
R
S
I
V
V
A
N
Y
E
Site 18
Y232
R
S
I
V
V
A
N
Y
E
E
S
I
K
M
P
Site 19
S250
P
A
P
G
K
K
K
S
Q
I
Q
E
Y
V
D
Site 20
Y255
K
K
S
Q
I
Q
E
Y
V
D
Y
N
G
G
A
Site 21
Y258
Q
I
Q
E
Y
V
D
Y
N
G
G
A
G
V
Q
Site 22
T276
L
K
T
E
D
I
I
T
A
I
R
H
L
R
E
Site 23
S290
E
R
G
L
E
F
L
S
V
P
S
T
Y
Y
K
Site 24
T294
E
F
L
S
V
P
S
T
Y
Y
K
Q
L
R
E
Site 25
Y295
F
L
S
V
P
S
T
Y
Y
K
Q
L
R
E
K
Site 26
Y296
L
S
V
P
S
T
Y
Y
K
Q
L
R
E
K
L
Site 27
T305
Q
L
R
E
K
L
K
T
A
K
I
K
V
K
E
Site 28
Y326
E
L
K
I
L
V
D
Y
D
E
K
G
Y
L
L
Site 29
T345
K
P
V
Q
D
R
P
T
L
F
L
E
V
I
Q
Site 30
S366
F
G
A
G
N
F
N
S
L
F
K
A
F
E
E
Site 31
T386
G
N
L
T
N
M
E
T
N
G
V
V
P
G
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation