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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCX1
Full Name:
Sodium/calcium exchanger 1
Alias:
CNC; Na/Ca-exchange protein 1; Na+/Ca++ exchanger; NAC1; SLC8A1; Solute carrier family 8 (sodium/calcium exchanger) member 1
Type:
Transport protein
Mass (Da):
108547
Number AA:
973
UniProt ID:
P32418
International Prot ID:
IPI00028450
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0015085
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0060401
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
Y
N
M
R
R
L
S
L
S
P
T
F
S
M
Site 2
S10
N
M
R
R
L
S
L
S
P
T
F
S
M
G
F
Site 3
T12
R
R
L
S
L
S
P
T
F
S
M
G
F
H
L
Site 4
T46
M
E
G
E
G
N
E
T
G
E
C
T
G
S
Y
Site 5
Y53
T
G
E
C
T
G
S
Y
Y
C
K
K
G
V
I
Site 6
Y54
G
E
C
T
G
S
Y
Y
C
K
K
G
V
I
L
Site 7
S70
I
W
E
P
Q
D
P
S
F
G
D
K
I
A
R
Site 8
S108
S
S
I
E
V
I
T
S
Q
E
K
E
I
T
I
Site 9
T114
T
S
Q
E
K
E
I
T
I
K
K
P
N
G
E
Site 10
T125
P
N
G
E
T
T
K
T
T
V
R
I
W
N
E
Site 11
T126
N
G
E
T
T
K
T
T
V
R
I
W
N
E
T
Site 12
T138
N
E
T
V
S
N
L
T
L
M
A
L
G
S
S
Site 13
S145
T
L
M
A
L
G
S
S
A
P
E
I
L
L
S
Site 14
Y259
A
D
R
R
L
L
F
Y
K
Y
V
Y
K
R
Y
Site 15
Y261
R
R
L
L
F
Y
K
Y
V
Y
K
R
Y
R
A
Site 16
Y263
L
L
F
Y
K
Y
V
Y
K
R
Y
R
A
G
K
Site 17
S284
E
H
E
G
D
R
P
S
S
K
T
E
I
E
M
Site 18
S285
H
E
G
D
R
P
S
S
K
T
E
I
E
M
D
Site 19
T287
G
D
R
P
S
S
K
T
E
I
E
M
D
G
K
Site 20
Y351
Q
L
I
E
L
A
N
Y
Q
V
L
S
Q
Q
Q
Site 21
S355
L
A
N
Y
Q
V
L
S
Q
Q
Q
K
S
R
A
Site 22
S360
V
L
S
Q
Q
Q
K
S
R
A
F
Y
R
I
Q
Site 23
Y364
Q
Q
K
S
R
A
F
Y
R
I
Q
A
T
R
L
Site 24
T369
A
F
Y
R
I
Q
A
T
R
L
M
T
G
A
G
Site 25
T373
I
Q
A
T
R
L
M
T
G
A
G
N
I
L
K
Site 26
S392
D
Q
A
R
K
A
V
S
M
H
E
V
N
T
E
Site 27
S407
V
T
E
N
D
P
V
S
K
I
F
F
E
Q
G
Site 28
Y416
I
F
F
E
Q
G
T
Y
Q
C
L
E
N
C
G
Site 29
T439
R
G
G
D
L
T
N
T
V
F
V
D
F
R
T
Site 30
T450
D
F
R
T
E
D
G
T
A
N
A
G
S
D
Y
Site 31
S455
D
G
T
A
N
A
G
S
D
Y
E
F
T
E
G
Site 32
Y457
T
A
N
A
G
S
D
Y
E
F
T
E
G
T
V
Site 33
T463
D
Y
E
F
T
E
G
T
V
V
F
K
P
G
D
Site 34
S496
E
N
F
L
V
H
L
S
N
V
K
V
S
S
E
Site 35
S502
L
S
N
V
K
V
S
S
E
A
S
E
D
G
I
Site 36
S505
V
K
V
S
S
E
A
S
E
D
G
I
L
E
A
Site 37
T528
L
G
S
P
S
T
A
T
V
T
I
F
D
D
D
Site 38
T541
D
D
H
A
G
I
F
T
F
E
E
P
V
T
H
Site 39
T547
F
T
F
E
E
P
V
T
H
V
S
E
S
I
G
Site 40
S564
E
V
K
V
L
R
T
S
G
A
R
G
N
V
I
Site 41
Y574
R
G
N
V
I
V
P
Y
K
T
I
E
G
T
A
Site 42
T580
P
Y
K
T
I
E
G
T
A
R
G
G
G
E
D
Site 43
T591
G
G
E
D
F
E
D
T
C
G
E
L
E
F
Q
Site 44
T605
Q
N
D
E
I
V
K
T
I
S
V
K
V
I
D
Site 45
Y616
K
V
I
D
D
E
E
Y
E
K
N
K
T
F
F
Site 46
T621
E
E
Y
E
K
N
K
T
F
F
L
E
I
G
E
Site 47
S635
E
P
R
L
V
E
M
S
E
K
K
A
L
L
L
Site 48
Y682
V
I
T
I
A
D
E
Y
D
D
K
Q
P
L
T
Site 49
Y720
E
V
I
I
E
E
S
Y
E
F
K
S
T
V
D
Site 50
S724
E
E
S
Y
E
F
K
S
T
V
D
K
L
I
K
Site 51
T725
E
S
Y
E
F
K
S
T
V
D
K
L
I
K
K
Site 52
S743
A
L
V
V
G
T
N
S
W
R
E
Q
F
I
E
Site 53
T753
E
Q
F
I
E
A
I
T
V
S
A
G
E
D
D
Site 54
S834
C
T
I
G
L
K
D
S
V
T
A
V
V
F
V
Site 55
Y862
V
A
A
T
Q
D
Q
Y
A
D
A
S
I
G
N
Site 56
S866
Q
D
Q
Y
A
D
A
S
I
G
N
V
T
G
S
Site 57
Y892
A
W
S
I
A
A
I
Y
H
A
A
N
G
E
Q
Site 58
S903
N
G
E
Q
F
K
V
S
P
G
T
L
A
F
S
Site 59
T942
G
E
L
G
G
P
R
T
A
K
L
L
T
S
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation