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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OTX2
Full Name:
Homeobox protein OTX2
Alias:
Orthodenticle homolog 2
Type:
Mass (Da):
31636
Number AA:
289
UniProt ID:
P32243
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
S
Y
L
K
Q
P
P
Y
A
V
N
G
L
S
L
Site 2
S16
P
Y
A
V
N
G
L
S
L
T
T
S
G
M
D
Site 3
T18
A
V
N
G
L
S
L
T
T
S
G
M
D
L
L
Site 4
S20
N
G
L
S
L
T
T
S
G
M
D
L
L
H
P
Site 5
S28
G
M
D
L
L
H
P
S
V
G
Y
P
A
T
P
Site 6
Y31
L
L
H
P
S
V
G
Y
P
A
T
P
R
K
Q
Site 7
T34
P
S
V
G
Y
P
A
T
P
R
K
Q
R
R
E
Site 8
T43
R
K
Q
R
R
E
R
T
T
F
T
R
A
Q
L
Site 9
T44
K
Q
R
R
E
R
T
T
F
T
R
A
Q
L
D
Site 10
Y62
A
L
F
A
K
T
R
Y
P
D
I
F
M
R
E
Site 11
S80
L
K
I
N
L
P
E
S
R
V
Q
V
W
F
K
Site 12
S116
R
P
A
K
K
K
T
S
P
A
R
E
V
S
S
Site 13
S122
T
S
P
A
R
E
V
S
S
E
S
G
T
S
G
Site 14
S123
S
P
A
R
E
V
S
S
E
S
G
T
S
G
Q
Site 15
T127
E
V
S
S
E
S
G
T
S
G
Q
F
T
P
P
Site 16
S128
V
S
S
E
S
G
T
S
G
Q
F
T
P
P
S
Site 17
T132
S
G
T
S
G
Q
F
T
P
P
S
S
T
S
V
Site 18
S135
S
G
Q
F
T
P
P
S
S
T
S
V
P
T
I
Site 19
S136
G
Q
F
T
P
P
S
S
T
S
V
P
T
I
A
Site 20
S138
F
T
P
P
S
S
T
S
V
P
T
I
A
S
S
Site 21
T141
P
S
S
T
S
V
P
T
I
A
S
S
S
A
P
Site 22
S161
P
A
S
I
S
P
L
S
D
P
L
S
T
S
S
Site 23
S165
S
P
L
S
D
P
L
S
T
S
S
S
C
M
Q
Site 24
S167
L
S
D
P
L
S
T
S
S
S
C
M
Q
R
S
Site 25
S168
S
D
P
L
S
T
S
S
S
C
M
Q
R
S
Y
Site 26
S169
D
P
L
S
T
S
S
S
C
M
Q
R
S
Y
P
Site 27
Y175
S
S
C
M
Q
R
S
Y
P
M
T
Y
T
Q
A
Site 28
T178
M
Q
R
S
Y
P
M
T
Y
T
Q
A
S
G
Y
Site 29
Y179
Q
R
S
Y
P
M
T
Y
T
Q
A
S
G
Y
S
Site 30
T180
R
S
Y
P
M
T
Y
T
Q
A
S
G
Y
S
Q
Site 31
S183
P
M
T
Y
T
Q
A
S
G
Y
S
Q
G
Y
A
Site 32
Y189
A
S
G
Y
S
Q
G
Y
A
G
S
T
S
Y
F
Site 33
S192
Y
S
Q
G
Y
A
G
S
T
S
Y
F
G
G
M
Site 34
Y195
G
Y
A
G
S
T
S
Y
F
G
G
M
D
C
G
Site 35
Y204
G
G
M
D
C
G
S
Y
L
T
P
M
H
H
Q
Site 36
T218
Q
L
P
G
P
G
A
T
L
S
P
M
G
T
N
Site 37
S229
M
G
T
N
A
V
T
S
H
L
N
Q
S
P
A
Site 38
S234
V
T
S
H
L
N
Q
S
P
A
S
L
S
T
Q
Site 39
S237
H
L
N
Q
S
P
A
S
L
S
T
Q
G
Y
G
Site 40
S239
N
Q
S
P
A
S
L
S
T
Q
G
Y
G
A
S
Site 41
S246
S
T
Q
G
Y
G
A
S
S
L
G
F
N
S
T
Site 42
S247
T
Q
G
Y
G
A
S
S
L
G
F
N
S
T
T
Site 43
S252
A
S
S
L
G
F
N
S
T
T
D
C
L
D
Y
Site 44
T253
S
S
L
G
F
N
S
T
T
D
C
L
D
Y
K
Site 45
Y259
S
T
T
D
C
L
D
Y
K
D
Q
T
A
S
W
Site 46
Y277
F
N
A
D
C
L
D
Y
K
D
Q
T
S
S
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation