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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPS1
Full Name:
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Alias:
Carbamoyl-phosphate synthetase I; CPSase I; CPSM; EC 6.3.4.16
Type:
Intracellular, Mitochondrion protein
Mass (Da):
164939
Number AA:
1500
UniProt ID:
P31327
International Prot ID:
IPI00011062
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042645
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004087
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0070409
GO:0019240
GO:0006541
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
R
P
G
I
R
L
L
S
V
K
A
Q
T
A
H
Site 2
T54
H
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
Site 3
Y59
D
G
T
K
M
K
G
Y
S
F
G
H
P
S
S
Site 4
S60
G
T
K
M
K
G
Y
S
F
G
H
P
S
S
V
Site 5
Y80
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
Site 6
Y89
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
Site 7
T109
G
N
G
G
A
P
D
T
T
A
L
D
E
L
G
Site 8
T110
N
G
G
A
P
D
T
T
A
L
D
E
L
G
L
Site 9
S118
A
L
D
E
L
G
L
S
K
Y
L
E
S
N
G
Site 10
Y120
D
E
L
G
L
S
K
Y
L
E
S
N
G
I
K
Site 11
S123
G
L
S
K
Y
L
E
S
N
G
I
K
V
S
G
Site 12
Y136
S
G
L
L
V
L
D
Y
S
K
D
Y
N
H
W
Site 13
Y140
V
L
D
Y
S
K
D
Y
N
H
W
L
A
T
K
Site 14
Y162
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
Site 15
T170
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
Site 16
T178
K
I
I
R
D
K
G
T
M
L
G
K
I
E
F
Site 17
S205
Q
N
L
I
A
E
V
S
T
K
D
V
K
V
Y
Site 18
Y212
S
T
K
D
V
K
V
Y
G
K
G
N
P
T
K
Site 19
S284
N
V
R
K
I
L
E
S
D
R
K
E
P
L
F
Site 20
S294
K
E
P
L
F
G
I
S
T
G
N
L
I
T
G
Site 21
T295
E
P
L
F
G
I
S
T
G
N
L
I
T
G
L
Site 22
T308
G
L
A
A
G
A
K
T
Y
K
M
S
M
A
N
Site 23
T344
H
G
Y
A
L
D
N
T
L
P
A
G
W
K
P
Site 24
T381
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Site 25
T387
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
Site 26
Y389
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
S
Site 27
S393
D
T
E
Y
L
F
D
S
F
F
S
L
I
K
K
Site 28
T404
L
I
K
K
G
K
A
T
T
I
T
S
V
L
P
Site 29
T405
I
K
K
G
K
A
T
T
I
T
S
V
L
P
K
Site 30
S430
S
K
V
L
I
L
G
S
G
G
L
S
I
G
Q
Site 31
Y443
G
Q
A
G
E
F
D
Y
S
G
S
Q
A
V
K
Site 32
S444
Q
A
G
E
F
D
Y
S
G
S
Q
A
V
K
A
Site 33
S446
G
E
F
D
Y
S
G
S
Q
A
V
K
A
M
K
Site 34
T459
M
K
E
E
N
V
K
T
V
L
M
N
P
N
I
Site 35
T488
T
V
Y
F
L
P
I
T
P
Q
F
V
T
E
V
Site 36
Y529
K
R
G
V
L
K
E
Y
G
V
K
V
L
G
T
Site 37
S537
G
V
K
V
L
G
T
S
V
E
S
I
M
A
T
Site 38
T544
S
V
E
S
I
M
A
T
E
D
R
Q
L
F
S
Site 39
S588
G
Y
P
V
M
I
R
S
A
Y
A
L
G
G
L
Site 40
Y590
P
V
M
I
R
S
A
Y
A
L
G
G
L
G
S
Site 41
S597
Y
A
L
G
G
L
G
S
G
I
C
P
N
R
E
Site 42
T605
G
I
C
P
N
R
E
T
L
M
D
L
S
T
K
Site 43
T611
E
T
L
M
D
L
S
T
K
A
F
A
M
T
N
Site 44
S625
N
Q
I
L
V
E
K
S
V
T
G
W
K
E
I
Site 45
T627
I
L
V
E
K
S
V
T
G
W
K
E
I
E
Y
Site 46
Y634
T
G
W
K
E
I
E
Y
E
V
V
R
D
A
D
Site 47
T683
E
F
Q
M
L
R
R
T
S
I
N
V
V
R
H
Site 48
S684
F
Q
M
L
R
R
T
S
I
N
V
V
R
H
L
Site 49
S720
I
E
V
N
A
R
L
S
R
S
S
A
L
A
S
Site 50
S722
V
N
A
R
L
S
R
S
S
A
L
A
S
K
A
Site 51
S723
N
A
R
L
S
R
S
S
A
L
A
S
K
A
T
Site 52
S727
S
R
S
S
A
L
A
S
K
A
T
G
Y
P
L
Site 53
Y732
L
A
S
K
A
T
G
Y
P
L
A
F
I
A
A
Site 54
S755
P
E
I
K
N
V
V
S
G
K
T
S
A
C
F
Site 55
S765
T
S
A
C
F
E
P
S
L
D
Y
M
V
T
K
Site 56
Y768
C
F
E
P
S
L
D
Y
M
V
T
K
I
P
R
Site 57
T771
P
S
L
D
Y
M
V
T
K
I
P
R
W
D
L
Site 58
T784
D
L
D
R
F
H
G
T
S
S
R
I
G
S
S
Site 59
S785
L
D
R
F
H
G
T
S
S
R
I
G
S
S
M
Site 60
S786
D
R
F
H
G
T
S
S
R
I
G
S
S
M
K
Site 61
S790
G
T
S
S
R
I
G
S
S
M
K
S
V
G
E
Site 62
S791
T
S
S
R
I
G
S
S
M
K
S
V
G
E
V
Site 63
T804
E
V
M
A
I
G
R
T
F
E
E
S
F
Q
K
Site 64
S808
I
G
R
T
F
E
E
S
F
Q
K
A
L
R
M
Site 65
S819
A
L
R
M
C
H
P
S
I
E
G
F
T
P
R
Site 66
T824
H
P
S
I
E
G
F
T
P
R
L
P
M
N
K
Site 67
S835
P
M
N
K
E
W
P
S
N
L
D
L
R
K
E
Site 68
S844
L
D
L
R
K
E
L
S
E
P
S
S
T
R
I
Site 69
S847
R
K
E
L
S
E
P
S
S
T
R
I
Y
A
I
Site 70
S848
K
E
L
S
E
P
S
S
T
R
I
Y
A
I
A
Site 71
T849
E
L
S
E
P
S
S
T
R
I
Y
A
I
A
K
Site 72
Y852
E
P
S
S
T
R
I
Y
A
I
A
K
A
I
D
Site 73
S863
K
A
I
D
D
N
M
S
L
D
E
I
E
K
L
Site 74
Y872
D
E
I
E
K
L
T
Y
I
D
K
W
F
L
Y
Site 75
Y879
Y
I
D
K
W
F
L
Y
K
M
R
D
I
L
N
Site 76
T890
D
I
L
N
M
E
K
T
L
K
G
L
N
S
E
Site 77
S896
K
T
L
K
G
L
N
S
E
S
M
T
E
E
T
Site 78
S898
L
K
G
L
N
S
E
S
M
T
E
E
T
L
K
Site 79
T900
G
L
N
S
E
S
M
T
E
E
T
L
K
R
A
Site 80
S913
R
A
K
E
I
G
F
S
D
K
Q
I
S
K
C
Site 81
S918
G
F
S
D
K
Q
I
S
K
C
L
G
L
T
E
Site 82
T924
I
S
K
C
L
G
L
T
E
A
Q
T
R
E
L
Site 83
T946
P
W
V
K
Q
I
D
T
L
A
A
E
Y
P
S
Site 84
Y957
E
Y
P
S
V
T
N
Y
L
Y
V
T
Y
N
G
Site 85
Y959
P
S
V
T
N
Y
L
Y
V
T
Y
N
G
Q
E
Site 86
T1002
C
A
V
S
S
I
R
T
L
R
Q
L
G
K
K
Site 87
T1010
L
R
Q
L
G
K
K
T
V
V
V
N
C
N
P
Site 88
T1019
V
V
N
C
N
P
E
T
V
S
T
D
F
D
E
Site 89
T1022
C
N
P
E
T
V
S
T
D
F
D
E
C
D
K
Site 90
Y1031
F
D
E
C
D
K
L
Y
F
E
E
L
S
L
E
Site 91
Y1044
L
E
R
I
L
D
I
Y
H
Q
E
A
C
G
G
Site 92
S1055
A
C
G
G
C
I
I
S
V
G
G
Q
I
P
N
Site 93
Y1069
N
N
L
A
V
P
L
Y
K
N
G
V
K
I
M
Site 94
T1078
N
G
V
K
I
M
G
T
S
P
L
Q
I
D
R
Site 95
S1079
G
V
K
I
M
G
T
S
P
L
Q
I
D
R
A
Site 96
S1090
I
D
R
A
E
D
R
S
I
F
S
A
V
L
D
Site 97
Y1124
E
F
A
K
S
V
D
Y
P
C
L
L
R
P
S
Site 98
S1137
P
S
Y
V
L
S
G
S
A
M
N
V
V
F
S
Site 99
S1144
S
A
M
N
V
V
F
S
E
D
E
M
K
K
F
Site 100
S1159
L
E
E
A
T
R
V
S
Q
E
H
P
V
V
L
Site 101
S1189
G
K
D
G
R
V
I
S
H
A
I
S
E
H
V
Site 102
S1193
R
V
I
S
H
A
I
S
E
H
V
E
D
A
G
Site 103
T1207
G
V
H
S
G
D
A
T
L
M
L
P
T
Q
T
Site 104
S1261
I
E
C
N
L
R
A
S
R
S
F
P
F
V
S
Site 105
S1263
C
N
L
R
A
S
R
S
F
P
F
V
S
K
T
Site 106
T1295
V
D
E
K
H
L
P
T
L
D
H
P
I
I
P
Site 107
Y1305
H
P
I
I
P
A
D
Y
V
A
I
K
A
P
M
Site 108
S1314
A
I
K
A
P
M
F
S
W
P
R
L
R
D
A
Site 109
T1391
E
G
F
K
L
F
A
T
E
A
T
S
D
W
L
Site 110
T1406
N
A
N
N
V
P
A
T
P
V
A
W
P
S
Q
Site 111
S1412
A
T
P
V
A
W
P
S
Q
E
G
Q
N
P
S
Site 112
S1419
S
Q
E
G
Q
N
P
S
L
S
S
I
R
K
L
Site 113
S1421
E
G
Q
N
P
S
L
S
S
I
R
K
L
I
R
Site 114
S1422
G
Q
N
P
S
L
S
S
I
R
K
L
I
R
D
Site 115
Y1450
T
K
F
V
H
D
N
Y
V
I
R
R
T
A
V
Site 116
T1455
D
N
Y
V
I
R
R
T
A
V
D
S
G
I
P
Site 117
S1480
F
A
E
A
V
Q
K
S
R
K
V
D
S
K
S
Site 118
S1485
Q
K
S
R
K
V
D
S
K
S
L
F
H
Y
R
Site 119
S1487
S
R
K
V
D
S
K
S
L
F
H
Y
R
Q
Y
Site 120
Y1491
D
S
K
S
L
F
H
Y
R
Q
Y
S
A
G
K
Site 121
Y1494
S
L
F
H
Y
R
Q
Y
S
A
G
K
A
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation