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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKLR
Full Name:
Pyruvate kinase isozymes R/L
Alias:
KPYR; PK1; PK1, PKL; PKL; Pyruvate kinase 1; Pyruvate kinase R/L; Pyruvate kinase, liver and RBC; Red cell/liver pyruvate kinase; R-type/L-type pyruvate kinase
Type:
Nucleotide Metabolism - purine; EC 2.7.1.40; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase (non-protein); Carbohydrate Metabolism - pyruvate
Mass (Da):
61830
Number AA:
574
UniProt ID:
P30613
International Prot ID:
IPI00027165
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
I
Q
E
N
I
S
S
L
Q
L
R
S
W
V
Site 2
S14
I
S
S
L
Q
L
R
S
W
V
S
K
S
Q
R
Site 3
S19
L
R
S
W
V
S
K
S
Q
R
D
L
A
K
S
Site 4
S26
S
Q
R
D
L
A
K
S
I
L
I
G
A
P
G
Site 5
Y38
A
P
G
G
P
A
G
Y
L
R
R
A
S
V
A
Site 6
S43
A
G
Y
L
R
R
A
S
V
A
Q
L
T
Q
E
Site 7
T48
R
A
S
V
A
Q
L
T
Q
E
L
G
T
A
F
Site 8
T53
Q
L
T
Q
E
L
G
T
A
F
F
Q
Q
Q
Q
Site 9
S89
P
V
A
A
R
S
T
S
I
I
A
T
I
G
P
Site 10
T93
R
S
T
S
I
I
A
T
I
G
P
A
S
R
S
Site 11
S98
I
A
T
I
G
P
A
S
R
S
V
E
R
L
K
Site 12
S100
T
I
G
P
A
S
R
S
V
E
R
L
K
E
M
Site 13
Y126
F
S
H
G
S
H
E
Y
H
A
E
S
I
A
N
Site 14
S140
N
V
R
E
A
V
E
S
F
A
G
S
P
L
S
Site 15
Y148
F
A
G
S
P
L
S
Y
R
P
V
A
I
A
L
Site 16
T157
P
V
A
I
A
L
D
T
K
G
P
E
I
R
T
Site 17
S173
I
L
Q
G
G
P
E
S
E
V
E
L
V
K
G
Site 18
T199
R
T
R
G
N
A
N
T
V
W
V
D
Y
P
N
Site 19
Y218
V
P
V
G
G
R
I
Y
I
D
D
G
L
I
S
Site 20
S292
A
S
F
V
R
K
A
S
D
V
A
A
V
R
A
Site 21
T379
Q
M
L
E
S
M
I
T
K
P
R
P
T
R
A
Site 22
T384
M
I
T
K
P
R
P
T
R
A
E
T
S
D
V
Site 23
T388
P
R
P
T
R
A
E
T
S
D
V
A
N
A
V
Site 24
S405
G
A
D
C
I
M
L
S
G
E
T
A
K
G
N
Site 25
Y433
R
E
A
E
A
A
V
Y
H
R
Q
L
F
E
E
Site 26
S448
L
R
R
A
A
P
L
S
R
D
P
T
E
V
T
Site 27
T452
A
P
L
S
R
D
P
T
E
V
T
A
I
G
A
Site 28
S485
G
R
S
A
Q
L
L
S
R
Y
R
P
R
A
A
Site 29
Y517
R
G
V
F
P
L
L
Y
R
E
P
P
E
A
I
Site 30
S539
R
V
Q
F
G
I
E
S
G
K
L
R
G
F
L
Site 31
T556
G
D
L
V
I
V
V
T
G
W
R
P
G
S
G
Site 32
S562
V
T
G
W
R
P
G
S
G
Y
T
N
I
M
R
Site 33
Y564
G
W
R
P
G
S
G
Y
T
N
I
M
R
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation