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Updated November 2019
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Protein Info
Short Name:
RbBP2
Full Name:
Lysine-specific demethylase 5A
Alias:
EC 1.14.11.-;; Histone demethylase JARID1A; JAD1A; JARID1A; Jumonji/ARID domain-containing protein 1A; Lysine (K)-specific demethylase 5A; RBB2; RBBP2; RBBP-2; RBP2; Retinoblastoma-binding protein 2
Type:
Transcription factor; EC 1.14.11.-; Oxidoreductase
Mass (Da):
192095
Number AA:
1690
UniProt ID:
P29375
International Prot ID:
IPI00021363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0016702
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0007275
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
E
C
P
V
F
E
P
S
W
E
E
F
T
D
P
Site 2
T30
E
P
S
W
E
E
F
T
D
P
L
S
F
I
G
Site 3
S34
E
E
F
T
D
P
L
S
F
I
G
R
I
R
P
Site 4
T46
I
R
P
L
A
E
K
T
G
I
C
K
I
R
P
Site 5
S67
P
F
A
C
E
V
K
S
F
R
F
T
P
R
V
Site 6
T71
E
V
K
S
F
R
F
T
P
R
V
Q
R
L
N
Site 7
T134
K
G
G
F
E
M
V
T
K
E
K
K
W
S
K
Site 8
S140
V
T
K
E
K
K
W
S
K
V
G
S
R
L
G
Site 9
S144
K
K
W
S
K
V
G
S
R
L
G
Y
L
P
G
Site 10
Y148
K
V
G
S
R
L
G
Y
L
P
G
K
G
T
G
Site 11
S156
L
P
G
K
G
T
G
S
L
L
K
S
H
Y
E
Site 12
S160
G
T
G
S
L
L
K
S
H
Y
E
R
I
L
Y
Site 13
Y162
G
S
L
L
K
S
H
Y
E
R
I
L
Y
P
Y
Site 14
Y167
S
H
Y
E
R
I
L
Y
P
Y
E
L
F
Q
S
Site 15
Y169
Y
E
R
I
L
Y
P
Y
E
L
F
Q
S
G
V
Site 16
S198
K
V
E
P
E
V
L
S
T
D
T
Q
T
S
P
Site 17
T199
V
E
P
E
V
L
S
T
D
T
Q
T
S
P
E
Site 18
S204
L
S
T
D
T
Q
T
S
P
E
P
G
T
R
M
Site 19
T223
K
R
T
R
R
V
K
T
Q
S
E
S
G
D
V
Site 20
S225
T
R
R
V
K
T
Q
S
E
S
G
D
V
S
R
Site 21
S227
R
V
K
T
Q
S
E
S
G
D
V
S
R
N
T
Site 22
S231
Q
S
E
S
G
D
V
S
R
N
T
E
L
K
K
Site 23
T234
S
G
D
V
S
R
N
T
E
L
K
K
L
Q
I
Site 24
T263
K
D
K
E
D
E
V
T
R
R
R
K
V
T
N
Site 25
T269
V
T
R
R
R
K
V
T
N
R
S
D
A
F
N
Site 26
T285
Q
M
R
Q
R
K
G
T
L
S
V
N
F
V
D
Site 27
S287
R
Q
R
K
G
T
L
S
V
N
F
V
D
L
Y
Site 28
S346
K
C
V
A
E
E
C
S
K
P
R
E
A
F
G
Site 29
Y361
F
E
Q
A
V
R
E
Y
T
L
Q
S
F
G
E
Site 30
T362
E
Q
A
V
R
E
Y
T
L
Q
S
F
G
E
M
Site 31
S365
V
R
E
Y
T
L
Q
S
F
G
E
M
A
D
N
Site 32
Y377
A
D
N
F
K
S
D
Y
F
N
M
P
V
H
M
Site 33
S399
K
E
F
W
R
L
V
S
S
I
E
E
D
V
I
Site 34
Y409
E
E
D
V
I
V
E
Y
G
A
D
I
S
S
K
Site 35
S414
V
E
Y
G
A
D
I
S
S
K
D
F
G
S
G
Site 36
S415
E
Y
G
A
D
I
S
S
K
D
F
G
S
G
F
Site 37
S420
I
S
S
K
D
F
G
S
G
F
P
V
K
D
G
Site 38
Y438
I
L
P
E
E
E
E
Y
A
L
S
G
W
N
L
Site 39
Y504
W
G
E
P
K
T
W
Y
G
V
P
S
H
A
A
Site 40
S528
L
A
P
E
L
F
E
S
Q
P
D
L
L
H
Q
Site 41
Y553
M
E
H
G
V
P
V
Y
R
T
N
Q
C
A
G
Site 42
Y570
V
V
T
F
P
R
A
Y
H
S
G
F
N
Q
G
Site 43
Y602
G
R
Q
C
V
N
H
Y
R
R
L
R
R
H
C
Site 44
S612
L
R
R
H
C
V
F
S
H
E
E
L
I
F
K
Site 45
S652
E
E
T
R
L
R
E
S
V
V
Q
M
G
V
L
Site 46
Y701
P
E
R
L
V
C
L
Y
H
P
T
D
L
C
P
Site 47
Y718
M
Q
K
K
C
L
R
Y
R
Y
P
L
E
D
L
Site 48
Y720
K
K
C
L
R
Y
R
Y
P
L
E
D
L
P
S
Site 49
Y730
E
D
L
P
S
L
L
Y
G
V
K
V
R
A
Q
Site 50
S738
G
V
K
V
R
A
Q
S
Y
D
T
W
V
S
R
Site 51
T747
D
T
W
V
S
R
V
T
E
A
L
S
A
N
F
Site 52
Y775
E
D
A
E
D
R
K
Y
P
E
N
D
L
F
R
Site 53
S803
S
V
A
Q
L
L
L
S
K
K
Q
K
H
R
Q
Site 54
S811
K
K
Q
K
H
R
Q
S
P
D
S
G
R
T
R
Site 55
S814
K
H
R
Q
S
P
D
S
G
R
T
R
T
K
L
Site 56
T819
P
D
S
G
R
T
R
T
K
L
T
V
E
E
L
Site 57
T822
G
R
T
R
T
K
L
T
V
E
E
L
K
A
F
Site 58
S841
F
S
L
P
C
V
I
S
Q
A
R
Q
V
K
N
Site 59
T868
Q
E
A
M
M
D
E
T
P
D
S
S
K
L
Q
Site 60
S871
M
M
D
E
T
P
D
S
S
K
L
Q
M
L
I
Site 61
S872
M
D
E
T
P
D
S
S
K
L
Q
M
L
I
D
Site 62
T910
W
L
D
E
V
R
L
T
L
S
D
P
Q
Q
V
Site 63
S912
D
E
V
R
L
T
L
S
D
P
Q
Q
V
T
L
Site 64
T918
L
S
D
P
Q
Q
V
T
L
D
V
M
K
K
L
Site 65
T950
A
E
L
Q
E
L
L
T
V
S
E
R
W
E
E
Site 66
S952
L
Q
E
L
L
T
V
S
E
R
W
E
E
K
A
Site 67
S970
L
Q
A
R
P
R
H
S
V
A
S
L
E
S
I
Site 68
S973
R
P
R
H
S
V
A
S
L
E
S
I
V
N
E
Site 69
T1005
L
Q
K
A
R
E
W
T
A
K
V
E
A
I
Q
Site 70
S1013
A
K
V
E
A
I
Q
S
G
S
N
Y
A
Y
L
Site 71
Y1017
A
I
Q
S
G
S
N
Y
A
Y
L
E
Q
L
E
Site 72
Y1019
Q
S
G
S
N
Y
A
Y
L
E
Q
L
E
S
L
Site 73
S1025
A
Y
L
E
Q
L
E
S
L
S
A
K
G
R
P
Site 74
S1027
L
E
Q
L
E
S
L
S
A
K
G
R
P
I
P
Site 75
S1045
E
A
L
P
Q
V
E
S
Q
V
A
A
A
R
A
Site 76
T1057
A
R
A
W
R
E
R
T
G
R
T
F
L
K
K
Site 77
T1060
W
R
E
R
T
G
R
T
F
L
K
K
N
S
S
Site 78
S1066
R
T
F
L
K
K
N
S
S
H
T
L
L
Q
V
Site 79
S1067
T
F
L
K
K
N
S
S
H
T
L
L
Q
V
L
Site 80
Y1083
P
R
T
D
I
G
V
Y
G
S
G
K
N
R
R
Site 81
S1085
T
D
I
G
V
Y
G
S
G
K
N
R
R
K
K
Site 82
S1111
D
L
D
L
E
P
L
S
D
L
E
E
G
L
E
Site 83
S1143
K
E
I
E
A
M
H
S
L
R
A
A
N
L
A
Site 84
S1194
S
C
V
P
L
P
K
S
S
S
Q
K
K
G
S
Site 85
S1195
C
V
P
L
P
K
S
S
S
Q
K
K
G
S
S
Site 86
S1196
V
P
L
P
K
S
S
S
Q
K
K
G
S
S
W
Site 87
S1218
L
C
P
L
C
M
R
S
R
R
P
R
L
E
T
Site 88
T1225
S
R
R
P
R
L
E
T
I
L
S
L
L
V
S
Site 89
T1250
G
E
A
L
Q
C
L
T
E
R
A
M
S
W
Q
Site 90
S1255
C
L
T
E
R
A
M
S
W
Q
D
R
A
R
Q
Site 91
T1266
R
A
R
Q
A
L
A
T
D
E
L
S
S
A
L
Site 92
T1292
E
Q
A
A
R
E
K
T
E
K
I
I
S
A
E
Site 93
S1315
D
L
Q
G
H
L
P
S
F
Q
Q
S
A
F
N
Site 94
S1319
H
L
P
S
F
Q
Q
S
A
F
N
R
V
V
S
Site 95
S1326
S
A
F
N
R
V
V
S
S
V
S
S
S
P
R
Site 96
S1327
A
F
N
R
V
V
S
S
V
S
S
S
P
R
Q
Site 97
S1329
N
R
V
V
S
S
V
S
S
S
P
R
Q
T
M
Site 98
S1330
R
V
V
S
S
V
S
S
S
P
R
Q
T
M
D
Site 99
S1331
V
V
S
S
V
S
S
S
P
R
Q
T
M
D
Y
Site 100
T1335
V
S
S
S
P
R
Q
T
M
D
Y
D
D
E
E
Site 101
Y1338
S
P
R
Q
T
M
D
Y
D
D
E
E
T
D
S
Site 102
T1343
M
D
Y
D
D
E
E
T
D
S
D
E
D
I
R
Site 103
S1345
Y
D
D
E
E
T
D
S
D
E
D
I
R
E
T
Site 104
T1352
S
D
E
D
I
R
E
T
Y
G
Y
D
M
K
D
Site 105
Y1353
D
E
D
I
R
E
T
Y
G
Y
D
M
K
D
T
Site 106
Y1355
D
I
R
E
T
Y
G
Y
D
M
K
D
T
A
S
Site 107
T1360
Y
G
Y
D
M
K
D
T
A
S
V
K
S
S
S
Site 108
S1362
Y
D
M
K
D
T
A
S
V
K
S
S
S
S
L
Site 109
S1365
K
D
T
A
S
V
K
S
S
S
S
L
E
P
N
Site 110
S1366
D
T
A
S
V
K
S
S
S
S
L
E
P
N
L
Site 111
S1368
A
S
V
K
S
S
S
S
L
E
P
N
L
F
C
Site 112
S1383
D
E
E
I
P
I
K
S
E
E
V
V
T
H
M
Site 113
T1388
I
K
S
E
E
V
V
T
H
M
W
T
A
P
S
Site 114
Y1402
S
F
C
A
E
H
A
Y
S
S
A
S
K
S
C
Site 115
S1403
F
C
A
E
H
A
Y
S
S
A
S
K
S
C
S
Site 116
S1404
C
A
E
H
A
Y
S
S
A
S
K
S
C
S
Q
Site 117
S1406
E
H
A
Y
S
S
A
S
K
S
C
S
Q
G
S
Site 118
S1408
A
Y
S
S
A
S
K
S
C
S
Q
G
S
S
T
Site 119
S1410
S
S
A
S
K
S
C
S
Q
G
S
S
T
P
R
Site 120
S1413
S
K
S
C
S
Q
G
S
S
T
P
R
K
Q
P
Site 121
S1414
K
S
C
S
Q
G
S
S
T
P
R
K
Q
P
R
Site 122
T1415
S
C
S
Q
G
S
S
T
P
R
K
Q
P
R
K
Site 123
S1423
P
R
K
Q
P
R
K
S
P
L
V
P
R
S
L
Site 124
S1429
K
S
P
L
V
P
R
S
L
E
P
P
V
L
E
Site 125
S1438
E
P
P
V
L
E
L
S
P
G
A
K
A
Q
L
Site 126
T1462
L
E
V
S
L
D
E
T
Q
H
I
W
R
I
L
Site 127
T1472
I
W
R
I
L
Q
A
T
H
P
P
S
E
D
R
Site 128
S1476
L
Q
A
T
H
P
P
S
E
D
R
F
L
H
I
Site 129
S1488
L
H
I
M
E
D
D
S
M
E
E
K
P
L
K
Site 130
S1502
K
V
K
G
K
D
S
S
E
K
K
R
K
R
K
Site 131
S1524
F
G
E
G
K
Q
K
S
K
E
L
K
K
M
D
Site 132
S1545
L
K
L
G
A
D
K
S
K
E
L
N
K
L
A
Site 133
S1593
K
K
V
L
D
I
P
S
K
Y
D
W
S
G
A
Site 134
Y1595
V
L
D
I
P
S
K
Y
D
W
S
G
A
E
E
Site 135
S1598
I
P
S
K
Y
D
W
S
G
A
E
E
S
D
D
Site 136
S1603
D
W
S
G
A
E
E
S
D
D
E
N
A
V
C
Site 137
S1644
H
Q
V
C
V
G
V
S
P
E
M
A
E
N
E
Site 138
Y1653
E
M
A
E
N
E
D
Y
I
C
I
N
C
A
K
Site 139
S1666
A
K
K
Q
G
P
V
S
P
G
P
A
P
P
P
Site 140
S1674
P
G
P
A
P
P
P
S
F
I
M
S
Y
K
L
Site 141
S1678
P
P
P
S
F
I
M
S
Y
K
L
P
M
E
D
Site 142
Y1679
P
P
S
F
I
M
S
Y
K
L
P
M
E
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation