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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPP2
Full Name:
Tripeptidyl-peptidase 2
Alias:
TPP-II; tripeptidyl aminopeptidase; tripeptidyl peptidase II
Type:
EC 3.4.14.10; Protease
Mass (Da):
138350
Number AA:
1248
UniProt ID:
P29144
International Prot ID:
IPI00020416
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0004252
GO:0008240
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
K
K
E
T
G
A
A
S
F
L
C
R
Y
P
E
Site 2
Y30
A
A
S
F
L
C
R
Y
P
E
Y
D
G
R
G
Site 3
T70
K
I
V
D
I
I
D
T
T
G
S
G
D
V
N
Site 4
S73
D
I
I
D
T
T
G
S
G
D
V
N
T
A
T
Site 5
T78
T
G
S
G
D
V
N
T
A
T
E
V
E
P
K
Site 6
T80
S
G
D
V
N
T
A
T
E
V
E
P
K
D
G
Site 7
S102
R
V
L
K
I
P
A
S
W
T
N
P
S
G
K
Site 8
T104
L
K
I
P
A
S
W
T
N
P
S
G
K
Y
H
Site 9
Y118
H
I
G
I
K
N
G
Y
D
F
Y
P
K
A
L
Site 10
Y121
I
K
N
G
Y
D
F
Y
P
K
A
L
K
E
R
Site 11
S164
D
V
A
N
N
G
S
S
Q
A
N
K
L
I
K
Site 12
S176
L
I
K
E
E
L
Q
S
Q
V
E
L
L
N
S
Site 13
S183
S
Q
V
E
L
L
N
S
F
E
K
K
Y
S
D
Site 14
Y188
L
N
S
F
E
K
K
Y
S
D
P
G
P
V
Y
Site 15
S189
N
S
F
E
K
K
Y
S
D
P
G
P
V
Y
D
Site 16
Y195
Y
S
D
P
G
P
V
Y
D
C
L
V
W
H
D
Site 17
S212
V
W
R
A
C
I
D
S
N
E
D
G
D
L
S
Site 18
S219
S
N
E
D
G
D
L
S
K
S
T
V
L
R
N
Site 19
S221
E
D
G
D
L
S
K
S
T
V
L
R
N
Y
K
Site 20
T222
D
G
D
L
S
K
S
T
V
L
R
N
Y
K
E
Site 21
Y227
K
S
T
V
L
R
N
Y
K
E
A
Q
E
Y
G
Site 22
Y233
N
Y
K
E
A
Q
E
Y
G
S
F
G
T
A
E
Site 23
S235
K
E
A
Q
E
Y
G
S
F
G
T
A
E
M
L
Site 24
Y244
G
T
A
E
M
L
N
Y
S
V
N
I
Y
D
D
Site 25
Y249
L
N
Y
S
V
N
I
Y
D
D
G
N
L
L
S
Site 26
S302
K
I
G
D
T
R
L
S
T
M
E
T
G
T
G
Site 27
T303
I
G
D
T
R
L
S
T
M
E
T
G
T
G
L
Site 28
T306
T
R
L
S
T
M
E
T
G
T
G
L
I
R
A
Site 29
Y356
V
W
K
H
N
I
I
Y
V
S
S
A
G
N
N
Site 30
S368
G
N
N
G
P
C
L
S
T
V
G
C
P
G
G
Site 31
T369
N
N
G
P
C
L
S
T
V
G
C
P
G
G
T
Site 32
S397
D
M
M
V
A
E
Y
S
L
R
E
K
L
P
A
Site 33
Y407
E
K
L
P
A
N
Q
Y
T
W
S
S
R
G
P
Site 34
T408
K
L
P
A
N
Q
Y
T
W
S
S
R
G
P
S
Site 35
S410
P
A
N
Q
Y
T
W
S
S
R
G
P
S
A
D
Site 36
S411
A
N
Q
Y
T
W
S
S
R
G
P
S
A
D
G
Site 37
S415
T
W
S
S
R
G
P
S
A
D
G
A
L
G
V
Site 38
T442
P
N
W
T
L
R
G
T
Q
L
M
N
G
T
S
Site 39
T448
G
T
Q
L
M
N
G
T
S
M
S
S
P
N
A
Site 40
S449
T
Q
L
M
N
G
T
S
M
S
S
P
N
A
C
Site 41
S451
L
M
N
G
T
S
M
S
S
P
N
A
C
G
G
Site 42
S452
M
N
G
T
S
M
S
S
P
N
A
C
G
G
I
Site 43
Y473
L
K
A
N
N
I
D
Y
T
V
H
S
V
R
R
Site 44
T474
K
A
N
N
I
D
Y
T
V
H
S
V
R
R
A
Site 45
S477
N
I
D
Y
T
V
H
S
V
R
R
A
L
E
N
Site 46
T485
V
R
R
A
L
E
N
T
A
V
K
A
D
N
I
Site 47
Y508
I
I
Q
V
D
K
A
Y
D
Y
L
V
Q
N
T
Site 48
Y510
Q
V
D
K
A
Y
D
Y
L
V
Q
N
T
S
F
Site 49
S516
D
Y
L
V
Q
N
T
S
F
A
N
K
L
G
F
Site 50
T524
F
A
N
K
L
G
F
T
V
T
V
G
N
N
R
Site 51
T526
N
K
L
G
F
T
V
T
V
G
N
N
R
G
I
Site 52
Y534
V
G
N
N
R
G
I
Y
L
R
D
P
V
Q
V
Site 53
S562
F
P
E
N
T
E
N
S
E
K
I
S
L
Q
L
Site 54
S566
T
E
N
S
E
K
I
S
L
Q
L
H
L
A
L
Site 55
S575
Q
L
H
L
A
L
T
S
N
S
S
W
V
Q
C
Site 56
S578
L
A
L
T
S
N
S
S
W
V
Q
C
P
S
H
Site 57
Y610
G
L
R
E
G
L
H
Y
T
E
V
C
G
Y
D
Site 58
Y616
H
Y
T
E
V
C
G
Y
D
I
A
S
P
N
A
Site 59
Y645
K
V
N
E
S
S
H
Y
D
L
A
F
T
D
V
Site 60
T650
S
H
Y
D
L
A
F
T
D
V
H
F
K
P
G
Site 61
Y701
Q
L
V
K
Q
R
A
Y
R
S
H
E
F
Y
K
Site 62
Y707
A
Y
R
S
H
E
F
Y
K
F
C
S
L
P
E
Site 63
S767
P
Q
L
N
I
H
A
S
E
G
I
N
R
F
D
Site 64
S777
I
N
R
F
D
V
Q
S
S
L
K
Y
E
D
L
Site 65
Y781
D
V
Q
S
S
L
K
Y
E
D
L
A
P
C
I
Site 66
T796
T
L
K
N
W
V
Q
T
L
R
P
V
S
A
K
Site 67
S801
V
Q
T
L
R
P
V
S
A
K
T
K
P
L
G
Site 68
Y820
L
P
N
N
R
Q
L
Y
E
M
V
L
T
Y
N
Site 69
Y826
L
Y
E
M
V
L
T
Y
N
F
H
Q
P
K
S
Site 70
S833
Y
N
F
H
Q
P
K
S
G
E
V
T
P
S
C
Site 71
T837
Q
P
K
S
G
E
V
T
P
S
C
P
L
L
C
Site 72
Y848
P
L
L
C
E
L
L
Y
E
S
E
F
D
S
Q
Site 73
S850
L
C
E
L
L
Y
E
S
E
F
D
S
Q
L
W
Site 74
S869
Q
N
K
R
Q
M
G
S
G
D
A
Y
P
H
Q
Site 75
Y873
Q
M
G
S
G
D
A
Y
P
H
Q
Y
S
L
K
Site 76
Y886
L
K
L
E
K
G
D
Y
T
I
R
L
Q
I
R
Site 77
T887
K
L
E
K
G
D
Y
T
I
R
L
Q
I
R
H
Site 78
S898
Q
I
R
H
E
Q
I
S
D
L
E
R
L
K
D
Site 79
S911
K
D
L
P
F
I
V
S
H
R
L
S
N
T
L
Site 80
T917
V
S
H
R
L
S
N
T
L
S
L
D
I
H
E
Site 81
S919
H
R
L
S
N
T
L
S
L
D
I
H
E
N
H
Site 82
S927
L
D
I
H
E
N
H
S
F
A
L
L
G
K
K
Site 83
S936
A
L
L
G
K
K
K
S
S
N
L
T
L
P
P
Site 84
T940
K
K
K
S
S
N
L
T
L
P
P
K
Y
N
Q
Site 85
Y945
N
L
T
L
P
P
K
Y
N
Q
P
F
F
V
T
Site 86
S972
P
G
C
Y
L
A
G
S
L
T
L
S
K
T
E
Site 87
S976
L
A
G
S
L
T
L
S
K
T
E
L
G
K
K
Site 88
T978
G
S
L
T
L
S
K
T
E
L
G
K
K
A
D
Site 89
T998
Y
Y
L
I
P
P
P
T
K
T
K
N
G
S
K
Site 90
T1000
L
I
P
P
P
T
K
T
K
N
G
S
K
D
K
Site 91
S1011
S
K
D
K
E
K
D
S
E
K
E
K
D
L
K
Site 92
S1039
W
M
T
K
L
D
S
S
D
I
Y
N
E
L
K
Site 93
Y1042
K
L
D
S
S
D
I
Y
N
E
L
K
E
T
Y
Site 94
T1048
I
Y
N
E
L
K
E
T
Y
P
N
Y
L
P
L
Site 95
Y1049
Y
N
E
L
K
E
T
Y
P
N
Y
L
P
L
Y
Site 96
Y1052
L
K
E
T
Y
P
N
Y
L
P
L
Y
V
A
R
Site 97
Y1056
Y
P
N
Y
L
P
L
Y
V
A
R
L
H
Q
L
Site 98
T1100
A
V
Y
I
A
M
K
T
D
P
R
P
D
A
A
Site 99
T1108
D
P
R
P
D
A
A
T
I
K
N
D
M
D
K
Site 100
T1119
D
M
D
K
Q
K
S
T
L
V
D
A
L
C
R
Site 101
S1158
G
K
E
E
E
G
E
S
P
L
D
S
L
A
E
Site 102
S1162
E
G
E
S
P
L
D
S
L
A
E
T
F
W
E
Site 103
T1166
P
L
D
S
L
A
E
T
F
W
E
T
T
K
W
Site 104
Y1195
H
A
L
V
N
K
M
Y
G
R
G
L
K
F
A
Site 105
T1211
K
L
V
E
E
K
P
T
K
E
N
W
K
N
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation