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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCSK1
Full Name:
Neuroendocrine convertase 1
Alias:
Prohormone convertase 1;Proprotein convertase 1
Type:
Mass (Da):
84152
Number AA:
753
UniProt ID:
P29120
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
P
G
G
P
E
A
A
S
A
I
A
E
E
L
G
Site 2
Y68
I
G
S
L
E
N
H
Y
L
F
K
H
K
N
H
Site 3
S79
H
K
N
H
P
R
R
S
R
R
S
A
F
H
I
Site 4
S82
H
P
R
R
S
R
R
S
A
F
H
I
T
K
R
Site 5
T87
R
R
S
A
F
H
I
T
K
R
L
S
D
D
D
Site 6
S91
F
H
I
T
K
R
L
S
D
D
D
R
V
I
W
Site 7
S108
Q
Q
Y
E
K
E
R
S
K
R
S
A
L
R
D
Site 8
S111
E
K
E
R
S
K
R
S
A
L
R
D
S
A
L
Site 9
S116
K
R
S
A
L
R
D
S
A
L
N
L
F
N
D
Site 10
T138
Y
L
Q
D
T
R
M
T
A
A
L
P
K
L
D
Site 11
Y178
E
W
N
H
T
D
I
Y
A
N
Y
D
P
E
A
Site 12
Y181
H
T
D
I
Y
A
N
Y
D
P
E
A
S
Y
D
Site 13
Y200
D
H
D
P
F
P
R
Y
D
P
T
N
E
N
K
Site 14
T203
P
F
P
R
Y
D
P
T
N
E
N
K
H
G
T
Site 15
Y264
N
P
G
H
V
D
I
Y
S
A
S
W
G
P
N
Site 16
S265
P
G
H
V
D
I
Y
S
A
S
W
G
P
N
D
Site 17
S267
H
V
D
I
Y
S
A
S
W
G
P
N
D
D
G
Site 18
T276
G
P
N
D
D
G
K
T
V
E
G
P
G
R
L
Site 19
Y290
L
A
Q
K
A
F
E
Y
G
V
K
Q
G
R
Q
Site 20
S301
Q
G
R
Q
G
K
G
S
I
F
V
W
A
S
G
Site 21
S307
G
S
I
F
V
W
A
S
G
N
G
G
R
Q
G
Site 22
Y322
D
N
C
D
C
D
G
Y
T
D
S
I
Y
T
I
Site 23
Y327
D
G
Y
T
D
S
I
Y
T
I
S
I
S
S
A
Site 24
T328
G
Y
T
D
S
I
Y
T
I
S
I
S
S
A
S
Site 25
S330
T
D
S
I
Y
T
I
S
I
S
S
A
S
Q
Q
Site 26
S335
T
I
S
I
S
S
A
S
Q
Q
G
L
S
P
W
Site 27
S340
S
A
S
Q
Q
G
L
S
P
W
Y
A
E
K
C
Site 28
Y343
Q
Q
G
L
S
P
W
Y
A
E
K
C
S
S
T
Site 29
S349
W
Y
A
E
K
C
S
S
T
L
A
T
S
Y
S
Site 30
T350
Y
A
E
K
C
S
S
T
L
A
T
S
Y
S
S
Site 31
T353
K
C
S
S
T
L
A
T
S
Y
S
S
G
D
Y
Site 32
S354
C
S
S
T
L
A
T
S
Y
S
S
G
D
Y
T
Site 33
S356
S
T
L
A
T
S
Y
S
S
G
D
Y
T
D
Q
Site 34
Y360
T
S
Y
S
S
G
D
Y
T
D
Q
R
I
T
S
Site 35
T361
S
Y
S
S
G
D
Y
T
D
Q
R
I
T
S
A
Site 36
T366
D
Y
T
D
Q
R
I
T
S
A
D
L
H
N
D
Site 37
T375
A
D
L
H
N
D
C
T
E
T
H
T
G
T
S
Site 38
T457
V
D
L
A
D
P
R
T
W
R
S
V
P
E
K
Site 39
S460
A
D
P
R
T
W
R
S
V
P
E
K
K
E
C
Site 40
S503
G
Q
E
N
A
I
K
S
L
E
H
V
Q
F
E
Site 41
Y515
Q
F
E
A
T
I
E
Y
S
R
R
G
D
L
H
Site 42
S516
F
E
A
T
I
E
Y
S
R
R
G
D
L
H
V
Site 43
T524
R
R
G
D
L
H
V
T
L
T
S
A
A
G
T
Site 44
T543
L
A
E
R
E
R
D
T
S
P
N
G
F
K
N
Site 45
S544
A
E
R
E
R
D
T
S
P
N
G
F
K
N
W
Site 46
T568
E
N
P
I
G
T
W
T
L
R
I
T
D
M
S
Site 47
T572
G
T
W
T
L
R
I
T
D
M
S
G
R
I
Q
Site 48
S575
T
L
R
I
T
D
M
S
G
R
I
Q
N
E
G
Site 49
T594
W
K
L
I
L
H
G
T
S
S
Q
P
E
H
M
Site 50
S596
L
I
L
H
G
T
S
S
Q
P
E
H
M
K
Q
Site 51
Y607
H
M
K
Q
P
R
V
Y
T
S
Y
N
T
V
Q
Site 52
T608
M
K
Q
P
R
V
Y
T
S
Y
N
T
V
Q
N
Site 53
Y610
Q
P
R
V
Y
T
S
Y
N
T
V
Q
N
D
R
Site 54
T632
D
P
G
E
E
Q
P
T
Q
E
N
P
K
E
N
Site 55
T640
Q
E
N
P
K
E
N
T
L
V
S
K
S
P
S
Site 56
S643
P
K
E
N
T
L
V
S
K
S
P
S
S
S
S
Site 57
S645
E
N
T
L
V
S
K
S
P
S
S
S
S
V
G
Site 58
S647
T
L
V
S
K
S
P
S
S
S
S
V
G
G
R
Site 59
S648
L
V
S
K
S
P
S
S
S
S
V
G
G
R
R
Site 60
S649
V
S
K
S
P
S
S
S
S
V
G
G
R
R
D
Site 61
S650
S
K
S
P
S
S
S
S
V
G
G
R
R
D
E
Site 62
S664
E
L
E
E
G
A
P
S
Q
A
M
L
R
L
L
Site 63
S673
A
M
L
R
L
L
Q
S
A
F
S
K
N
S
P
Site 64
S676
R
L
L
Q
S
A
F
S
K
N
S
P
P
K
Q
Site 65
S679
Q
S
A
F
S
K
N
S
P
P
K
Q
S
P
K
Site 66
S684
K
N
S
P
P
K
Q
S
P
K
K
S
P
S
A
Site 67
S688
P
K
Q
S
P
K
K
S
P
S
A
K
L
N
I
Site 68
S690
Q
S
P
K
K
S
P
S
A
K
L
N
I
P
Y
Site 69
Y697
S
A
K
L
N
I
P
Y
E
N
F
Y
E
A
L
Site 70
Y701
N
I
P
Y
E
N
F
Y
E
A
L
E
K
L
N
Site 71
S711
L
E
K
L
N
K
P
S
Q
L
K
D
S
E
D
Site 72
S716
K
P
S
Q
L
K
D
S
E
D
S
L
Y
N
D
Site 73
S719
Q
L
K
D
S
E
D
S
L
Y
N
D
Y
V
D
Site 74
Y721
K
D
S
E
D
S
L
Y
N
D
Y
V
D
V
F
Site 75
Y724
E
D
S
L
Y
N
D
Y
V
D
V
F
Y
N
T
Site 76
Y729
N
D
Y
V
D
V
F
Y
N
T
K
P
Y
K
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation