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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF2E1
Full Name:
General transcription factor IIE subunit 1
Alias:
FE; General transcription factor IIE 56 kDa; General transcription factor IIE, polypeptide 1, alpha 56kDa; T2EA; TF2E1; TFIIE-A; TFIIE-alpha; Transcription initiation factor IIE alpha
Type:
Transcription initiation complex
Mass (Da):
49452
Number AA:
439
UniProt ID:
P29083
International Prot ID:
IPI00019977
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005654
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006368
GO:0045449
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
D
P
D
V
L
T
E
V
P
A
A
L
K
Site 2
S41
L
D
I
L
I
R
N
S
C
V
K
E
E
D
M
Site 3
S61
F
D
R
K
Q
L
R
S
V
L
N
N
L
K
G
Site 4
T80
K
C
R
M
R
V
E
T
A
A
D
G
K
T
T
Site 5
T86
E
T
A
A
D
G
K
T
T
R
H
N
Y
Y
F
Site 6
Y91
G
K
T
T
R
H
N
Y
Y
F
I
N
Y
R
T
Site 7
Y92
K
T
T
R
H
N
Y
Y
F
I
N
Y
R
T
L
Site 8
T98
Y
Y
F
I
N
Y
R
T
L
V
N
V
V
K
Y
Site 9
Y105
T
L
V
N
V
V
K
Y
K
L
D
H
M
R
R
Site 10
T116
H
M
R
R
R
I
E
T
D
E
R
D
S
T
N
Site 11
S121
I
E
T
D
E
R
D
S
T
N
R
A
S
F
K
Site 12
T122
E
T
D
E
R
D
S
T
N
R
A
S
F
K
C
Site 13
S126
R
D
S
T
N
R
A
S
F
K
C
P
V
C
S
Site 14
S133
S
F
K
C
P
V
C
S
S
T
F
T
D
L
E
Site 15
T135
K
C
P
V
C
S
S
T
F
T
D
L
E
A
N
Site 16
T137
P
V
C
S
S
T
F
T
D
L
E
A
N
Q
L
Site 17
S166
T
E
V
E
E
D
E
S
A
M
P
K
K
D
A
Site 18
Y188
N
E
Q
I
E
P
I
Y
A
L
L
R
E
T
E
Site 19
Y201
T
E
D
V
N
L
A
Y
E
I
L
E
P
E
P
Site 20
T209
E
I
L
E
P
E
P
T
E
I
P
A
L
K
Q
Site 21
S229
A
T
T
A
G
A
A
S
L
A
G
G
H
H
R
Site 22
T241
H
H
R
E
A
W
A
T
K
G
P
S
Y
E
D
Site 23
Y246
W
A
T
K
G
P
S
Y
E
D
L
Y
T
Q
N
Site 24
Y250
G
P
S
Y
E
D
L
Y
T
Q
N
V
V
I
N
Site 25
S268
Q
E
D
L
H
R
A
S
L
E
G
K
S
A
K
Site 26
S284
R
P
I
W
L
R
E
S
T
V
Q
G
A
Y
G
Site 27
T285
P
I
W
L
R
E
S
T
V
Q
G
A
Y
G
S
Site 28
S292
T
V
Q
G
A
Y
G
S
E
D
M
K
E
G
G
Site 29
T332
L
L
I
H
E
K
K
T
S
S
A
M
A
G
S
Site 30
S333
L
I
H
E
K
K
T
S
S
A
M
A
G
S
V
Site 31
S334
I
H
E
K
K
T
S
S
A
M
A
G
S
V
G
Site 32
S339
T
S
S
A
M
A
G
S
V
G
A
A
A
P
V
Site 33
T347
V
G
A
A
A
P
V
T
A
A
N
G
S
D
S
Site 34
S352
P
V
T
A
A
N
G
S
D
S
E
S
E
T
S
Site 35
S354
T
A
A
N
G
S
D
S
E
S
E
T
S
E
S
Site 36
S356
A
N
G
S
D
S
E
S
E
T
S
E
S
D
D
Site 37
T358
G
S
D
S
E
S
E
T
S
E
S
D
D
D
S
Site 38
S359
S
D
S
E
S
E
T
S
E
S
D
D
D
S
P
Site 39
S361
S
E
S
E
T
S
E
S
D
D
D
S
P
P
R
Site 40
S365
T
S
E
S
D
D
D
S
P
P
R
P
A
A
V
Site 41
S404
M
V
A
G
R
P
F
S
Y
S
E
V
S
Q
R
Site 42
Y405
V
A
G
R
P
F
S
Y
S
E
V
S
Q
R
P
Site 43
S406
A
G
R
P
F
S
Y
S
E
V
S
Q
R
P
E
Site 44
S409
P
F
S
Y
S
E
V
S
Q
R
P
E
L
V
A
Site 45
T419
P
E
L
V
A
Q
M
T
P
E
E
K
E
A
Y
Site 46
Y426
T
P
E
E
K
E
A
Y
I
A
M
G
Q
R
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation