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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN4
Full Name:
Tyrosine-protein phosphatase non-receptor type 4
Alias:
EC 3.1.3.48; MEG1; Megakaryocyte protein-tyrosine phosphatase; PTN4; PTPase-MEG1; PTPMEG1
Type:
Protein-tyrosine phosphatase
Mass (Da):
105911
Number AA:
926
UniProt ID:
P29074
International Prot ID:
IPI00019949
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008092
GO:0004726
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
R
L
P
A
G
R
T
Y
N
V
R
A
S
E
L
Site 2
S18
R
T
Y
N
V
R
A
S
E
L
A
R
D
R
Q
Site 3
T27
L
A
R
D
R
Q
H
T
E
V
V
C
N
I
L
Site 4
T65
V
F
K
H
L
D
L
T
E
Q
D
Y
F
G
L
Site 5
Y69
L
D
L
T
E
Q
D
Y
F
G
L
Q
L
A
D
Site 6
S78
G
L
Q
L
A
D
D
S
T
D
N
P
R
W
L
Site 7
T79
L
Q
L
A
D
D
S
T
D
N
P
R
W
L
D
Site 8
S99
R
K
Q
L
K
R
G
S
P
Y
S
L
N
F
R
Site 9
S102
L
K
R
G
S
P
Y
S
L
N
F
R
V
K
F
Site 10
S112
F
R
V
K
F
F
V
S
D
P
N
K
L
Q
E
Site 11
Y121
P
N
K
L
Q
E
E
Y
T
R
Y
Q
Y
F
L
Site 12
Y124
L
Q
E
E
Y
T
R
Y
Q
Y
F
L
Q
I
K
Site 13
Y126
E
E
Y
T
R
Y
Q
Y
F
L
Q
I
K
Q
D
Site 14
T136
Q
I
K
Q
D
I
L
T
G
R
L
P
C
P
S
Site 15
Y161
V
Q
S
E
L
G
D
Y
D
Q
S
E
N
L
S
Site 16
S164
E
L
G
D
Y
D
Q
S
E
N
L
S
G
Y
L
Site 17
S168
Y
D
Q
S
E
N
L
S
G
Y
L
S
D
Y
S
Site 18
Y170
Q
S
E
N
L
S
G
Y
L
S
D
Y
S
F
I
Site 19
S172
E
N
L
S
G
Y
L
S
D
Y
S
F
I
P
N
Site 20
Y174
L
S
G
Y
L
S
D
Y
S
F
I
P
N
Q
P
Site 21
S175
S
G
Y
L
S
D
Y
S
F
I
P
N
Q
P
Q
Site 22
S199
H
Q
Q
H
I
G
L
S
P
A
E
A
E
F
N
Site 23
Y207
P
A
E
A
E
F
N
Y
L
N
T
A
R
T
L
Site 24
Y217
T
A
R
T
L
E
L
Y
G
V
E
F
H
Y
A
Site 25
Y223
L
Y
G
V
E
F
H
Y
A
R
D
Q
S
N
N
Site 26
S228
F
H
Y
A
R
D
Q
S
N
N
E
I
M
I
G
Site 27
S238
E
I
M
I
G
V
M
S
G
G
I
L
I
Y
K
Site 28
Y244
M
S
G
G
I
L
I
Y
K
N
R
V
R
M
N
Site 29
T252
K
N
R
V
R
M
N
T
F
P
W
L
K
I
V
Site 30
S279
L
R
K
E
L
H
E
S
R
E
T
L
L
G
F
Site 31
T282
E
L
H
E
S
R
E
T
L
L
G
F
N
M
V
Site 32
Y291
L
G
F
N
M
V
N
Y
R
A
C
K
N
L
W
Site 33
T306
K
A
C
V
E
H
H
T
F
F
R
L
D
R
P
Site 34
Y324
Q
K
N
F
F
A
H
Y
F
T
L
G
S
K
F
Site 35
Y333
T
L
G
S
K
F
R
Y
C
G
R
T
E
V
Q
Site 36
T337
K
F
R
Y
C
G
R
T
E
V
Q
S
V
Q
Y
Site 37
S341
C
G
R
T
E
V
Q
S
V
Q
Y
G
K
E
K
Site 38
S358
K
D
R
V
F
A
R
S
P
S
K
P
L
A
R
Site 39
S360
R
V
F
A
R
S
P
S
K
P
L
A
R
K
L
Site 40
S377
W
E
V
V
S
R
N
S
I
S
D
D
R
L
E
Site 41
S379
V
V
S
R
N
S
I
S
D
D
R
L
E
T
Q
Site 42
T385
I
S
D
D
R
L
E
T
Q
S
L
P
S
R
S
Site 43
S387
D
D
R
L
E
T
Q
S
L
P
S
R
S
P
P
Site 44
S390
L
E
T
Q
S
L
P
S
R
S
P
P
G
T
P
Site 45
S392
T
Q
S
L
P
S
R
S
P
P
G
T
P
N
H
Site 46
T396
P
S
R
S
P
P
G
T
P
N
H
R
N
S
T
Site 47
S402
G
T
P
N
H
R
N
S
T
F
T
Q
E
G
T
Site 48
T403
T
P
N
H
R
N
S
T
F
T
Q
E
G
T
R
Site 49
T405
N
H
R
N
S
T
F
T
Q
E
G
T
R
L
R
Site 50
S414
E
G
T
R
L
R
P
S
S
V
G
H
L
V
D
Site 51
S415
G
T
R
L
R
P
S
S
V
G
H
L
V
D
H
Site 52
S427
V
D
H
M
V
H
T
S
P
S
E
V
F
V
N
Site 53
S429
H
M
V
H
T
S
P
S
E
V
F
V
N
Q
R
Site 54
S437
E
V
F
V
N
Q
R
S
P
S
S
T
Q
A
N
Site 55
S439
F
V
N
Q
R
S
P
S
S
T
Q
A
N
S
I
Site 56
S440
V
N
Q
R
S
P
S
S
T
Q
A
N
S
I
V
Site 57
T441
N
Q
R
S
P
S
S
T
Q
A
N
S
I
V
L
Site 58
S445
P
S
S
T
Q
A
N
S
I
V
L
E
S
S
P
Site 59
S451
N
S
I
V
L
E
S
S
P
S
Q
E
T
P
G
Site 60
S453
I
V
L
E
S
S
P
S
Q
E
T
P
G
D
G
Site 61
T456
E
S
S
P
S
Q
E
T
P
G
D
G
K
P
P
Site 62
S470
P
A
L
P
P
K
Q
S
K
K
N
S
W
N
Q
Site 63
S474
P
K
Q
S
K
K
N
S
W
N
Q
I
H
Y
S
Site 64
S483
N
Q
I
H
Y
S
H
S
Q
Q
D
L
E
S
H
Site 65
S489
H
S
Q
Q
D
L
E
S
H
I
N
E
T
F
D
Site 66
T494
L
E
S
H
I
N
E
T
F
D
I
P
S
S
P
Site 67
S499
N
E
T
F
D
I
P
S
S
P
E
K
P
T
P
Site 68
S500
E
T
F
D
I
P
S
S
P
E
K
P
T
P
N
Site 69
T505
P
S
S
P
E
K
P
T
P
N
G
G
I
P
H
Site 70
S594
K
A
S
C
E
R
H
S
G
E
L
M
L
L
V
Site 71
Y622
E
N
E
P
D
F
Q
Y
I
P
E
K
A
P
L
Site 72
S631
P
E
K
A
P
L
D
S
V
H
Q
D
D
H
S
Site 73
S638
S
V
H
Q
D
D
H
S
L
R
E
S
M
I
Q
Site 74
S642
D
D
H
S
L
R
E
S
M
I
Q
L
A
E
G
Site 75
Y663
L
T
Q
F
D
Q
L
Y
R
K
K
P
G
M
T
Site 76
S672
K
K
P
G
M
T
M
S
C
A
K
L
P
Q
N
Site 77
S681
A
K
L
P
Q
N
I
S
K
N
R
Y
R
D
I
Site 78
Y685
Q
N
I
S
K
N
R
Y
R
D
I
S
P
Y
D
Site 79
S689
K
N
R
Y
R
D
I
S
P
Y
D
A
T
R
V
Site 80
Y691
R
Y
R
D
I
S
P
Y
D
A
T
R
V
I
L
Site 81
T694
D
I
S
P
Y
D
A
T
R
V
I
L
K
G
N
Site 82
Y704
I
L
K
G
N
E
D
Y
I
N
A
N
Y
I
N
Site 83
Y709
E
D
Y
I
N
A
N
Y
I
N
M
E
I
P
S
Site 84
S718
N
M
E
I
P
S
S
S
I
I
N
Q
Y
I
A
Site 85
T753
S
S
M
V
V
M
L
T
T
Q
V
E
R
G
R
Site 86
Y766
G
R
V
K
C
H
Q
Y
W
P
E
P
T
G
S
Site 87
T771
H
Q
Y
W
P
E
P
T
G
S
S
S
Y
G
C
Site 88
S775
P
E
P
T
G
S
S
S
Y
G
C
Y
Q
V
T
Site 89
Y779
G
S
S
S
Y
G
C
Y
Q
V
T
C
H
S
E
Site 90
Y792
S
E
E
G
N
T
A
Y
I
F
R
K
M
T
L
Site 91
T798
A
Y
I
F
R
K
M
T
L
F
N
Q
E
K
N
Site 92
T811
K
N
E
S
R
P
L
T
Q
I
Q
Y
I
A
W
Site 93
Y815
R
P
L
T
Q
I
Q
Y
I
A
W
P
D
H
G
Site 94
S827
D
H
G
V
P
D
D
S
S
D
F
L
D
F
V
Site 95
S828
H
G
V
P
D
D
S
S
D
F
L
D
F
V
C
Site 96
Y879
I
E
C
N
Q
P
V
Y
P
L
D
I
V
R
T
Site 97
T886
Y
P
L
D
I
V
R
T
M
R
D
Q
R
A
M
Site 98
T897
Q
R
A
M
M
I
Q
T
P
S
Q
Y
R
F
V
Site 99
T921
E
G
F
V
K
P
L
T
T
S
T
N
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation