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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRM
Full Name:
Receptor-type tyrosine-protein phosphatase mu
Alias:
EC 3.1.3.48; HR-PTPu; Protein-tyrosine phosphatase mu; PTPRL1; RPTPM; R-PTP-MU; RPTPU
Type:
Protein-tyrosine phosphatase (receptor)
Mass (Da):
163633
Number AA:
1452
UniProt ID:
P28827
International Prot ID:
IPI00293849
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005913
GO:0005887
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0045296
GO:0005001
PhosphoSite+
KinaseNET
Biological Process:
GO:0007156
GO:0016525
GO:0010596
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S524
E
I
T
Y
K
A
V
S
S
F
D
P
E
I
D
Site 2
S525
I
T
Y
K
A
V
S
S
F
D
P
E
I
D
L
Site 3
S533
F
D
P
E
I
D
L
S
N
Q
S
G
R
V
S
Site 4
S536
E
I
D
L
S
N
Q
S
G
R
V
S
K
L
G
Site 5
S540
S
N
Q
S
G
R
V
S
K
L
G
N
E
T
H
Site 6
Y621
R
G
A
P
V
S
V
Y
Q
I
V
V
E
E
E
Site 7
T637
P
R
R
T
K
K
T
T
E
I
L
K
C
Y
P
Site 8
T776
L
A
K
K
R
K
E
T
M
S
S
T
R
Q
E
Site 9
S778
K
K
R
K
E
T
M
S
S
T
R
Q
E
M
T
Site 10
S779
K
R
K
E
T
M
S
S
T
R
Q
E
M
T
V
Site 11
T785
S
S
T
R
Q
E
M
T
V
M
V
N
S
M
D
Site 12
S790
E
M
T
V
M
V
N
S
M
D
K
S
Y
A
E
Site 13
S794
M
V
N
S
M
D
K
S
Y
A
E
Q
G
T
N
Site 14
Y795
V
N
S
M
D
K
S
Y
A
E
Q
G
T
N
C
Site 15
T811
E
A
F
S
F
M
D
T
H
N
L
N
G
R
S
Site 16
S818
T
H
N
L
N
G
R
S
V
S
S
P
S
S
F
Site 17
S820
N
L
N
G
R
S
V
S
S
P
S
S
F
T
M
Site 18
S821
L
N
G
R
S
V
S
S
P
S
S
F
T
M
K
Site 19
S823
G
R
S
V
S
S
P
S
S
F
T
M
K
T
N
Site 20
S824
R
S
V
S
S
P
S
S
F
T
M
K
T
N
T
Site 21
T829
P
S
S
F
T
M
K
T
N
T
L
S
T
S
V
Site 22
T831
S
F
T
M
K
T
N
T
L
S
T
S
V
P
N
Site 23
S833
T
M
K
T
N
T
L
S
T
S
V
P
N
S
Y
Site 24
T834
M
K
T
N
T
L
S
T
S
V
P
N
S
Y
Y
Site 25
S835
K
T
N
T
L
S
T
S
V
P
N
S
Y
Y
P
Site 26
S839
L
S
T
S
V
P
N
S
Y
Y
P
D
E
T
H
Site 27
Y840
S
T
S
V
P
N
S
Y
Y
P
D
E
T
H
T
Site 28
Y841
T
S
V
P
N
S
Y
Y
P
D
E
T
H
T
M
Site 29
T847
Y
Y
P
D
E
T
H
T
M
A
S
D
T
S
S
Site 30
S850
D
E
T
H
T
M
A
S
D
T
S
S
L
V
Q
Site 31
T852
T
H
T
M
A
S
D
T
S
S
L
V
Q
S
H
Site 32
S853
H
T
M
A
S
D
T
S
S
L
V
Q
S
H
T
Site 33
S854
T
M
A
S
D
T
S
S
L
V
Q
S
H
T
Y
Site 34
S858
D
T
S
S
L
V
Q
S
H
T
Y
K
K
R
E
Site 35
T860
S
S
L
V
Q
S
H
T
Y
K
K
R
E
P
A
Site 36
Y861
S
L
V
Q
S
H
T
Y
K
K
R
E
P
A
D
Site 37
Y871
R
E
P
A
D
V
P
Y
Q
T
G
Q
L
H
P
Site 38
Y904
G
Y
G
F
K
E
E
Y
E
S
F
F
E
G
Q
Site 39
S906
G
F
K
E
E
Y
E
S
F
F
E
G
Q
S
A
Site 40
Y929
E
N
R
M
K
N
R
Y
G
N
I
I
A
Y
D
Site 41
Y935
R
Y
G
N
I
I
A
Y
D
H
S
R
V
R
L
Site 42
T944
H
S
R
V
R
L
Q
T
I
E
G
D
T
N
S
Site 43
Y953
E
G
D
T
N
S
D
Y
I
N
G
N
Y
I
D
Site 44
Y958
S
D
Y
I
N
G
N
Y
I
D
G
Y
H
R
P
Site 45
Y962
N
G
N
Y
I
D
G
Y
H
R
P
N
H
Y
I
Site 46
Y968
G
Y
H
R
P
N
H
Y
I
A
T
Q
G
P
M
Site 47
T971
R
P
N
H
Y
I
A
T
Q
G
P
M
Q
E
T
Site 48
Y1068
W
P
D
H
G
V
P
Y
H
A
T
G
L
L
G
Site 49
S1082
G
F
V
R
Q
V
K
S
K
S
P
P
S
A
G
Site 50
S1084
V
R
Q
V
K
S
K
S
P
P
S
A
G
P
L
Site 51
S1087
V
K
S
K
S
P
P
S
A
G
P
L
V
V
H
Site 52
Y1124
R
E
G
V
V
D
I
Y
N
C
V
R
E
L
R
Site 53
S1132
N
C
V
R
E
L
R
S
R
R
V
N
M
V
Q
Site 54
S1165
G
D
T
S
V
P
A
S
Q
V
R
S
L
Y
Y
Site 55
S1169
V
P
A
S
Q
V
R
S
L
Y
Y
D
M
N
K
Site 56
Y1171
A
S
Q
V
R
S
L
Y
Y
D
M
N
K
L
D
Site 57
Y1172
S
Q
V
R
S
L
Y
Y
D
M
N
K
L
D
P
Site 58
T1181
M
N
K
L
D
P
Q
T
N
S
S
Q
I
K
E
Site 59
S1184
L
D
P
Q
T
N
S
S
Q
I
K
E
E
F
R
Site 60
T1192
Q
I
K
E
E
F
R
T
L
N
M
V
T
P
T
Site 61
T1197
F
R
T
L
N
M
V
T
P
T
L
R
V
E
D
Site 62
T1199
T
L
N
M
V
T
P
T
L
R
V
E
D
C
S
Site 63
Y1242
I
D
G
E
S
S
N
Y
I
N
A
A
L
M
D
Site 64
S1250
I
N
A
A
L
M
D
S
Y
K
Q
P
S
A
F
Site 65
Y1251
N
A
A
L
M
D
S
Y
K
Q
P
S
A
F
I
Site 66
T1260
Q
P
S
A
F
I
V
T
Q
H
P
L
P
N
T
Site 67
T1267
T
Q
H
P
L
P
N
T
V
K
D
F
W
R
L
Site 68
Y1298
P
A
Q
L
C
P
Q
Y
W
P
E
N
G
V
H
Site 69
Y1331
I
S
R
I
F
R
I
Y
N
A
A
R
P
Q
D
Site 70
Y1340
A
A
R
P
Q
D
G
Y
R
M
V
Q
Q
F
Q
Site 71
Y1354
Q
F
L
G
W
P
M
Y
R
D
T
P
V
S
K
Site 72
T1357
G
W
P
M
Y
R
D
T
P
V
S
K
R
S
F
Site 73
S1360
M
Y
R
D
T
P
V
S
K
R
S
F
L
K
L
Site 74
S1363
D
T
P
V
S
K
R
S
F
L
K
L
I
R
Q
Site 75
Y1378
V
D
K
W
Q
E
E
Y
N
G
G
E
G
R
T
Site 76
T1385
Y
N
G
G
E
G
R
T
V
V
H
C
L
N
G
Site 77
T1414
E
M
L
R
H
Q
R
T
V
D
V
F
H
A
V
Site 78
T1423
D
V
F
H
A
V
K
T
L
R
N
N
K
P
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation