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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NDUFS1
Full Name:
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Alias:
CI-75Kd; Complex I-75kD; NADH dehydrogenase (ubiquinone) Fe-S protein 1; NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; NDUS1
Type:
Oxidoreductase; EC 1.6.99.3; EC 1.6.5.3; Energy Metabolism - oxidative phosphorylation
Mass (Da):
79468
Number AA:
727
UniProt ID:
P28331
International Prot ID:
IPI00604664
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005758
GO:0005747
Uniprot
OncoNet
Molecular Function:
GO:0051537
GO:0051539
GO:0008137
PhosphoSite+
KinaseNET
Biological Process:
GO:0046034
GO:0006915
GO:0006120
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
K
A
L
V
G
L
S
K
S
P
K
G
C
V
Site 2
S16
A
L
V
G
L
S
K
S
P
K
G
C
V
R
T
Site 3
T24
P
K
G
C
V
R
T
T
A
T
A
A
S
N
L
Site 4
Y65
M
Q
I
P
R
F
C
Y
H
E
R
L
S
V
A
Site 5
T104
M
K
G
W
N
I
L
T
N
S
E
K
S
K
K
Site 6
S106
G
W
N
I
L
T
N
S
E
K
S
K
K
A
R
Site 7
S151
M
M
F
G
N
D
R
S
R
F
L
E
G
K
R
Site 8
S187
T
R
C
I
R
F
A
S
E
I
A
G
V
D
D
Site 9
T197
A
G
V
D
D
L
G
T
T
G
R
G
N
D
M
Site 10
Y236
G
A
L
T
S
K
P
Y
A
F
T
A
R
P
W
Site 11
T239
T
S
K
P
Y
A
F
T
A
R
P
W
E
T
R
Site 12
T248
R
P
W
E
T
R
K
T
E
S
I
D
V
M
D
Site 13
S250
W
E
T
R
K
T
E
S
I
D
V
M
D
A
V
Site 14
T290
E
E
W
I
S
D
K
T
R
F
A
Y
D
G
L
Site 15
Y294
S
D
K
T
R
F
A
Y
D
G
L
K
R
Q
R
Site 16
T303
G
L
K
R
Q
R
L
T
E
P
M
V
R
N
E
Site 17
Y316
N
E
K
G
L
L
T
Y
T
S
W
E
D
A
L
Site 18
S318
K
G
L
L
T
Y
T
S
W
E
D
A
L
S
R
Site 19
S324
T
S
W
E
D
A
L
S
R
V
A
G
M
L
Q
Site 20
S332
R
V
A
G
M
L
Q
S
F
Q
G
K
D
V
A
Site 21
S363
D
L
L
N
R
V
D
S
D
T
L
C
T
E
E
Site 22
T365
L
N
R
V
D
S
D
T
L
C
T
E
E
V
F
Site 23
T379
F
P
T
A
G
A
G
T
D
L
R
S
N
Y
L
Site 24
Y385
G
T
D
L
R
S
N
Y
L
L
N
T
T
I
A
Site 25
T439
I
G
S
P
V
D
L
T
Y
T
Y
D
H
L
G
Site 26
Y440
G
S
P
V
D
L
T
Y
T
Y
D
H
L
G
D
Site 27
T441
S
P
V
D
L
T
Y
T
Y
D
H
L
G
D
S
Site 28
Y442
P
V
D
L
T
Y
T
Y
D
H
L
G
D
S
P
Site 29
S448
T
Y
D
H
L
G
D
S
P
K
I
L
Q
D
I
Site 30
S457
K
I
L
Q
D
I
A
S
G
S
H
P
F
S
Q
Site 31
S459
L
Q
D
I
A
S
G
S
H
P
F
S
Q
V
L
Site 32
S463
A
S
G
S
H
P
F
S
Q
V
L
K
E
A
K
Site 33
S478
K
P
M
V
V
L
G
S
S
A
L
Q
R
N
D
Site 34
S479
P
M
V
V
L
G
S
S
A
L
Q
R
N
D
G
Site 35
S495
A
I
L
A
A
V
S
S
I
A
Q
K
I
R
M
Site 36
T503
I
A
Q
K
I
R
M
T
S
G
V
T
G
D
W
Site 37
S504
A
Q
K
I
R
M
T
S
G
V
T
G
D
W
K
Site 38
T507
I
R
M
T
S
G
V
T
G
D
W
K
V
M
N
Site 39
Y568
P
K
D
C
F
I
I
Y
Q
G
H
H
G
D
V
Site 40
S593
G
A
A
Y
T
E
K
S
A
T
Y
V
N
T
E
Site 41
T595
A
Y
T
E
K
S
A
T
Y
V
N
T
E
G
R
Site 42
Y596
Y
T
E
K
S
A
T
Y
V
N
T
E
G
R
A
Site 43
T599
K
S
A
T
Y
V
N
T
E
G
R
A
Q
Q
T
Site 44
T611
Q
Q
T
K
V
A
V
T
P
P
G
L
A
R
E
Site 45
T638
G
M
T
L
P
Y
D
T
L
D
Q
V
R
N
R
Site 46
S650
R
N
R
L
E
E
V
S
P
N
L
V
R
Y
D
Site 47
Y656
V
S
P
N
L
V
R
Y
D
D
I
E
G
A
N
Site 48
Y664
D
D
I
E
G
A
N
Y
F
Q
Q
A
N
E
L
Site 49
Y695
Q
L
T
I
K
D
F
Y
M
T
D
S
I
S
R
Site 50
T697
T
I
K
D
F
Y
M
T
D
S
I
S
R
A
S
Site 51
S699
K
D
F
Y
M
T
D
S
I
S
R
A
S
Q
T
Site 52
S701
F
Y
M
T
D
S
I
S
R
A
S
Q
T
M
A
Site 53
S704
T
D
S
I
S
R
A
S
Q
T
M
A
K
C
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation