PhosphoNET

           
Protein Info 
   
Short Name:  PSMB8
Full Name:  Proteasome subunit beta type-8
Alias:  beta5i; D6S216E; large multifunctional peptidase 7; LMP7; macropain C13; multicatalytic endopeptidase complex subunit C13; proteasome (prosome, macropain) subunit, beta type, 8; proteasome beta type 8; PSB8; PSMB5i; RING10; Y2
Type:  EC 3.4.25.1; Proteasome complex; Protease
Mass (Da):  30354
Number AA:  276
UniProt ID:  P28062
International Prot ID:  IPI00000783
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005634  GO:0005839 Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0004298   PhosphoSite+ KinaseNET
Biological Process:  GO:0031145  GO:0006955  GO:0051436 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S17PRGQRPESALPVAGS
Site 2S24SALPVAGSGRRSDPG
Site 3S28VAGSGRRSDPGHYSF
Site 4S34RSDPGHYSFSMRSPE
Site 5S36DPGHYSFSMRSPELA
Site 6S39HYSFSMRSPELALPR
Site 7T51LPRGMKPTEFFQSLG
Site 8S56KPTEFFQSLGGDGER
Site 9T75EMAHGTTTLAFKFQH
Site 10S96DSRASAGSYISALRV
Site 11Y97SRASAGSYISALRVN
Site 12Y112KVIEINPYLLGTMSG
Site 13Y126GCAADCQYWERLLAK
Site 14Y138LAKECRLYYLRNGER
Site 15Y139AKECRLYYLRNGERI
Site 16S147LRNGERISVSAASKL
Site 17S149NGERISVSAASKLLS
Site 18S156SAASKLLSNMMCQYR
Site 19Y162LSNMMCQYRGMGLSM
Site 20Y184DKKGPGLYYVDEHGT
Site 21Y185KKGPGLYYVDEHGTR
Site 22S194DEHGTRLSGNMFSTG
Site 23S199RLSGNMFSTGSGNTY
Site 24T200LSGNMFSTGSGNTYA
Site 25S202GNMFSTGSGNTYAYG
Site 26Y206STGSGNTYAYGVMDS
Site 27Y208GSGNTYAYGVMDSGY
Site 28S213YAYGVMDSGYRPNLS
Site 29Y215YGVMDSGYRPNLSPE
Site 30S220SGYRPNLSPEEAYDL
Site 31Y234LGRRAIAYATHRDSY
Site 32T236RRAIAYATHRDSYSG
Site 33S240AYATHRDSYSGGVVN
Site 34Y241YATHRDSYSGGVVNM
Site 35S242ATHRDSYSGGVVNMY
Site 36Y249SGGVVNMYHMKEDGW
Site 37S261DGWVKVESTDVSDLL
Site 38S265KVESTDVSDLLHQYR
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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