PhosphoNET

           
Protein Info 
   
Short Name:  APEX1
Full Name:  DNA-(apurinic or apyrimidinic site) lyase
Alias:  AP endonuclease 1; APE; APE1; APE-1; APEN; APEX; APEX nuclease; APEX nuclease (multifunctional DNA repair enzyme) 1; APX; EC 4.2.99.18; HAP1; REF1; REF-1; REF-1 protein
Type:  Transcription, coactivator/corepressor; Endoplasmic reticulum; Lyase; DNA repair; EC 4.2.99.18; Hydrolase; Deoxyribonuclease
Mass (Da):  35423
Number AA:  317
UniProt ID:  P27695
International Prot ID:  IPI00215911
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005813  GO:0005783  GO:0005654 Uniprot OncoNet
Molecular Function:  GO:0008408  GO:0003677  GO:0003906 PhosphoSite+ KinaseNET
Biological Process:  GO:0006284  GO:0051101  GO:0006366 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T19EDGDELRTEPEAKKS
Site 2S26TEPEAKKSKTAAKKN
Site 3Y45AGEGPALYEDPPDQK
Site 4T53EDPPDQKTSPSGKPA
Site 5S54DPPDQKTSPSGKPAT
Site 6S56PDQKTSPSGKPATLK
Site 7T61SPSGKPATLKICSWN
Site 8S100CLQETKCSENKLPAE
Site 9S115LQELPGLSHQYWSAP
Site 10Y118LPGLSHQYWSAPSDK
Site 11S120GLSHQYWSAPSDKEG
Site 12Y128APSDKEGYSGVGLLS
Site 13S129PSDKEGYSGVGLLSR
Site 14Y171SFVLVTAYVPNAGRG
Site 15Y184RGLVRLEYRQRWDEA
Site 16T233NKKNAGFTPQERQGF
Site 17S252QAVPLADSFRHLYPN
Site 18Y257ADSFRHLYPNTPYAY
Site 19Y262HLYPNTPYAYTFWTY
Site 20S290DYFLLSHSLLPALCD
Site 21S302LCDSKIRSKALGSDH
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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