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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARNT
Full Name:
Aryl hydrocarbon receptor nuclear translocator
Alias:
bHLHe2; Dioxin receptor, nuclear translocator; HIF-1 beta; HIF-1beta; Hypoxia-inducible factor 1 beta
Type:
Receptor, nuclear
Mass (Da):
86636
Number AA:
789
UniProt ID:
P27540
International Prot ID:
IPI00514749
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0017162
GO:0046982
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0042789
GO:0001938
GO:0045648
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
T
A
N
P
E
M
T
S
D
V
P
S
L
G
P
Site 2
S26
P
A
I
A
S
G
N
S
G
P
G
I
Q
G
G
Site 3
S68
R
C
D
D
D
Q
M
S
N
D
K
E
R
F
A
Site 4
S77
D
K
E
R
F
A
R
S
D
D
E
Q
S
S
A
Site 5
S82
A
R
S
D
D
E
Q
S
S
A
D
K
E
R
L
Site 6
S83
R
S
D
D
E
Q
S
S
A
D
K
E
R
L
A
Site 7
T106
R
R
R
R
N
K
M
T
A
Y
I
T
E
L
S
Site 8
Y108
R
R
N
K
M
T
A
Y
I
T
E
L
S
D
M
Site 9
S120
S
D
M
V
P
T
C
S
A
L
A
R
K
P
D
Site 10
T130
A
R
K
P
D
K
L
T
I
L
R
M
A
V
S
Site 11
S141
D
K
E
R
F
A
R
S
D
D
E
Q
S
S
A
Site 12
T145
H
M
K
S
L
R
G
T
G
N
T
S
T
D
G
Site 13
T148
S
L
R
G
T
G
N
T
S
T
D
G
S
Y
K
Site 14
S149
L
R
G
T
G
N
T
S
T
D
G
S
Y
K
P
Site 15
T150
R
G
T
G
N
T
S
T
D
G
S
Y
K
P
S
Site 16
S153
G
N
T
S
T
D
G
S
Y
K
P
S
F
L
T
Site 17
Y154
N
T
S
T
D
G
S
Y
K
P
S
F
L
T
D
Site 18
S157
T
D
G
S
Y
K
P
S
F
L
T
D
Q
E
L
Site 19
T160
S
Y
K
P
S
F
L
T
D
Q
E
L
K
H
L
Site 20
Y188
C
E
T
G
R
V
V
Y
V
S
D
S
V
T
P
Site 21
T194
V
Y
V
S
D
S
V
T
P
V
L
N
Q
P
Q
Site 22
S202
P
V
L
N
Q
P
Q
S
E
W
F
G
S
T
L
Site 23
Y210
E
W
F
G
S
T
L
Y
D
Q
V
H
P
D
D
Site 24
S226
D
K
L
R
E
Q
L
S
T
S
E
N
A
L
T
Site 25
T227
K
L
R
E
Q
L
S
T
S
E
N
A
L
T
G
Site 26
S228
L
R
E
Q
L
S
T
S
E
N
A
L
T
G
R
Site 27
T233
S
T
S
E
N
A
L
T
G
R
I
L
D
L
K
Site 28
T241
G
R
I
L
D
L
K
T
G
T
V
K
K
E
G
Site 29
S252
K
K
E
G
Q
Q
S
S
M
R
M
C
M
G
S
Site 30
S271
I
C
R
M
R
C
G
S
S
S
V
D
P
V
S
Site 31
S273
R
M
R
C
G
S
S
S
V
D
P
V
S
V
N
Site 32
S283
P
V
S
V
N
R
L
S
F
V
R
N
R
C
R
Site 33
S295
R
C
R
N
G
L
G
S
V
K
D
G
E
P
H
Site 34
T346
A
I
G
R
L
Q
V
T
S
S
P
N
C
T
D
Site 35
S347
I
G
R
L
Q
V
T
S
S
P
N
C
T
D
M
Site 36
S348
G
R
L
Q
V
T
S
S
P
N
C
T
D
M
S
Site 37
T383
V
D
H
R
C
V
A
T
V
G
Y
Q
P
Q
E
Site 38
S411
D
Q
Q
L
L
R
D
S
F
Q
Q
V
V
K
L
Site 39
S424
K
L
K
G
Q
V
L
S
V
M
F
R
F
R
S
Site 40
T445
W
M
R
T
S
S
F
T
F
Q
N
P
Y
S
D
Site 41
T462
E
Y
I
I
C
T
N
T
N
V
K
N
S
S
Q
Site 42
S468
N
T
N
V
K
N
S
S
Q
E
P
R
P
T
L
Site 43
T474
S
S
Q
E
P
R
P
T
L
S
N
T
I
Q
R
Site 44
S476
Q
E
P
R
P
T
L
S
N
T
I
Q
R
P
Q
Site 45
T478
P
R
P
T
L
S
N
T
I
Q
R
P
Q
L
G
Site 46
S521
P
G
R
D
G
L
A
S
Y
N
H
S
Q
V
V
Site 47
Y522
G
R
D
G
L
A
S
Y
N
H
S
Q
V
V
Q
Site 48
S525
G
L
A
S
Y
N
H
S
Q
V
V
Q
P
V
T
Site 49
T532
S
Q
V
V
Q
P
V
T
T
T
G
P
E
H
S
Site 50
S545
H
S
K
P
L
E
K
S
D
G
L
F
A
Q
D
Site 51
S558
Q
D
R
D
P
R
F
S
E
I
Y
H
N
I
N
Site 52
Y561
D
P
R
F
S
E
I
Y
H
N
I
N
A
D
Q
Site 53
S569
H
N
I
N
A
D
Q
S
K
G
I
S
S
S
T
Site 54
S573
A
D
Q
S
K
G
I
S
S
S
T
V
P
A
T
Site 55
S575
Q
S
K
G
I
S
S
S
T
V
P
A
T
Q
Q
Site 56
T576
S
K
G
I
S
S
S
T
V
P
A
T
Q
Q
L
Site 57
T580
S
S
S
T
V
P
A
T
Q
Q
L
F
S
Q
G
Site 58
S585
P
A
T
Q
Q
L
F
S
Q
G
N
T
F
P
P
Site 59
T589
Q
L
F
S
Q
G
N
T
F
P
P
T
P
R
P
Site 60
T593
Q
G
N
T
F
P
P
T
P
R
P
A
E
N
F
Site 61
S603
P
A
E
N
F
R
N
S
G
L
A
P
P
V
T
Site 62
S629
L
A
Q
I
S
R
H
S
N
P
T
Q
G
A
T
Site 63
T632
I
S
R
H
S
N
P
T
Q
G
A
T
P
T
W
Site 64
T636
S
N
P
T
Q
G
A
T
P
T
W
T
P
T
T
Site 65
T638
P
T
Q
G
A
T
P
T
W
T
P
T
T
R
S
Site 66
T640
Q
G
A
T
P
T
W
T
P
T
T
R
S
G
F
Site 67
T642
A
T
P
T
W
T
P
T
T
R
S
G
F
S
A
Site 68
T643
T
P
T
W
T
P
T
T
R
S
G
F
S
A
Q
Site 69
S663
A
T
A
K
T
R
T
S
Q
F
G
V
G
S
F
Site 70
S669
T
S
Q
F
G
V
G
S
F
Q
T
P
S
S
F
Site 71
T672
F
G
V
G
S
F
Q
T
P
S
S
F
S
S
M
Site 72
S674
V
G
S
F
Q
T
P
S
S
F
S
S
M
S
L
Site 73
S675
G
S
F
Q
T
P
S
S
F
S
S
M
S
L
P
Site 74
S677
F
Q
T
P
S
S
F
S
S
M
S
L
P
G
A
Site 75
S678
Q
T
P
S
S
F
S
S
M
S
L
P
G
A
P
Site 76
S680
P
S
S
F
S
S
M
S
L
P
G
A
P
T
A
Site 77
Y694
A
S
P
G
A
A
A
Y
P
S
L
T
N
R
G
Site 78
S696
P
G
A
A
A
Y
P
S
L
T
N
R
G
S
N
Site 79
T698
A
A
A
Y
P
S
L
T
N
R
G
S
N
F
A
Site 80
S702
P
S
L
T
N
R
G
S
N
F
A
P
E
T
G
Site 81
T711
F
A
P
E
T
G
Q
T
A
G
Q
F
Q
T
R
Site 82
T719
A
G
Q
F
Q
T
R
T
A
E
G
V
G
V
W
Site 83
S738
G
Q
Q
P
H
H
R
S
S
S
S
E
Q
H
V
Site 84
S739
Q
Q
P
H
H
R
S
S
S
S
E
Q
H
V
Q
Site 85
S740
Q
P
H
H
R
S
S
S
S
E
Q
H
V
Q
Q
Site 86
S741
P
H
H
R
S
S
S
S
E
Q
H
V
Q
Q
P
Site 87
S764
E
V
F
Q
E
M
L
S
M
L
G
D
Q
S
N
Site 88
S770
L
S
M
L
G
D
Q
S
N
S
Y
N
N
E
E
Site 89
Y773
L
G
D
Q
S
N
S
Y
N
N
E
E
F
P
D
Site 90
T782
N
E
E
F
P
D
L
T
M
F
P
P
F
S
E
Site 91
S788
L
T
M
F
P
P
F
S
E
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation