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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TARS
Full Name:
Threonyl-tRNA synthetase, cytoplasmic
Alias:
EC 6.1.1.3; SYTC; Threonine--tRNA ligase; ThrRS, Threonine-tRNA ligase
Type:
Ligase; EC 6.1.1.3
Mass (Da):
83435
Number AA:
723
UniProt ID:
P26639
International Prot ID:
IPI00329633
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042803
GO:0004829
PhosphoSite+
KinaseNET
Biological Process:
GO:0006435
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
F
E
E
K
A
S
S
P
S
G
K
M
G
G
Site 2
S39
K
K
K
N
K
E
G
S
G
D
G
G
R
A
E
Site 3
Y53
E
L
N
P
W
P
E
Y
I
Y
T
R
L
E
M
Site 4
Y55
N
P
W
P
E
Y
I
Y
T
R
L
E
M
Y
N
Site 5
S80
A
E
K
A
E
K
D
S
K
P
I
K
V
T
L
Site 6
T86
D
S
K
P
I
K
V
T
L
P
D
G
K
Q
V
Site 7
S97
G
K
Q
V
D
A
E
S
W
K
T
T
P
Y
Q
Site 8
T100
V
D
A
E
S
W
K
T
T
P
Y
Q
I
A
C
Site 9
T101
D
A
E
S
W
K
T
T
P
Y
Q
I
A
C
G
Site 10
Y103
E
S
W
K
T
T
P
Y
Q
I
A
C
G
I
S
Site 11
T117
S
Q
G
L
A
D
N
T
V
I
A
K
V
N
N
Site 12
T138
R
P
L
E
E
D
C
T
L
E
L
L
K
F
E
Site 13
Y153
D
E
E
A
Q
A
V
Y
W
H
S
S
A
H
I
Site 14
Y184
P
P
I
E
N
G
F
Y
Y
D
M
Y
L
E
E
Site 15
Y185
P
I
E
N
G
F
Y
Y
D
M
Y
L
E
E
G
Site 16
Y188
N
G
F
Y
Y
D
M
Y
L
E
E
G
G
V
S
Site 17
S195
Y
L
E
E
G
G
V
S
S
N
D
F
S
S
L
Site 18
S196
L
E
E
G
G
V
S
S
N
D
F
S
S
L
E
Site 19
S200
G
V
S
S
N
D
F
S
S
L
E
A
L
C
K
Site 20
S201
V
S
S
N
D
F
S
S
L
E
A
L
C
K
K
Site 21
T246
I
L
N
E
K
V
N
T
P
T
T
T
V
Y
R
Site 22
T249
E
K
V
N
T
P
T
T
T
V
Y
R
C
G
P
Site 23
T250
K
V
N
T
P
T
T
T
V
Y
R
C
G
P
L
Site 24
Y252
N
T
P
T
T
T
V
Y
R
C
G
P
L
I
D
Site 25
T269
R
G
P
H
V
R
H
T
G
K
I
K
A
L
K
Site 26
S282
L
K
I
H
K
N
S
S
T
Y
W
E
G
K
A
Site 27
T293
E
G
K
A
D
M
E
T
L
Q
R
I
Y
G
I
Site 28
Y298
M
E
T
L
Q
R
I
Y
G
I
S
F
P
D
P
Site 29
S301
L
Q
R
I
Y
G
I
S
F
P
D
P
K
M
L
Site 30
Y333
I
G
R
D
Q
E
L
Y
F
F
H
E
L
S
P
Site 31
S362
A
L
I
E
F
I
R
S
E
Y
R
K
R
G
F
Site 32
Y364
I
E
F
I
R
S
E
Y
R
K
R
G
F
Q
E
Site 33
T374
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
Site 34
S398
H
Y
S
E
N
M
F
S
F
E
V
E
K
E
L
Site 35
S426
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
Site 36
T450
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
Site 37
T453
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
Site 38
S499
F
S
F
K
L
N
L
S
T
R
P
E
K
F
L
Site 39
S522
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
Site 40
T574
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
Site 41
Y575
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
Site 42
S577
R
F
N
L
T
Y
V
S
H
D
G
D
D
K
K
Site 43
T605
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
Site 44
S617
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
Site 45
Y633
V
G
P
T
C
D
E
Y
A
Q
K
V
R
Q
Q
Site 46
T657
I
D
L
D
P
G
C
T
L
N
K
K
I
R
N
Site 47
T685
E
K
E
K
I
S
G
T
V
N
I
R
T
R
D
Site 48
T690
S
G
T
V
N
I
R
T
R
D
N
K
V
H
G
Site 49
S702
V
H
G
E
R
T
I
S
E
T
I
E
R
L
Q
Site 50
T704
G
E
R
T
I
S
E
T
I
E
R
L
Q
Q
L
Site 51
S716
Q
Q
L
K
E
F
R
S
K
Q
A
E
E
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation