KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CHML
Full Name:
Rab proteins geranylgeranyltransferase component A 2
Alias:
Choroideraemia-like protein; Choroideremia-like; Choroideremia-like (Rab escort protein 2); Rab escort protein 2; RAE2; REP2; REP-2
Type:
Mass (Da):
74070
Number AA:
UniProt ID:
P26374
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005968
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0004663
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0043087
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
Q
R
V
L
H
I
D
S
R
S
Y
Y
G
G
N
Site 2
Y42
L
H
I
D
S
R
S
Y
Y
G
G
N
W
A
S
Site 3
Y43
H
I
D
S
R
S
Y
Y
G
G
N
W
A
S
F
Site 4
S57
F
S
F
S
G
L
L
S
W
L
K
E
Y
Q
Q
Site 5
T88
H
E
T
E
E
A
I
T
L
R
K
K
D
E
T
Site 6
T95
T
L
R
K
K
D
E
T
I
Q
H
T
E
A
F
Site 7
Y104
Q
H
T
E
A
F
C
Y
A
S
Q
D
M
E
D
Site 8
S124
G
A
L
Q
K
N
P
S
L
G
V
S
N
T
F
Site 9
S128
K
N
P
S
L
G
V
S
N
T
F
T
E
V
L
Site 10
T130
P
S
L
G
V
S
N
T
F
T
E
V
L
D
S
Site 11
S137
T
F
T
E
V
L
D
S
A
L
P
E
E
S
Q
Site 12
S143
D
S
A
L
P
E
E
S
Q
L
S
Y
F
N
S
Site 13
S146
L
P
E
E
S
Q
L
S
Y
F
N
S
D
E
M
Site 14
Y147
P
E
E
S
Q
L
S
Y
F
N
S
D
E
M
P
Site 15
S150
S
Q
L
S
Y
F
N
S
D
E
M
P
A
K
H
Site 16
S161
P
A
K
H
T
Q
K
S
D
T
E
I
S
L
E
Site 17
S166
Q
K
S
D
T
E
I
S
L
E
V
T
D
V
E
Site 18
T170
T
E
I
S
L
E
V
T
D
V
E
E
S
V
E
Site 19
S175
E
V
T
D
V
E
E
S
V
E
K
E
K
Y
C
Site 20
Y181
E
S
V
E
K
E
K
Y
C
G
D
K
T
C
M
Site 21
T190
G
D
K
T
C
M
H
T
V
S
D
K
D
G
D
Site 22
S203
G
D
K
D
E
S
K
S
T
V
E
D
K
A
D
Site 23
T204
D
K
D
E
S
K
S
T
V
E
D
K
A
D
E
Site 24
T218
E
P
I
R
N
R
I
T
Y
S
Q
I
V
K
E
Site 25
Y219
P
I
R
N
R
I
T
Y
S
Q
I
V
K
E
G
Site 26
S220
I
R
N
R
I
T
Y
S
Q
I
V
K
E
G
R
Site 27
S235
R
F
N
I
D
L
V
S
K
L
L
Y
S
Q
G
Site 28
Y256
I
K
S
D
V
S
R
Y
V
E
F
K
N
V
T
Site 29
S279
K
V
E
Q
V
P
C
S
R
A
D
V
F
N
S
Site 30
T290
V
F
N
S
K
E
L
T
M
V
E
K
R
M
L
Site 31
Y314
Y
E
Q
H
P
D
E
Y
Q
A
F
R
Q
C
S
Site 32
S321
Y
Q
A
F
R
Q
C
S
F
S
E
Y
L
K
T
Site 33
S323
A
F
R
Q
C
S
F
S
E
Y
L
K
T
K
K
Site 34
Y325
R
Q
C
S
F
S
E
Y
L
K
T
K
K
L
T
Site 35
T328
S
F
S
E
Y
L
K
T
K
K
L
T
P
N
L
Site 36
T332
Y
L
K
T
K
K
L
T
P
N
L
Q
H
F
V
Site 37
S349
S
I
A
M
T
S
E
S
S
C
T
T
I
D
G
Site 38
T352
M
T
S
E
S
S
C
T
T
I
D
G
L
N
A
Site 39
T353
T
S
E
S
S
C
T
T
I
D
G
L
N
A
T
Site 40
Y380
T
P
F
L
F
P
L
Y
G
Q
G
E
I
P
Q
Site 41
Y433
G
Q
R
I
N
A
K
Y
F
I
V
E
D
S
Y
Site 42
S439
K
Y
F
I
V
E
D
S
Y
L
S
E
E
T
C
Site 43
Y440
Y
F
I
V
E
D
S
Y
L
S
E
E
T
C
S
Site 44
S442
I
V
E
D
S
Y
L
S
E
E
T
C
S
N
V
Site 45
Y451
E
T
C
S
N
V
Q
Y
K
Q
I
S
R
A
V
Site 46
T468
T
D
Q
S
I
L
K
T
D
L
D
Q
Q
T
S
Site 47
T500
E
L
C
S
S
T
M
T
C
M
K
D
T
Y
L
Site 48
T511
D
T
Y
L
V
H
L
T
C
S
S
S
K
T
A
Site 49
S515
V
H
L
T
C
S
S
S
K
T
A
R
E
D
L
Site 50
T517
L
T
C
S
S
S
K
T
A
R
E
D
L
E
S
Site 51
S524
T
A
R
E
D
L
E
S
V
V
K
K
L
F
T
Site 52
T531
S
V
V
K
K
L
F
T
P
Y
T
E
T
E
I
Site 53
T534
K
K
L
F
T
P
Y
T
E
T
E
I
N
E
E
Site 54
T544
E
I
N
E
E
E
L
T
K
P
R
L
L
W
A
Site 55
Y553
P
R
L
L
W
A
L
Y
F
N
M
R
D
S
S
Site 56
S559
L
Y
F
N
M
R
D
S
S
G
I
S
R
S
S
Site 57
S560
Y
F
N
M
R
D
S
S
G
I
S
R
S
S
Y
Site 58
S563
M
R
D
S
S
G
I
S
R
S
S
Y
N
G
L
Site 59
S565
D
S
S
G
I
S
R
S
S
Y
N
G
L
P
S
Site 60
S566
S
S
G
I
S
R
S
S
Y
N
G
L
P
S
N
Site 61
Y567
S
G
I
S
R
S
S
Y
N
G
L
P
S
N
V
Site 62
S572
S
S
Y
N
G
L
P
S
N
V
Y
V
C
S
G
Site 63
Y575
N
G
L
P
S
N
V
Y
V
C
S
G
P
D
C
Site 64
T603
L
F
Q
E
I
F
P
T
E
E
F
C
P
P
P
Site 65
T630
K
Q
P
E
A
P
G
T
N
N
V
V
M
A
K
Site 66
S644
K
L
E
S
S
E
E
S
K
N
L
E
S
P
E
Site 67
S649
E
E
S
K
N
L
E
S
P
E
K
H
L
Q
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation