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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UCP1
Full Name:
Mitochondrial brown fat uncoupling protein 1
Alias:
Mitochondrial brown fat uncoupling 1; SLC25A7; Thermogenin; UCP; UCP 1; Uncoupling protein 1 (mitochondrial, proton carrier)
Type:
Mitochondrial
Mass (Da):
33005
Number AA:
307
UniProt ID:
P25874
International Prot ID:
IPI00299306
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005743
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0050873
GO:0006839
GO:0015992
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S50
V
Q
G
E
C
P
T
S
S
V
I
R
Y
K
G
Site 2
S51
Q
G
E
C
P
T
S
S
V
I
R
Y
K
G
V
Site 3
Y55
P
T
S
S
V
I
R
Y
K
G
V
L
G
T
I
Site 4
T61
R
Y
K
G
V
L
G
T
I
T
A
V
V
K
T
Site 5
S76
E
G
R
M
K
L
Y
S
G
L
P
A
G
L
Q
Site 6
S87
A
G
L
Q
R
Q
I
S
S
A
S
L
R
I
G
Site 7
S90
Q
R
Q
I
S
S
A
S
L
R
I
G
L
Y
D
Site 8
S112
A
G
K
E
T
A
P
S
L
G
S
K
I
L
A
Site 9
S145
K
V
R
L
Q
A
Q
S
H
L
H
G
I
K
P
Site 10
Y154
L
H
G
I
K
P
R
Y
T
G
T
Y
N
A
Y
Site 11
T155
H
G
I
K
P
R
Y
T
G
T
Y
N
A
Y
R
Site 12
Y158
K
P
R
Y
T
G
T
Y
N
A
Y
R
I
I
A
Site 13
T178
T
G
L
W
K
G
T
T
P
N
L
M
R
S
V
Site 14
Y195
N
C
T
E
L
V
T
Y
D
L
M
K
E
A
F
Site 15
T238
S
P
V
D
V
V
K
T
R
F
I
N
S
P
P
Site 16
S243
V
K
T
R
F
I
N
S
P
P
G
Q
Y
K
S
Site 17
S250
S
P
P
G
Q
Y
K
S
V
P
N
C
A
M
K
Site 18
T260
N
C
A
M
K
V
F
T
N
E
G
P
T
A
F
Site 19
T265
V
F
T
N
E
G
P
T
A
F
F
K
G
L
V
Site 20
S297
E
Q
L
K
R
E
L
S
K
S
R
Q
T
M
D
Site 21
S299
L
K
R
E
L
S
K
S
R
Q
T
M
D
C
A
Site 22
T302
E
L
S
K
S
R
Q
T
M
D
C
A
T
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation