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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EDNRA
Full Name:
Endothelin-1 receptor
Alias:
Endothelin A receptor; Endothelin receptor type A; ETA; ET-A; ETA-R; ETRA; G protein-coupled receptor
Type:
Receptor, G protein-coupled
Mass (Da):
48722
Number AA:
427
UniProt ID:
P25101
International Prot ID:
IPI00434353
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0001599
GO:0004435
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007190
GO:0014824
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
A
L
V
G
C
V
I
S
D
N
P
E
R
Y
S
Site 2
S27
S
D
N
P
E
R
Y
S
T
N
L
S
N
H
V
Site 3
T28
D
N
P
E
R
Y
S
T
N
L
S
N
H
V
D
Site 4
S31
E
R
Y
S
T
N
L
S
N
H
V
D
D
F
T
Site 5
T38
S
N
H
V
D
D
F
T
T
F
R
G
T
E
L
Site 6
T39
N
H
V
D
D
F
T
T
F
R
G
T
E
L
S
Site 7
S46
T
F
R
G
T
E
L
S
F
L
V
T
T
H
Q
Site 8
T50
T
E
L
S
F
L
V
T
T
H
Q
P
T
N
L
Site 9
S61
P
T
N
L
V
L
P
S
N
G
S
M
H
N
Y
Site 10
Y68
S
N
G
S
M
H
N
Y
C
P
Q
Q
T
K
I
Site 11
Y106
A
T
L
L
R
I
I
Y
Q
N
K
C
M
R
N
Site 12
Y184
C
A
L
S
V
D
R
Y
R
A
V
A
S
W
S
Site 13
S189
D
R
Y
R
A
V
A
S
W
S
R
V
Q
G
I
Site 14
Y263
D
W
W
L
F
G
F
Y
F
C
M
P
L
V
C
Site 15
Y275
L
V
C
T
A
I
F
Y
T
L
M
T
C
E
M
Site 16
S289
M
L
N
R
R
N
G
S
L
R
I
A
L
S
E
Site 17
S295
G
S
L
R
I
A
L
S
E
H
L
K
Q
R
R
Site 18
T331
L
S
R
I
L
K
K
T
V
Y
N
E
M
D
K
Site 19
Y333
R
I
L
K
K
T
V
Y
N
E
M
D
K
N
R
Site 20
S382
K
F
K
N
C
F
Q
S
C
L
C
C
C
C
Y
Site 21
Y389
S
C
L
C
C
C
C
Y
Q
S
K
S
L
M
T
Site 22
S391
L
C
C
C
C
Y
Q
S
K
S
L
M
T
S
V
Site 23
S393
C
C
C
Y
Q
S
K
S
L
M
T
S
V
P
M
Site 24
T396
Y
Q
S
K
S
L
M
T
S
V
P
M
N
G
T
Site 25
S397
Q
S
K
S
L
M
T
S
V
P
M
N
G
T
S
Site 26
T403
T
S
V
P
M
N
G
T
S
I
Q
W
K
N
H
Site 27
S404
S
V
P
M
N
G
T
S
I
Q
W
K
N
H
D
Site 28
T417
H
D
Q
N
N
H
N
T
D
R
S
S
H
K
D
Site 29
S420
N
N
H
N
T
D
R
S
S
H
K
D
S
M
N
Site 30
S421
N
H
N
T
D
R
S
S
H
K
D
S
M
N
_
Site 31
S425
D
R
S
S
H
K
D
S
M
N
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation