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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APC
Full Name:
Adenomatous polyposis coli protein
Alias:
Adenomatous polyposis coli; Adenomatous polyposis of the colon gene; APC protein; Deleted in polyposis 2.5; DP2; DP2.5; DP3; MAPC
Type:
Tumour suppressor protein
Mass (Da):
311646
Number AA:
2843
UniProt ID:
P25054
International Prot ID:
IPI00012391
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034747
GO:0005912
GO:0030877
Uniprot
OncoNet
Molecular Function:
GO:0008013
GO:0008017
GO:0019901
PhosphoSite+
KinaseNET
Biological Process:
GO:0060070
GO:0007155
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
E
A
L
K
M
E
N
S
N
L
R
Q
E
L
E
Site 2
S31
R
Q
E
L
E
D
N
S
N
H
L
T
K
L
E
Site 3
T35
E
D
N
S
N
H
L
T
K
L
E
T
E
A
S
Site 4
S42
T
K
L
E
T
E
A
S
N
M
K
E
V
L
K
Site 5
S80
K
E
L
N
L
D
S
S
N
F
P
G
V
K
L
Site 6
S89
F
P
G
V
K
L
R
S
K
M
S
L
R
S
Y
Site 7
S92
V
K
L
R
S
K
M
S
L
R
S
Y
G
S
R
Site 8
S95
R
S
K
M
S
L
R
S
Y
G
S
R
E
G
S
Site 9
Y96
S
K
M
S
L
R
S
Y
G
S
R
E
G
S
V
Site 10
S98
M
S
L
R
S
Y
G
S
R
E
G
S
V
S
S
Site 11
S102
S
Y
G
S
R
E
G
S
V
S
S
R
S
G
E
Site 12
S104
G
S
R
E
G
S
V
S
S
R
S
G
E
C
S
Site 13
S105
S
R
E
G
S
V
S
S
R
S
G
E
C
S
P
Site 14
S107
E
G
S
V
S
S
R
S
G
E
C
S
P
V
P
Site 15
S111
S
S
R
S
G
E
C
S
P
V
P
M
G
S
F
Site 16
S127
R
R
G
F
V
N
G
S
R
E
S
T
G
Y
L
Site 17
S130
F
V
N
G
S
R
E
S
T
G
Y
L
E
E
L
Site 18
T131
V
N
G
S
R
E
S
T
G
Y
L
E
E
L
E
Site 19
Y133
G
S
R
E
S
T
G
Y
L
E
E
L
E
K
E
Site 20
S142
E
E
L
E
K
E
R
S
L
L
L
A
D
L
D
Site 21
Y158
E
E
K
E
K
D
W
Y
Y
A
Q
L
Q
N
L
Site 22
Y159
E
K
E
K
D
W
Y
Y
A
Q
L
Q
N
L
T
Site 23
S171
N
L
T
K
R
I
D
S
L
P
L
T
E
N
F
Site 24
T175
R
I
D
S
L
P
L
T
E
N
F
S
L
Q
T
Site 25
S179
L
P
L
T
E
N
F
S
L
Q
T
D
M
T
R
Site 26
T185
F
S
L
Q
T
D
M
T
R
R
Q
L
E
Y
E
Site 27
Y191
M
T
R
R
Q
L
E
Y
E
A
R
Q
I
R
V
Site 28
T206
A
M
E
E
Q
L
G
T
C
Q
D
M
E
K
R
Site 29
S237
R
I
R
Q
L
L
Q
S
Q
A
T
E
A
E
R
Site 30
S245
Q
A
T
E
A
E
R
S
S
Q
N
K
H
E
T
Site 31
S246
A
T
E
A
E
R
S
S
Q
N
K
H
E
T
G
Site 32
S274
G
E
I
N
M
A
T
S
G
N
G
Q
G
S
T
Site 33
S280
T
S
G
N
G
Q
G
S
T
T
R
M
D
H
E
Site 34
T281
S
G
N
G
Q
G
S
T
T
R
M
D
H
E
T
Site 35
T288
T
T
R
M
D
H
E
T
A
S
V
L
S
S
S
Site 36
S290
R
M
D
H
E
T
A
S
V
L
S
S
S
S
T
Site 37
S293
H
E
T
A
S
V
L
S
S
S
S
T
H
S
A
Site 38
S294
E
T
A
S
V
L
S
S
S
S
T
H
S
A
P
Site 39
S295
T
A
S
V
L
S
S
S
S
T
H
S
A
P
R
Site 40
S296
A
S
V
L
S
S
S
S
T
H
S
A
P
R
R
Site 41
T297
S
V
L
S
S
S
S
T
H
S
A
P
R
R
L
Site 42
S299
L
S
S
S
S
T
H
S
A
P
R
R
L
T
S
Site 43
T305
H
S
A
P
R
R
L
T
S
H
L
G
T
K
V
Site 44
S306
S
A
P
R
R
L
T
S
H
L
G
T
K
V
E
Site 45
T310
R
L
T
S
H
L
G
T
K
V
E
M
V
Y
S
Site 46
Y316
G
T
K
V
E
M
V
Y
S
L
L
S
M
L
G
Site 47
S317
T
K
V
E
M
V
Y
S
L
L
S
M
L
G
T
Site 48
T324
S
L
L
S
M
L
G
T
H
D
K
D
D
M
S
Site 49
S331
T
H
D
K
D
D
M
S
R
T
L
L
A
M
S
Site 50
T333
D
K
D
D
M
S
R
T
L
L
A
M
S
S
S
Site 51
S338
S
R
T
L
L
A
M
S
S
S
Q
D
S
C
I
Site 52
S339
R
T
L
L
A
M
S
S
S
Q
D
S
C
I
S
Site 53
S343
A
M
S
S
S
Q
D
S
C
I
S
M
R
Q
S
Site 54
S346
S
S
Q
D
S
C
I
S
M
R
Q
S
G
C
L
Site 55
S367
L
H
G
N
D
K
D
S
V
L
L
G
N
S
R
Site 56
S376
L
L
G
N
S
R
G
S
K
E
A
R
A
R
A
Site 57
S384
K
E
A
R
A
R
A
S
A
A
L
H
N
I
I
Site 58
S393
A
L
H
N
I
I
H
S
Q
P
D
D
K
R
G
Site 59
S457
V
C
V
L
M
K
L
S
F
D
E
E
H
R
H
Site 60
Y493
Y
G
L
T
N
D
H
Y
S
I
T
L
R
R
Y
Site 61
T496
T
N
D
H
Y
S
I
T
L
R
R
Y
A
G
M
Site 62
Y500
Y
S
I
T
L
R
R
Y
A
G
M
A
L
T
N
Site 63
S535
A
L
V
A
Q
L
K
S
E
S
E
D
L
Q
Q
Site 64
S552
A
S
V
L
R
N
L
S
W
R
A
D
V
N
S
Site 65
S559
S
W
R
A
D
V
N
S
K
K
T
L
R
E
V
Site 66
T562
A
D
V
N
S
K
K
T
L
R
E
V
G
S
V
Site 67
S568
K
T
L
R
E
V
G
S
V
K
A
L
M
E
C
Site 68
T584
L
E
V
K
K
E
S
T
L
K
S
V
L
S
A
Site 69
S587
K
K
E
S
T
L
K
S
V
L
S
A
L
W
N
Site 70
S596
L
S
A
L
W
N
L
S
A
H
C
T
E
N
K
Site 71
T600
W
N
L
S
A
H
C
T
E
N
K
A
D
I
C
Site 72
T621
A
F
L
V
G
T
L
T
Y
R
S
Q
T
N
T
Site 73
S624
V
G
T
L
T
Y
R
S
Q
T
N
T
L
A
I
Site 74
T626
T
L
T
Y
R
S
Q
T
N
T
L
A
I
I
E
Site 75
T628
T
Y
R
S
Q
T
N
T
L
A
I
I
E
S
G
Site 76
S644
G
I
L
R
N
V
S
S
L
I
A
T
N
E
D
Site 77
T648
N
V
S
S
L
I
A
T
N
E
D
H
R
Q
I
Site 78
S673
L
Q
H
L
K
S
H
S
L
T
I
V
S
N
A
Site 79
S713
M
L
K
N
L
I
H
S
K
H
K
M
I
A
M
Site 80
Y737
M
A
N
R
P
A
K
Y
K
D
A
N
I
M
S
Site 81
S744
Y
K
D
A
N
I
M
S
P
G
S
S
L
P
S
Site 82
S747
A
N
I
M
S
P
G
S
S
L
P
S
L
H
V
Site 83
S748
N
I
M
S
P
G
S
S
L
P
S
L
H
V
R
Site 84
S751
S
P
G
S
S
L
P
S
L
H
V
R
K
Q
K
Site 85
S770
E
L
D
A
Q
H
L
S
E
T
F
D
N
I
D
Site 86
T772
D
A
Q
H
L
S
E
T
F
D
N
I
D
N
L
Site 87
S780
F
D
N
I
D
N
L
S
P
K
A
S
H
R
S
Site 88
S784
D
N
L
S
P
K
A
S
H
R
S
K
Q
R
H
Site 89
S787
S
P
K
A
S
H
R
S
K
Q
R
H
K
Q
S
Site 90
S794
S
K
Q
R
H
K
Q
S
L
Y
G
D
Y
V
F
Site 91
Y796
Q
R
H
K
Q
S
L
Y
G
D
Y
V
F
D
T
Site 92
Y799
K
Q
S
L
Y
G
D
Y
V
F
D
T
N
R
H
Site 93
T803
Y
G
D
Y
V
F
D
T
N
R
H
D
D
N
R
Site 94
S811
N
R
H
D
D
N
R
S
D
N
F
N
T
G
N
Site 95
T820
N
F
N
T
G
N
M
T
V
L
S
P
Y
L
N
Site 96
T828
V
L
S
P
Y
L
N
T
T
V
L
P
S
S
S
Site 97
T829
L
S
P
Y
L
N
T
T
V
L
P
S
S
S
S
Site 98
S833
L
N
T
T
V
L
P
S
S
S
S
S
R
G
S
Site 99
S834
N
T
T
V
L
P
S
S
S
S
S
R
G
S
L
Site 100
S835
T
T
V
L
P
S
S
S
S
S
R
G
S
L
D
Site 101
S836
T
V
L
P
S
S
S
S
S
R
G
S
L
D
S
Site 102
S837
V
L
P
S
S
S
S
S
R
G
S
L
D
S
S
Site 103
S840
S
S
S
S
S
R
G
S
L
D
S
S
R
S
E
Site 104
S843
S
S
R
G
S
L
D
S
S
R
S
E
K
D
R
Site 105
S844
S
R
G
S
L
D
S
S
R
S
E
K
D
R
S
Site 106
S846
G
S
L
D
S
S
R
S
E
K
D
R
S
L
E
Site 107
S851
S
R
S
E
K
D
R
S
L
E
R
E
R
G
I
Site 108
Y863
R
G
I
G
L
G
N
Y
H
P
A
T
E
N
P
Site 109
T867
L
G
N
Y
H
P
A
T
E
N
P
G
T
S
S
Site 110
T872
P
A
T
E
N
P
G
T
S
S
K
R
G
L
Q
Site 111
S874
T
E
N
P
G
T
S
S
K
R
G
L
Q
I
S
Site 112
S881
S
K
R
G
L
Q
I
S
T
T
A
A
Q
I
A
Site 113
T883
R
G
L
Q
I
S
T
T
A
A
Q
I
A
K
V
Site 114
S895
A
K
V
M
E
E
V
S
A
I
H
T
S
Q
E
Site 115
T899
E
E
V
S
A
I
H
T
S
Q
E
D
R
S
S
Site 116
S900
E
V
S
A
I
H
T
S
Q
E
D
R
S
S
G
Site 117
S905
H
T
S
Q
E
D
R
S
S
G
S
T
T
E
L
Site 118
S906
T
S
Q
E
D
R
S
S
G
S
T
T
E
L
H
Site 119
T909
E
D
R
S
S
G
S
T
T
E
L
H
C
V
T
Site 120
T910
D
R
S
S
G
S
T
T
E
L
H
C
V
T
D
Site 121
S925
E
R
N
A
L
R
R
S
S
A
A
H
T
H
S
Site 122
S926
R
N
A
L
R
R
S
S
A
A
H
T
H
S
N
Site 123
T930
R
R
S
S
A
A
H
T
H
S
N
T
Y
N
F
Site 124
S932
S
S
A
A
H
T
H
S
N
T
Y
N
F
T
K
Site 125
S943
N
F
T
K
S
E
N
S
N
R
T
C
S
M
P
Site 126
S948
E
N
S
N
R
T
C
S
M
P
Y
A
K
L
E
Site 127
Y951
N
R
T
C
S
M
P
Y
A
K
L
E
Y
K
R
Site 128
Y956
M
P
Y
A
K
L
E
Y
K
R
S
S
N
D
S
Site 129
S959
A
K
L
E
Y
K
R
S
S
N
D
S
L
N
S
Site 130
S960
K
L
E
Y
K
R
S
S
N
D
S
L
N
S
V
Site 131
S963
Y
K
R
S
S
N
D
S
L
N
S
V
S
S
S
Site 132
S966
S
S
N
D
S
L
N
S
V
S
S
S
D
G
Y
Site 133
S968
N
D
S
L
N
S
V
S
S
S
D
G
Y
G
K
Site 134
S969
D
S
L
N
S
V
S
S
S
D
G
Y
G
K
R
Site 135
S970
S
L
N
S
V
S
S
S
D
G
Y
G
K
R
G
Site 136
Y973
S
V
S
S
S
D
G
Y
G
K
R
G
Q
M
K
Site 137
S982
K
R
G
Q
M
K
P
S
I
E
S
Y
S
E
D
Site 138
Y986
M
K
P
S
I
E
S
Y
S
E
D
D
E
S
K
Site 139
S987
K
P
S
I
E
S
Y
S
E
D
D
E
S
K
F
Site 140
S992
S
Y
S
E
D
D
E
S
K
F
C
S
Y
G
Q
Site 141
S996
D
D
E
S
K
F
C
S
Y
G
Q
Y
P
A
D
Site 142
Y1000
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S
S
I
L
S
A
S
S
E
Site 446
S2575
G
S
S
S
S
I
L
S
A
S
S
E
S
S
E
Site 447
S2577
S
S
S
I
L
S
A
S
S
E
S
S
E
K
A
Site 448
S2578
S
S
I
L
S
A
S
S
E
S
S
E
K
A
K
Site 449
S2581
L
S
A
S
S
E
S
S
E
K
A
K
S
E
D
Site 450
S2586
E
S
S
E
K
A
K
S
E
D
E
K
H
V
N
Site 451
S2596
E
K
H
V
N
S
I
S
G
T
K
Q
S
K
E
Site 452
T2598
H
V
N
S
I
S
G
T
K
Q
S
K
E
N
Q
Site 453
S2601
S
I
S
G
T
K
Q
S
K
E
N
Q
V
S
A
Site 454
S2607
Q
S
K
E
N
Q
V
S
A
K
G
T
W
R
K
Site 455
T2611
N
Q
V
S
A
K
G
T
W
R
K
I
K
E
N
Site 456
S2621
K
I
K
E
N
E
F
S
P
T
N
S
T
S
Q
Site 457
T2623
K
E
N
E
F
S
P
T
N
S
T
S
Q
T
V
Site 458
S2625
N
E
F
S
P
T
N
S
T
S
Q
T
V
S
S
Site 459
T2626
E
F
S
P
T
N
S
T
S
Q
T
V
S
S
G
Site 460
S2627
F
S
P
T
N
S
T
S
Q
T
V
S
S
G
A
Site 461
T2629
P
T
N
S
T
S
Q
T
V
S
S
G
A
T
N
Site 462
S2631
N
S
T
S
Q
T
V
S
S
G
A
T
N
G
A
Site 463
T2642
T
N
G
A
E
S
K
T
L
I
Y
Q
M
A
P
Site 464
Y2645
A
E
S
K
T
L
I
Y
Q
M
A
P
A
V
S
Site 465
S2671
C
P
I
N
N
P
R
S
G
R
S
P
T
G
N
Site 466
S2674
N
N
P
R
S
G
R
S
P
T
G
N
T
P
P
Site 467
T2676
P
R
S
G
R
S
P
T
G
N
T
P
P
V
I
Site 468
T2679
G
R
S
P
T
G
N
T
P
P
V
I
D
S
V
Site 469
S2685
N
T
P
P
V
I
D
S
V
S
E
K
A
N
P
Site 470
S2687
P
P
V
I
D
S
V
S
E
K
A
N
P
N
I
Site 471
S2697
A
N
P
N
I
K
D
S
K
D
N
Q
A
K
Q
Site 472
S2710
K
Q
N
V
G
N
G
S
V
P
M
R
T
V
G
Site 473
T2715
N
G
S
V
P
M
R
T
V
G
L
E
N
R
L
Site 474
S2724
G
L
E
N
R
L
N
S
F
I
Q
V
D
A
P
Site 475
S2749
Q
N
N
P
V
P
V
S
E
T
N
E
S
S
I
Site 476
S2755
V
S
E
T
N
E
S
S
I
V
E
R
T
P
F
Site 477
T2760
E
S
S
I
V
E
R
T
P
F
S
S
S
S
S
Site 478
S2763
I
V
E
R
T
P
F
S
S
S
S
S
S
K
H
Site 479
S2764
V
E
R
T
P
F
S
S
S
S
S
S
K
H
S
Site 480
S2765
E
R
T
P
F
S
S
S
S
S
S
K
H
S
S
Site 481
S2766
R
T
P
F
S
S
S
S
S
S
K
H
S
S
P
Site 482
S2767
T
P
F
S
S
S
S
S
S
K
H
S
S
P
S
Site 483
S2768
P
F
S
S
S
S
S
S
K
H
S
S
P
S
G
Site 484
S2771
S
S
S
S
S
K
H
S
S
P
S
G
T
V
A
Site 485
S2772
S
S
S
S
K
H
S
S
P
S
G
T
V
A
A
Site 486
S2774
S
S
K
H
S
S
P
S
G
T
V
A
A
R
V
Site 487
T2776
K
H
S
S
P
S
G
T
V
A
A
R
V
T
P
Site 488
T2782
G
T
V
A
A
R
V
T
P
F
N
Y
N
P
S
Site 489
S2789
T
P
F
N
Y
N
P
S
P
R
K
S
S
A
D
Site 490
S2793
Y
N
P
S
P
R
K
S
S
A
D
S
T
S
A
Site 491
S2794
N
P
S
P
R
K
S
S
A
D
S
T
S
A
R
Site 492
S2797
P
R
K
S
S
A
D
S
T
S
A
R
P
S
Q
Site 493
T2798
R
K
S
S
A
D
S
T
S
A
R
P
S
Q
I
Site 494
S2799
K
S
S
A
D
S
T
S
A
R
P
S
Q
I
P
Site 495
S2803
D
S
T
S
A
R
P
S
Q
I
P
T
P
V
N
Site 496
T2807
A
R
P
S
Q
I
P
T
P
V
N
N
N
T
K
Site 497
S2818
N
N
T
K
K
R
D
S
K
T
D
S
T
E
S
Site 498
T2820
T
K
K
R
D
S
K
T
D
S
T
E
S
S
G
Site 499
S2822
K
R
D
S
K
T
D
S
T
E
S
S
G
T
Q
Site 500
T2823
R
D
S
K
T
D
S
T
E
S
S
G
T
Q
S
Site 501
S2825
S
K
T
D
S
T
E
S
S
G
T
Q
S
P
K
Site 502
S2826
K
T
D
S
T
E
S
S
G
T
Q
S
P
K
R
Site 503
T2828
D
S
T
E
S
S
G
T
Q
S
P
K
R
H
S
Site 504
S2830
T
E
S
S
G
T
Q
S
P
K
R
H
S
G
S
Site 505
S2835
T
Q
S
P
K
R
H
S
G
S
Y
L
V
T
S
Site 506
S2837
S
P
K
R
H
S
G
S
Y
L
V
T
S
V
_
Site 507
Y2838
P
K
R
H
S
G
S
Y
L
V
T
S
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation