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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKCh
Full Name:
Protein kinase C eta type
Alias:
EC 2.7.11.13; Kinase PKC-eta; KPCL; NPKC-eta; PKCL; PKC-L; PRKCH; PRKCL; Protein kinase C, eta; Protein kinase C, eta type
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; AGC group; PKC family; Eta subfamily
Mass (Da):
77828
Number AA:
683
UniProt ID:
P24723
International Prot ID:
IPI00184572
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0019899
GO:0004697
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
G
T
M
K
F
N
G
Y
L
R
V
R
I
G
E
Site 2
T25
E
A
V
G
L
Q
P
T
R
W
S
L
R
H
S
Site 3
S28
G
L
Q
P
T
R
W
S
L
R
H
S
L
F
K
Site 4
S32
T
R
W
S
L
R
H
S
L
F
K
K
G
H
Q
Site 5
Y44
G
H
Q
L
L
D
P
Y
L
T
V
S
V
D
Q
Site 6
T46
Q
L
L
D
P
Y
L
T
V
S
V
D
Q
V
R
Site 7
T57
D
Q
V
R
V
G
Q
T
S
T
K
Q
K
T
N
Site 8
S58
Q
V
R
V
G
Q
T
S
T
K
Q
K
T
N
K
Site 9
Y68
Q
K
T
N
K
P
T
Y
N
E
E
F
C
A
N
Site 10
T90
E
L
A
V
F
H
E
T
P
L
G
Y
D
H
F
Site 11
Y94
F
H
E
T
P
L
G
Y
D
H
F
V
A
N
C
Site 12
T111
Q
F
Q
E
L
R
G
T
T
G
A
S
D
T
F
Site 13
T112
F
Q
E
L
R
G
T
T
G
A
S
D
T
F
E
Site 14
S115
L
R
G
T
T
G
A
S
D
T
F
E
G
W
V
Site 15
T117
G
T
T
G
A
S
D
T
F
E
G
W
V
D
L
Site 16
T144
T
G
S
F
T
E
A
T
L
Q
R
D
R
I
F
Site 17
T177
N
G
H
K
F
M
A
T
Y
L
R
Q
P
T
Y
Site 18
Y178
G
H
K
F
M
A
T
Y
L
R
Q
P
T
Y
C
Site 19
T183
A
T
Y
L
R
Q
P
T
Y
C
S
H
C
R
E
Site 20
Y184
T
Y
L
R
Q
P
T
Y
C
S
H
C
R
E
F
Site 21
S317
G
L
Q
P
G
N
I
S
P
T
S
K
L
V
S
Site 22
S320
P
G
N
I
S
P
T
S
K
L
V
S
R
S
T
Site 23
S324
S
P
T
S
K
L
V
S
R
S
T
L
R
R
Q
Site 24
S326
T
S
K
L
V
S
R
S
T
L
R
R
Q
G
K
Site 25
T327
S
K
L
V
S
R
S
T
L
R
R
Q
G
K
E
Site 26
S335
L
R
R
Q
G
K
E
S
S
K
E
G
N
G
I
Site 27
S336
R
R
Q
G
K
E
S
S
K
E
G
N
G
I
G
Site 28
S346
G
N
G
I
G
V
N
S
S
N
R
L
G
I
D
Site 29
S347
N
G
I
G
V
N
S
S
N
R
L
G
I
D
N
Site 30
Y381
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
Site 31
T402
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
Site 32
S408
M
T
E
K
R
I
L
S
L
A
R
N
H
P
F
Site 33
S448
L
M
F
H
I
Q
K
S
R
R
F
D
E
A
R
Site 34
Y459
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
Site 35
T513
C
N
G
V
T
T
A
T
F
C
G
T
P
D
Y
Site 36
T517
T
T
A
T
F
C
G
T
P
D
Y
I
A
P
E
Site 37
Y520
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
Q
Site 38
Y573
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
Site 39
T582
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
Site 40
S587
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
Site 41
T590
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
Site 42
T594
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Site 43
S599
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
H
Site 44
T601
T
M
R
L
G
S
L
T
Q
G
G
E
H
A
I
Site 45
S637
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
Site 46
T656
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
Site 47
S675
Q
D
E
F
R
N
F
S
Y
V
S
P
E
L
Q
Site 48
Y676
D
E
F
R
N
F
S
Y
V
S
P
E
L
Q
P
Site 49
S678
F
R
N
F
S
Y
V
S
P
E
L
Q
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation