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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPT
Full Name:
Alanine aminotransferase 1
Alias:
ALT1
Type:
Mass (Da):
54619
Number AA:
496
UniProt ID:
P24298
International Prot ID:
IPI00217458
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005829
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004021
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0005996
GO:0006006
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
A
S
S
T
G
D
R
S
Q
A
V
Site 2
S9
A
S
S
T
G
D
R
S
Q
A
V
R
H
G
L
Site 3
T22
G
L
R
A
K
V
L
T
L
D
G
M
N
P
R
Site 4
Y35
P
R
V
R
R
V
E
Y
A
V
R
G
P
I
V
Site 5
T61
Q
G
V
K
K
P
F
T
E
V
I
R
A
N
I
Site 6
S96
C
V
N
P
D
L
L
S
S
P
N
F
P
D
D
Site 7
S97
V
N
P
D
L
L
S
S
P
N
F
P
D
D
A
Site 8
Y123
G
G
H
S
L
G
A
Y
S
V
S
S
G
I
Q
Site 9
Y139
I
R
E
D
V
A
R
Y
I
E
R
R
D
G
G
Site 10
S157
D
P
N
N
V
F
L
S
T
G
A
S
D
A
I
Site 11
T178
L
V
A
G
E
G
H
T
R
T
G
V
L
I
P
Site 12
Y206
L
G
A
V
Q
V
D
Y
Y
L
D
E
E
R
A
Site 13
Y207
G
A
V
Q
V
D
Y
Y
L
D
E
E
R
A
W
Site 14
Y280
E
V
Y
Q
D
N
V
Y
A
A
G
S
Q
F
H
Site 15
S284
D
N
V
Y
A
A
G
S
Q
F
H
S
F
K
K
Site 16
S288
A
A
G
S
Q
F
H
S
F
K
K
V
L
M
E
Site 17
Y300
L
M
E
M
G
P
P
Y
A
G
Q
Q
E
L
A
Site 18
S308
A
G
Q
Q
E
L
A
S
F
H
S
T
S
K
G
Site 19
S311
Q
E
L
A
S
F
H
S
T
S
K
G
Y
M
G
Site 20
T312
E
L
A
S
F
H
S
T
S
K
G
Y
M
G
E
Site 21
S313
L
A
S
F
H
S
T
S
K
G
Y
M
G
E
C
Site 22
Y316
F
H
S
T
S
K
G
Y
M
G
E
C
G
F
R
Site 23
Y326
E
C
G
F
R
G
G
Y
V
E
V
V
N
M
D
Site 24
S371
P
P
A
P
T
D
P
S
F
A
Q
F
Q
A
E
Site 25
Y413
N
P
V
Q
G
A
M
Y
S
F
P
R
V
Q
L
Site 26
S414
P
V
Q
G
A
M
Y
S
F
P
R
V
Q
L
P
Site 27
Y464
F
G
Q
R
E
G
T
Y
H
F
R
M
T
I
L
Site 28
T469
G
T
Y
H
F
R
M
T
I
L
P
P
L
E
K
Site 29
S485
R
L
L
L
E
K
L
S
R
F
H
A
K
F
T
Site 30
S496
A
K
F
T
L
E
Y
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation