KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MCC
Full Name:
Colorectal mutant cancer protein
Alias:
CRCM; Mutated in colorectal cancers
Type:
Cell cycle regulation
Mass (Da):
93055
Number AA:
829
UniProt ID:
P23508
International Prot ID:
IPI00011957
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
N
S
G
V
A
M
K
Y
G
N
D
S
S
A
E
Site 2
S13
A
M
K
Y
G
N
D
S
S
A
E
L
S
E
L
Site 3
S14
M
K
Y
G
N
D
S
S
A
E
L
S
E
L
H
Site 4
S18
N
D
S
S
A
E
L
S
E
L
H
S
A
A
L
Site 5
T75
E
D
V
Q
E
R
T
T
L
R
Y
E
E
R
I
Site 6
Y78
Q
E
R
T
T
L
R
Y
E
E
R
I
T
E
L
Site 7
T83
L
R
Y
E
E
R
I
T
E
L
H
S
V
I
A
Site 8
T103
I
D
R
L
Q
G
T
T
I
R
E
E
D
E
Y
Site 9
Y110
T
I
R
E
E
D
E
Y
S
E
L
R
S
E
L
Site 10
S111
I
R
E
E
D
E
Y
S
E
L
R
S
E
L
S
Site 11
S115
D
E
Y
S
E
L
R
S
E
L
S
Q
S
Q
H
Site 12
S118
S
E
L
R
S
E
L
S
Q
S
Q
H
E
V
N
Site 13
S120
L
R
S
E
L
S
Q
S
Q
H
E
V
N
E
D
Site 14
S130
E
V
N
E
D
S
R
S
M
D
Q
D
Q
T
S
Site 15
T136
R
S
M
D
Q
D
Q
T
S
V
S
I
P
E
N
Site 16
S137
S
M
D
Q
D
Q
T
S
V
S
I
P
E
N
Q
Site 17
S139
D
Q
D
Q
T
S
V
S
I
P
E
N
Q
S
T
Site 18
T146
S
I
P
E
N
Q
S
T
M
V
T
A
D
M
D
Site 19
S156
T
A
D
M
D
N
C
S
D
L
N
S
E
L
Q
Site 20
S160
D
N
C
S
D
L
N
S
E
L
Q
R
V
L
T
Site 21
S179
V
V
C
G
R
K
K
S
S
C
S
L
S
V
A
Site 22
S180
V
C
G
R
K
K
S
S
C
S
L
S
V
A
E
Site 23
S182
G
R
K
K
S
S
C
S
L
S
V
A
E
V
D
Site 24
S184
K
K
S
S
C
S
L
S
V
A
E
V
D
R
H
Site 25
T196
D
R
H
I
E
Q
L
T
T
A
S
E
H
C
D
Site 26
T197
R
H
I
E
Q
L
T
T
A
S
E
H
C
D
L
Site 27
Y221
G
V
L
G
R
D
L
Y
P
N
L
A
E
E
R
Site 28
S229
P
N
L
A
E
E
R
S
R
W
E
K
E
L
A
Site 29
S244
G
L
R
E
E
N
E
S
L
T
A
M
L
C
S
Site 30
S251
S
L
T
A
M
L
C
S
K
E
E
E
L
N
R
Site 31
T259
K
E
E
E
L
N
R
T
K
A
T
M
N
A
I
Site 32
S286
E
L
Q
T
R
L
Q
S
V
Q
A
T
G
P
S
Site 33
T290
R
L
Q
S
V
Q
A
T
G
P
S
S
P
G
R
Site 34
S294
V
Q
A
T
G
P
S
S
P
G
R
L
T
S
T
Site 35
T299
P
S
S
P
G
R
L
T
S
T
N
R
P
I
N
Site 36
S300
S
S
P
G
R
L
T
S
T
N
R
P
I
N
P
Site 37
T301
S
P
G
R
L
T
S
T
N
R
P
I
N
P
S
Site 38
S308
T
N
R
P
I
N
P
S
T
G
E
L
S
T
S
Site 39
T309
N
R
P
I
N
P
S
T
G
E
L
S
T
S
S
Site 40
S313
N
P
S
T
G
E
L
S
T
S
S
S
S
N
D
Site 41
T314
P
S
T
G
E
L
S
T
S
S
S
S
N
D
I
Site 42
S315
S
T
G
E
L
S
T
S
S
S
S
N
D
I
P
Site 43
S316
T
G
E
L
S
T
S
S
S
S
N
D
I
P
I
Site 44
S317
G
E
L
S
T
S
S
S
S
N
D
I
P
I
A
Site 45
S333
I
A
E
R
V
K
L
S
K
T
R
S
E
S
S
Site 46
T335
E
R
V
K
L
S
K
T
R
S
E
S
S
S
S
Site 47
S337
V
K
L
S
K
T
R
S
E
S
S
S
S
D
R
Site 48
S339
L
S
K
T
R
S
E
S
S
S
S
D
R
P
V
Site 49
S340
S
K
T
R
S
E
S
S
S
S
D
R
P
V
L
Site 50
S341
K
T
R
S
E
S
S
S
S
D
R
P
V
L
G
Site 51
S342
T
R
S
E
S
S
S
S
D
R
P
V
L
G
S
Site 52
S367
V
A
E
H
L
A
H
S
L
Q
D
C
S
N
I
Site 53
T380
N
I
Q
E
I
F
Q
T
L
Y
S
H
G
S
A
Site 54
Y382
Q
E
I
F
Q
T
L
Y
S
H
G
S
A
I
S
Site 55
S383
E
I
F
Q
T
L
Y
S
H
G
S
A
I
S
E
Site 56
S386
Q
T
L
Y
S
H
G
S
A
I
S
E
S
K
I
Site 57
S389
Y
S
H
G
S
A
I
S
E
S
K
I
R
E
F
Site 58
S391
H
G
S
A
I
S
E
S
K
I
R
E
F
E
V
Site 59
S405
V
E
T
E
R
L
N
S
R
I
E
H
L
K
S
Site 60
S412
S
R
I
E
H
L
K
S
Q
N
D
L
L
T
I
Site 61
T418
K
S
Q
N
D
L
L
T
I
T
L
E
E
C
K
Site 62
S426
I
T
L
E
E
C
K
S
N
A
E
R
M
S
M
Site 63
S432
K
S
N
A
E
R
M
S
M
L
V
G
K
Y
E
Site 64
T443
G
K
Y
E
S
N
A
T
A
L
R
L
A
L
Q
Site 65
S452
L
R
L
A
L
Q
Y
S
E
Q
C
I
E
A
Y
Site 66
S471
A
L
A
E
S
E
Q
S
L
I
L
G
Q
F
R
Site 67
S484
F
R
A
A
G
V
G
S
S
P
G
D
Q
S
G
Site 68
S485
R
A
A
G
V
G
S
S
P
G
D
Q
S
G
D
Site 69
S490
G
S
S
P
G
D
Q
S
G
D
E
N
I
T
Q
Site 70
T508
R
A
H
D
C
R
K
T
A
E
N
A
A
K
A
Site 71
S540
C
S
V
Q
P
W
E
S
L
S
S
N
S
H
T
Site 72
S542
V
Q
P
W
E
S
L
S
S
N
S
H
T
S
T
Site 73
S543
Q
P
W
E
S
L
S
S
N
S
H
T
S
T
T
Site 74
S545
W
E
S
L
S
S
N
S
H
T
S
T
T
S
S
Site 75
T547
S
L
S
S
N
S
H
T
S
T
T
S
S
T
A
Site 76
S548
L
S
S
N
S
H
T
S
T
T
S
S
T
A
S
Site 77
T549
S
S
N
S
H
T
S
T
T
S
S
T
A
S
S
Site 78
T550
S
N
S
H
T
S
T
T
S
S
T
A
S
S
C
Site 79
S551
N
S
H
T
S
T
T
S
S
T
A
S
S
C
D
Site 80
S552
S
H
T
S
T
T
S
S
T
A
S
S
C
D
T
Site 81
S555
S
T
T
S
S
T
A
S
S
C
D
T
E
F
T
Site 82
S556
T
T
S
S
T
A
S
S
C
D
T
E
F
T
K
Site 83
T559
S
T
A
S
S
C
D
T
E
F
T
K
E
D
E
Site 84
Y572
D
E
Q
R
L
K
D
Y
I
Q
Q
L
K
N
D
Site 85
S599
S
I
H
I
D
P
L
S
Y
D
V
K
P
R
G
Site 86
S608
D
V
K
P
R
G
D
S
Q
R
L
D
L
E
N
Site 87
Y637
A
E
L
K
A
Q
L
Y
L
L
E
K
E
K
K
Site 88
S651
K
A
L
E
L
K
L
S
T
R
E
A
Q
E
Q
Site 89
Y660
R
E
A
Q
E
Q
A
Y
L
V
H
I
E
H
L
Site 90
S669
V
H
I
E
H
L
K
S
E
V
E
E
Q
K
E
Site 91
S681
Q
K
E
Q
R
M
R
S
L
S
S
T
S
S
G
Site 92
S683
E
Q
R
M
R
S
L
S
S
T
S
S
G
S
K
Site 93
S684
Q
R
M
R
S
L
S
S
T
S
S
G
S
K
D
Site 94
T685
R
M
R
S
L
S
S
T
S
S
G
S
K
D
K
Site 95
S687
R
S
L
S
S
T
S
S
G
S
K
D
K
P
G
Site 96
S689
L
S
S
T
S
S
G
S
K
D
K
P
G
K
E
Site 97
S702
K
E
C
A
D
A
A
S
P
A
L
S
L
A
E
Site 98
T712
L
S
L
A
E
L
R
T
T
C
S
E
N
E
L
Site 99
T713
S
L
A
E
L
R
T
T
C
S
E
N
E
L
A
Site 100
S715
A
E
L
R
T
T
C
S
E
N
E
L
A
A
E
Site 101
T748
V
S
A
L
E
R
L
T
K
S
S
E
I
R
H
Site 102
S751
L
E
R
L
T
K
S
S
E
I
R
H
Q
Q
S
Site 103
S770
N
D
L
K
R
A
N
S
N
L
V
A
A
Y
E
Site 104
S792
N
K
L
K
K
L
E
S
Q
M
M
A
M
V
E
Site 105
T803
A
M
V
E
R
H
E
T
Q
V
R
M
L
K
Q
Site 106
S820
A
L
L
E
E
E
N
S
R
P
H
T
N
E
T
Site 107
T824
E
E
N
S
R
P
H
T
N
E
T
S
L
_
_
Site 108
S828
R
P
H
T
N
E
T
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation