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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SP100
Full Name:
Nuclear autoantigen Sp-100
Alias:
Lysp100b; Nuclear antigen Sp100; Nuclear autoantigen; Nuclear dot-associated Sp100 protein; SP100 nuclear antigen; SP100-HMG nuclear autoantigen; Speckled 100 kDa
Type:
Transcription, coactivator/corepressor
Mass (Da):
100417
Number AA:
879
UniProt ID:
P23497
International Prot ID:
IPI00011675
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0005694
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0070087
GO:0016565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006978
GO:0060333
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
G
G
G
G
D
L
S
T
R
R
L
N
E
C
Site 2
T10
G
G
G
G
D
L
S
T
R
R
L
N
E
C
I
Site 3
S18
R
R
L
N
E
C
I
S
P
V
A
N
E
M
N
Site 4
T39
H
D
L
Q
R
M
F
T
E
D
Q
G
V
D
D
Site 5
Y50
G
V
D
D
R
L
L
Y
D
I
V
F
K
H
F
Site 6
T85
L
R
D
R
D
L
I
T
N
K
M
F
E
D
S
Site 7
S92
T
N
K
M
F
E
D
S
Q
D
S
C
R
N
L
Site 8
S95
M
F
E
D
S
Q
D
S
C
R
N
L
V
P
V
Site 9
S111
R
V
V
Y
N
V
L
S
E
L
E
K
T
F
N
Site 10
S127
P
V
L
E
A
L
F
S
D
V
N
M
Q
E
Y
Site 11
Y134
S
D
V
N
M
Q
E
Y
P
D
L
I
H
I
Y
Site 12
S157
D
K
L
P
L
Q
E
S
E
E
E
E
R
E
E
Site 13
S171
E
R
S
G
L
Q
L
S
L
E
Q
G
T
G
E
Site 14
S180
E
Q
G
T
G
E
N
S
F
R
S
L
T
W
P
Site 15
S183
T
G
E
N
S
F
R
S
L
T
W
P
P
S
G
Site 16
T185
E
N
S
F
R
S
L
T
W
P
P
S
G
S
P
Site 17
S189
R
S
L
T
W
P
P
S
G
S
P
S
H
A
G
Site 18
S191
L
T
W
P
P
S
G
S
P
S
H
A
G
T
T
Site 19
S193
W
P
P
S
G
S
P
S
H
A
G
T
T
P
P
Site 20
T197
G
S
P
S
H
A
G
T
T
P
P
E
N
G
L
Site 21
T198
S
P
S
H
A
G
T
T
P
P
E
N
G
L
S
Site 22
S205
T
P
P
E
N
G
L
S
E
H
P
C
E
T
E
Site 23
T221
I
N
A
K
R
K
D
T
T
S
D
K
D
D
S
Site 24
T222
N
A
K
R
K
D
T
T
S
D
K
D
D
S
L
Site 25
S223
A
K
R
K
D
T
T
S
D
K
D
D
S
L
G
Site 26
S228
T
T
S
D
K
D
D
S
L
G
S
Q
Q
T
N
Site 27
S231
D
K
D
D
S
L
G
S
Q
Q
T
N
E
Q
C
Site 28
S247
Q
K
A
E
P
T
E
S
C
E
Q
I
A
V
Q
Site 29
S274
P
L
P
C
D
E
E
S
P
E
A
E
L
H
N
Site 30
S303
I
K
K
E
K
P
F
S
N
S
K
V
E
C
Q
Site 31
S327
A
S
D
I
I
V
I
S
S
E
D
S
E
G
S
Site 32
S328
S
D
I
I
V
I
S
S
E
D
S
E
G
S
T
Site 33
S331
I
V
I
S
S
E
D
S
E
G
S
T
D
V
D
Site 34
S334
S
S
E
D
S
E
G
S
T
D
V
D
E
P
L
Site 35
T335
S
E
D
S
E
G
S
T
D
V
D
E
P
L
E
Site 36
S346
E
P
L
E
V
F
I
S
A
P
R
S
E
P
V
Site 37
S350
V
F
I
S
A
P
R
S
E
P
V
I
N
N
D
Site 38
S362
N
N
D
N
P
L
E
S
N
D
E
K
E
G
Q
Site 39
S374
E
G
Q
E
A
T
C
S
R
P
Q
I
V
P
E
Site 40
S389
P
M
D
F
R
K
L
S
T
F
R
E
S
F
K
Site 41
T390
M
D
F
R
K
L
S
T
F
R
E
S
F
K
K
Site 42
S394
K
L
S
T
F
R
E
S
F
K
K
R
V
I
G
Site 43
S407
I
G
Q
D
H
D
F
S
E
S
S
E
E
E
A
Site 44
S409
Q
D
H
D
F
S
E
S
S
E
E
E
A
P
A
Site 45
S410
D
H
D
F
S
E
S
S
E
E
E
A
P
A
E
Site 46
S425
A
S
S
G
A
L
R
S
K
H
G
E
K
A
P
Site 47
T434
H
G
E
K
A
P
M
T
S
R
S
T
S
T
W
Site 48
S435
G
E
K
A
P
M
T
S
R
S
T
S
T
W
R
Site 49
S437
K
A
P
M
T
S
R
S
T
S
T
W
R
I
P
Site 50
T438
A
P
M
T
S
R
S
T
S
T
W
R
I
P
S
Site 51
S439
P
M
T
S
R
S
T
S
T
W
R
I
P
S
R
Site 52
T440
M
T
S
R
S
T
S
T
W
R
I
P
S
R
K
Site 53
S445
T
S
T
W
R
I
P
S
R
K
R
R
F
S
S
Site 54
S451
P
S
R
K
R
R
F
S
S
S
D
F
S
D
L
Site 55
S452
S
R
K
R
R
F
S
S
S
D
F
S
D
L
S
Site 56
S453
R
K
R
R
F
S
S
S
D
F
S
D
L
S
N
Site 57
S456
R
F
S
S
S
D
F
S
D
L
S
N
G
E
E
Site 58
S459
S
S
D
F
S
D
L
S
N
G
E
E
L
Q
E
Site 59
T467
N
G
E
E
L
Q
E
T
C
S
S
S
L
R
R
Site 60
S469
E
E
L
Q
E
T
C
S
S
S
L
R
R
G
S
Site 61
S470
E
L
Q
E
T
C
S
S
S
L
R
R
G
S
G
Site 62
S471
L
Q
E
T
C
S
S
S
L
R
R
G
S
G
S
Site 63
S476
S
S
S
L
R
R
G
S
G
S
Q
P
Q
E
P
Site 64
S478
S
L
R
R
G
S
G
S
Q
P
Q
E
P
E
N
Site 65
S501
F
P
K
G
V
P
R
S
Q
E
A
R
T
E
S
Site 66
T506
P
R
S
Q
E
A
R
T
E
S
S
Q
A
S
D
Site 67
S508
S
Q
E
A
R
T
E
S
S
Q
A
S
D
M
M
Site 68
S509
Q
E
A
R
T
E
S
S
Q
A
S
D
M
M
D
Site 69
S512
R
T
E
S
S
Q
A
S
D
M
M
D
T
M
D
Site 70
T517
Q
A
S
D
M
M
D
T
M
D
V
E
N
N
S
Site 71
T525
M
D
V
E
N
N
S
T
L
E
K
H
S
G
K
Site 72
S541
R
K
K
R
R
H
R
S
K
V
N
G
L
Q
R
Site 73
T560
D
R
P
R
K
H
L
T
L
N
N
K
V
Q
K
Site 74
S603
E
N
I
N
F
K
Q
S
E
L
P
V
T
C
G
Site 75
T608
K
Q
S
E
L
P
V
T
C
G
E
V
K
G
T
Site 76
T615
T
C
G
E
V
K
G
T
L
Y
K
E
R
F
K
Site 77
Y617
G
E
V
K
G
T
L
Y
K
E
R
F
K
Q
G
Site 78
T625
K
E
R
F
K
Q
G
T
S
K
K
C
I
Q
S
Site 79
T639
S
E
D
K
K
W
F
T
P
R
E
F
E
I
E
Site 80
S652
I
E
G
D
R
G
A
S
K
N
W
K
L
S
I
Site 81
S680
K
F
L
P
E
P
P
S
T
R
K
K
R
I
L
Site 82
T681
F
L
P
E
P
P
S
T
R
K
K
R
I
L
E
Site 83
T693
I
L
E
S
H
N
N
T
L
V
D
P
C
E
E
Site 84
S709
K
K
K
N
P
D
A
S
V
K
F
S
E
F
L
Site 85
S713
P
D
A
S
V
K
F
S
E
F
L
K
K
C
S
Site 86
T725
K
C
S
E
T
W
K
T
I
F
A
K
E
K
G
Site 87
Y745
A
K
A
D
K
A
H
Y
E
R
E
M
K
T
Y
Site 88
T751
H
Y
E
R
E
M
K
T
Y
I
P
P
K
G
E
Site 89
Y752
Y
E
R
E
M
K
T
Y
I
P
P
K
G
E
K
Site 90
Y783
F
F
L
F
C
S
E
Y
R
P
K
I
K
G
E
Site 91
Y818
A
A
A
D
K
Q
F
Y
E
K
K
A
A
K
L
Site 92
S844
R
A
K
G
K
P
N
S
A
K
K
R
V
V
K
Site 93
S855
R
V
V
K
A
E
K
S
K
K
K
K
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation