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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRZ1
Full Name:
Receptor-type tyrosine-protein phosphatase zeta
Alias:
EC 3.1.3.48; HPTPZ; Phosphacan; Protein tyrosine phosphatase, receptor-type, Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; PTP18; PTPRZ; PTPZ; Receptor-type tyrosine-protein phosphatase zeta; RPTPB; R-PTP-zeta; R-PTP-zeta-2
Type:
Receptor protein phosphatase, tyrosine; EC 3.1.3.48
Mass (Da):
254587
Number AA:
2315
UniProt ID:
P23471
International Prot ID:
IPI00748312
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008330
GO:0005001
PhosphoSite+
KinaseNET
Biological Process:
GO:0007417
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T93
D
K
T
S
L
E
N
T
F
I
H
N
T
G
K
Site 2
T512
Q
P
V
T
K
L
A
T
E
K
D
I
S
L
T
Site 3
T1668
Y
W
R
K
C
F
Q
T
A
H
F
Y
L
E
D
Site 4
Y1672
C
F
Q
T
A
H
F
Y
L
E
D
S
T
S
P
Site 5
S1676
A
H
F
Y
L
E
D
S
T
S
P
R
V
I
S
Site 6
S1678
F
Y
L
E
D
S
T
S
P
R
V
I
S
T
P
Site 7
S1683
S
T
S
P
R
V
I
S
T
P
P
T
P
I
F
Site 8
T1684
T
S
P
R
V
I
S
T
P
P
T
P
I
F
P
Site 9
T1718
L
H
A
S
S
G
F
T
E
E
F
E
T
L
K
Site 10
T1723
G
F
T
E
E
F
E
T
L
K
E
F
Y
Q
E
Site 11
Y1728
F
E
T
L
K
E
F
Y
Q
E
V
Q
S
C
T
Site 12
S1745
L
G
I
T
A
D
S
S
N
H
P
D
N
K
H
Site 13
Y1756
D
N
K
H
K
N
R
Y
I
N
I
V
A
Y
D
Site 14
Y1762
R
Y
I
N
I
V
A
Y
D
H
S
R
V
K
L
Site 15
Y1782
K
D
G
K
L
T
D
Y
I
N
A
N
Y
V
D
Site 16
Y1787
T
D
Y
I
N
A
N
Y
V
D
G
Y
N
R
P
Site 17
Y1791
N
A
N
Y
V
D
G
Y
N
R
P
K
A
Y
I
Site 18
S1806
A
A
Q
G
P
L
K
S
T
A
E
D
F
W
R
Site 19
Y1840
G
R
R
K
C
D
Q
Y
W
P
A
D
G
S
E
Site 20
Y1864
K
S
V
Q
V
L
A
Y
Y
T
V
R
N
F
T
Site 21
T1871
Y
Y
T
V
R
N
F
T
L
R
N
T
K
I
K
Site 22
T1875
R
N
F
T
L
R
N
T
K
I
K
K
G
S
Q
Site 23
S1881
N
T
K
I
K
K
G
S
Q
K
G
R
P
S
G
Site 24
S1887
G
S
Q
K
G
R
P
S
G
R
V
V
T
Q
Y
Site 25
T1892
R
P
S
G
R
V
V
T
Q
Y
H
Y
T
Q
W
Site 26
Y1894
S
G
R
V
V
T
Q
Y
H
Y
T
Q
W
P
D
Site 27
Y1896
R
V
V
T
Q
Y
H
Y
T
Q
W
P
D
M
G
Site 28
Y1907
P
D
M
G
V
P
E
Y
S
L
P
V
L
T
F
Site 29
T1958
Q
Q
I
Q
H
E
G
T
V
N
I
F
G
F
L
Site 30
S1970
G
F
L
K
H
I
R
S
Q
R
N
Y
L
V
Q
Site 31
Y1974
H
I
R
S
Q
R
N
Y
L
V
Q
T
E
E
Q
Site 32
Y1982
L
V
Q
T
E
E
Q
Y
V
F
I
H
D
T
L
Site 33
S2003
K
E
T
E
V
L
D
S
H
I
H
A
Y
V
N
Site 34
S2031
E
K
Q
F
Q
L
L
S
Q
S
N
I
Q
Q
S
Site 35
S2033
Q
F
Q
L
L
S
Q
S
N
I
Q
Q
S
D
Y
Site 36
Y2040
S
N
I
Q
Q
S
D
Y
S
A
A
L
K
Q
C
Site 37
T2054
C
N
R
E
K
N
R
T
S
S
I
I
P
V
E
Site 38
S2055
N
R
E
K
N
R
T
S
S
I
I
P
V
E
R
Site 39
S2056
R
E
K
N
R
T
S
S
I
I
P
V
E
R
S
Site 40
S2069
R
S
R
V
G
I
S
S
L
S
G
E
G
T
D
Site 41
S2071
R
V
G
I
S
S
L
S
G
E
G
T
D
Y
I
Site 42
T2075
S
S
L
S
G
E
G
T
D
Y
I
N
A
S
Y
Site 43
Y2077
L
S
G
E
G
T
D
Y
I
N
A
S
Y
I
M
Site 44
T2095
Q
S
N
E
F
I
I
T
Q
H
P
L
L
H
T
Site 45
T2150
N
C
E
S
F
K
V
T
L
M
A
E
E
H
K
Site 46
S2160
A
E
E
H
K
C
L
S
N
E
E
K
L
I
I
Site 47
Y2179
L
E
A
T
Q
D
D
Y
V
L
E
V
R
H
F
Site 48
S2196
P
K
W
P
N
P
D
S
P
I
S
K
T
F
E
Site 49
S2199
P
N
P
D
S
P
I
S
K
T
F
E
L
I
S
Site 50
S2248
H
Q
L
E
K
E
N
S
V
D
V
Y
Q
V
A
Site 51
Y2252
K
E
N
S
V
D
V
Y
Q
V
A
K
M
I
N
Site 52
Y2276
I
E
Q
Y
Q
F
L
Y
K
V
I
L
S
L
V
Site 53
S2284
K
V
I
L
S
L
V
S
T
R
Q
E
E
N
P
Site 54
T2285
V
I
L
S
L
V
S
T
R
Q
E
E
N
P
S
Site 55
S2292
T
R
Q
E
E
N
P
S
T
S
L
D
S
N
G
Site 56
T2293
R
Q
E
E
N
P
S
T
S
L
D
S
N
G
A
Site 57
S2294
Q
E
E
N
P
S
T
S
L
D
S
N
G
A
A
Site 58
S2297
N
P
S
T
S
L
D
S
N
G
A
A
L
P
D
Site 59
S2310
P
D
G
N
I
A
E
S
L
E
S
L
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation