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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WARS
Full Name:
Tryptophanyl-tRNA synthetase, cytoplasmic
Alias:
GAMMA-2; HWRS; IFI53; IFP53; Interferon-induced protein 53; SYW; SYWC; TrpRS; Tryptophan tRNA ligase 1, cytoplasmic; Tryptophan--tRNA ligase; Tryptophanyl-tRNA synthetase; WRS
Type:
Ligase; Amino Acid Metabolism - tryptophan; EC 6.1.1.2
Mass (Da):
53165
Number AA:
471
UniProt ID:
P23381
International Prot ID:
IPI00295400
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004830
PhosphoSite+
KinaseNET
Biological Process:
GO:0008285
GO:0045765
GO:0006436
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
P
N
S
E
P
A
S
L
L
E
Site 2
S8
M
P
N
S
E
P
A
S
L
L
E
L
F
N
S
Site 3
S25
T
Q
G
E
L
V
R
S
L
K
A
G
N
A
S
Site 4
S38
A
S
K
D
E
I
D
S
A
V
K
M
L
V
S
Site 5
Y58
K
A
A
A
G
E
D
Y
K
A
D
C
P
P
G
Site 6
S71
P
G
N
P
A
P
T
S
N
H
G
P
D
A
T
Site 7
T78
S
N
H
G
P
D
A
T
E
A
E
E
D
F
V
Site 8
T89
E
D
F
V
D
P
W
T
V
Q
T
S
S
A
K
Site 9
S94
P
W
T
V
Q
T
S
S
A
K
G
I
D
Y
D
Site 10
Y100
S
S
A
K
G
I
D
Y
D
K
L
I
V
R
F
Site 11
S109
K
L
I
V
R
F
G
S
S
K
I
D
K
E
L
Site 12
T124
I
N
R
I
E
R
A
T
G
Q
R
P
H
H
F
Site 13
S139
L
R
R
G
I
F
F
S
H
R
D
M
N
Q
V
Site 14
Y150
M
N
Q
V
L
D
A
Y
E
N
K
K
P
F
Y
Site 15
Y157
Y
E
N
K
K
P
F
Y
L
Y
T
G
R
G
P
Site 16
Y159
N
K
K
P
F
Y
L
Y
T
G
R
G
P
S
S
Site 17
T160
K
K
P
F
Y
L
Y
T
G
R
G
P
S
S
E
Site 18
S165
L
Y
T
G
R
G
P
S
S
E
A
M
H
V
G
Site 19
S166
Y
T
G
R
G
P
S
S
E
A
M
H
V
G
H
Site 20
T196
V
P
L
V
I
Q
M
T
D
D
E
K
Y
L
W
Site 21
Y201
Q
M
T
D
D
E
K
Y
L
W
K
D
L
T
L
Site 22
T207
K
Y
L
W
K
D
L
T
L
D
Q
A
Y
S
Y
Site 23
Y212
D
L
T
L
D
Q
A
Y
S
Y
A
V
E
N
A
Site 24
S213
L
T
L
D
Q
A
Y
S
Y
A
V
E
N
A
K
Site 25
Y248
M
G
M
S
S
G
F
Y
K
N
V
V
K
I
Q
Site 26
T259
V
K
I
Q
K
H
V
T
F
N
Q
V
K
G
I
Site 27
S288
P
A
I
Q
A
A
P
S
F
S
N
S
F
P
Q
Site 28
S292
A
A
P
S
F
S
N
S
F
P
Q
I
F
R
D
Site 29
T301
P
Q
I
F
R
D
R
T
D
I
Q
C
L
I
P
Site 30
Y316
C
A
I
D
Q
D
P
Y
F
R
M
T
R
D
V
Site 31
T320
Q
D
P
Y
F
R
M
T
R
D
V
A
P
R
I
Site 32
Y329
D
V
A
P
R
I
G
Y
P
K
P
A
L
L
H
Site 33
S351
Q
G
A
Q
T
K
M
S
A
S
D
P
N
S
S
Site 34
S353
A
Q
T
K
M
S
A
S
D
P
N
S
S
I
F
Site 35
S357
M
S
A
S
D
P
N
S
S
I
F
L
T
D
T
Site 36
T362
P
N
S
S
I
F
L
T
D
T
A
K
Q
I
K
Site 37
T364
S
S
I
F
L
T
D
T
A
K
Q
I
K
T
K
Site 38
T370
D
T
A
K
Q
I
K
T
K
V
N
K
H
A
F
Site 39
T383
A
F
S
G
G
R
D
T
I
E
E
H
R
Q
F
Site 40
Y420
L
E
Q
I
R
K
D
Y
T
S
G
A
M
L
T
Site 41
T421
E
Q
I
R
K
D
Y
T
S
G
A
M
L
T
G
Site 42
S422
Q
I
R
K
D
Y
T
S
G
A
M
L
T
G
E
Site 43
T453
Q
A
R
R
K
E
V
T
D
E
I
V
K
E
F
Site 44
T462
E
I
V
K
E
F
M
T
P
R
K
L
S
F
D
Site 45
S467
F
M
T
P
R
K
L
S
F
D
F
Q
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation