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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GLDC
Full Name:
Glycine dehydrogenase [decarboxylating], mitochondrial
Alias:
GCE; GCSP; glycine cleavage system P-protein; glycine cleavage system protein P; glycine decarboxylase; glycine decarboxylase P-protein; glycine decarboxylase, glycine cleavage system protein P); glycine dehydrogenase (decarboxylating; glycine dehydrogenase (decarboxylating); glycine dehydrogenase [decarboxylating], mitochondrial; HYGN1; NKH
Type:
EC 1.4.4.2; Oxidoreductase; Amino Acid Metabolism - glycine, serine and threonine
Mass (Da):
112710
Number AA:
UniProt ID:
P23378
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0009055
GO:0004375
GO:0030170
PhosphoSite+
KinaseNET
Biological Process:
GO:0006546
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
G
R
R
L
A
G
G
S
G
P
C
W
A
P
R
Site 2
S34
G
P
C
W
A
P
R
S
R
D
S
S
S
G
G
Site 3
S37
W
A
P
R
S
R
D
S
S
S
G
G
G
D
S
Site 4
S38
A
P
R
S
R
D
S
S
S
G
G
G
D
S
A
Site 5
S39
P
R
S
R
D
S
S
S
G
G
G
D
S
A
A
Site 6
S44
S
S
S
G
G
G
D
S
A
A
A
G
A
S
R
Site 7
T81
D
Q
R
E
M
L
Q
T
L
G
L
A
S
I
D
Site 8
S125
A
T
L
H
A
I
S
S
K
N
Q
I
W
R
S
Site 9
Y138
R
S
Y
I
G
M
G
Y
Y
N
C
S
V
P
Q
Site 10
Y139
S
Y
I
G
M
G
Y
Y
N
C
S
V
P
Q
T
Site 11
T146
Y
N
C
S
V
P
Q
T
I
L
R
N
L
L
E
Site 12
T159
L
E
N
S
G
W
I
T
Q
Y
T
P
Y
Q
P
Site 13
Y161
N
S
G
W
I
T
Q
Y
T
P
Y
Q
P
E
V
Site 14
T162
S
G
W
I
T
Q
Y
T
P
Y
Q
P
E
V
S
Site 15
Y164
W
I
T
Q
Y
T
P
Y
Q
P
E
V
S
Q
G
Site 16
S169
T
P
Y
Q
P
E
V
S
Q
G
R
L
E
S
L
Site 17
S175
V
S
Q
G
R
L
E
S
L
L
N
Y
Q
T
M
Site 18
T229
D
P
R
C
H
P
Q
T
I
A
V
V
Q
T
R
Site 19
T244
A
K
Y
T
G
V
L
T
E
L
K
L
P
C
E
Site 20
S255
L
P
C
E
M
D
F
S
G
K
D
V
S
G
V
Site 21
S260
D
F
S
G
K
D
V
S
G
V
L
F
Q
Y
P
Site 22
Y266
V
S
G
V
L
F
Q
Y
P
D
T
E
G
K
V
Site 23
T269
V
L
F
Q
Y
P
D
T
E
G
K
V
E
D
F
Site 24
T277
E
G
K
V
E
D
F
T
E
L
V
E
R
A
H
Site 25
S288
E
R
A
H
Q
S
G
S
L
A
C
C
A
T
D
Site 26
T352
P
G
R
M
V
G
V
T
R
D
A
T
G
K
E
Site 27
T356
V
G
V
T
R
D
A
T
G
K
E
V
Y
R
L
Site 28
T367
V
Y
R
L
A
L
Q
T
R
E
Q
H
I
R
R
Site 29
T378
H
I
R
R
D
K
A
T
S
N
I
C
T
A
Q
Site 30
S379
I
R
R
D
K
A
T
S
N
I
C
T
A
Q
A
Site 31
S419
H
N
A
T
L
I
L
S
E
G
L
K
R
A
G
Site 32
T467
F
R
L
F
E
D
G
T
L
G
I
S
L
D
E
Site 33
S471
E
D
G
T
L
G
I
S
L
D
E
T
V
N
E
Site 34
T475
L
G
I
S
L
D
E
T
V
N
E
K
D
L
D
Site 35
S511
E
C
R
G
I
P
G
S
V
F
K
R
T
S
P
Site 36
T516
P
G
S
V
F
K
R
T
S
P
F
L
T
H
Q
Site 37
S517
G
S
V
F
K
R
T
S
P
F
L
T
H
Q
V
Site 38
T521
K
R
T
S
P
F
L
T
H
Q
V
F
N
S
Y
Site 39
Y537
S
E
T
N
I
V
R
Y
M
K
K
L
E
N
K
Site 40
S547
K
L
E
N
K
D
I
S
L
V
H
S
M
I
P
Site 41
S557
H
S
M
I
P
L
G
S
C
T
M
K
L
N
S
Site 42
S564
S
C
T
M
K
L
N
S
S
S
E
L
A
P
I
Site 43
S566
T
M
K
L
N
S
S
S
E
L
A
P
I
T
W
Site 44
T572
S
S
E
L
A
P
I
T
W
K
E
F
A
N
I
Site 45
Y591
P
L
D
Q
A
Q
G
Y
Q
Q
L
F
R
E
L
Site 46
Y608
D
L
C
E
L
T
G
Y
D
Q
V
C
F
Q
P
Site 47
S617
Q
V
C
F
Q
P
N
S
G
A
Q
G
E
Y
A
Site 48
T628
G
E
Y
A
G
L
A
T
I
R
A
Y
L
N
Q
Site 49
Y632
G
L
A
T
I
R
A
Y
L
N
Q
K
G
E
G
Site 50
T642
Q
K
G
E
G
H
R
T
V
C
L
I
P
K
S
Site 51
T653
I
P
K
S
A
H
G
T
N
P
A
S
A
H
M
Site 52
Y673
Q
P
V
E
V
D
K
Y
G
N
I
D
A
V
H
Site 53
Y725
H
Q
H
G
G
Q
V
Y
L
D
G
A
N
M
N
Site 54
S745
C
R
P
G
D
F
G
S
D
V
S
H
L
N
L
Site 55
S748
G
D
F
G
S
D
V
S
H
L
N
L
H
K
T
Site 56
T830
G
K
G
L
K
Q
A
T
E
T
A
I
L
N
A
Site 57
T832
G
L
K
Q
A
T
E
T
A
I
L
N
A
N
Y
Site 58
Y839
T
A
I
L
N
A
N
Y
M
A
K
R
L
E
T
Site 59
T846
Y
M
A
K
R
L
E
T
H
Y
R
I
L
F
R
Site 60
Y848
A
K
R
L
E
T
H
Y
R
I
L
F
R
G
A
Site 61
T867
G
H
E
F
I
L
D
T
R
P
F
K
K
S
A
Site 62
S873
D
T
R
P
F
K
K
S
A
N
I
E
A
V
D
Site 63
Y888
V
A
K
R
L
Q
D
Y
G
F
H
A
P
T
M
Site 64
S910
L
M
V
E
P
T
E
S
E
D
K
A
E
L
D
Site 65
S925
R
F
C
D
A
M
I
S
I
R
Q
E
I
A
D
Site 66
S948
R
V
N
P
L
K
M
S
P
H
S
L
T
C
V
Site 67
S951
P
L
K
M
S
P
H
S
L
T
C
V
T
S
S
Site 68
T953
K
M
S
P
H
S
L
T
C
V
T
S
S
H
W
Site 69
S958
S
L
T
C
V
T
S
S
H
W
D
R
P
Y
S
Site 70
Y964
S
S
H
W
D
R
P
Y
S
R
E
V
A
A
F
Site 71
S965
S
H
W
D
R
P
Y
S
R
E
V
A
A
F
P
Site 72
Y1008
T
C
P
P
M
E
V
Y
E
S
P
F
S
E
Q
Site 73
S1010
P
P
M
E
V
Y
E
S
P
F
S
E
Q
K
R
Site 74
S1013
E
V
Y
E
S
P
F
S
E
Q
K
R
A
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation