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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CES1
Full Name:
Liver carboxylesterase 1
Alias:
Acyl-coenzyme A:cholesterol acyltransferase;Brain carboxylesterase hBr1;Cocaine carboxylesterase;Egasyn;HMSE;Monocyte/macrophage serine esterase;Retinyl ester hydrolase;Serine esterase 1;Triacylglycerol hydrolase
Type:
Mass (Da):
62521
Number AA:
567
UniProt ID:
P23141
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
S
A
A
W
G
H
P
S
S
P
P
V
V
D
T
Site 2
S22
A
A
W
G
H
P
S
S
P
P
V
V
D
T
V
Site 3
T66
P
L
G
P
L
R
F
T
P
P
Q
P
A
E
P
Site 4
S75
P
Q
P
A
E
P
W
S
F
V
K
N
A
T
S
Site 5
Y83
F
V
K
N
A
T
S
Y
P
P
M
C
T
Q
D
Site 6
T88
T
S
Y
P
P
M
C
T
Q
D
P
K
A
G
Q
Site 7
S98
P
K
A
G
Q
L
L
S
E
L
F
T
N
R
K
Site 8
T102
Q
L
L
S
E
L
F
T
N
R
K
E
N
I
P
Site 9
Y118
K
L
S
E
D
C
L
Y
L
N
I
Y
T
P
A
Site 10
Y122
D
C
L
Y
L
N
I
Y
T
P
A
D
L
T
K
Site 11
T123
C
L
Y
L
N
I
Y
T
P
A
D
L
T
K
K
Site 12
T128
I
Y
T
P
A
D
L
T
K
K
N
R
L
P
V
Site 13
S179
L
G
I
W
G
F
F
S
T
G
D
E
H
S
R
Site 14
S185
F
S
T
G
D
E
H
S
R
G
N
W
G
H
L
Site 15
S207
W
V
Q
D
N
I
A
S
F
G
G
N
P
G
S
Site 16
S214
S
F
G
G
N
P
G
S
V
T
I
F
G
E
S
Site 17
T216
G
G
N
P
G
S
V
T
I
F
G
E
S
A
G
Site 18
T290
V
H
C
L
R
Q
K
T
E
E
E
L
L
E
T
Site 19
T297
T
E
E
E
L
L
E
T
T
L
K
M
K
F
L
Site 20
S315
L
Q
G
D
P
R
E
S
Q
P
L
L
G
T
V
Site 21
T331
D
G
M
L
L
L
K
T
P
E
E
L
Q
A
E
Site 22
Y346
R
N
F
H
T
V
P
Y
M
V
G
I
N
K
Q
Site 23
S369
Q
L
M
S
Y
P
L
S
E
G
Q
L
D
Q
K
Site 24
T377
E
G
Q
L
D
Q
K
T
A
M
S
L
L
W
K
Site 25
S380
L
D
Q
K
T
A
M
S
L
L
W
K
S
Y
P
Site 26
Y403
I
P
E
A
T
E
K
Y
L
G
G
T
D
D
T
Site 27
T407
T
E
K
Y
L
G
G
T
D
D
T
V
K
K
K
Site 28
T410
Y
L
G
G
T
D
D
T
V
K
K
K
D
L
F
Site 29
T444
H
R
D
A
G
A
P
T
Y
M
Y
E
F
Q
Y
Site 30
Y445
R
D
A
G
A
P
T
Y
M
Y
E
F
Q
Y
R
Site 31
Y447
A
G
A
P
T
Y
M
Y
E
F
Q
Y
R
P
S
Site 32
Y451
T
Y
M
Y
E
F
Q
Y
R
P
S
F
S
S
D
Site 33
S454
Y
E
F
Q
Y
R
P
S
F
S
S
D
M
K
P
Site 34
S457
Q
Y
R
P
S
F
S
S
D
M
K
P
K
T
V
Site 35
T463
S
S
D
M
K
P
K
T
V
I
G
D
H
G
D
Site 36
S486
P
F
L
K
E
G
A
S
E
E
E
I
R
L
S
Site 37
Y520
G
L
P
H
W
P
E
Y
N
Q
K
E
G
Y
L
Site 38
Y526
E
Y
N
Q
K
E
G
Y
L
Q
I
G
A
N
T
Site 39
T562
A
V
E
K
P
P
Q
T
E
H
I
E
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation