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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEMH
Full Name:
Ferrochelatase, mitochondrial
Alias:
EC 4.99.1.1; FECH; Ferrochelatase; Heme synthetase; Protoheme ferro-lyase; Protoporphyria
Type:
Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 4.99.1.1; Lyase
Mass (Da):
47862
Number AA:
423
UniProt ID:
P22830
International Prot ID:
IPI00027776
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005743
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0051537
GO:0004325
GO:0008198
PhosphoSite+
KinaseNET
Biological Process:
GO:0006091
GO:0006783
GO:0046501
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
L
L
R
D
P
L
A
S
S
S
W
R
V
C
Q
Site 2
S27
R
D
P
L
A
S
S
S
W
R
V
C
Q
P
W
Site 3
T69
P
Q
K
R
K
P
K
T
G
I
L
M
L
N
M
Site 4
T81
L
N
M
G
G
P
E
T
L
G
D
V
H
D
F
Site 5
T100
F
L
D
R
D
L
M
T
L
P
I
Q
N
K
L
Site 6
T116
P
F
I
A
K
R
R
T
P
K
I
Q
E
Q
Y
Site 7
Y123
T
P
K
I
Q
E
Q
Y
R
R
I
G
G
G
S
Site 8
S130
Y
R
R
I
G
G
G
S
P
I
K
I
W
T
S
Site 9
S137
S
P
I
K
I
W
T
S
K
Q
G
E
G
M
V
Site 10
S151
V
K
L
L
D
E
L
S
P
N
T
A
P
H
K
Site 11
Y159
P
N
T
A
P
H
K
Y
Y
I
G
F
R
Y
V
Site 12
Y165
K
Y
Y
I
G
F
R
Y
V
H
P
L
T
E
E
Site 13
T170
F
R
Y
V
H
P
L
T
E
E
A
I
E
E
M
Site 14
T189
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
Site 15
Y191
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
Site 16
Y194
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
Site 17
S195
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
Site 18
S197
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
Site 19
T199
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Site 20
S201
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Site 21
S202
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Site 22
Y209
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
R
K
Site 23
Y210
L
N
A
I
Y
R
Y
Y
N
Q
V
G
R
K
P
Site 24
T218
N
Q
V
G
R
K
P
T
M
K
W
S
T
I
D
Site 25
T229
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
Site 26
S268
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Site 27
Y276
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
Site 28
T283
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
Site 29
Y293
K
V
M
E
R
L
E
Y
C
N
P
Y
R
L
V
Site 30
Y297
R
L
E
Y
C
N
P
Y
R
L
V
W
Q
S
K
Site 31
S303
P
Y
R
L
V
W
Q
S
K
V
G
P
M
P
W
Site 32
T315
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
Site 33
S318
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
R
Site 34
Y346
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
S
Site 35
Y352
L
Y
E
L
D
I
E
Y
S
Q
V
L
A
K
E
Site 36
S353
Y
E
L
D
I
E
Y
S
Q
V
L
A
K
E
C
Site 37
S370
E
N
I
R
R
A
E
S
L
N
G
N
P
L
F
Site 38
S387
A
L
A
D
L
V
H
S
H
I
Q
S
N
E
L
Site 39
S391
L
V
H
S
H
I
Q
S
N
E
L
C
S
K
Q
Site 40
T414
V
N
P
V
C
R
E
T
K
S
F
F
T
S
Q
Site 41
S416
P
V
C
R
E
T
K
S
F
F
T
S
Q
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation