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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP7A1
Full Name:
Cholesterol 7-alpha-monooxygenase
Alias:
CYPVII;Cholesterol 7-alpha-hydroxylase;Cytochrome P450 7A1
Type:
Mass (Da):
57661
Number AA:
504
UniProt ID:
P22680
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
M
T
T
S
L
I
W
G
I
A
Site 2
T29
L
G
I
R
R
R
Q
T
G
E
P
P
L
E
N
Site 3
Y75
T
C
K
L
M
G
K
Y
V
H
F
I
T
N
P
Site 4
T80
G
K
Y
V
H
F
I
T
N
P
L
S
Y
H
K
Site 5
S105
K
K
F
H
F
A
T
S
A
K
A
F
G
H
R
Site 6
S113
A
K
A
F
G
H
R
S
I
D
P
M
D
G
N
Site 7
T128
T
T
E
N
I
N
D
T
F
I
K
T
L
Q
G
Site 8
T132
I
N
D
T
F
I
K
T
L
Q
G
H
A
L
N
Site 9
S140
L
Q
G
H
A
L
N
S
L
T
E
S
M
M
E
Site 10
T142
G
H
A
L
N
S
L
T
E
S
M
M
E
N
L
Site 11
S144
A
L
N
S
L
T
E
S
M
M
E
N
L
Q
R
Site 12
S158
R
I
M
R
P
P
V
S
S
N
S
K
T
A
A
Site 13
S159
I
M
R
P
P
V
S
S
N
S
K
T
A
A
W
Site 14
T163
P
V
S
S
N
S
K
T
A
A
W
V
T
E
G
Site 15
T193
T
I
F
G
R
D
L
T
R
R
D
T
Q
K
A
Site 16
T197
R
D
L
T
R
R
D
T
Q
K
A
H
I
L
N
Site 17
S241
A
R
E
K
L
A
E
S
L
R
H
E
N
L
Q
Site 18
S252
E
N
L
Q
K
R
E
S
I
S
E
L
I
S
L
Site 19
S254
L
Q
K
R
E
S
I
S
E
L
I
S
L
R
M
Site 20
T266
L
R
M
F
L
N
D
T
L
S
T
F
D
D
L
Site 21
S268
M
F
L
N
D
T
L
S
T
F
D
D
L
E
K
Site 22
T269
F
L
N
D
T
L
S
T
F
D
D
L
E
K
A
Site 23
T278
D
D
L
E
K
A
K
T
H
L
V
V
L
W
A
Site 24
T318
A
T
E
E
V
K
R
T
L
E
N
A
G
Q
K
Site 25
S327
E
N
A
G
Q
K
V
S
L
E
G
N
P
I
C
Site 26
S336
E
G
N
P
I
C
L
S
Q
A
E
L
N
D
L
Site 27
S348
N
D
L
P
V
L
D
S
I
I
K
E
S
L
R
Site 28
S353
L
D
S
I
I
K
E
S
L
R
L
S
S
A
S
Site 29
S357
I
K
E
S
L
R
L
S
S
A
S
L
N
I
R
Site 30
S358
K
E
S
L
R
L
S
S
A
S
L
N
I
R
T
Site 31
S360
S
L
R
L
S
S
A
S
L
N
I
R
T
A
K
Site 32
T371
R
T
A
K
E
D
F
T
L
H
L
E
D
G
S
Site 33
Y379
L
H
L
E
D
G
S
Y
N
I
R
K
D
D
I
Site 34
Y390
K
D
D
I
I
A
L
Y
P
Q
L
M
H
L
D
Site 35
Y401
M
H
L
D
P
E
I
Y
P
D
P
L
T
F
K
Site 36
T406
E
I
Y
P
D
P
L
T
F
K
Y
D
R
Y
L
Site 37
Y409
P
D
P
L
T
F
K
Y
D
R
Y
L
D
E
N
Site 38
Y412
L
T
F
K
Y
D
R
Y
L
D
E
N
G
K
T
Site 39
T419
Y
L
D
E
N
G
K
T
K
T
T
F
Y
C
N
Site 40
T422
E
N
G
K
T
K
T
T
F
Y
C
N
G
L
K
Site 41
Y424
G
K
T
K
T
T
F
Y
C
N
G
L
K
L
K
Site 42
Y432
C
N
G
L
K
L
K
Y
Y
Y
M
P
F
G
S
Site 43
Y433
N
G
L
K
L
K
Y
Y
Y
M
P
F
G
S
G
Site 44
Y434
G
L
K
L
K
Y
Y
Y
M
P
F
G
S
G
A
Site 45
S482
K
C
P
P
L
D
Q
S
R
A
G
L
G
I
L
Site 46
Y499
L
N
D
I
E
F
K
Y
K
F
K
H
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation