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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GART
Full Name:
Trifunctional purine biosynthetic protein adenosine-3
Alias:
AIRS; EC 2.1.2.2; EC 6.3.3.1; EC 6.3.4.13; GARS, Glycinamide ribonucleotide synthetase; PGFT; Phosphoribosylamine--glycine ligase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide synthetase; PRGS
Type:
Enzyme, phosphoribosylamine-glycine ligase
Mass (Da):
107767
Number AA:
1010
UniProt ID:
P22102
International Prot ID:
IPI00025273
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005829
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004372
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006144
GO:0006163
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
G
S
G
G
R
E
H
T
L
A
W
K
L
A
Q
Site 2
S42
G
N
A
G
T
A
C
S
E
K
I
S
N
T
A
Site 3
S106
E
A
A
Q
L
E
S
S
K
R
F
A
K
E
F
Site 4
T121
M
D
R
H
G
I
P
T
A
Q
W
K
A
F
T
Site 5
S135
T
K
P
E
E
A
C
S
F
I
L
S
A
D
F
Site 6
S150
P
A
L
V
V
K
A
S
G
L
A
A
G
K
G
Site 7
S163
K
G
V
I
V
A
K
S
K
E
E
A
C
K
A
Site 8
T230
E
G
D
G
G
P
N
T
G
G
M
G
A
Y
C
Site 9
T258
K
D
T
V
L
Q
R
T
V
D
G
M
Q
Q
E
Site 10
T267
D
G
M
Q
Q
E
G
T
P
Y
T
G
I
L
Y
Site 11
Y269
M
Q
Q
E
G
T
P
Y
T
G
I
L
Y
A
G
Site 12
T333
P
V
W
L
E
N
H
T
A
L
T
V
V
M
A
Site 13
Y344
V
V
M
A
S
K
G
Y
P
G
D
Y
T
K
G
Site 14
Y348
S
K
G
Y
P
G
D
Y
T
K
G
V
E
I
T
Site 15
T349
K
G
Y
P
G
D
Y
T
K
G
V
E
I
T
G
Site 16
S398
A
I
R
E
N
L
I
S
A
L
E
E
A
K
K
Site 17
Y417
I
K
F
E
G
A
I
Y
R
K
D
V
G
F
R
Site 18
S434
A
F
L
Q
Q
P
R
S
L
T
Y
K
E
S
G
Site 19
T436
L
Q
Q
P
R
S
L
T
Y
K
E
S
G
V
D
Site 20
S440
R
S
L
T
Y
K
E
S
G
V
D
I
A
A
G
Site 21
S462
Q
P
L
A
K
A
T
S
R
S
G
C
K
V
D
Site 22
S491
F
K
D
P
L
L
A
S
G
T
D
G
V
G
T
Site 23
Y578
T
A
E
M
P
D
M
Y
P
P
G
E
Y
D
L
Site 24
S625
G
L
H
S
N
G
F
S
L
V
R
K
I
V
A
Site 25
S634
V
R
K
I
V
A
K
S
S
L
Q
Y
S
S
P
Site 26
S635
R
K
I
V
A
K
S
S
L
Q
Y
S
S
P
A
Site 27
Y638
V
A
K
S
S
L
Q
Y
S
S
P
A
P
D
G
Site 28
S639
A
K
S
S
L
Q
Y
S
S
P
A
P
D
G
C
Site 29
S640
K
S
S
L
Q
Y
S
S
P
A
P
D
G
C
G
Site 30
T650
P
D
G
C
G
D
Q
T
L
G
D
L
L
L
T
Site 31
S665
P
T
R
I
Y
S
H
S
L
L
P
V
L
R
S
Site 32
S672
S
L
L
P
V
L
R
S
G
H
V
K
A
F
A
Site 33
T682
V
K
A
F
A
H
I
T
G
G
G
L
L
E
N
Site 34
T706
G
V
D
L
D
A
Q
T
W
R
I
P
R
V
F
Site 35
S723
L
Q
Q
E
G
H
L
S
E
E
E
M
A
R
T
Site 36
T730
S
E
E
E
M
A
R
T
F
N
C
G
V
G
A
Site 37
S773
V
V
A
R
A
E
G
S
P
R
V
K
V
K
N
Site 38
S790
E
S
M
Q
I
N
G
S
V
L
K
N
G
S
L
Site 39
S796
G
S
V
L
K
N
G
S
L
T
N
H
F
S
F
Site 40
T798
V
L
K
N
G
S
L
T
N
H
F
S
F
E
K
Site 41
S802
G
S
L
T
N
H
F
S
F
E
K
K
K
A
R
Site 42
T817
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
Site 43
S819
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
Site 44
S827
N
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
Site 45
T828
L
Q
A
L
I
D
S
T
R
E
P
N
S
S
A
Site 46
S833
D
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
Site 47
S834
S
T
R
E
P
N
S
S
A
Q
I
D
I
V
I
Site 48
Y868
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
Site 49
S876
K
N
R
V
E
F
D
S
A
I
D
L
V
L
E
Site 50
S900
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
Site 51
S917
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
Site 52
S921
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
Site 53
S925
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
Site 54
T968
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
Site 55
S973
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation