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Updated November 2019
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Protein Info
Short Name:
RYR1
Full Name:
Ryanodine receptor 1
Alias:
CCO; MHS; MHS1; Ryanodine receptor 1 (skeletal); RYDR; RYR; RYR-1; Skeletal muscle calcium release channel; Skeletal muscle-type ryanodine receptor
Type:
Channel, calcium
Mass (Da):
565176
Number AA:
5038
UniProt ID:
P21817
International Prot ID:
IPI00783826
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031674
GO:0005938
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005516
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0006936
GO:0051209
GO:0031000
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S52
L
C
F
L
E
P
T
S
N
A
Q
N
V
P
P
Site 2
S91
T
V
E
A
G
V
E
S
S
Q
G
G
G
H
R
Site 3
T99
S
Q
G
G
G
H
R
T
L
L
Y
G
H
A
I
Site 4
Y116
R
H
A
H
S
R
M
Y
L
S
C
L
T
T
S
Site 5
S118
A
H
S
R
M
Y
L
S
C
L
T
T
S
R
S
Site 6
T121
R
M
Y
L
S
C
L
T
T
S
R
S
M
T
D
Site 7
T122
M
Y
L
S
C
L
T
T
S
R
S
M
T
D
K
Site 8
S125
S
C
L
T
T
S
R
S
M
T
D
K
L
A
F
Site 9
T127
L
T
T
S
R
S
M
T
D
K
L
A
F
D
V
Site 10
S157
H
P
A
S
K
Q
R
S
E
G
E
K
V
R
V
Site 11
Y178
V
S
V
S
S
E
R
Y
L
H
L
S
T
A
S
Site 12
S182
S
E
R
Y
L
H
L
S
T
A
S
G
E
L
Q
Site 13
T183
E
R
Y
L
H
L
S
T
A
S
G
E
L
Q
V
Site 14
T214
R
C
E
E
G
F
V
T
G
G
H
V
L
R
L
Site 15
T231
G
H
M
D
E
C
L
T
I
S
P
A
D
S
D
Site 16
S233
M
D
E
C
L
T
I
S
P
A
D
S
D
D
Q
Site 17
S237
L
T
I
S
P
A
D
S
D
D
Q
R
R
L
V
Site 18
Y245
D
D
Q
R
R
L
V
Y
Y
E
G
G
A
V
C
Site 19
Y246
D
Q
R
R
L
V
Y
Y
E
G
G
A
V
C
T
Site 20
T253
Y
E
G
G
A
V
C
T
H
A
R
S
L
W
R
Site 21
S267
R
L
E
P
L
R
I
S
W
S
G
S
H
L
R
Site 22
S269
E
P
L
R
I
S
W
S
G
S
H
L
R
W
G
Site 23
S271
L
R
I
S
W
S
G
S
H
L
R
W
G
Q
P
Site 24
T308
V
D
A
S
K
A
H
T
K
A
T
S
F
C
F
Site 25
S312
K
A
H
T
K
A
T
S
F
C
F
R
I
S
K
Site 26
S318
T
S
F
C
F
R
I
S
K
E
K
L
D
V
A
Site 27
Y358
A
S
G
L
W
L
T
Y
A
A
P
D
P
K
A
Site 28
S388
G
H
M
D
D
A
L
S
L
T
R
C
Q
Q
E
Site 29
Y410
I
H
S
T
N
G
L
Y
N
Q
F
I
K
S
L
Site 30
S416
L
Y
N
Q
F
I
K
S
L
D
S
F
S
G
K
Site 31
S419
Q
F
I
K
S
L
D
S
F
S
G
K
P
R
G
Site 32
S421
I
K
S
L
D
S
F
S
G
K
P
R
G
S
G
Site 33
S427
F
S
G
K
P
R
G
S
G
P
P
A
G
T
A
Site 34
Y450
S
L
Q
D
L
I
I
Y
F
E
P
P
S
E
D
Site 35
S455
I
I
Y
F
E
P
P
S
E
D
L
Q
H
E
E
Site 36
S465
L
Q
H
E
E
K
Q
S
K
L
R
S
L
R
N
Site 37
S469
E
K
Q
S
K
L
R
S
L
R
N
R
Q
S
L
Site 38
S475
R
S
L
R
N
R
Q
S
L
F
Q
E
E
G
M
Site 39
T497
I
D
R
L
N
V
Y
T
T
A
A
H
F
A
E
Site 40
S513
A
G
E
E
A
A
E
S
W
K
E
I
V
N
L
Site 41
S534
S
L
I
R
G
N
R
S
N
C
A
L
F
S
T
Site 42
S548
T
N
L
D
W
L
V
S
K
L
D
R
L
E
A
Site 43
S584
I
Q
E
N
H
I
K
S
I
I
S
L
L
D
K
Site 44
T621
R
S
N
Q
D
L
I
T
E
N
L
L
P
G
R
Site 45
Y639
L
Q
T
N
L
I
N
Y
V
T
S
I
R
P
N
Site 46
Y662
T
T
Q
Y
S
K
W
Y
F
E
V
M
V
D
E
Site 47
T688
L
R
V
G
W
A
L
T
E
G
Y
T
P
Y
P
Site 48
T692
W
A
L
T
E
G
Y
T
P
Y
P
G
A
G
E
Site 49
Y694
L
T
E
G
Y
T
P
Y
P
G
A
G
E
G
W
Site 50
Y711
N
G
V
G
D
D
L
Y
S
Y
G
F
D
G
L
Site 51
S712
G
V
G
D
D
L
Y
S
Y
G
F
D
G
L
H
Site 52
Y713
V
G
D
D
L
Y
S
Y
G
F
D
G
L
H
L
Site 53
T730
G
H
V
A
R
P
V
T
S
P
G
Q
H
L
L
Site 54
S731
H
V
A
R
P
V
T
S
P
G
Q
H
L
L
A
Site 55
S781
G
L
F
F
P
V
V
S
F
S
A
G
V
K
V
Site 56
Y807
K
F
L
P
P
P
G
Y
A
P
C
H
E
A
V
Site 57
Y828
H
L
E
P
I
K
E
Y
R
R
E
G
P
R
G
Site 58
S842
G
P
H
L
V
G
P
S
R
C
L
S
H
T
D
Site 59
T848
P
S
R
C
L
S
H
T
D
F
V
P
C
P
V
Site 60
T891
T
R
I
E
Q
G
W
T
Y
G
P
V
R
D
D
Site 61
Y892
R
I
E
Q
G
W
T
Y
G
P
V
R
D
D
N
Site 62
S911
P
C
L
V
D
F
H
S
L
P
E
P
E
R
N
Site 63
Y919
L
P
E
P
E
R
N
Y
N
L
Q
M
S
G
E
Site 64
T952
A
E
D
N
L
K
K
T
K
L
P
K
T
Y
M
Site 65
T957
K
K
T
K
L
P
K
T
Y
M
M
S
N
G
Y
Site 66
Y958
K
T
K
L
P
K
T
Y
M
M
S
N
G
Y
K
Site 67
S972
K
P
A
P
L
D
L
S
H
V
R
L
T
P
A
Site 68
S1005
D
R
V
G
Q
G
W
S
Y
S
A
V
Q
D
I
Site 69
Y1006
R
V
G
Q
G
W
S
Y
S
A
V
Q
D
I
P
Site 70
S1007
V
G
Q
G
W
S
Y
S
A
V
Q
D
I
P
A
Site 71
Y1023
R
N
P
R
L
V
P
Y
R
L
L
D
E
A
T
Site 72
T1030
Y
R
L
L
D
E
A
T
K
R
S
N
R
D
S
Site 73
S1033
L
D
E
A
T
K
R
S
N
R
D
S
L
C
Q
Site 74
S1037
T
K
R
S
N
R
D
S
L
C
Q
A
V
R
T
Site 75
Y1048
A
V
R
T
L
L
G
Y
G
Y
N
I
E
P
P
Site 76
Y1050
R
T
L
L
G
Y
G
Y
N
I
E
P
P
D
Q
Site 77
S1060
E
P
P
D
Q
E
P
S
Q
V
E
N
Q
S
R
Site 78
S1079
R
I
F
R
A
E
K
S
Y
T
V
Q
S
G
R
Site 79
Y1080
I
F
R
A
E
K
S
Y
T
V
Q
S
G
R
W
Site 80
T1081
F
R
A
E
K
S
Y
T
V
Q
S
G
R
W
Y
Site 81
Y1088
T
V
Q
S
G
R
W
Y
F
E
F
E
A
V
T
Site 82
T1096
F
E
F
E
A
V
T
T
G
E
M
R
V
G
W
Site 83
Y1121
L
G
A
D
E
L
A
Y
V
F
N
G
H
R
G
Site 84
S1135
G
Q
R
W
H
L
G
S
E
P
F
G
R
P
W
Site 85
S1170
L
N
G
E
V
L
M
S
D
S
G
S
E
T
A
Site 86
S1172
G
E
V
L
M
S
D
S
G
S
E
T
A
F
R
Site 87
S1174
V
L
M
S
D
S
G
S
E
T
A
F
R
E
I
Site 88
T1176
M
S
D
S
G
S
E
T
A
F
R
E
I
E
I
Site 89
T1234
I
N
M
Q
R
P
V
T
T
W
F
S
K
G
L
Site 90
Y1254
V
P
L
E
H
P
H
Y
E
V
S
R
V
D
G
Site 91
S1257
E
H
P
H
Y
E
V
S
R
V
D
G
T
V
D
Site 92
T1262
E
V
S
R
V
D
G
T
V
D
T
P
P
C
L
Site 93
T1265
R
V
D
G
T
V
D
T
P
P
C
L
R
L
T
Site 94
T1272
T
P
P
C
L
R
L
T
H
R
T
W
G
S
Q
Site 95
T1275
C
L
R
L
T
H
R
T
W
G
S
Q
N
S
L
Site 96
S1278
L
T
H
R
T
W
G
S
Q
N
S
L
V
E
M
Site 97
S1281
R
T
W
G
S
Q
N
S
L
V
E
M
L
F
L
Site 98
Y1331
A
A
E
P
D
P
D
Y
E
N
L
R
R
S
A
Site 99
S1337
D
Y
E
N
L
R
R
S
A
G
G
W
S
E
A
Site 100
T1360
K
E
G
A
P
G
G
T
P
Q
A
G
G
E
A
Site 101
T1379
A
E
N
E
K
D
A
T
T
E
K
N
K
K
R
Site 102
T1399
A
K
K
V
A
M
M
T
Q
P
P
A
T
P
T
Site 103
T1404
M
M
T
Q
P
P
A
T
P
T
L
P
R
L
P
Site 104
T1406
T
Q
P
P
A
T
P
T
L
P
R
L
P
H
D
Site 105
S1462
D
Y
H
Q
H
D
M
S
F
D
L
S
K
V
R
Site 106
T1472
L
S
K
V
R
V
V
T
V
T
M
G
D
E
Q
Site 107
T1474
K
V
R
V
V
T
V
T
M
G
D
E
Q
G
N
Site 108
S1484
D
E
Q
G
N
V
H
S
S
L
K
C
S
N
C
Site 109
S1501
V
W
G
G
D
F
V
S
P
G
Q
Q
G
R
I
Site 110
S1509
P
G
Q
Q
G
R
I
S
H
T
D
L
V
I
G
Site 111
T1527
D
L
A
T
G
L
M
T
F
T
A
N
G
K
E
Site 112
T1537
A
N
G
K
E
S
N
T
F
F
Q
V
E
P
N
Site 113
S1575
Q
K
N
I
M
P
L
S
A
A
M
F
Q
S
E
Site 114
S1581
L
S
A
A
M
F
Q
S
E
R
K
N
P
A
P
Site 115
S1653
C
M
D
I
L
E
L
S
E
R
L
D
L
Q
R
Site 116
S1663
L
D
L
Q
R
F
H
S
H
T
L
R
L
Y
R
Site 117
T1665
L
Q
R
F
H
S
H
T
L
R
L
Y
R
A
V
Site 118
S1721
L
I
S
I
H
L
E
S
A
C
R
S
R
R
S
Site 119
S1725
H
L
E
S
A
C
R
S
R
R
S
M
L
S
E
Site 120
S1728
S
A
C
R
S
R
R
S
M
L
S
E
Y
I
V
Site 121
S1731
R
S
R
R
S
M
L
S
E
Y
I
V
P
L
T
Site 122
Y1733
R
R
S
M
L
S
E
Y
I
V
P
L
T
P
E
Site 123
T1738
S
E
Y
I
V
P
L
T
P
E
T
R
A
I
T
Site 124
T1745
T
P
E
T
R
A
I
T
L
F
P
P
G
R
S
Site 125
T1753
L
F
P
P
G
R
S
T
E
N
G
H
P
R
H
Site 126
T1769
L
P
G
V
G
V
T
T
S
L
R
P
P
H
H
Site 127
S1770
P
G
V
G
V
T
T
S
L
R
P
P
H
H
F
Site 128
Y1945
Q
M
C
H
L
L
E
Y
F
C
D
Q
E
L
Q
Site 129
S1957
E
L
Q
H
R
V
E
S
L
A
A
F
A
E
R
Site 130
Y1965
L
A
A
F
A
E
R
Y
V
D
K
L
Q
A
N
Site 131
Y1977
Q
A
N
Q
R
S
R
Y
G
L
L
I
K
A
F
Site 132
T1991
F
S
M
T
A
A
E
T
A
R
R
T
R
E
F
Site 133
T1995
A
A
E
T
A
R
R
T
R
E
F
R
S
P
P
Site 134
S2000
R
R
T
R
E
F
R
S
P
P
Q
E
Q
I
N
Site 135
T2016
L
L
Q
F
K
D
G
T
D
E
E
D
C
P
L
Site 136
T2058
E
E
P
E
E
E
T
T
L
G
S
R
L
M
S
Site 137
S2061
E
E
E
T
T
L
G
S
R
L
M
S
L
L
E
Site 138
S2065
T
L
G
S
R
L
M
S
L
L
E
K
V
R
L
Site 139
S2085
E
K
P
E
E
E
R
S
A
E
E
S
K
P
R
Site 140
S2089
E
E
R
S
A
E
E
S
K
P
R
S
L
Q
E
Site 141
S2093
A
E
E
S
K
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D
M
Site 293
S4596
G
E
D
D
M
E
G
S
A
A
G
D
V
S
G
Site 294
S4602
G
S
A
A
G
D
V
S
G
A
G
S
G
G
S
Site 295
S4606
G
D
V
S
G
A
G
S
G
G
S
S
G
W
G
Site 296
S4609
S
G
A
G
S
G
G
S
S
G
W
G
L
G
A
Site 297
S4610
G
A
G
S
G
G
S
S
G
W
G
L
G
A
G
Site 298
Y4630
D
E
D
E
N
M
V
Y
Y
F
L
E
E
S
T
Site 299
Y4631
E
D
E
N
M
V
Y
Y
F
L
E
E
S
T
G
Site 300
Y4639
F
L
E
E
S
T
G
Y
M
E
P
A
L
R
C
Site 301
Y4688
K
L
E
F
D
G
L
Y
I
T
E
Q
P
E
D
Site 302
T4690
E
F
D
G
L
Y
I
T
E
Q
P
E
D
D
D
Site 303
T4709
W
D
R
L
V
L
N
T
P
S
F
P
S
N
Y
Site 304
S4711
R
L
V
L
N
T
P
S
F
P
S
N
Y
W
D
Site 305
Y4716
T
P
S
F
P
S
N
Y
W
D
K
F
V
K
R
Site 306
Y4733
L
D
K
H
G
D
I
Y
G
R
E
R
I
A
E
Site 307
T4823
D
I
A
M
G
V
K
T
L
R
T
I
L
S
S
Site 308
T4826
M
G
V
K
T
L
R
T
I
L
S
S
V
T
H
Site 309
S4829
K
T
L
R
T
I
L
S
S
V
T
H
N
G
K
Site 310
S4830
T
L
R
T
I
L
S
S
V
T
H
N
G
K
Q
Site 311
T4832
R
T
I
L
S
S
V
T
H
N
G
K
Q
L
V
Site 312
Y4864
F
N
F
F
R
K
F
Y
N
K
S
E
D
E
D
Site 313
S4867
F
R
K
F
Y
N
K
S
E
D
E
D
E
P
D
Site 314
Y4910
E
D
P
A
G
D
E
Y
E
L
Y
R
V
V
F
Site 315
Y4913
A
G
D
E
Y
E
L
Y
R
V
V
F
D
I
T
Site 316
Y4968
I
C
G
I
G
S
D
Y
F
D
T
T
P
H
G
Site 317
T4971
I
G
S
D
Y
F
D
T
T
P
H
G
F
E
T
Site 318
T4972
G
S
D
Y
F
D
T
T
P
H
G
F
E
T
H
Site 319
Y4995
N
Y
M
F
F
L
M
Y
L
I
N
K
D
E
T
Site 320
T5002
Y
L
I
N
K
D
E
T
E
H
T
G
Q
E
S
Site 321
T5005
N
K
D
E
T
E
H
T
G
Q
E
S
Y
V
W
Site 322
Y5010
E
H
T
G
Q
E
S
Y
V
W
K
M
Y
Q
E
Site 323
Y5033
G
D
C
F
R
K
Q
Y
E
D
Q
L
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation