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Updated November 2019
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Protein Info
Short Name:
TAF1
Full Name:
Transcription initiation factor TFIID subunit 1
Alias:
BA2R; CCG1; CCGS; Cell cycle gene 1 protein; DYT3; DYT3/TAF1; KAT4; Kinase TAF1; NSCL2; P250; T2D1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF2A; TAFII250; TAFII-250; TBP-associated factor 250 kDa; Transcription initiation factor TFIID 250 kDa subunit
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor; ATYPICAL group; TAF1 family
Mass (Da):
212677
Number AA:
1872
UniProt ID:
P21675
International Prot ID:
IPI00009891
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005669
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0017025
GO:0070577
PhosphoSite+
KinaseNET
Biological Process:
GO:0000080
GO:0006368
GO:0051123
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
L
L
L
R
T
A
A
T
I
T
A
A
A
I
M
Site 2
S22
I
T
A
A
A
I
M
S
D
T
D
S
D
E
D
Site 3
T24
A
A
A
I
M
S
D
T
D
S
D
E
D
S
A
Site 4
S26
A
I
M
S
D
T
D
S
D
E
D
S
A
G
G
Site 5
S30
D
T
D
S
D
E
D
S
A
G
G
G
P
F
S
Site 6
S37
S
A
G
G
G
P
F
S
L
A
G
F
L
F
G
Site 7
T82
G
S
L
I
T
E
L
T
A
N
E
E
L
T
G
Site 8
T90
A
N
E
E
L
T
G
T
D
G
A
L
V
N
D
Site 9
T104
D
E
G
W
V
R
S
T
E
D
A
V
D
Y
S
Site 10
Y110
S
T
E
D
A
V
D
Y
S
D
I
N
E
V
A
Site 11
S111
T
E
D
A
V
D
Y
S
D
I
N
E
V
A
E
Site 12
S121
N
E
V
A
E
D
E
S
R
R
Y
Q
Q
T
M
Site 13
Y124
A
E
D
E
S
R
R
Y
Q
Q
T
M
G
S
L
Site 14
T127
E
S
R
R
Y
Q
Q
T
M
G
S
L
Q
P
L
Site 15
S130
R
Y
Q
Q
T
M
G
S
L
Q
P
L
C
H
S
Site 16
S137
S
L
Q
P
L
C
H
S
D
Y
D
E
D
D
Y
Site 17
Y139
Q
P
L
C
H
S
D
Y
D
E
D
D
Y
D
A
Site 18
Y144
S
D
Y
D
E
D
D
Y
D
A
D
C
E
D
I
Site 19
S174
K
K
D
K
D
Q
D
S
I
T
G
E
K
V
D
Site 20
T176
D
K
D
Q
D
S
I
T
G
E
K
V
D
F
S
Site 21
S183
T
G
E
K
V
D
F
S
S
S
S
D
S
E
S
Site 22
S184
G
E
K
V
D
F
S
S
S
S
D
S
E
S
E
Site 23
S185
E
K
V
D
F
S
S
S
S
D
S
E
S
E
M
Site 24
S186
K
V
D
F
S
S
S
S
D
S
E
S
E
M
G
Site 25
S188
D
F
S
S
S
S
D
S
E
S
E
M
G
P
Q
Site 26
S190
S
S
S
S
D
S
E
S
E
M
G
P
Q
E
A
Site 27
T198
E
M
G
P
Q
E
A
T
Q
A
E
S
E
D
G
Site 28
S202
Q
E
A
T
Q
A
E
S
E
D
G
K
L
T
L
Site 29
T208
E
S
E
D
G
K
L
T
L
P
L
A
G
I
M
Site 30
S225
D
A
T
K
L
L
P
S
V
T
E
L
F
P
E
Site 31
S253
G
P
G
K
N
V
P
S
V
W
R
S
A
R
R
Site 32
S257
N
V
P
S
V
W
R
S
A
R
R
K
R
K
K
Site 33
S281
Q
I
Q
E
V
E
C
S
V
E
S
E
V
S
Q
Site 34
S284
E
V
E
C
S
V
E
S
E
V
S
Q
K
S
L
Site 35
S287
C
S
V
E
S
E
V
S
Q
K
S
L
W
N
Y
Site 36
S290
E
S
E
V
S
Q
K
S
L
W
N
Y
D
Y
A
Site 37
Y294
S
Q
K
S
L
W
N
Y
D
Y
A
P
P
P
P
Site 38
Y296
K
S
L
W
N
Y
D
Y
A
P
P
P
P
P
E
Site 39
S307
P
P
P
E
Q
C
L
S
D
D
E
I
T
M
M
Site 40
S319
T
M
M
A
P
V
E
S
K
F
S
Q
S
T
G
Site 41
S322
A
P
V
E
S
K
F
S
Q
S
T
G
D
I
D
Site 42
T332
T
G
D
I
D
K
V
T
D
T
K
P
R
V
A
Site 43
T334
D
I
D
K
V
T
D
T
K
P
R
V
A
E
W
Site 44
Y343
P
R
V
A
E
W
R
Y
G
P
A
R
L
W
Y
Site 45
Y350
Y
G
P
A
R
L
W
Y
D
M
L
G
V
P
E
Site 46
S360
L
G
V
P
E
D
G
S
G
F
D
Y
G
F
K
Site 47
Y364
E
D
G
S
G
F
D
Y
G
F
K
L
R
K
T
Site 48
T371
Y
G
F
K
L
R
K
T
E
H
E
P
V
I
K
Site 49
S379
E
H
E
P
V
I
K
S
R
M
I
E
E
F
R
Site 50
S432
G
T
K
P
Q
R
A
S
L
A
G
W
L
P
S
Site 51
S439
S
L
A
G
W
L
P
S
S
M
T
R
N
A
M
Site 52
Y448
M
T
R
N
A
M
A
Y
N
V
Q
Q
G
F
A
Site 53
Y465
L
D
D
D
K
P
W
Y
S
I
F
P
I
D
N
Site 54
Y477
I
D
N
E
D
L
V
Y
G
R
W
E
D
N
I
Site 55
T501
L
L
E
P
P
V
L
T
L
D
P
N
D
E
N
Site 56
T521
P
D
E
K
E
E
A
T
S
N
S
P
S
K
E
Site 57
S522
D
E
K
E
E
A
T
S
N
S
P
S
K
E
S
Site 58
S524
K
E
E
A
T
S
N
S
P
S
K
E
S
K
K
Site 59
S526
E
A
T
S
N
S
P
S
K
E
S
K
K
E
S
Site 60
S529
S
N
S
P
S
K
E
S
K
K
E
S
S
L
K
Site 61
S533
S
K
E
S
K
K
E
S
S
L
K
K
S
R
I
Site 62
S534
K
E
S
K
K
E
S
S
L
K
K
S
R
I
L
Site 63
S538
K
E
S
S
L
K
K
S
R
I
L
L
G
K
T
Site 64
S557
E
E
P
Q
Q
N
M
S
Q
P
E
V
K
D
P
Site 65
Y572
W
N
L
S
N
D
E
Y
Y
Y
P
K
Q
Q
G
Site 66
Y573
N
L
S
N
D
E
Y
Y
Y
P
K
Q
Q
G
L
Site 67
Y574
L
S
N
D
E
Y
Y
Y
P
K
Q
Q
G
L
R
Site 68
T583
K
Q
Q
G
L
R
G
T
F
G
G
N
I
I
Q
Site 69
Y623
H
R
P
P
L
K
K
Y
S
F
G
A
L
S
Q
Site 70
S624
R
P
P
L
K
K
Y
S
F
G
A
L
S
Q
P
Site 71
S629
K
Y
S
F
G
A
L
S
Q
P
G
P
H
S
V
Site 72
S635
L
S
Q
P
G
P
H
S
V
Q
P
L
L
K
H
Site 73
S657
R
E
Q
E
R
Q
A
S
G
G
G
E
M
F
F
Site 74
T667
G
E
M
F
F
M
R
T
P
Q
D
L
T
G
K
Site 75
T672
M
R
T
P
Q
D
L
T
G
K
D
G
D
L
I
Site 76
Y683
G
D
L
I
L
A
E
Y
S
E
E
N
G
P
L
Site 77
S684
D
L
I
L
A
E
Y
S
E
E
N
G
P
L
M
Site 78
Y703
M
A
T
K
I
K
N
Y
Y
K
R
K
P
G
K
Site 79
Y704
A
T
K
I
K
N
Y
Y
K
R
K
P
G
K
D
Site 80
Y719
P
G
A
P
D
C
K
Y
G
E
T
V
Y
C
H
Site 81
Y724
C
K
Y
G
E
T
V
Y
C
H
T
S
P
F
L
Site 82
S728
E
T
V
Y
C
H
T
S
P
F
L
G
S
L
H
Site 83
S733
H
T
S
P
F
L
G
S
L
H
P
G
Q
L
L
Site 84
Y753
N
L
F
R
A
P
I
Y
L
H
K
M
P
E
T
Site 85
Y771
I
I
R
T
R
Q
G
Y
Y
I
R
E
L
V
D
Site 86
S796
F
E
V
P
G
P
N
S
K
R
A
N
T
H
I
Site 87
T801
P
N
S
K
R
A
N
T
H
I
R
D
F
L
Q
Site 88
S836
D
I
K
K
A
F
P
S
H
S
E
S
S
I
R
Site 89
S838
K
K
A
F
P
S
H
S
E
S
S
I
R
K
R
Site 90
S840
A
F
P
S
H
S
E
S
S
I
R
K
R
L
K
Site 91
S841
F
P
S
H
S
E
S
S
I
R
K
R
L
K
L
Site 92
S866
S
N
W
W
V
L
K
S
D
F
R
L
P
T
E
Site 93
T872
K
S
D
F
R
L
P
T
E
E
E
I
R
A
M
Site 94
S881
E
E
I
R
A
M
V
S
P
E
Q
C
C
A
Y
Site 95
Y888
S
P
E
Q
C
C
A
Y
Y
S
M
I
A
A
E
Site 96
Y889
P
E
Q
C
C
A
Y
Y
S
M
I
A
A
E
Q
Site 97
Y903
Q
R
L
K
D
A
G
Y
G
E
K
S
F
F
A
Site 98
S907
D
A
G
Y
G
E
K
S
F
F
A
P
E
E
E
Site 99
S964
T
G
C
G
E
G
F
S
Y
V
K
I
P
N
K
Site 100
Y965
G
C
G
E
G
F
S
Y
V
K
I
P
N
K
P
Site 101
T987
E
P
Q
P
V
K
K
T
V
T
G
T
D
A
D
Site 102
S999
D
A
D
L
R
R
L
S
L
K
N
A
K
Q
L
Site 103
S1033
I
D
V
V
R
T
M
S
T
E
Q
A
R
S
G
Site 104
S1039
M
S
T
E
Q
A
R
S
G
E
G
P
M
S
K
Site 105
S1045
R
S
G
E
G
P
M
S
K
F
A
R
G
S
R
Site 106
S1051
M
S
K
F
A
R
G
S
R
F
S
V
A
E
H
Site 107
S1054
F
A
R
G
S
R
F
S
V
A
E
H
Q
E
R
Site 108
S1079
L
Q
N
K
V
L
S
S
T
E
V
L
S
T
D
Site 109
S1084
L
S
S
T
E
V
L
S
T
D
T
D
S
S
S
Site 110
T1085
S
S
T
E
V
L
S
T
D
T
D
S
S
S
A
Site 111
T1087
T
E
V
L
S
T
D
T
D
S
S
S
A
E
D
Site 112
S1089
V
L
S
T
D
T
D
S
S
S
A
E
D
S
D
Site 113
S1091
S
T
D
T
D
S
S
S
A
E
D
S
D
F
E
Site 114
S1095
D
S
S
S
A
E
D
S
D
F
E
E
M
G
K
Site 115
T1113
N
M
L
Q
N
K
K
T
S
S
Q
L
S
R
E
Site 116
S1115
L
Q
N
K
K
T
S
S
Q
L
S
R
E
R
E
Site 117
S1118
K
K
T
S
S
Q
L
S
R
E
R
E
E
Q
E
Site 118
S1138
R
M
L
L
A
A
G
S
A
A
S
G
N
N
H
Site 119
T1150
N
N
H
R
D
D
D
T
A
S
V
T
S
L
N
Site 120
S1152
H
R
D
D
D
T
A
S
V
T
S
L
N
S
S
Site 121
T1154
D
D
D
T
A
S
V
T
S
L
N
S
S
A
T
Site 122
S1155
D
D
T
A
S
V
T
S
L
N
S
S
A
T
G
Site 123
S1158
A
S
V
T
S
L
N
S
S
A
T
G
R
C
L
Site 124
S1159
S
V
T
S
L
N
S
S
A
T
G
R
C
L
K
Site 125
T1161
T
S
L
N
S
S
A
T
G
R
C
L
K
I
Y
Site 126
Y1168
T
G
R
C
L
K
I
Y
R
T
F
R
D
E
E
Site 127
T1170
R
C
L
K
I
Y
R
T
F
R
D
E
E
G
K
Site 128
Y1179
R
D
E
E
G
K
E
Y
V
R
C
E
T
V
R
Site 129
T1184
K
E
Y
V
R
C
E
T
V
R
K
P
A
V
I
Site 130
Y1194
K
P
A
V
I
D
A
Y
V
R
I
R
T
T
K
Site 131
T1199
D
A
Y
V
R
I
R
T
T
K
D
E
E
F
I
Site 132
T1200
A
Y
V
R
I
R
T
T
K
D
E
E
F
I
R
Site 133
Y1282
T
N
K
F
C
P
L
Y
Y
Q
T
N
A
P
P
Site 134
Y1283
N
K
F
C
P
L
Y
Y
Q
T
N
A
P
P
S
Site 135
T1285
F
C
P
L
Y
Y
Q
T
N
A
P
P
S
N
P
Site 136
S1290
Y
Q
T
N
A
P
P
S
N
P
V
A
M
T
E
Site 137
T1306
Q
E
E
E
L
E
K
T
V
I
H
N
D
N
E
Site 138
S1340
A
D
E
V
R
R
K
S
L
V
L
K
F
P
K
Site 139
T1360
K
K
K
R
R
V
G
T
T
V
H
C
D
Y
L
Site 140
T1361
K
K
R
R
V
G
T
T
V
H
C
D
Y
L
N
Site 141
Y1366
G
T
T
V
H
C
D
Y
L
N
R
P
H
K
S
Site 142
S1373
Y
L
N
R
P
H
K
S
I
H
R
R
R
T
D
Site 143
T1379
K
S
I
H
R
R
R
T
D
P
M
V
T
L
S
Site 144
T1384
R
R
T
D
P
M
V
T
L
S
S
I
L
E
S
Site 145
S1391
T
L
S
S
I
L
E
S
I
I
N
D
M
R
D
Site 146
T1402
D
M
R
D
L
P
N
T
Y
P
F
H
T
P
V
Site 147
Y1403
M
R
D
L
P
N
T
Y
P
F
H
T
P
V
N
Site 148
T1407
P
N
T
Y
P
F
H
T
P
V
N
A
K
V
V
Site 149
Y1417
N
A
K
V
V
K
D
Y
Y
K
I
I
T
R
P
Site 150
Y1418
A
K
V
V
K
D
Y
Y
K
I
I
T
R
P
M
Site 151
T1429
T
R
P
M
D
L
Q
T
L
R
E
N
V
R
K
Site 152
Y1439
E
N
V
R
K
R
L
Y
P
S
R
E
E
F
R
Site 153
S1441
V
R
K
R
L
Y
P
S
R
E
E
F
R
E
H
Site 154
S1456
L
E
L
I
V
K
N
S
A
T
Y
N
G
P
K
Site 155
T1458
L
I
V
K
N
S
A
T
Y
N
G
P
K
H
S
Site 156
Y1459
I
V
K
N
S
A
T
Y
N
G
P
K
H
S
L
Site 157
S1465
T
Y
N
G
P
K
H
S
L
T
Q
I
S
Q
S
Site 158
T1467
N
G
P
K
H
S
L
T
Q
I
S
Q
S
M
L
Site 159
S1470
K
H
S
L
T
Q
I
S
Q
S
M
L
D
L
C
Site 160
S1472
S
L
T
Q
I
S
Q
S
M
L
D
L
C
D
E
Site 161
Y1540
N
K
K
F
V
P
D
Y
Y
K
V
I
V
N
P
Site 162
Y1541
K
K
F
V
P
D
Y
Y
K
V
I
V
N
P
M
Site 163
T1552
V
N
P
M
D
L
E
T
I
R
K
N
I
S
K
Site 164
Y1562
K
N
I
S
K
H
K
Y
Q
S
R
E
S
F
L
Site 165
S1564
I
S
K
H
K
Y
Q
S
R
E
S
F
L
D
D
Site 166
S1567
H
K
Y
Q
S
R
E
S
F
L
D
D
V
N
L
Site 167
S1579
V
N
L
I
L
A
N
S
V
K
Y
N
G
P
E
Site 168
Y1582
I
L
A
N
S
V
K
Y
N
G
P
E
S
Q
Y
Site 169
S1587
V
K
Y
N
G
P
E
S
Q
Y
T
K
T
A
Q
Site 170
T1590
N
G
P
E
S
Q
Y
T
K
T
A
Q
E
I
V
Site 171
Y1601
Q
E
I
V
N
V
C
Y
Q
T
L
T
E
Y
D
Site 172
Y1607
C
Y
Q
T
L
T
E
Y
D
E
H
L
T
Q
L
Site 173
T1620
Q
L
E
K
D
I
C
T
A
K
E
A
A
L
E
Site 174
S1633
L
E
E
A
E
L
E
S
L
D
P
M
T
P
G
Site 175
T1638
L
E
S
L
D
P
M
T
P
G
P
Y
T
P
Q
Site 176
T1643
P
M
T
P
G
P
Y
T
P
Q
P
P
D
L
Y
Site 177
Y1650
T
P
Q
P
P
D
L
Y
D
T
N
T
S
L
S
Site 178
T1652
Q
P
P
D
L
Y
D
T
N
T
S
L
S
M
S
Site 179
T1654
P
D
L
Y
D
T
N
T
S
L
S
M
S
R
D
Site 180
S1655
D
L
Y
D
T
N
T
S
L
S
M
S
R
D
A
Site 181
S1657
Y
D
T
N
T
S
L
S
M
S
R
D
A
S
V
Site 182
S1659
T
N
T
S
L
S
M
S
R
D
A
S
V
F
Q
Site 183
S1663
L
S
M
S
R
D
A
S
V
F
Q
D
E
S
N
Site 184
S1669
A
S
V
F
Q
D
E
S
N
M
S
V
L
D
I
Site 185
S1672
F
Q
D
E
S
N
M
S
V
L
D
I
P
S
A
Site 186
S1678
M
S
V
L
D
I
P
S
A
T
P
E
K
Q
V
Site 187
T1680
V
L
D
I
P
S
A
T
P
E
K
Q
V
T
Q
Site 188
T1686
A
T
P
E
K
Q
V
T
Q
E
G
E
D
G
D
Site 189
T1703
L
A
D
E
E
E
G
T
V
Q
Q
P
Q
A
S
Site 190
S1730
D
D
E
E
D
A
G
S
D
E
E
G
D
N
P
Site 191
S1739
E
E
G
D
N
P
F
S
A
I
Q
L
S
E
S
Site 192
S1744
P
F
S
A
I
Q
L
S
E
S
G
S
D
S
D
Site 193
S1746
S
A
I
Q
L
S
E
S
G
S
D
S
D
V
G
Site 194
S1748
I
Q
L
S
E
S
G
S
D
S
D
V
G
S
G
Site 195
S1750
L
S
E
S
G
S
D
S
D
V
G
S
G
G
I
Site 196
S1754
G
S
D
S
D
V
G
S
G
G
I
R
P
K
Q
Site 197
S1781
E
N
E
E
S
M
M
S
Y
E
G
D
G
G
E
Site 198
Y1782
N
E
E
S
M
M
S
Y
E
G
D
G
G
E
A
Site 199
S1790
E
G
D
G
G
E
A
S
H
G
L
E
D
S
N
Site 200
S1796
A
S
H
G
L
E
D
S
N
I
S
Y
G
S
Y
Site 201
S1799
G
L
E
D
S
N
I
S
Y
G
S
Y
E
E
P
Site 202
Y1800
L
E
D
S
N
I
S
Y
G
S
Y
E
E
P
D
Site 203
S1802
D
S
N
I
S
Y
G
S
Y
E
E
P
D
P
K
Site 204
Y1803
S
N
I
S
Y
G
S
Y
E
E
P
D
P
K
S
Site 205
S1810
Y
E
E
P
D
P
K
S
N
T
Q
D
T
S
F
Site 206
T1812
E
P
D
P
K
S
N
T
Q
D
T
S
F
S
S
Site 207
T1815
P
K
S
N
T
Q
D
T
S
F
S
S
I
G
G
Site 208
S1816
K
S
N
T
Q
D
T
S
F
S
S
I
G
G
Y
Site 209
Y1823
S
F
S
S
I
G
G
Y
E
V
S
E
E
E
E
Site 210
S1826
S
I
G
G
Y
E
V
S
E
E
E
E
D
E
E
Site 211
S1839
E
E
E
E
E
Q
R
S
G
P
S
V
L
S
Q
Site 212
S1842
E
E
Q
R
S
G
P
S
V
L
S
Q
V
H
L
Site 213
S1845
R
S
G
P
S
V
L
S
Q
V
H
L
S
E
D
Site 214
S1850
V
L
S
Q
V
H
L
S
E
D
E
E
D
S
E
Site 215
S1856
L
S
E
D
E
E
D
S
E
D
F
H
S
I
A
Site 216
S1861
E
D
S
E
D
F
H
S
I
A
G
D
S
D
L
Site 217
S1866
F
H
S
I
A
G
D
S
D
L
D
S
D
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation