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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NF1
Full Name:
Neurofibromin
Alias:
Neurofibromatosis; Neurofibromatosis-related protein NF-1; Neurofibromin 1; Neurofibromin truncated; Von Recklinghausen disease; Watson disease
Type:
Tumor suppressor; GTPase activating protein, Ras
Mass (Da):
319372
Number AA:
2839
UniProt ID:
P21359
International Prot ID:
IPI00304235
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030424
GO:0005737
GO:0030425
Uniprot
OncoNet
Molecular Function:
GO:0005099
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000165
GO:0007265
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T32
T
G
Q
Q
N
T
H
T
K
V
S
T
E
H
N
Site 2
S56
Y
K
F
S
L
V
I
S
G
L
T
T
I
L
K
Site 3
T59
S
L
V
I
S
G
L
T
T
I
L
K
N
V
N
Site 4
T60
L
V
I
S
G
L
T
T
I
L
K
N
V
N
N
Site 5
T107
D
T
M
R
L
D
E
T
M
L
V
K
Q
L
L
Site 6
S137
H
A
A
E
L
R
N
S
A
S
G
V
L
F
S
Site 7
S155
N
N
F
N
A
V
F
S
R
I
S
T
R
L
Q
Site 8
S158
N
A
V
F
S
R
I
S
T
R
L
Q
E
L
T
Site 9
T165
S
T
R
L
Q
E
L
T
V
C
S
E
D
N
V
Site 10
Y182
H
D
I
E
L
L
Q
Y
I
N
V
D
C
A
K
Site 11
T197
L
K
R
L
L
K
E
T
A
F
K
F
K
A
L
Site 12
Y235
P
D
E
F
T
K
L
Y
Q
I
P
Q
T
D
M
Site 13
S259
L
V
D
G
F
A
E
S
T
K
R
K
A
A
V
Site 14
S285
P
E
I
I
Q
D
I
S
K
D
V
V
D
E
N
Site 15
S302
N
K
K
L
F
L
D
S
L
R
K
A
L
A
G
Site 16
T317
H
G
G
S
R
Q
L
T
E
S
A
A
I
A
C
Site 17
S361
K
N
L
L
F
N
P
S
K
P
F
S
R
G
S
Site 18
S365
F
N
P
S
K
P
F
S
R
G
S
Q
P
A
D
Site 19
S368
S
K
P
F
S
R
G
S
Q
P
A
D
V
D
L
Site 20
S402
K
I
C
L
A
Q
N
S
P
S
T
F
H
Y
V
Site 21
T405
L
A
Q
N
S
P
S
T
F
H
Y
V
L
V
N
Site 22
Y408
N
S
P
S
T
F
H
Y
V
L
V
N
S
L
H
Site 23
Y433
W
P
K
I
D
A
V
Y
C
H
S
V
E
L
R
Site 24
S465
P
A
I
R
M
A
P
S
L
T
F
K
E
K
V
Site 25
T467
I
R
M
A
P
S
L
T
F
K
E
K
V
T
S
Site 26
S474
T
F
K
E
K
V
T
S
L
K
F
K
E
K
P
Site 27
T486
E
K
P
T
D
L
E
T
R
S
Y
K
Y
L
L
Site 28
S488
P
T
D
L
E
T
R
S
Y
K
Y
L
L
L
S
Site 29
Y489
T
D
L
E
T
R
S
Y
K
Y
L
L
L
S
M
Site 30
Y491
L
E
T
R
S
Y
K
Y
L
L
L
S
M
V
K
Site 31
T518
P
R
K
Q
G
P
E
T
Q
G
S
T
A
E
L
Site 32
S521
Q
G
P
E
T
Q
G
S
T
A
E
L
I
T
G
Site 33
S557
L
V
L
H
Q
L
D
S
I
D
L
W
N
P
D
Site 34
T569
N
P
D
A
P
V
E
T
F
W
E
I
S
S
Q
Site 35
S587
Y
I
C
K
K
L
T
S
H
Q
M
L
S
S
T
Site 36
S620
K
N
K
Q
A
D
R
S
S
C
H
F
L
L
F
Site 37
S636
G
V
G
C
D
I
P
S
S
G
N
T
S
Q
M
Site 38
S637
V
G
C
D
I
P
S
S
G
N
T
S
Q
M
S
Site 39
T640
D
I
P
S
S
G
N
T
S
Q
M
S
M
D
H
Site 40
S641
I
P
S
S
G
N
T
S
Q
M
S
M
D
H
E
Site 41
S644
S
G
N
T
S
Q
M
S
M
D
H
E
E
L
L
Site 42
T653
D
H
E
E
L
L
R
T
P
G
A
S
L
R
K
Site 43
S657
L
L
R
T
P
G
A
S
L
R
K
G
K
G
N
Site 44
S665
L
R
K
G
K
G
N
S
S
M
D
S
A
A
G
Site 45
S666
R
K
G
K
G
N
S
S
M
D
S
A
A
G
C
Site 46
S669
K
G
N
S
S
M
D
S
A
A
G
C
S
G
T
Site 47
S674
M
D
S
A
A
G
C
S
G
T
P
P
I
C
R
Site 48
T676
S
A
A
G
C
S
G
T
P
P
I
C
R
Q
A
Site 49
S727
R
C
G
V
D
E
V
S
V
H
N
L
L
P
N
Site 50
Y735
V
H
N
L
L
P
N
Y
N
T
F
M
E
F
A
Site 51
S743
N
T
F
M
E
F
A
S
V
S
N
M
M
S
T
Site 52
S749
A
S
V
S
N
M
M
S
T
G
R
A
A
L
Q
Site 53
T750
S
V
S
N
M
M
S
T
G
R
A
A
L
Q
K
Site 54
T770
L
R
R
I
E
H
P
T
A
G
N
T
E
A
W
Site 55
Y794
A
T
K
L
I
L
N
Y
P
K
A
K
M
E
D
Site 56
S807
E
D
G
Q
A
A
E
S
L
H
K
T
I
V
K
Site 57
T811
A
A
E
S
L
H
K
T
I
V
K
R
R
M
S
Site 58
S818
T
I
V
K
R
R
M
S
H
V
S
G
G
G
S
Site 59
S821
K
R
R
M
S
H
V
S
G
G
G
S
I
D
L
Site 60
S825
S
H
V
S
G
G
G
S
I
D
L
S
D
T
D
Site 61
S829
G
G
G
S
I
D
L
S
D
T
D
S
L
Q
E
Site 62
T831
G
S
I
D
L
S
D
T
D
S
L
Q
E
W
I
Site 63
S833
I
D
L
S
D
T
D
S
L
Q
E
W
I
N
M
Site 64
S856
G
V
C
L
Q
Q
R
S
N
S
G
L
A
T
Y
Site 65
S858
C
L
Q
Q
R
S
N
S
G
L
A
T
Y
S
P
Site 66
T862
R
S
N
S
G
L
A
T
Y
S
P
P
M
G
P
Site 67
Y863
S
N
S
G
L
A
T
Y
S
P
P
M
G
P
V
Site 68
S864
N
S
G
L
A
T
Y
S
P
P
M
G
P
V
S
Site 69
S871
S
P
P
M
G
P
V
S
E
R
K
G
S
M
I
Site 70
S876
P
V
S
E
R
K
G
S
M
I
S
V
M
S
S
Site 71
S879
E
R
K
G
S
M
I
S
V
M
S
S
E
G
N
Site 72
S882
G
S
M
I
S
V
M
S
S
E
G
N
A
D
T
Site 73
S883
S
M
I
S
V
M
S
S
E
G
N
A
D
T
P
Site 74
T889
S
S
E
G
N
A
D
T
P
V
S
K
F
M
D
Site 75
S892
G
N
A
D
T
P
V
S
K
F
M
D
R
L
L
Site 76
T940
L
F
N
K
L
K
N
T
I
S
K
F
F
D
S
Site 77
S942
N
K
L
K
N
T
I
S
K
F
F
D
S
Q
G
Site 78
T954
S
Q
G
Q
V
L
L
T
D
T
N
T
Q
F
V
Site 79
T956
G
Q
V
L
L
T
D
T
N
T
Q
F
V
E
Q
Site 80
T976
K
N
L
L
D
N
H
T
E
G
S
S
E
H
L
Site 81
Y1044
F
R
N
K
M
V
E
Y
L
T
D
W
V
M
G
Site 82
S1072
T
R
D
L
D
Q
A
S
M
E
A
V
V
S
L
Site 83
S1118
M
N
L
L
N
D
C
S
E
V
E
D
E
S
A
Site 84
T1127
V
E
D
E
S
A
Q
T
G
G
R
K
R
G
M
Site 85
S1135
G
G
R
K
R
G
M
S
R
R
L
A
S
L
R
Site 86
S1164
V
D
S
G
L
M
H
S
I
G
L
G
Y
H
K
Site 87
T1175
G
Y
H
K
D
L
Q
T
R
A
T
F
M
E
V
Site 88
T1178
K
D
L
Q
T
R
A
T
F
M
E
V
L
T
K
Site 89
T1195
Q
Q
G
T
E
F
D
T
L
A
E
T
V
L
A
Site 90
S1234
L
A
N
V
V
P
C
S
Q
W
D
E
L
A
R
Site 91
S1262
Q
L
L
W
N
M
F
S
K
E
V
E
L
A
D
Site 92
S1270
K
E
V
E
L
A
D
S
M
Q
T
L
F
R
G
Site 93
S1279
Q
T
L
F
R
G
N
S
L
A
S
K
I
M
T
Site 94
S1318
S
S
D
W
Q
H
V
S
F
E
V
D
P
T
R
Site 95
T1324
V
S
F
E
V
D
P
T
R
L
E
P
S
E
S
Site 96
S1329
D
P
T
R
L
E
P
S
E
S
L
E
E
N
Q
Site 97
S1331
T
R
L
E
P
S
E
S
L
E
E
N
Q
R
N
Site 98
S1352
K
F
F
H
A
I
I
S
S
S
S
E
F
P
P
Site 99
S1353
F
F
H
A
I
I
S
S
S
S
E
F
P
P
Q
Site 100
S1355
H
A
I
I
S
S
S
S
E
F
P
P
Q
L
R
Site 101
S1391
E
K
K
E
N
K
K
S
V
V
S
Q
R
F
P
Site 102
S1394
E
N
K
K
S
V
V
S
Q
R
F
P
Q
N
S
Site 103
S1401
S
Q
R
F
P
Q
N
S
I
G
A
V
G
S
A
Site 104
S1470
P
F
N
D
F
V
K
S
N
F
D
A
A
R
R
Site 105
S1484
R
F
F
L
D
I
A
S
D
C
P
T
S
D
A
Site 106
T1488
D
I
A
S
D
C
P
T
S
D
A
V
N
H
S
Site 107
S1489
I
A
S
D
C
P
T
S
D
A
V
N
H
S
L
Site 108
S1495
T
S
D
A
V
N
H
S
L
S
F
I
S
D
G
Site 109
S1497
D
A
V
N
H
S
L
S
F
I
S
D
G
N
V
Site 110
Y1521
N
Q
E
K
I
G
Q
Y
L
S
S
N
R
D
H
Site 111
S1523
E
K
I
G
Q
Y
L
S
S
N
R
D
H
K
A
Site 112
S1524
K
I
G
Q
Y
L
S
S
N
R
D
H
K
A
V
Site 113
Y1545
K
M
A
T
L
L
A
Y
L
G
P
P
E
H
K
Site 114
T1557
E
H
K
P
V
A
D
T
H
W
S
S
L
N
L
Site 115
S1560
P
V
A
D
T
H
W
S
S
L
N
L
T
S
S
Site 116
S1561
V
A
D
T
H
W
S
S
L
N
L
T
S
S
K
Site 117
T1565
H
W
S
S
L
N
L
T
S
S
K
F
E
E
F
Site 118
S1567
S
S
L
N
L
T
S
S
K
F
E
E
F
M
T
Site 119
T1589
E
E
F
K
A
L
K
T
L
S
I
F
Y
Q
A
Site 120
Y1607
K
A
G
N
P
I
F
Y
Y
V
A
R
R
F
K
Site 121
Y1608
A
G
N
P
I
F
Y
Y
V
A
R
R
F
K
T
Site 122
T1615
Y
V
A
R
R
F
K
T
G
Q
I
N
G
D
L
Site 123
T1646
Y
E
I
V
V
D
L
T
H
T
G
P
S
N
R
Site 124
S1651
D
L
T
H
T
G
P
S
N
R
F
K
T
D
F
Site 125
T1656
G
P
S
N
R
F
K
T
D
F
L
S
K
W
F
Site 126
Y1680
N
V
S
A
V
Y
I
Y
N
C
N
S
W
V
R
Site 127
Y1689
C
N
S
W
V
R
E
Y
T
K
Y
H
E
R
L
Site 128
T1690
N
S
W
V
R
E
Y
T
K
Y
H
E
R
L
L
Site 129
Y1692
W
V
R
E
Y
T
K
Y
H
E
R
L
L
T
G
Site 130
T1698
K
Y
H
E
R
L
L
T
G
L
K
G
S
K
R
Site 131
T1770
Q
V
T
S
A
E
R
T
K
V
L
G
Q
S
V
Site 132
S1776
R
T
K
V
L
G
Q
S
V
F
L
N
D
I
Y
Site 133
Y1783
S
V
F
L
N
D
I
Y
Y
A
S
E
I
E
E
Site 134
T1800
L
V
D
E
N
Q
F
T
L
T
I
A
N
Q
G
Site 135
S1834
I
R
T
R
W
E
L
S
Q
P
D
S
I
P
Q
Site 136
S1838
W
E
L
S
Q
P
D
S
I
P
Q
H
T
K
I
Site 137
S1865
A
L
L
N
L
G
S
S
D
P
S
L
R
S
A
Site 138
S1868
N
L
G
S
S
D
P
S
L
R
S
A
A
Y
N
Site 139
S1871
S
S
D
P
S
L
R
S
A
A
Y
N
L
L
C
Site 140
T1923
A
A
N
E
P
H
L
T
L
E
F
L
E
E
C
Site 141
S1932
E
F
L
E
E
C
I
S
G
F
S
K
S
S
I
Site 142
Y1948
L
K
H
L
C
L
E
Y
M
T
P
W
L
S
N
Site 143
T1972
D
A
K
R
Q
R
V
T
A
I
L
D
K
L
I
Site 144
Y1989
T
I
N
E
K
Q
M
Y
P
S
I
Q
A
K
I
Site 145
S2064
I
I
D
K
T
C
L
S
P
T
P
T
L
E
Q
Site 146
T2066
D
K
T
C
L
S
P
T
P
T
L
E
Q
H
L
Site 147
T2068
T
C
L
S
P
T
P
T
L
E
Q
H
L
M
W
Site 148
S2181
A
V
I
A
F
R
S
S
Y
R
D
R
S
F
S
Site 149
Y2182
V
I
A
F
R
S
S
Y
R
D
R
S
F
S
P
Site 150
S2186
R
S
S
Y
R
D
R
S
F
S
P
G
S
Y
E
Site 151
S2188
S
Y
R
D
R
S
F
S
P
G
S
Y
E
R
E
Site 152
S2191
D
R
S
F
S
P
G
S
Y
E
R
E
T
F
A
Site 153
Y2192
R
S
F
S
P
G
S
Y
E
R
E
T
F
A
L
Site 154
T2196
P
G
S
Y
E
R
E
T
F
A
L
T
S
L
E
Site 155
Y2240
A
Q
R
F
A
F
Q
Y
N
P
S
L
Q
P
R
Site 156
S2260
G
C
I
S
K
R
V
S
H
G
Q
I
K
Q
I
Site 157
T2284
S
C
L
K
G
P
D
T
Y
N
S
Q
V
L
I
Site 158
Y2285
C
L
K
G
P
D
T
Y
N
S
Q
V
L
I
E
Site 159
S2287
K
G
P
D
T
Y
N
S
Q
V
L
I
E
A
T
Site 160
S2309
Q
P
L
L
N
K
D
S
P
L
H
K
A
L
F
Site 161
S2347
Q
N
L
H
T
L
D
S
L
R
I
F
N
D
K
Site 162
S2355
L
R
I
F
N
D
K
S
P
E
E
V
F
M
A
Site 163
Y2398
V
G
H
L
L
K
G
Y
R
H
P
S
P
A
I
Site 164
S2402
L
K
G
Y
R
H
P
S
P
A
I
V
A
R
T
Site 165
T2418
R
I
L
H
T
L
L
T
L
V
N
K
H
R
N
Site 166
T2444
A
Y
L
A
A
L
L
T
V
S
E
E
V
R
S
Site 167
S2446
L
A
A
L
L
T
V
S
E
E
V
R
S
R
C
Site 168
S2451
T
V
S
E
E
V
R
S
R
C
S
L
K
H
R
Site 169
S2454
E
E
V
R
S
R
C
S
L
K
H
R
K
S
L
Site 170
S2460
C
S
L
K
H
R
K
S
L
L
L
T
D
I
S
Site 171
T2464
H
R
K
S
L
L
L
T
D
I
S
M
E
N
V
Site 172
Y2476
E
N
V
P
M
D
T
Y
P
I
H
H
G
D
P
Site 173
S2484
P
I
H
H
G
D
P
S
Y
R
T
L
K
E
T
Site 174
Y2485
I
H
H
G
D
P
S
Y
R
T
L
K
E
T
Q
Site 175
T2491
S
Y
R
T
L
K
E
T
Q
P
W
S
S
P
K
Site 176
S2495
L
K
E
T
Q
P
W
S
S
P
K
G
S
E
G
Site 177
S2496
K
E
T
Q
P
W
S
S
P
K
G
S
E
G
Y
Site 178
S2500
P
W
S
S
P
K
G
S
E
G
Y
L
A
A
T
Site 179
Y2503
S
P
K
G
S
E
G
Y
L
A
A
T
Y
P
T
Site 180
Y2508
E
G
Y
L
A
A
T
Y
P
T
V
G
Q
T
S
Site 181
T2514
T
Y
P
T
V
G
Q
T
S
P
R
A
R
K
S
Site 182
S2515
Y
P
T
V
G
Q
T
S
P
R
A
R
K
S
M
Site 183
S2521
T
S
P
R
A
R
K
S
M
S
L
D
M
G
Q
Site 184
S2523
P
R
A
R
K
S
M
S
L
D
M
G
Q
P
S
Site 185
S2530
S
L
D
M
G
Q
P
S
Q
A
N
T
K
K
L
Site 186
T2534
G
Q
P
S
Q
A
N
T
K
K
L
L
G
T
R
Site 187
S2543
K
L
L
G
T
R
K
S
F
D
H
L
I
S
D
Site 188
S2549
K
S
F
D
H
L
I
S
D
T
K
A
P
K
R
Site 189
T2551
F
D
H
L
I
S
D
T
K
A
P
K
R
Q
E
Site 190
S2561
P
K
R
Q
E
M
E
S
G
I
T
T
P
P
K
Site 191
T2564
Q
E
M
E
S
G
I
T
T
P
P
K
M
R
R
Site 192
T2565
E
M
E
S
G
I
T
T
P
P
K
M
R
R
V
Site 193
T2575
K
M
R
R
V
A
E
T
D
Y
E
M
E
T
Q
Site 194
Y2577
R
R
V
A
E
T
D
Y
E
M
E
T
Q
R
I
Site 195
T2581
E
T
D
Y
E
M
E
T
Q
R
I
S
S
S
Q
Site 196
S2585
E
M
E
T
Q
R
I
S
S
S
Q
Q
H
P
H
Site 197
S2586
M
E
T
Q
R
I
S
S
S
Q
Q
H
P
H
L
Site 198
S2587
E
T
Q
R
I
S
S
S
Q
Q
H
P
H
L
R
Site 199
S2597
H
P
H
L
R
K
V
S
V
S
E
S
N
V
L
Site 200
S2599
H
L
R
K
V
S
V
S
E
S
N
V
L
L
D
Site 201
S2601
R
K
V
S
V
S
E
S
N
V
L
L
D
E
E
Site 202
Y2629
V
L
A
T
L
V
K
Y
T
T
D
E
F
D
Q
Site 203
Y2640
E
F
D
Q
R
I
L
Y
E
Y
L
A
E
A
S
Site 204
S2670
S
K
I
N
T
L
L
S
L
C
Q
D
P
N
L
Site 205
S2687
P
I
H
G
I
V
Q
S
V
V
Y
H
E
E
S
Site 206
Y2690
G
I
V
Q
S
V
V
Y
H
E
E
S
P
P
Q
Site 207
S2694
S
V
V
Y
H
E
E
S
P
P
Q
Y
Q
T
S
Site 208
Y2698
H
E
E
S
P
P
Q
Y
Q
T
S
Y
L
Q
S
Site 209
S2701
S
P
P
Q
Y
Q
T
S
Y
L
Q
S
F
G
F
Site 210
Y2702
P
P
Q
Y
Q
T
S
Y
L
Q
S
F
G
F
N
Site 211
T2722
A
G
P
F
S
K
Q
T
Q
I
P
D
Y
A
E
Site 212
Y2727
K
Q
T
Q
I
P
D
Y
A
E
L
I
V
K
F
Site 213
T2750
L
P
G
I
D
E
E
T
S
E
E
S
L
L
T
Site 214
S2751
P
G
I
D
E
E
T
S
E
E
S
L
L
T
P
Site 215
T2757
T
S
E
E
S
L
L
T
P
T
S
P
Y
P
P
Site 216
S2760
E
S
L
L
T
P
T
S
P
Y
P
P
A
L
Q
Site 217
Y2762
L
L
T
P
T
S
P
Y
P
P
A
L
Q
S
Q
Site 218
S2768
P
Y
P
P
A
L
Q
S
Q
L
S
I
T
A
N
Site 219
S2781
A
N
L
N
L
S
N
S
M
T
S
L
A
T
S
Site 220
T2783
L
N
L
S
N
S
M
T
S
L
A
T
S
Q
H
Site 221
S2784
N
L
S
N
S
M
T
S
L
A
T
S
Q
H
S
Site 222
S2788
S
M
T
S
L
A
T
S
Q
H
S
P
G
I
D
Site 223
S2791
S
L
A
T
S
Q
H
S
P
G
I
D
K
E
N
Site 224
S2802
D
K
E
N
V
E
L
S
P
T
T
G
H
C
N
Site 225
T2804
E
N
V
E
L
S
P
T
T
G
H
C
N
S
G
Site 226
S2810
P
T
T
G
H
C
N
S
G
R
T
R
H
G
S
Site 227
S2817
S
G
R
T
R
H
G
S
A
S
Q
V
Q
K
Q
Site 228
S2819
R
T
R
H
G
S
A
S
Q
V
Q
K
Q
R
S
Site 229
S2829
Q
K
Q
R
S
A
G
S
F
K
R
N
S
I
K
Site 230
S2834
A
G
S
F
K
R
N
S
I
K
K
I
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation