KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FLG
Full Name:
Filaggrin
Alias:
Epidermal filaggrin; FILA; PREDICTED: filaggrin variant; Profilaggrin
Type:
Cytoskeletal protein
Mass (Da):
435170
Number AA:
4061
UniProt ID:
P20930
International Prot ID:
IPI00026256
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0030216
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
I
I
N
L
F
K
Q
Y
S
K
K
D
K
N
T
Site 2
S19
I
N
L
F
K
Q
Y
S
K
K
D
K
N
T
D
Site 3
T25
Y
S
K
K
D
K
N
T
D
T
L
S
K
K
E
Site 4
T27
K
K
D
K
N
T
D
T
L
S
K
K
E
L
K
Site 5
Y85
V
F
K
L
A
Q
A
Y
Y
E
S
T
R
K
E
Site 6
Y86
F
K
L
A
Q
A
Y
Y
E
S
T
R
K
E
N
Site 7
S88
L
A
Q
A
Y
Y
E
S
T
R
K
E
N
L
P
Site 8
S97
R
K
E
N
L
P
I
S
G
H
K
H
R
K
H
Site 9
S126
K
E
N
R
K
R
P
S
S
L
E
R
R
N
N
Site 10
S127
E
N
R
K
R
P
S
S
L
E
R
R
N
N
R
Site 11
S143
G
N
K
G
R
S
K
S
P
R
E
T
G
G
K
Site 12
T147
R
S
K
S
P
R
E
T
G
G
K
R
H
E
S
Site 13
S154
T
G
G
K
R
H
E
S
S
S
E
K
K
E
R
Site 14
S156
G
K
R
H
E
S
S
S
E
K
K
E
R
K
G
Site 15
Y164
E
K
K
E
R
K
G
Y
S
P
T
H
R
E
E
Site 16
S165
K
K
E
R
K
G
Y
S
P
T
H
R
E
E
E
Site 17
T167
E
R
K
G
Y
S
P
T
H
R
E
E
E
Y
G
Site 18
S180
Y
G
K
N
H
H
N
S
S
K
K
E
K
N
K
Site 19
S181
G
K
N
H
H
N
S
S
K
K
E
K
N
K
T
Site 20
T188
S
K
K
E
K
N
K
T
E
N
T
R
L
G
D
Site 21
S201
G
D
N
R
K
R
L
S
E
R
L
E
E
K
E
Site 22
Y215
E
D
N
E
E
G
V
Y
D
Y
E
N
T
G
R
Site 23
Y217
N
E
E
G
V
Y
D
Y
E
N
T
G
R
M
T
Site 24
Y236
Q
S
G
H
I
A
T
Y
Y
T
I
Q
D
E
A
Site 25
Y237
S
G
H
I
A
T
Y
Y
T
I
Q
D
E
A
Y
Site 26
Y244
Y
T
I
Q
D
E
A
Y
D
T
T
D
S
L
L
Site 27
T246
I
Q
D
E
A
Y
D
T
T
D
S
L
L
E
E
Site 28
S249
E
A
Y
D
T
T
D
S
L
L
E
E
N
K
I
Site 29
Y257
L
L
E
E
N
K
I
Y
E
R
S
R
S
S
D
Site 30
S260
E
N
K
I
Y
E
R
S
R
S
S
D
G
K
S
Site 31
S262
K
I
Y
E
R
S
R
S
S
D
G
K
S
S
S
Site 32
S263
I
Y
E
R
S
R
S
S
D
G
K
S
S
S
Q
Site 33
S267
S
R
S
S
D
G
K
S
S
S
Q
V
N
R
S
Site 34
S269
S
S
D
G
K
S
S
S
Q
V
N
R
S
R
H
Site 35
S274
S
S
S
Q
V
N
R
S
R
H
E
N
T
S
Q
Site 36
S280
R
S
R
H
E
N
T
S
Q
V
P
L
Q
E
S
Site 37
T289
V
P
L
Q
E
S
R
T
R
K
R
R
G
S
R
Site 38
S295
R
T
R
K
R
R
G
S
R
V
S
Q
D
R
D
Site 39
S298
K
R
R
G
S
R
V
S
Q
D
R
D
S
E
G
Site 40
S303
R
V
S
Q
D
R
D
S
E
G
H
S
E
D
S
Site 41
S307
D
R
D
S
E
G
H
S
E
D
S
E
R
H
S
Site 42
S310
S
E
G
H
S
E
D
S
E
R
H
S
G
S
A
Site 43
S314
S
E
D
S
E
R
H
S
G
S
A
S
R
N
H
Site 44
S316
D
S
E
R
H
S
G
S
A
S
R
N
H
H
G
Site 45
S318
E
R
H
S
G
S
A
S
R
N
H
H
G
S
A
Site 46
S324
A
S
R
N
H
H
G
S
A
W
E
Q
S
R
D
Site 47
S329
H
G
S
A
W
E
Q
S
R
D
G
S
R
H
P
Site 48
S333
W
E
Q
S
R
D
G
S
R
H
P
R
S
H
D
Site 49
S338
D
G
S
R
H
P
R
S
H
D
E
D
R
A
S
Site 50
S345
S
H
D
E
D
R
A
S
H
G
H
S
A
D
S
Site 51
S349
D
R
A
S
H
G
H
S
A
D
S
S
R
Q
S
Site 52
S352
S
H
G
H
S
A
D
S
S
R
Q
S
G
T
R
Site 53
S353
H
G
H
S
A
D
S
S
R
Q
S
G
T
R
H
Site 54
S356
S
A
D
S
S
R
Q
S
G
T
R
H
A
E
T
Site 55
T363
S
G
T
R
H
A
E
T
S
S
R
G
Q
T
A
Site 56
S364
G
T
R
H
A
E
T
S
S
R
G
Q
T
A
S
Site 57
T369
E
T
S
S
R
G
Q
T
A
S
S
H
E
Q
A
Site 58
S371
S
S
R
G
Q
T
A
S
S
H
E
Q
A
R
S
Site 59
S372
S
R
G
Q
T
A
S
S
H
E
Q
A
R
S
S
Site 60
S378
S
S
H
E
Q
A
R
S
S
P
G
E
R
H
G
Site 61
S379
S
H
E
Q
A
R
S
S
P
G
E
R
H
G
S
Site 62
S386
S
P
G
E
R
H
G
S
G
H
Q
Q
S
A
D
Site 63
S391
H
G
S
G
H
Q
Q
S
A
D
S
S
R
H
S
Site 64
S394
G
H
Q
Q
S
A
D
S
S
R
H
S
A
T
G
Site 65
S395
H
Q
Q
S
A
D
S
S
R
H
S
A
T
G
R
Site 66
S398
S
A
D
S
S
R
H
S
A
T
G
R
G
Q
A
Site 67
T400
D
S
S
R
H
S
A
T
G
R
G
Q
A
S
S
Site 68
S406
A
T
G
R
G
Q
A
S
S
A
V
S
D
R
G
Site 69
S407
T
G
R
G
Q
A
S
S
A
V
S
D
R
G
H
Site 70
S410
G
Q
A
S
S
A
V
S
D
R
G
H
R
G
S
Site 71
S417
S
D
R
G
H
R
G
S
S
G
S
Q
A
S
D
Site 72
S418
D
R
G
H
R
G
S
S
G
S
Q
A
S
D
S
Site 73
S420
G
H
R
G
S
S
G
S
Q
A
S
D
S
E
G
Site 74
S423
G
S
S
G
S
Q
A
S
D
S
E
G
H
S
E
Site 75
S425
S
G
S
Q
A
S
D
S
E
G
H
S
E
N
S
Site 76
S429
A
S
D
S
E
G
H
S
E
N
S
D
T
Q
S
Site 77
S432
S
E
G
H
S
E
N
S
D
T
Q
S
V
S
G
Site 78
T434
G
H
S
E
N
S
D
T
Q
S
V
S
G
H
G
Site 79
S436
S
E
N
S
D
T
Q
S
V
S
G
H
G
K
A
Site 80
S449
K
A
G
L
R
Q
Q
S
H
Q
E
S
T
R
G
Site 81
S453
R
Q
Q
S
H
Q
E
S
T
R
G
R
S
G
E
Site 82
S458
Q
E
S
T
R
G
R
S
G
E
R
S
G
R
S
Site 83
S462
R
G
R
S
G
E
R
S
G
R
S
G
S
S
L
Site 84
S465
S
G
E
R
S
G
R
S
G
S
S
L
Y
Q
V
Site 85
S467
E
R
S
G
R
S
G
S
S
L
Y
Q
V
S
T
Site 86
S468
R
S
G
R
S
G
S
S
L
Y
Q
V
S
T
H
Site 87
Y470
G
R
S
G
S
S
L
Y
Q
V
S
T
H
E
Q
Site 88
S473
G
S
S
L
Y
Q
V
S
T
H
E
Q
P
D
S
Site 89
T474
S
S
L
Y
Q
V
S
T
H
E
Q
P
D
S
A
Site 90
S480
S
T
H
E
Q
P
D
S
A
H
G
R
T
G
T
Site 91
T487
S
A
H
G
R
T
G
T
S
T
G
G
R
Q
G
Site 92
S488
A
H
G
R
T
G
T
S
T
G
G
R
Q
G
S
Site 93
T489
H
G
R
T
G
T
S
T
G
G
R
Q
G
S
H
Site 94
S495
S
T
G
G
R
Q
G
S
H
H
E
Q
A
R
D
Site 95
S503
H
H
E
Q
A
R
D
S
S
R
H
S
A
S
Q
Site 96
S504
H
E
Q
A
R
D
S
S
R
H
S
A
S
Q
E
Site 97
S507
A
R
D
S
S
R
H
S
A
S
Q
E
G
Q
D
Site 98
S509
D
S
S
R
H
S
A
S
Q
E
G
Q
D
T
I
Site 99
T515
A
S
Q
E
G
Q
D
T
I
R
G
H
P
G
S
Site 100
S522
T
I
R
G
H
P
G
S
S
R
G
G
R
Q
G
Site 101
S530
S
R
G
G
R
Q
G
S
H
H
E
Q
S
V
N
Site 102
S535
Q
G
S
H
H
E
Q
S
V
N
R
S
G
H
S
Site 103
S539
H
E
Q
S
V
N
R
S
G
H
S
G
S
H
H
Site 104
S542
S
V
N
R
S
G
H
S
G
S
H
H
S
H
T
Site 105
S544
N
R
S
G
H
S
G
S
H
H
S
H
T
T
S
Site 106
S547
G
H
S
G
S
H
H
S
H
T
T
S
Q
G
R
Site 107
T549
S
G
S
H
H
S
H
T
T
S
Q
G
R
S
D
Site 108
S551
S
H
H
S
H
T
T
S
Q
G
R
S
D
A
S
Site 109
S555
H
T
T
S
Q
G
R
S
D
A
S
H
G
Q
S
Site 110
S558
S
Q
G
R
S
D
A
S
H
G
Q
S
G
S
R
Site 111
S562
S
D
A
S
H
G
Q
S
G
S
R
S
A
S
R
Site 112
S564
A
S
H
G
Q
S
G
S
R
S
A
S
R
Q
T
Site 113
S566
H
G
Q
S
G
S
R
S
A
S
R
Q
T
R
N
Site 114
S568
Q
S
G
S
R
S
A
S
R
Q
T
R
N
E
E
Site 115
T571
S
R
S
A
S
R
Q
T
R
N
E
E
Q
S
G
Site 116
S577
Q
T
R
N
E
E
Q
S
G
D
G
T
R
H
S
Site 117
T581
E
E
Q
S
G
D
G
T
R
H
S
G
S
R
H
Site 118
S584
S
G
D
G
T
R
H
S
G
S
R
H
H
E
A
Site 119
S586
D
G
T
R
H
S
G
S
R
H
H
E
A
S
S
Site 120
S592
G
S
R
H
H
E
A
S
S
Q
A
D
S
S
R
Site 121
S593
S
R
H
H
E
A
S
S
Q
A
D
S
S
R
H
Site 122
S597
E
A
S
S
Q
A
D
S
S
R
H
S
Q
V
G
Site 123
S598
A
S
S
Q
A
D
S
S
R
H
S
Q
V
G
Q
Site 124
S601
Q
A
D
S
S
R
H
S
Q
V
G
Q
G
Q
S
Site 125
S608
S
Q
V
G
Q
G
Q
S
S
G
P
R
T
S
R
Site 126
S609
Q
V
G
Q
G
Q
S
S
G
P
R
T
S
R
N
Site 127
T613
G
Q
S
S
G
P
R
T
S
R
N
Q
G
S
S
Site 128
S614
Q
S
S
G
P
R
T
S
R
N
Q
G
S
S
V
Site 129
S619
R
T
S
R
N
Q
G
S
S
V
S
Q
D
S
D
Site 130
S620
T
S
R
N
Q
G
S
S
V
S
Q
D
S
D
S
Site 131
S622
R
N
Q
G
S
S
V
S
Q
D
S
D
S
Q
G
Site 132
S625
G
S
S
V
S
Q
D
S
D
S
Q
G
H
S
E
Site 133
S627
S
V
S
Q
D
S
D
S
Q
G
H
S
E
D
S
Site 134
S631
D
S
D
S
Q
G
H
S
E
D
S
E
R
W
S
Site 135
S634
S
Q
G
H
S
E
D
S
E
R
W
S
G
S
A
Site 136
S638
S
E
D
S
E
R
W
S
G
S
A
S
R
N
H
Site 137
S640
D
S
E
R
W
S
G
S
A
S
R
N
H
H
G
Site 138
S642
E
R
W
S
G
S
A
S
R
N
H
H
G
S
A
Site 139
S648
A
S
R
N
H
H
G
S
A
Q
E
Q
S
R
D
Site 140
S653
H
G
S
A
Q
E
Q
S
R
D
G
S
R
H
P
Site 141
S657
Q
E
Q
S
R
D
G
S
R
H
P
R
S
H
H
Site 142
S662
D
G
S
R
H
P
R
S
H
H
E
D
R
A
G
Site 143
S673
D
R
A
G
H
G
H
S
A
D
S
S
R
K
S
Site 144
S676
G
H
G
H
S
A
D
S
S
R
K
S
G
T
R
Site 145
S677
H
G
H
S
A
D
S
S
R
K
S
G
T
R
H
Site 146
S680
S
A
D
S
S
R
K
S
G
T
R
H
T
Q
N
Site 147
T685
R
K
S
G
T
R
H
T
Q
N
S
S
S
G
Q
Site 148
S688
G
T
R
H
T
Q
N
S
S
S
G
Q
A
A
S
Site 149
S690
R
H
T
Q
N
S
S
S
G
Q
A
A
S
S
H
Site 150
S695
S
S
S
G
Q
A
A
S
S
H
E
Q
A
R
S
Site 151
S696
S
S
G
Q
A
A
S
S
H
E
Q
A
R
S
S
Site 152
S702
S
S
H
E
Q
A
R
S
S
A
G
E
R
H
G
Site 153
S703
S
H
E
Q
A
R
S
S
A
G
E
R
H
G
S
Site 154
S710
S
A
G
E
R
H
G
S
R
H
Q
L
Q
S
A
Site 155
S716
G
S
R
H
Q
L
Q
S
A
D
S
S
R
H
S
Site 156
S719
H
Q
L
Q
S
A
D
S
S
R
H
S
G
T
G
Site 157
S720
Q
L
Q
S
A
D
S
S
R
H
S
G
T
G
H
Site 158
S723
S
A
D
S
S
R
H
S
G
T
G
H
G
Q
A
Site 159
S731
G
T
G
H
G
Q
A
S
S
A
V
R
D
S
G
Site 160
S732
T
G
H
G
Q
A
S
S
A
V
R
D
S
G
H
Site 161
S737
A
S
S
A
V
R
D
S
G
H
R
G
S
S
G
Site 162
S742
R
D
S
G
H
R
G
S
S
G
S
Q
A
T
D
Site 163
S743
D
S
G
H
R
G
S
S
G
S
Q
A
T
D
S
Site 164
S745
G
H
R
G
S
S
G
S
Q
A
T
D
S
E
G
Site 165
S750
S
G
S
Q
A
T
D
S
E
G
H
S
E
D
S
Site 166
S754
A
T
D
S
E
G
H
S
E
D
S
D
T
Q
S
Site 167
S757
S
E
G
H
S
E
D
S
D
T
Q
S
V
S
G
Site 168
T759
G
H
S
E
D
S
D
T
Q
S
V
S
G
H
G
Site 169
S761
S
E
D
S
D
T
Q
S
V
S
G
H
G
Q
A
Site 170
S778
H
Q
Q
S
H
Q
E
S
A
R
D
R
S
G
E
Site 171
S783
Q
E
S
A
R
D
R
S
G
E
R
S
R
R
S
Site 172
S787
R
D
R
S
G
E
R
S
R
R
S
G
S
F
L
Site 173
S790
S
G
E
R
S
R
R
S
G
S
F
L
Y
Q
V
Site 174
S792
E
R
S
R
R
S
G
S
F
L
Y
Q
V
S
T
Site 175
Y795
R
R
S
G
S
F
L
Y
Q
V
S
T
H
K
Q
Site 176
S798
G
S
F
L
Y
Q
V
S
T
H
K
Q
S
E
S
Site 177
T799
S
F
L
Y
Q
V
S
T
H
K
Q
S
E
S
S
Site 178
S803
Q
V
S
T
H
K
Q
S
E
S
S
H
G
W
T
Site 179
S805
S
T
H
K
Q
S
E
S
S
H
G
W
T
G
P
Site 180
T810
S
E
S
S
H
G
W
T
G
P
S
T
G
V
R
Site 181
S813
S
H
G
W
T
G
P
S
T
G
V
R
Q
G
S
Site 182
T814
H
G
W
T
G
P
S
T
G
V
R
Q
G
S
H
Site 183
S820
S
T
G
V
R
Q
G
S
H
H
E
Q
A
R
D
Site 184
S829
H
E
Q
A
R
D
N
S
R
H
S
A
S
Q
D
Site 185
S832
A
R
D
N
S
R
H
S
A
S
Q
D
G
Q
D
Site 186
S834
D
N
S
R
H
S
A
S
Q
D
G
Q
D
T
I
Site 187
T840
A
S
Q
D
G
Q
D
T
I
R
G
H
P
G
S
Site 188
S847
T
I
R
G
H
P
G
S
S
R
R
G
R
Q
G
Site 189
S848
I
R
G
H
P
G
S
S
R
R
G
R
Q
G
S
Site 190
S855
S
R
R
G
R
Q
G
S
H
H
E
Q
S
V
D
Site 191
S860
Q
G
S
H
H
E
Q
S
V
D
R
S
G
H
S
Site 192
S864
H
E
Q
S
V
D
R
S
G
H
S
G
S
H
H
Site 193
S867
S
V
D
R
S
G
H
S
G
S
H
H
S
H
T
Site 194
S869
D
R
S
G
H
S
G
S
H
H
S
H
T
T
S
Site 195
S880
H
T
T
S
Q
G
R
S
D
A
S
R
G
Q
S
Site 196
S883
S
Q
G
R
S
D
A
S
R
G
Q
S
G
S
R
Site 197
S887
S
D
A
S
R
G
Q
S
G
S
R
S
A
S
R
Site 198
S889
A
S
R
G
Q
S
G
S
R
S
A
S
R
T
T
Site 199
S891
R
G
Q
S
G
S
R
S
A
S
R
T
T
R
N
Site 200
S893
Q
S
G
S
R
S
A
S
R
T
T
R
N
E
E
Site 201
T895
G
S
R
S
A
S
R
T
T
R
N
E
E
Q
S
Site 202
T896
S
R
S
A
S
R
T
T
R
N
E
E
Q
S
R
Site 203
S902
T
T
R
N
E
E
Q
S
R
D
G
S
R
H
S
Site 204
S906
E
E
Q
S
R
D
G
S
R
H
S
G
S
R
H
Site 205
S909
S
R
D
G
S
R
H
S
G
S
R
H
H
E
A
Site 206
S911
D
G
S
R
H
S
G
S
R
H
H
E
A
S
S
Site 207
S917
G
S
R
H
H
E
A
S
S
H
A
D
I
S
R
Site 208
S918
S
R
H
H
E
A
S
S
H
A
D
I
S
R
H
Site 209
S923
A
S
S
H
A
D
I
S
R
H
S
Q
A
G
Q
Site 210
S926
H
A
D
I
S
R
H
S
Q
A
G
Q
G
Q
S
Site 211
S933
S
Q
A
G
Q
G
Q
S
E
G
S
R
T
S
R
Site 212
T938
G
Q
S
E
G
S
R
T
S
R
R
Q
G
S
S
Site 213
S939
Q
S
E
G
S
R
T
S
R
R
Q
G
S
S
V
Site 214
S944
R
T
S
R
R
Q
G
S
S
V
S
Q
D
S
D
Site 215
S945
T
S
R
R
Q
G
S
S
V
S
Q
D
S
D
S
Site 216
S947
R
R
Q
G
S
S
V
S
Q
D
S
D
S
E
G
Site 217
S950
G
S
S
V
S
Q
D
S
D
S
E
G
H
S
E
Site 218
S952
S
V
S
Q
D
S
D
S
E
G
H
S
E
D
S
Site 219
S956
D
S
D
S
E
G
H
S
E
D
S
E
R
W
S
Site 220
S959
S
E
G
H
S
E
D
S
E
R
W
S
G
S
A
Site 221
S965
D
S
E
R
W
S
G
S
A
S
R
N
H
R
G
Site 222
S967
E
R
W
S
G
S
A
S
R
N
H
R
G
S
A
Site 223
S973
A
S
R
N
H
R
G
S
A
Q
E
Q
S
R
H
Site 224
S978
R
G
S
A
Q
E
Q
S
R
H
G
S
R
H
P
Site 225
S982
Q
E
Q
S
R
H
G
S
R
H
P
R
S
H
H
Site 226
S987
H
G
S
R
H
P
R
S
H
H
E
D
R
A
G
Site 227
S998
D
R
A
G
H
G
H
S
A
D
S
S
R
Q
S
Site 228
S1001
G
H
G
H
S
A
D
S
S
R
Q
S
G
T
P
Site 229
S1002
H
G
H
S
A
D
S
S
R
Q
S
G
T
P
H
Site 230
S1005
S
A
D
S
S
R
Q
S
G
T
P
H
A
E
T
Site 231
T1007
D
S
S
R
Q
S
G
T
P
H
A
E
T
S
S
Site 232
T1012
S
G
T
P
H
A
E
T
S
S
G
G
Q
A
A
Site 233
S1013
G
T
P
H
A
E
T
S
S
G
G
Q
A
A
S
Site 234
S1014
T
P
H
A
E
T
S
S
G
G
Q
A
A
S
S
Site 235
S1020
S
S
G
G
Q
A
A
S
S
H
E
Q
A
R
S
Site 236
S1021
S
G
G
Q
A
A
S
S
H
E
Q
A
R
S
S
Site 237
S1035
S
P
G
E
R
H
G
S
R
H
Q
Q
S
A
D
Site 238
S1040
H
G
S
R
H
Q
Q
S
A
D
S
S
R
H
S
Site 239
S1043
R
H
Q
Q
S
A
D
S
S
R
H
S
G
I
P
Site 240
S1044
H
Q
Q
S
A
D
S
S
R
H
S
G
I
P
R
Site 241
S1047
S
A
D
S
S
R
H
S
G
I
P
R
R
Q
A
Site 242
S1055
G
I
P
R
R
Q
A
S
S
A
V
R
D
S
G
Site 243
S1056
I
P
R
R
Q
A
S
S
A
V
R
D
S
G
H
Site 244
S1061
A
S
S
A
V
R
D
S
G
H
W
G
S
S
G
Site 245
S1066
R
D
S
G
H
W
G
S
S
G
S
Q
A
S
D
Site 246
S1067
D
S
G
H
W
G
S
S
G
S
Q
A
S
D
S
Site 247
S1069
G
H
W
G
S
S
G
S
Q
A
S
D
S
E
G
Site 248
S1074
S
G
S
Q
A
S
D
S
E
G
H
S
E
E
S
Site 249
S1078
A
S
D
S
E
G
H
S
E
E
S
D
T
Q
S
Site 250
S1081
S
E
G
H
S
E
E
S
D
T
Q
S
V
S
G
Site 251
T1083
G
H
S
E
E
S
D
T
Q
S
V
S
G
H
G
Site 252
S1085
S
E
E
S
D
T
Q
S
V
S
G
H
G
Q
D
Site 253
S1087
E
S
D
T
Q
S
V
S
G
H
G
Q
D
G
P
Site 254
S1098
Q
D
G
P
H
Q
Q
S
H
Q
E
S
A
R
D
Site 255
S1102
H
Q
Q
S
H
Q
E
S
A
R
D
W
S
G
G
Site 256
S1107
Q
E
S
A
R
D
W
S
G
G
R
S
G
R
S
Site 257
S1111
R
D
W
S
G
G
R
S
G
R
S
G
S
F
I
Site 258
S1114
S
G
G
R
S
G
R
S
G
S
F
I
Y
Q
V
Site 259
S1116
G
R
S
G
R
S
G
S
F
I
Y
Q
V
S
T
Site 260
Y1119
G
R
S
G
S
F
I
Y
Q
V
S
T
H
E
Q
Site 261
S1122
G
S
F
I
Y
Q
V
S
T
H
E
Q
S
E
S
Site 262
T1123
S
F
I
Y
Q
V
S
T
H
E
Q
S
E
S
A
Site 263
S1129
S
T
H
E
Q
S
E
S
A
H
G
R
T
R
T
Site 264
T1136
S
A
H
G
R
T
R
T
S
T
G
R
R
Q
G
Site 265
S1137
A
H
G
R
T
R
T
S
T
G
R
R
Q
G
S
Site 266
T1138
H
G
R
T
R
T
S
T
G
R
R
Q
G
S
H
Site 267
S1144
S
T
G
R
R
Q
G
S
H
H
E
Q
A
R
D
Site 268
T1164
A
S
Q
E
G
Q
D
T
I
R
A
H
P
G
S
Site 269
S1171
T
I
R
A
H
P
G
S
R
R
G
G
R
Q
G
Site 270
S1179
R
R
G
G
R
Q
G
S
H
H
E
Q
S
V
D
Site 271
S1215
H
G
Q
S
G
S
R
S
A
S
R
Q
T
R
K
Site 272
S1217
Q
S
G
S
R
S
A
S
R
Q
T
R
K
D
K
Site 273
T1220
S
R
S
A
S
R
Q
T
R
K
D
K
Q
S
G
Site 274
S1226
Q
T
R
K
D
K
Q
S
G
D
G
S
R
H
S
Site 275
S1230
D
K
Q
S
G
D
G
S
R
H
S
G
S
R
H
Site 276
S1233
S
G
D
G
S
R
H
S
G
S
R
H
H
E
A
Site 277
S1235
D
G
S
R
H
S
G
S
R
H
H
E
A
A
S
Site 278
S1242
S
R
H
H
E
A
A
S
W
A
D
S
S
R
H
Site 279
S1246
E
A
A
S
W
A
D
S
S
R
H
S
Q
V
G
Site 280
S1250
W
A
D
S
S
R
H
S
Q
V
G
Q
E
Q
S
Site 281
S1257
S
Q
V
G
Q
E
Q
S
S
G
S
R
T
S
R
Site 282
S1258
Q
V
G
Q
E
Q
S
S
G
S
R
T
S
R
H
Site 283
S1260
G
Q
E
Q
S
S
G
S
R
T
S
R
H
Q
G
Site 284
T1262
E
Q
S
S
G
S
R
T
S
R
H
Q
G
S
S
Site 285
S1263
Q
S
S
G
S
R
T
S
R
H
Q
G
S
S
V
Site 286
S1268
R
T
S
R
H
Q
G
S
S
V
S
Q
D
S
D
Site 287
S1269
T
S
R
H
Q
G
S
S
V
S
Q
D
S
D
S
Site 288
S1271
R
H
Q
G
S
S
V
S
Q
D
S
D
S
E
R
Site 289
S1274
G
S
S
V
S
Q
D
S
D
S
E
R
H
S
D
Site 290
S1276
S
V
S
Q
D
S
D
S
E
R
H
S
D
D
S
Site 291
S1280
D
S
D
S
E
R
H
S
D
D
S
E
R
L
S
Site 292
S1283
S
E
R
H
S
D
D
S
E
R
L
S
G
S
A
Site 293
S1287
S
D
D
S
E
R
L
S
G
S
A
S
R
N
H
Site 294
S1289
D
S
E
R
L
S
G
S
A
S
R
N
H
H
G
Site 295
S1291
E
R
L
S
G
S
A
S
R
N
H
H
G
S
S
Site 296
S1297
A
S
R
N
H
H
G
S
S
R
E
Q
S
R
D
Site 297
S1298
S
R
N
H
H
G
S
S
R
E
Q
S
R
D
G
Site 298
S1302
H
G
S
S
R
E
Q
S
R
D
G
S
R
H
P
Site 299
S1306
R
E
Q
S
R
D
G
S
R
H
P
G
F
H
Q
Site 300
S1318
F
H
Q
E
D
R
A
S
H
G
H
S
A
D
S
Site 301
S1325
S
H
G
H
S
A
D
S
S
R
Q
S
G
T
H
Site 302
S1326
H
G
H
S
A
D
S
S
R
Q
S
G
T
H
H
Site 303
S1329
S
A
D
S
S
R
Q
S
G
T
H
H
T
E
S
Site 304
T1331
D
S
S
R
Q
S
G
T
H
H
T
E
S
S
S
Site 305
T1334
R
Q
S
G
T
H
H
T
E
S
S
S
H
G
Q
Site 306
S1336
S
G
T
H
H
T
E
S
S
S
H
G
Q
A
V
Site 307
S1344
S
S
H
G
Q
A
V
S
S
H
E
Q
A
R
S
Site 308
S1367
R
H
Q
Q
S
A
D
S
S
R
H
S
G
I
G
Site 309
S1368
H
Q
Q
S
A
D
S
S
R
H
S
G
I
G
H
Site 310
S1371
S
A
D
S
S
R
H
S
G
I
G
H
R
Q
A
Site 311
S1379
G
I
G
H
R
Q
A
S
S
A
V
R
D
S
G
Site 312
S1380
I
G
H
R
Q
A
S
S
A
V
R
D
S
G
H
Site 313
S1390
R
D
S
G
H
R
G
S
S
G
S
Q
V
T
N
Site 314
S1391
D
S
G
H
R
G
S
S
G
S
Q
V
T
N
S
Site 315
S1393
G
H
R
G
S
S
G
S
Q
V
T
N
S
E
G
Site 316
S1398
S
G
S
Q
V
T
N
S
E
G
H
S
E
D
S
Site 317
S1402
V
T
N
S
E
G
H
S
E
D
S
D
T
Q
S
Site 318
S1405
S
E
G
H
S
E
D
S
D
T
Q
S
V
S
A
Site 319
T1407
G
H
S
E
D
S
D
T
Q
S
V
S
A
H
G
Site 320
S1409
S
E
D
S
D
T
Q
S
V
S
A
H
G
Q
A
Site 321
S1422
Q
A
G
P
H
Q
Q
S
H
K
E
S
A
R
G
Site 322
S1426
H
Q
Q
S
H
K
E
S
A
R
G
Q
S
G
E
Site 323
S1431
K
E
S
A
R
G
Q
S
G
E
S
S
G
R
S
Site 324
S1434
A
R
G
Q
S
G
E
S
S
G
R
S
R
S
F
Site 325
S1435
R
G
Q
S
G
E
S
S
G
R
S
R
S
F
L
Site 326
S1438
S
G
E
S
S
G
R
S
R
S
F
L
Y
Q
V
Site 327
S1440
E
S
S
G
R
S
R
S
F
L
Y
Q
V
S
S
Site 328
Y1443
G
R
S
R
S
F
L
Y
Q
V
S
S
H
E
Q
Site 329
S1446
R
S
F
L
Y
Q
V
S
S
H
E
Q
S
E
S
Site 330
S1447
S
F
L
Y
Q
V
S
S
H
E
Q
S
E
S
T
Site 331
S1451
Q
V
S
S
H
E
Q
S
E
S
T
H
G
Q
T
Site 332
S1453
S
S
H
E
Q
S
E
S
T
H
G
Q
T
A
P
Site 333
S1461
T
H
G
Q
T
A
P
S
T
G
G
R
Q
G
S
Site 334
T1462
H
G
Q
T
A
P
S
T
G
G
R
Q
G
S
R
Site 335
S1468
S
T
G
G
R
Q
G
S
R
H
E
Q
A
R
N
Site 336
S1476
R
H
E
Q
A
R
N
S
S
R
H
S
A
S
Q
Site 337
S1477
H
E
Q
A
R
N
S
S
R
H
S
A
S
Q
D
Site 338
S1480
A
R
N
S
S
R
H
S
A
S
Q
D
G
Q
D
Site 339
S1482
N
S
S
R
H
S
A
S
Q
D
G
Q
D
T
I
Site 340
S1503
S
R
G
G
R
Q
G
S
Y
H
E
Q
S
V
D
Site 341
Y1504
R
G
G
R
Q
G
S
Y
H
E
Q
S
V
D
R
Site 342
S1508
Q
G
S
Y
H
E
Q
S
V
D
R
S
G
H
S
Site 343
S1512
H
E
Q
S
V
D
R
S
G
H
S
G
Y
H
H
Site 344
S1515
S
V
D
R
S
G
H
S
G
Y
H
H
S
H
T
Site 345
S1520
G
H
S
G
Y
H
H
S
H
T
T
P
Q
G
R
Site 346
T1522
S
G
Y
H
H
S
H
T
T
P
Q
G
R
S
D
Site 347
T1523
G
Y
H
H
S
H
T
T
P
Q
G
R
S
D
A
Site 348
S1531
P
Q
G
R
S
D
A
S
H
G
Q
S
G
P
R
Site 349
S1535
S
D
A
S
H
G
Q
S
G
P
R
S
A
S
R
Site 350
S1539
H
G
Q
S
G
P
R
S
A
S
R
Q
T
R
N
Site 351
S1541
Q
S
G
P
R
S
A
S
R
Q
T
R
N
E
E
Site 352
T1544
P
R
S
A
S
R
Q
T
R
N
E
E
Q
S
G
Site 353
S1550
Q
T
R
N
E
E
Q
S
G
D
G
S
R
H
S
Site 354
S1554
E
E
Q
S
G
D
G
S
R
H
S
G
S
R
H
Site 355
S1557
S
G
D
G
S
R
H
S
G
S
R
H
H
E
P
Site 356
S1559
D
G
S
R
H
S
G
S
R
H
H
E
P
S
T
Site 357
S1565
G
S
R
H
H
E
P
S
T
R
A
G
S
S
R
Site 358
T1566
S
R
H
H
E
P
S
T
R
A
G
S
S
R
H
Site 359
S1570
E
P
S
T
R
A
G
S
S
R
H
S
Q
V
G
Site 360
S1571
P
S
T
R
A
G
S
S
R
H
S
Q
V
G
Q
Site 361
S1574
R
A
G
S
S
R
H
S
Q
V
G
Q
G
E
S
Site 362
S1581
S
Q
V
G
Q
G
E
S
A
G
S
K
T
S
R
Site 363
S1584
G
Q
G
E
S
A
G
S
K
T
S
R
R
Q
G
Site 364
T1586
G
E
S
A
G
S
K
T
S
R
R
Q
G
S
S
Site 365
S1587
E
S
A
G
S
K
T
S
R
R
Q
G
S
S
V
Site 366
S1592
K
T
S
R
R
Q
G
S
S
V
S
Q
D
R
D
Site 367
S1593
T
S
R
R
Q
G
S
S
V
S
Q
D
R
D
S
Site 368
S1595
R
R
Q
G
S
S
V
S
Q
D
R
D
S
E
G
Site 369
S1600
S
V
S
Q
D
R
D
S
E
G
H
S
E
D
S
Site 370
S1604
D
R
D
S
E
G
H
S
E
D
S
E
R
R
S
Site 371
S1607
S
E
G
H
S
E
D
S
E
R
R
S
E
S
A
Site 372
S1611
S
E
D
S
E
R
R
S
E
S
A
S
R
N
H
Site 373
S1613
D
S
E
R
R
S
E
S
A
S
R
N
H
Y
G
Site 374
S1615
E
R
R
S
E
S
A
S
R
N
H
Y
G
S
A
Site 375
Y1619
E
S
A
S
R
N
H
Y
G
S
A
R
E
Q
S
Site 376
S1621
A
S
R
N
H
Y
G
S
A
R
E
Q
S
R
H
Site 377
S1626
Y
G
S
A
R
E
Q
S
R
H
G
S
R
N
P
Site 378
S1630
R
E
Q
S
R
H
G
S
R
N
P
R
S
H
Q
Site 379
S1635
H
G
S
R
N
P
R
S
H
Q
E
D
R
A
S
Site 380
S1642
S
H
Q
E
D
R
A
S
H
G
H
S
A
E
S
Site 381
S1646
D
R
A
S
H
G
H
S
A
E
S
S
R
Q
S
Site 382
S1649
S
H
G
H
S
A
E
S
S
R
Q
S
G
T
R
Site 383
S1650
H
G
H
S
A
E
S
S
R
Q
S
G
T
R
H
Site 384
S1653
S
A
E
S
S
R
Q
S
G
T
R
H
A
E
T
Site 385
T1660
S
G
T
R
H
A
E
T
S
S
G
G
Q
A
A
Site 386
S1661
G
T
R
H
A
E
T
S
S
G
G
Q
A
A
S
Site 387
S1668
S
S
G
G
Q
A
A
S
S
Q
E
Q
A
R
S
Site 388
S1669
S
G
G
Q
A
A
S
S
Q
E
Q
A
R
S
S
Site 389
S1675
S
S
Q
E
Q
A
R
S
S
P
G
E
R
H
G
Site 390
S1676
S
Q
E
Q
A
R
S
S
P
G
E
R
H
G
S
Site 391
S1688
H
G
S
R
H
Q
Q
S
A
D
S
S
T
D
S
Site 392
S1691
R
H
Q
Q
S
A
D
S
S
T
D
S
G
T
G
Site 393
S1692
H
Q
Q
S
A
D
S
S
T
D
S
G
T
G
R
Site 394
T1693
Q
Q
S
A
D
S
S
T
D
S
G
T
G
R
R
Site 395
S1695
S
A
D
S
S
T
D
S
G
T
G
R
R
Q
D
Site 396
T1697
D
S
S
T
D
S
G
T
G
R
R
Q
D
S
S
Site 397
S1703
G
T
G
R
R
Q
D
S
S
V
V
G
D
S
G
Site 398
S1704
T
G
R
R
Q
D
S
S
V
V
G
D
S
G
N
Site 399
S1709
D
S
S
V
V
G
D
S
G
N
R
G
S
S
G
Site 400
S1714
G
D
S
G
N
R
G
S
S
G
S
Q
A
S
D
Site 401
S1715
D
S
G
N
R
G
S
S
G
S
Q
A
S
D
S
Site 402
S1717
G
N
R
G
S
S
G
S
Q
A
S
D
S
E
G
Site 403
S1729
S
E
G
H
S
E
E
S
D
T
Q
S
V
S
A
Site 404
T1731
G
H
S
E
E
S
D
T
Q
S
V
S
A
H
G
Site 405
S1733
S
E
E
S
D
T
Q
S
V
S
A
H
G
Q
A
Site 406
S1746
Q
A
G
P
H
Q
Q
S
H
Q
E
S
T
R
G
Site 407
S1750
H
Q
Q
S
H
Q
E
S
T
R
G
Q
S
G
E
Site 408
S1755
Q
E
S
T
R
G
Q
S
G
E
R
S
G
R
S
Site 409
S1759
R
G
Q
S
G
E
R
S
G
R
S
G
S
F
L
Site 410
S1762
S
G
E
R
S
G
R
S
G
S
F
L
Y
Q
V
Site 411
S1764
E
R
S
G
R
S
G
S
F
L
Y
Q
V
S
T
Site 412
Y1767
G
R
S
G
S
F
L
Y
Q
V
S
T
H
E
Q
Site 413
S1770
G
S
F
L
Y
Q
V
S
T
H
E
Q
S
E
S
Site 414
T1771
S
F
L
Y
Q
V
S
T
H
E
Q
S
E
S
A
Site 415
S1777
S
T
H
E
Q
S
E
S
A
H
G
R
T
G
P
Site 416
T1786
H
G
R
T
G
P
S
T
G
G
R
Q
R
S
R
Site 417
S1792
S
T
G
G
R
Q
R
S
R
H
E
Q
A
R
D
Site 418
S1800
R
H
E
Q
A
R
D
S
S
R
H
S
A
S
Q
Site 419
S1827
S
R
G
G
R
Q
G
S
H
Y
E
Q
S
V
D
Site 420
Y1829
G
G
R
Q
G
S
H
Y
E
Q
S
V
D
S
S
Site 421
S1832
Q
G
S
H
Y
E
Q
S
V
D
S
S
G
H
S
Site 422
S1835
H
Y
E
Q
S
V
D
S
S
G
H
S
G
S
H
Site 423
S1836
Y
E
Q
S
V
D
S
S
G
H
S
G
S
H
H
Site 424
S1839
S
V
D
S
S
G
H
S
G
S
H
H
S
H
T
Site 425
S1841
D
S
S
G
H
S
G
S
H
H
S
H
T
T
S
Site 426
S1844
G
H
S
G
S
H
H
S
H
T
T
S
Q
E
R
Site 427
T1846
S
G
S
H
H
S
H
T
T
S
Q
E
R
S
D
Site 428
S1848
S
H
H
S
H
T
T
S
Q
E
R
S
D
V
S
Site 429
S1852
H
T
T
S
Q
E
R
S
D
V
S
R
G
Q
S
Site 430
S1855
S
Q
E
R
S
D
V
S
R
G
Q
S
G
S
R
Site 431
S1859
S
D
V
S
R
G
Q
S
G
S
R
S
V
S
R
Site 432
S1861
V
S
R
G
Q
S
G
S
R
S
V
S
R
Q
T
Site 433
S1863
R
G
Q
S
G
S
R
S
V
S
R
Q
T
R
N
Site 434
S1865
Q
S
G
S
R
S
V
S
R
Q
T
R
N
E
K
Site 435
T1868
S
R
S
V
S
R
Q
T
R
N
E
K
Q
S
G
Site 436
S1874
Q
T
R
N
E
K
Q
S
G
D
G
S
R
H
S
Site 437
S1878
E
K
Q
S
G
D
G
S
R
H
S
G
S
R
H
Site 438
S1889
G
S
R
H
H
E
A
S
S
R
A
D
S
S
R
Site 439
S1890
S
R
H
H
E
A
S
S
R
A
D
S
S
R
H
Site 440
S1894
E
A
S
S
R
A
D
S
S
R
H
S
Q
V
G
Site 441
S1895
A
S
S
R
A
D
S
S
R
H
S
Q
V
G
Q
Site 442
S1898
R
A
D
S
S
R
H
S
Q
V
G
Q
G
Q
S
Site 443
S1937
D
S
E
R
W
S
G
S
A
S
R
N
H
L
G
Site 444
S1939
E
R
W
S
G
S
A
S
R
N
H
L
G
S
A
Site 445
S1945
A
S
R
N
H
L
G
S
A
W
E
Q
S
R
D
Site 446
S1950
L
G
S
A
W
E
Q
S
R
D
G
S
R
H
P
Site 447
S1954
W
E
Q
S
R
D
G
S
R
H
P
G
S
H
H
Site 448
S1959
D
G
S
R
H
P
G
S
H
H
E
D
R
A
G
Site 449
S1973
G
H
G
H
S
A
D
S
S
R
Q
S
G
T
R
Site 450
S1977
S
A
D
S
S
R
Q
S
G
T
R
H
T
E
S
Site 451
T1982
R
Q
S
G
T
R
H
T
E
S
S
S
R
G
Q
Site 452
S1984
S
G
T
R
H
T
E
S
S
S
R
G
Q
A
A
Site 453
S1985
G
T
R
H
T
E
S
S
S
R
G
Q
A
A
S
Site 454
S1992
S
S
R
G
Q
A
A
S
S
H
E
Q
A
R
S
Site 455
S1993
S
R
G
Q
A
A
S
S
H
E
Q
A
R
S
S
Site 456
S2007
S
A
G
E
R
H
G
S
H
H
Q
L
Q
S
A
Site 457
S2013
G
S
H
H
Q
L
Q
S
A
D
S
S
R
H
S
Site 458
S2016
H
Q
L
Q
S
A
D
S
S
R
H
S
G
I
G
Site 459
S2017
Q
L
Q
S
A
D
S
S
R
H
S
G
I
G
H
Site 460
S2020
S
A
D
S
S
R
H
S
G
I
G
H
G
Q
A
Site 461
S2028
G
I
G
H
G
Q
A
S
S
A
V
R
D
S
G
Site 462
S2029
A
S
R
N
H
H
G
S
A
Q
E
Q
L
R
D
Site 463
S2034
A
S
S
A
V
R
D
S
G
H
R
G
Y
S
G
Site 464
Y2039
R
D
S
G
H
R
G
Y
S
G
S
Q
A
S
D
Site 465
S2040
D
S
G
H
R
G
Y
S
G
S
Q
A
S
D
S
Site 466
S2042
G
H
R
G
Y
S
G
S
Q
A
S
D
S
E
G
Site 467
S2045
G
Y
S
G
S
Q
A
S
D
S
E
G
H
S
E
Site 468
S2047
S
G
S
Q
A
S
D
S
E
G
H
S
E
D
S
Site 469
S2051
A
S
D
S
E
G
H
S
E
D
S
D
T
Q
S
Site 470
T2056
G
H
S
E
D
S
D
T
Q
S
V
S
A
Q
G
Site 471
S2058
S
E
D
S
D
T
Q
S
V
S
A
Q
G
K
A
Site 472
S2071
K
A
G
P
H
Q
Q
S
H
K
E
S
A
R
G
Site 473
S2083
A
R
G
Q
S
G
E
S
S
G
R
S
G
S
F
Site 474
S2084
R
G
Q
S
G
E
S
S
G
R
S
G
S
F
L
Site 475
S2087
S
G
E
S
S
G
R
S
G
S
F
L
Y
Q
V
Site 476
S2089
E
S
S
G
R
S
G
S
F
L
Y
Q
V
S
T
Site 477
T2096
S
F
L
Y
Q
V
S
T
H
E
Q
S
E
S
T
Site 478
S2102
S
T
H
E
Q
S
E
S
T
H
G
Q
S
A
P
Site 479
S2107
S
E
S
T
H
G
Q
S
A
P
S
T
G
G
R
Site 480
T2111
H
G
Q
S
A
P
S
T
G
G
R
Q
G
S
H
Site 481
S2117
S
T
G
G
R
Q
G
S
H
Y
D
Q
A
Q
D
Site 482
Y2119
G
G
R
Q
G
S
H
Y
D
Q
A
Q
D
S
S
Site 483
S2125
H
Y
D
Q
A
Q
D
S
S
R
H
S
A
S
Q
Site 484
S2129
A
Q
D
S
S
R
H
S
A
S
Q
E
G
Q
D
Site 485
T2137
A
S
Q
E
G
Q
D
T
I
R
G
H
P
G
P
Site 486
S2152
S
R
G
G
R
Q
G
S
H
Q
E
Q
S
V
D
Site 487
S2157
Q
G
S
H
Q
E
Q
S
V
D
R
S
G
H
S
Site 488
S2161
Q
E
Q
S
V
D
R
S
G
H
S
G
S
H
H
Site 489
S2186
A
S
R
G
Q
S
G
S
R
S
A
S
R
K
T
Site 490
S2188
R
G
Q
S
G
S
R
S
A
S
R
K
T
Y
D
Site 491
S2190
Q
S
G
S
R
S
A
S
R
K
T
Y
D
K
E
Site 492
T2193
S
R
S
A
S
R
K
T
Y
D
K
E
Q
S
G
Site 493
Y2194
R
S
A
S
R
K
T
Y
D
K
E
Q
S
G
D
Site 494
S2199
K
T
Y
D
K
E
Q
S
G
D
G
S
R
H
S
Site 495
S2203
K
E
Q
S
G
D
G
S
R
H
S
G
S
H
H
Site 496
S2206
S
G
D
G
S
R
H
S
G
S
H
H
H
E
A
Site 497
S2208
D
G
S
R
H
S
G
S
H
H
H
E
A
S
S
Site 498
S2214
G
S
H
H
H
E
A
S
S
W
A
D
S
S
R
Site 499
S2215
S
H
H
H
E
A
S
S
W
A
D
S
S
R
H
Site 500
S2219
E
A
S
S
W
A
D
S
S
R
H
S
L
V
G
Site 501
S2220
A
S
S
W
A
D
S
S
R
H
S
L
V
G
Q
Site 502
S2223
W
A
D
S
S
R
H
S
L
V
G
Q
G
Q
S
Site 503
S2230
S
L
V
G
Q
G
Q
S
S
G
P
R
T
S
R
Site 504
S2231
L
V
G
Q
G
Q
S
S
G
P
R
T
S
R
P
Site 505
T2235
G
Q
S
S
G
P
R
T
S
R
P
R
G
S
S
Site 506
S2236
Q
S
S
G
P
R
T
S
R
P
R
G
S
S
V
Site 507
S2241
R
T
S
R
P
R
G
S
S
V
S
Q
D
S
D
Site 508
S2242
T
S
R
P
R
G
S
S
V
S
Q
D
S
D
S
Site 509
S2244
R
P
R
G
S
S
V
S
Q
D
S
D
S
E
G
Site 510
S2253
D
S
D
S
E
G
H
S
E
D
S
E
R
R
S
Site 511
S2256
S
E
G
H
S
E
D
S
E
R
R
S
G
S
A
Site 512
S2260
S
E
D
S
E
R
R
S
G
S
A
S
R
N
H
Site 513
S2262
D
S
E
R
R
S
G
S
A
S
R
N
H
H
G
Site 514
S2264
E
R
R
S
G
S
A
S
R
N
H
H
G
S
A
Site 515
S2295
D
R
A
G
H
G
H
S
A
E
S
S
R
Q
S
Site 516
S2298
G
H
G
H
S
A
E
S
S
R
Q
S
G
T
H
Site 517
S2299
H
G
H
S
A
E
S
S
R
Q
S
G
T
H
H
Site 518
S2302
S
A
E
S
S
R
Q
S
G
T
H
H
A
E
N
Site 519
S2332
S
A
G
E
R
H
G
S
H
H
Q
Q
S
A
D
Site 520
S2337
H
G
S
H
H
Q
Q
S
A
D
S
S
R
H
S
Site 521
S2340
H
H
Q
Q
S
A
D
S
S
R
H
S
G
I
G
Site 522
S2363
R
D
S
G
H
R
G
S
S
G
S
Q
A
S
D
Site 523
S2364
D
S
G
H
R
G
S
S
G
S
Q
A
S
D
S
Site 524
S2399
H
Q
Q
S
H
Q
E
S
T
R
G
R
S
A
G
Site 525
S2404
Q
E
S
T
R
G
R
S
A
G
R
S
G
R
S
Site 526
S2408
R
G
R
S
A
G
R
S
G
R
S
G
S
F
L
Site 527
S2411
S
A
G
R
S
G
R
S
G
S
F
L
Y
Q
V
Site 528
S2413
G
R
S
G
R
S
G
S
F
L
Y
Q
V
S
T
Site 529
S2426
S
T
H
E
Q
S
E
S
A
H
G
R
T
G
T
Site 530
S2441
S
T
G
G
R
Q
G
S
H
H
K
Q
A
R
D
Site 531
S2449
H
H
K
Q
A
R
D
S
S
R
H
S
T
S
Q
Site 532
S2450
H
K
Q
A
R
D
S
S
R
H
S
T
S
Q
E
Site 533
S2453
A
R
D
S
S
R
H
S
T
S
Q
E
G
Q
D
Site 534
T2454
R
D
S
S
R
H
S
T
S
Q
E
G
Q
D
T
Site 535
S2455
D
S
S
R
H
S
T
S
Q
E
G
Q
D
T
I
Site 536
T2461
T
S
Q
E
G
Q
D
T
I
H
G
H
P
G
S
Site 537
S2468
T
I
H
G
H
P
G
S
S
S
G
G
R
Q
G
Site 538
S2470
H
G
H
P
G
S
S
S
G
G
R
Q
G
S
H
Site 539
S2476
S
S
G
G
R
Q
G
S
H
Y
E
Q
L
V
D
Site 540
Y2478
G
G
R
Q
G
S
H
Y
E
Q
L
V
D
R
S
Site 541
S2485
Y
E
Q
L
V
D
R
S
G
H
S
G
S
H
H
Site 542
S2488
L
V
D
R
S
G
H
S
G
S
H
H
S
H
T
Site 543
S2501
H
T
T
S
Q
G
R
S
D
A
S
H
G
H
S
Site 544
S2504
S
Q
G
R
S
D
A
S
H
G
H
S
G
S
R
Site 545
S2508
S
D
A
S
H
G
H
S
G
S
R
S
A
S
R
Site 546
S2510
A
S
H
G
H
S
G
S
R
S
A
S
R
Q
T
Site 547
S2512
H
G
H
S
G
S
R
S
A
S
R
Q
T
R
N
Site 548
S2514
H
S
G
S
R
S
A
S
R
Q
T
R
N
D
E
Site 549
T2517
S
R
S
A
S
R
Q
T
R
N
D
E
Q
S
G
Site 550
S2523
Q
T
R
N
D
E
Q
S
G
D
G
S
R
H
S
Site 551
S2527
D
E
Q
S
G
D
G
S
R
H
S
G
S
R
H
Site 552
S2538
G
S
R
H
H
E
A
S
S
R
A
D
S
S
G
Site 553
S2539
S
R
H
H
E
A
S
S
R
A
D
S
S
G
H
Site 554
S2543
E
A
S
S
R
A
D
S
S
G
H
S
Q
V
G
Site 555
S2544
A
S
S
R
A
D
S
S
G
H
S
Q
V
G
Q
Site 556
S2547
R
A
D
S
S
G
H
S
Q
V
G
Q
G
Q
S
Site 557
S2554
S
Q
V
G
Q
G
Q
S
E
G
P
R
T
S
R
Site 558
T2559
G
Q
S
E
G
P
R
T
S
R
N
W
G
S
S
Site 559
S2560
Q
S
E
G
P
R
T
S
R
N
W
G
S
S
F
Site 560
S2565
R
T
S
R
N
W
G
S
S
F
S
Q
D
S
D
Site 561
S2566
T
S
R
N
W
G
S
S
F
S
Q
D
S
D
S
Site 562
S2568
R
N
W
G
S
S
F
S
Q
D
S
D
S
Q
G
Site 563
S2571
G
S
S
F
S
Q
D
S
D
S
Q
G
H
S
E
Site 564
S2573
S
F
S
Q
D
S
D
S
Q
G
H
S
E
D
S
Site 565
S2594
T
G
H
G
Q
A
S
S
A
V
R
D
S
G
H
Site 566
S2603
Q
E
Q
L
R
D
G
S
R
H
P
R
S
H
Q
Site 567
S2608
D
G
S
R
H
P
R
S
H
Q
E
D
R
A
G
Site 568
S2626
S
A
D
S
S
R
Q
S
G
T
R
H
T
Q
T
Site 569
T2631
R
Q
S
G
T
R
H
T
Q
T
S
S
G
G
Q
Site 570
T2633
S
G
T
R
H
T
Q
T
S
S
G
G
Q
A
A
Site 571
S2634
G
T
R
H
T
Q
T
S
S
G
G
Q
A
A
S
Site 572
S2688
D
S
G
H
R
G
Y
S
G
S
Q
A
S
D
N
Site 573
S2690
G
H
R
G
Y
S
G
S
Q
A
S
D
N
E
G
Site 574
S2693
G
Y
S
G
S
Q
A
S
D
N
E
G
H
S
E
Site 575
S2699
A
S
D
N
E
G
H
S
E
D
S
D
T
Q
S
Site 576
S2702
N
E
G
H
S
E
D
S
D
T
Q
S
V
S
A
Site 577
S2715
S
A
H
G
Q
A
G
S
H
Q
Q
S
H
Q
E
Site 578
S2719
Q
A
G
S
H
Q
Q
S
H
Q
E
S
A
R
G
Site 579
S2723
H
Q
Q
S
H
Q
E
S
A
R
G
R
S
G
E
Site 580
S2728
Q
E
S
A
R
G
R
S
G
E
T
S
G
H
S
Site 581
S2732
R
G
R
S
G
E
T
S
G
H
S
G
S
F
L
Site 582
S2735
S
G
E
T
S
G
H
S
G
S
F
L
Y
Q
V
Site 583
S2737
E
T
S
G
H
S
G
S
F
L
Y
Q
V
S
T
Site 584
Y2740
G
H
S
G
S
F
L
Y
Q
V
S
T
H
E
Q
Site 585
T2744
S
F
L
Y
Q
V
S
T
H
E
Q
S
E
S
S
Site 586
S2748
Q
V
S
T
H
E
Q
S
E
S
S
H
G
W
T
Site 587
S2750
S
T
H
E
Q
S
E
S
S
H
G
W
T
G
P
Site 588
T2755
S
E
S
S
H
G
W
T
G
P
S
T
R
G
R
Site 589
S2758
S
H
G
W
T
G
P
S
T
R
G
R
Q
G
S
Site 590
T2759
H
G
W
T
G
P
S
T
R
G
R
Q
G
S
R
Site 591
S2765
S
T
R
G
R
Q
G
S
R
H
E
Q
A
Q
D
Site 592
S2773
R
H
E
Q
A
Q
D
S
S
R
H
S
A
S
Q
Site 593
S2777
A
Q
D
S
S
R
H
S
A
S
Q
D
G
Q
D
Site 594
S2779
D
S
S
R
H
S
A
S
Q
D
G
Q
D
T
I
Site 595
S2793
I
R
G
H
P
G
S
S
R
G
G
R
Q
G
Y
Site 596
Y2800
S
R
G
G
R
Q
G
Y
H
H
E
H
S
V
D
Site 597
S2805
Q
G
Y
H
H
E
H
S
V
D
S
S
G
H
S
Site 598
S2808
H
H
E
H
S
V
D
S
S
G
H
S
G
S
H
Site 599
S2809
H
E
H
S
V
D
S
S
G
H
S
G
S
H
H
Site 600
T2841
S
R
S
A
S
R
T
T
R
N
E
E
Q
S
G
Site 601
S2847
T
T
R
N
E
E
Q
S
G
D
G
S
R
H
S
Site 602
S2856
D
G
S
R
H
S
G
S
R
H
H
E
A
S
T
Site 603
S2862
G
S
R
H
H
E
A
S
T
H
A
D
I
S
R
Site 604
T2863
S
R
H
H
E
A
S
T
H
A
D
I
S
R
H
Site 605
S2871
H
A
D
I
S
R
H
S
Q
A
V
Q
G
Q
S
Site 606
S2881
V
Q
G
Q
S
E
G
S
R
R
S
R
R
Q
G
Site 607
S2884
Q
S
E
G
S
R
R
S
R
R
Q
G
S
S
V
Site 608
S2889
R
R
S
R
R
Q
G
S
S
V
S
Q
D
S
D
Site 609
S2890
R
S
R
R
Q
G
S
S
V
S
Q
D
S
D
S
Site 610
S3098
H
E
Q
A
Q
D
S
S
R
H
S
A
S
Q
Y
Site 611
S3101
A
Q
D
S
S
R
H
S
A
S
Q
Y
G
Q
D
Site 612
S3103
D
S
S
R
H
S
A
S
Q
Y
G
Q
D
T
I
Site 613
Y3105
S
R
H
S
A
S
Q
Y
G
Q
D
T
I
R
G
Site 614
T3109
A
S
Q
Y
G
Q
D
T
I
R
G
H
P
G
S
Site 615
S3171
T
T
R
N
E
E
Q
S
G
D
S
S
R
H
S
Site 616
S3174
N
E
E
Q
S
G
D
S
S
R
H
S
V
S
R
Site 617
S3175
E
E
Q
S
G
D
S
S
R
H
S
V
S
R
H
Site 618
S3178
S
G
D
S
S
R
H
S
V
S
R
H
H
E
A
Site 619
S3180
D
S
S
R
H
S
V
S
R
H
H
E
A
S
T
Site 620
S3186
V
S
R
H
H
E
A
S
T
H
A
D
I
S
R
Site 621
S3236
E
R
W
S
G
S
A
S
R
N
H
R
G
S
V
Site 622
S3242
A
S
R
N
H
R
G
S
V
Q
E
Q
S
R
H
Site 623
S3247
R
G
S
V
Q
E
Q
S
R
H
G
S
R
H
P
Site 624
S3267
D
R
A
G
H
G
H
S
A
D
R
S
R
Q
S
Site 625
S3271
H
G
H
S
A
D
R
S
R
Q
S
G
T
R
H
Site 626
S3274
S
A
D
R
S
R
Q
S
G
T
R
H
A
E
T
Site 627
S3316
S
A
D
S
S
R
H
S
G
I
P
R
G
Q
A
Site 628
S3324
G
I
P
R
G
Q
A
S
S
A
V
R
D
S
R
Site 629
S3325
I
P
R
G
Q
A
S
S
A
V
R
D
S
R
H
Site 630
S3330
A
S
S
A
V
R
D
S
R
H
W
G
S
S
G
Site 631
S3336
D
S
R
H
W
G
S
S
G
S
Q
A
S
D
S
Site 632
S3338
R
H
W
G
S
S
G
S
Q
A
S
D
S
E
G
Site 633
S3354
S
E
E
S
D
T
Q
S
V
S
G
H
G
Q
A
Site 634
S3367
Q
A
G
P
H
Q
Q
S
H
Q
E
S
A
R
D
Site 635
S3371
H
Q
Q
S
H
Q
E
S
A
R
D
R
S
G
G
Site 636
S3376
Q
E
S
A
R
D
R
S
G
G
R
S
G
R
S
Site 637
S3380
R
D
R
S
G
G
R
S
G
R
S
G
S
F
L
Site 638
S3383
S
G
G
R
S
G
R
S
G
S
F
L
Y
Q
V
Site 639
S3448
S
R
R
G
R
Q
G
S
H
Y
E
Q
S
V
D
Site 640
Y3450
R
G
R
Q
G
S
H
Y
E
Q
S
V
D
R
S
Site 641
S3453
Q
G
S
H
Y
E
Q
S
V
D
R
S
G
H
S
Site 642
S3457
Y
E
Q
S
V
D
R
S
G
H
S
G
S
H
H
Site 643
S3482
A
S
R
G
Q
S
G
S
R
S
A
S
R
Q
T
Site 644
S3484
R
G
Q
S
G
S
R
S
A
S
R
Q
T
R
N
Site 645
S3486
Q
S
G
S
R
S
A
S
R
Q
T
R
N
D
E
Site 646
S3499
D
E
Q
S
G
D
G
S
R
H
S
W
S
H
H
Site 647
S3502
S
G
D
G
S
R
H
S
W
S
H
H
H
E
A
Site 648
S3504
D
G
S
R
H
S
W
S
H
H
H
E
A
S
T
Site 649
S3510
W
S
H
H
H
E
A
S
T
Q
A
D
S
S
R
Site 650
T3511
S
H
H
H
E
A
S
T
Q
A
D
S
S
R
H
Site 651
S3515
E
A
S
T
Q
A
D
S
S
R
H
S
Q
S
G
Site 652
S3516
A
S
T
Q
A
D
S
S
R
H
S
Q
S
G
Q
Site 653
S3519
Q
A
D
S
S
R
H
S
Q
S
G
Q
G
Q
S
Site 654
S3521
D
S
S
R
H
S
Q
S
G
Q
G
Q
S
A
G
Site 655
S3526
S
Q
S
G
Q
G
Q
S
A
G
P
R
T
S
R
Site 656
T3531
G
Q
S
A
G
P
R
T
S
R
N
Q
G
S
S
Site 657
S3532
Q
S
A
G
P
R
T
S
R
N
Q
G
S
S
V
Site 658
S3566
A
S
R
N
H
R
G
S
A
Q
E
Q
S
R
D
Site 659
S3571
R
G
S
A
Q
E
Q
S
R
D
G
S
R
H
P
Site 660
S3575
Q
E
Q
S
R
D
G
S
R
H
P
T
S
H
H
Site 661
T3579
R
D
G
S
R
H
P
T
S
H
H
E
D
R
A
Site 662
S3580
D
G
S
R
H
P
T
S
H
H
E
D
R
A
G
Site 663
S3722
S
T
H
E
Q
S
E
S
A
H
G
R
A
G
P
Site 664
S3730
A
H
G
R
A
G
P
S
T
G
G
R
Q
G
S
Site 665
T3731
H
G
R
A
G
P
S
T
G
G
R
Q
G
S
R
Site 666
S3737
S
T
G
G
R
Q
G
S
R
H
E
Q
A
R
D
Site 667
S3764
T
I
R
G
H
P
G
S
R
R
G
G
R
Q
G
Site 668
S3772
R
R
G
G
R
Q
G
S
Y
H
E
Q
S
V
D
Site 669
S3806
A
S
H
G
Q
S
G
S
R
S
A
S
R
E
T
Site 670
S3808
H
G
Q
S
G
S
R
S
A
S
R
E
T
R
N
Site 671
S3810
Q
S
G
S
R
S
A
S
R
E
T
R
N
E
E
Site 672
T3813
S
R
S
A
S
R
E
T
R
N
E
E
Q
S
G
Site 673
S3819
E
T
R
N
E
E
Q
S
G
D
G
S
R
H
S
Site 674
S3834
G
S
R
H
H
E
A
S
T
Q
A
D
S
S
R
Site 675
T3835
S
R
H
H
E
A
S
T
Q
A
D
S
S
R
H
Site 676
S3843
Q
A
D
S
S
R
H
S
Q
S
G
Q
G
E
S
Site 677
S3845
D
S
S
R
H
S
Q
S
G
Q
G
E
S
A
G
Site 678
S3850
S
Q
S
G
Q
G
E
S
A
G
S
R
R
S
R
Site 679
S3853
G
Q
G
E
S
A
G
S
R
R
S
R
R
Q
G
Site 680
S3856
E
S
A
G
S
R
R
S
R
R
Q
G
S
S
V
Site 681
S3864
R
R
Q
G
S
S
V
S
Q
D
S
D
S
E
A
Site 682
S3867
G
S
S
V
S
Q
D
S
D
S
E
A
Y
P
E
Site 683
S3869
S
V
S
Q
D
S
D
S
E
A
Y
P
E
D
S
Site 684
Y3872
Q
D
S
D
S
E
A
Y
P
E
D
S
E
R
R
Site 685
S3876
S
E
A
Y
P
E
D
S
E
R
R
S
E
S
A
Site 686
S3880
P
E
D
S
E
R
R
S
E
S
A
S
R
N
H
Site 687
S3882
D
S
E
R
R
S
E
S
A
S
R
N
H
H
G
Site 688
S3884
E
R
R
S
E
S
A
S
R
N
H
H
G
S
S
Site 689
S3899
R
E
Q
S
R
D
G
S
R
H
P
G
S
S
H
Site 690
S3904
D
G
S
R
H
P
G
S
S
H
R
D
T
A
S
Site 691
S3905
G
S
R
H
P
G
S
S
H
R
D
T
A
S
H
Site 692
T3909
P
G
S
S
H
R
D
T
A
S
H
V
Q
S
S
Site 693
S3911
S
S
H
R
D
T
A
S
H
V
Q
S
S
P
V
Site 694
S3915
D
T
A
S
H
V
Q
S
S
P
V
Q
S
D
S
Site 695
S3916
T
A
S
H
V
Q
S
S
P
V
Q
S
D
S
S
Site 696
S3920
V
Q
S
S
P
V
Q
S
D
S
S
T
A
K
E
Site 697
S3922
S
S
P
V
Q
S
D
S
S
T
A
K
E
H
G
Site 698
S3923
S
P
V
Q
S
D
S
S
T
A
K
E
H
G
H
Site 699
T3924
P
V
Q
S
D
S
S
T
A
K
E
H
G
H
F
Site 700
S3932
A
K
E
H
G
H
F
S
S
L
S
Q
D
S
A
Site 701
S3933
K
E
H
G
H
F
S
S
L
S
Q
D
S
A
Y
Site 702
S3935
H
G
H
F
S
S
L
S
Q
D
S
A
Y
H
S
Site 703
S3938
F
S
S
L
S
Q
D
S
A
Y
H
S
G
I
Q
Site 704
Y3940
S
L
S
Q
D
S
A
Y
H
S
G
I
Q
S
R
Site 705
S3942
S
Q
D
S
A
Y
H
S
G
I
Q
S
R
G
S
Site 706
S3946
A
Y
H
S
G
I
Q
S
R
G
S
P
H
S
S
Site 707
S3949
S
G
I
Q
S
R
G
S
P
H
S
S
S
S
Y
Site 708
S3952
Q
S
R
G
S
P
H
S
S
S
S
Y
H
Y
Q
Site 709
S3953
S
R
G
S
P
H
S
S
S
S
Y
H
Y
Q
S
Site 710
S3954
R
G
S
P
H
S
S
S
S
Y
H
Y
Q
S
E
Site 711
S3955
G
S
P
H
S
S
S
S
Y
H
Y
Q
S
E
G
Site 712
Y3956
S
P
H
S
S
S
S
Y
H
Y
Q
S
E
G
T
Site 713
Y3958
H
S
S
S
S
Y
H
Y
Q
S
E
G
T
E
R
Site 714
S3960
S
S
S
Y
H
Y
Q
S
E
G
T
E
R
Q
K
Site 715
S3970
T
E
R
Q
K
G
Q
S
G
L
V
W
R
H
G
Site 716
S3978
G
L
V
W
R
H
G
S
Y
G
S
A
D
Y
D
Site 717
Y3984
G
S
Y
G
S
A
D
Y
D
Y
G
E
S
G
F
Site 718
Y3986
Y
G
S
A
D
Y
D
Y
G
E
S
G
F
R
H
Site 719
S3994
G
E
S
G
F
R
H
S
Q
H
G
S
V
S
Y
Site 720
S3998
F
R
H
S
Q
H
G
S
V
S
Y
N
S
N
P
Site 721
S4000
H
S
Q
H
G
S
V
S
Y
N
S
N
P
V
V
Site 722
Y4001
S
Q
H
G
S
V
S
Y
N
S
N
P
V
V
F
Site 723
S4012
P
V
V
F
K
E
R
S
D
I
C
K
A
S
A
Site 724
Y4027
F
G
K
D
H
P
R
Y
Y
A
T
Y
I
N
K
Site 725
Y4028
G
K
D
H
P
R
Y
Y
A
T
Y
I
N
K
D
Site 726
Y4031
H
P
R
Y
Y
A
T
Y
I
N
K
D
P
G
L
Site 727
S4043
P
G
L
C
G
H
S
S
D
I
S
K
Q
L
G
Site 728
S4046
C
G
H
S
S
D
I
S
K
Q
L
G
F
S
Q
Site 729
S4052
I
S
K
Q
L
G
F
S
Q
S
Q
R
Y
Y
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation