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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN3
Full Name:
Calpain-3
Alias:
Calpain L3
Type:
Mass (Da):
94236
Number AA:
821
UniProt ID:
P20807
International Prot ID:
IPI00025819
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005737
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004175
GO:0004197
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0007517
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
S
A
S
V
A
P
R
T
A
A
E
P
R
S
P
Site 2
S19
R
T
A
A
E
P
R
S
P
G
P
V
P
H
P
Site 3
S29
P
V
P
H
P
A
Q
S
K
A
T
E
A
G
G
Site 4
Y43
G
G
N
P
S
G
I
Y
S
A
I
I
S
R
N
Site 5
S44
G
N
P
S
G
I
Y
S
A
I
I
S
R
N
F
Site 6
T60
I
I
G
V
K
E
K
T
F
E
Q
L
H
K
K
Site 7
Y75
C
L
E
K
K
V
L
Y
V
D
P
E
F
P
P
Site 8
T85
P
E
F
P
P
D
E
T
S
L
F
Y
S
Q
K
Site 9
S86
E
F
P
P
D
E
T
S
L
F
Y
S
Q
K
F
Site 10
Y89
P
D
E
T
S
L
F
Y
S
Q
K
F
P
I
Q
Site 11
S90
D
E
T
S
L
F
Y
S
Q
K
F
P
I
Q
F
Site 12
S154
R
V
I
P
H
D
Q
S
F
I
E
N
Y
A
G
Site 13
Y159
D
Q
S
F
I
E
N
Y
A
G
I
F
H
F
Q
Site 14
Y185
I
D
D
C
L
P
T
Y
N
N
Q
L
V
F
T
Site 15
Y209
S
A
L
L
E
K
A
Y
A
K
L
H
G
S
Y
Site 16
S215
A
Y
A
K
L
H
G
S
Y
E
A
L
K
G
G
Site 17
Y249
R
D
A
P
S
D
M
Y
K
I
M
K
K
A
I
Site 18
S260
K
K
A
I
E
R
G
S
L
M
G
C
S
I
D
Site 19
S265
R
G
S
L
M
G
C
S
I
D
D
G
T
N
M
Site 20
T270
G
C
S
I
D
D
G
T
N
M
T
Y
G
T
S
Site 21
T273
I
D
D
G
T
N
M
T
Y
G
T
S
P
S
G
Site 22
Y274
D
D
G
T
N
M
T
Y
G
T
S
P
S
G
L
Site 23
S277
T
N
M
T
Y
G
T
S
P
S
G
L
N
M
G
Site 24
S279
M
T
Y
G
T
S
P
S
G
L
N
M
G
E
L
Site 25
S297
M
V
R
N
M
D
N
S
L
L
Q
D
S
D
L
Site 26
S302
D
N
S
L
L
Q
D
S
D
L
D
P
R
G
S
Site 27
S309
S
D
L
D
P
R
G
S
D
E
R
P
T
R
T
Site 28
T314
R
G
S
D
E
R
P
T
R
T
I
I
P
V
Q
Site 29
T316
S
D
E
R
P
T
R
T
I
I
P
V
Q
Y
E
Site 30
Y322
R
T
I
I
P
V
Q
Y
E
T
R
M
A
C
G
Site 31
S377
S
D
R
W
K
D
W
S
F
V
D
K
D
E
K
Site 32
T392
A
R
L
Q
H
Q
V
T
E
D
G
E
F
W
M
Site 33
Y406
M
S
Y
E
D
F
I
Y
H
F
T
K
L
E
I
Site 34
T417
K
L
E
I
C
N
L
T
A
D
A
L
Q
S
D
Site 35
S423
L
T
A
D
A
L
Q
S
D
K
L
Q
T
W
T
Site 36
T430
S
D
K
L
Q
T
W
T
V
S
V
N
E
G
R
Site 37
S432
K
L
Q
T
W
T
V
S
V
N
E
G
R
W
V
Site 38
S443
G
R
W
V
R
G
C
S
A
G
G
C
R
N
F
Site 39
Y460
T
F
W
T
N
P
Q
Y
R
L
K
L
L
E
E
Site 40
S474
E
D
D
D
P
D
D
S
E
V
I
C
S
F
L
Site 41
Y527
L
Q
K
D
F
F
L
Y
N
A
S
K
A
R
S
Site 42
S530
D
F
F
L
Y
N
A
S
K
A
R
S
K
T
Y
Site 43
S534
Y
N
A
S
K
A
R
S
K
T
Y
I
N
M
R
Site 44
T536
A
S
K
A
R
S
K
T
Y
I
N
M
R
E
V
Site 45
S544
Y
I
N
M
R
E
V
S
Q
R
F
R
L
P
P
Site 46
S552
Q
R
F
R
L
P
P
S
E
Y
V
I
V
P
S
Site 47
Y554
F
R
L
P
P
S
E
Y
V
I
V
P
S
T
Y
Site 48
S559
S
E
Y
V
I
V
P
S
T
Y
E
P
H
Q
E
Site 49
T560
E
Y
V
I
V
P
S
T
Y
E
P
H
Q
E
G
Site 50
S575
E
F
I
L
R
V
F
S
E
K
R
N
L
S
E
Site 51
S581
F
S
E
K
R
N
L
S
E
E
V
E
N
T
I
Site 52
T587
L
S
E
E
V
E
N
T
I
S
V
D
R
P
V
Site 53
S589
E
E
V
E
N
T
I
S
V
D
R
P
V
K
K
Site 54
T599
R
P
V
K
K
K
K
T
K
P
I
I
F
V
S
Site 55
S606
T
K
P
I
I
F
V
S
D
R
A
N
S
N
K
Site 56
S611
F
V
S
D
R
A
N
S
N
K
E
L
G
V
D
Site 57
S621
E
L
G
V
D
Q
E
S
E
E
G
K
G
K
T
Site 58
S629
E
E
G
K
G
K
T
S
P
D
K
Q
K
Q
S
Site 59
S636
S
P
D
K
Q
K
Q
S
P
Q
P
Q
P
G
S
Site 60
S643
S
P
Q
P
Q
P
G
S
S
D
Q
E
S
E
E
Site 61
S644
P
Q
P
Q
P
G
S
S
D
Q
E
S
E
E
Q
Site 62
S648
P
G
S
S
D
Q
E
S
E
E
Q
Q
Q
F
R
Site 63
T679
E
L
K
K
V
L
N
T
V
V
N
K
H
K
D
Site 64
T689
N
K
H
K
D
L
K
T
H
G
F
T
L
E
S
Site 65
S699
F
T
L
E
S
C
R
S
M
I
A
L
M
D
T
Site 66
T706
S
M
I
A
L
M
D
T
D
G
S
G
K
L
N
Site 67
S709
A
L
M
D
T
D
G
S
G
K
L
N
L
Q
E
Site 68
T736
K
I
F
K
H
Y
D
T
D
Q
S
G
T
I
N
Site 69
S739
K
H
Y
D
T
D
Q
S
G
T
I
N
S
Y
E
Site 70
S744
D
Q
S
G
T
I
N
S
Y
E
M
R
N
A
V
Site 71
Y763
F
H
L
N
N
Q
L
Y
D
I
I
T
M
R
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation