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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MX2
Full Name:
Interferon-induced GTP-binding protein Mx2
Alias:
Interferon-regulated resistance GTP-binding protein MxB; MXB; Myxovirus (influenza virus) resistance 2; Myxovirus (influenza virus) resistance 2 (mouse); Myxovirus (influenza) resistance 2, homolog of murine; Myxovirus (influenza) resistance 2, homologue of murine; Myxovirus resistance protein 2; P78-related protein; Second interferon-induced protein p78
Type:
G protein regulator, miscellaneous
Mass (Da):
82089
Number AA:
715
UniProt ID:
P20592
International Prot ID:
IPI00024684
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
PhosphoSite+
KinaseNET
Biological Process:
GO:0006952
GO:0009615
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
K
A
H
K
P
W
P
Y
R
R
R
S
Q
F
S
Site 2
S14
P
W
P
Y
R
R
R
S
Q
F
S
S
R
K
Y
Site 3
S17
Y
R
R
R
S
Q
F
S
S
R
K
Y
L
K
K
Site 4
S18
R
R
R
S
Q
F
S
S
R
K
Y
L
K
K
E
Site 5
Y21
S
Q
F
S
S
R
K
Y
L
K
K
E
M
N
S
Site 6
S28
Y
L
K
K
E
M
N
S
F
Q
Q
Q
P
P
P
Site 7
T38
Q
Q
P
P
P
F
G
T
V
P
P
Q
M
M
F
Site 8
T67
A
K
D
F
N
F
L
T
L
N
N
Q
P
P
P
Site 9
S78
Q
P
P
P
G
N
R
S
Q
P
R
A
M
G
P
Site 10
Y90
M
G
P
E
N
N
L
Y
S
Q
Y
E
Q
K
V
Site 11
S91
G
P
E
N
N
L
Y
S
Q
Y
E
Q
K
V
R
Site 12
Y93
E
N
N
L
Y
S
Q
Y
E
Q
K
V
R
P
C
Site 13
S129
A
V
I
G
D
Q
S
S
G
K
S
S
V
L
E
Site 14
S132
G
D
Q
S
S
G
K
S
S
V
L
E
A
L
S
Site 15
S133
D
Q
S
S
G
K
S
S
V
L
E
A
L
S
G
Site 16
S172
E
A
W
A
G
R
I
S
Y
R
N
T
E
L
E
Site 17
Y173
A
W
A
G
R
I
S
Y
R
N
T
E
L
E
L
Site 18
T176
G
R
I
S
Y
R
N
T
E
L
E
L
Q
D
P
Site 19
S205
A
G
N
G
R
G
I
S
H
E
L
I
S
L
E
Site 20
S210
G
I
S
H
E
L
I
S
L
E
I
T
S
P
E
Site 21
Y252
I
K
A
L
I
K
K
Y
I
Q
R
Q
Q
T
I
Site 22
T258
K
Y
I
Q
R
Q
Q
T
I
N
L
V
V
V
P
Site 23
T273
C
N
V
D
I
A
T
T
E
A
L
S
M
A
H
Site 24
T289
V
D
P
E
G
D
R
T
I
G
I
L
T
K
P
Site 25
T303
P
D
L
M
D
R
G
T
E
K
S
V
M
N
V
Site 26
S306
M
D
R
G
T
E
K
S
V
M
N
V
V
R
N
Site 27
T315
M
N
V
V
R
N
L
T
Y
P
L
K
K
G
Y
Site 28
Y316
N
V
V
R
N
L
T
Y
P
L
K
K
G
Y
M
Site 29
T334
C
R
G
Q
Q
E
I
T
N
R
L
S
L
A
E
Site 30
S338
Q
E
I
T
N
R
L
S
L
A
E
A
T
K
K
Site 31
T348
E
A
T
K
K
E
I
T
F
F
Q
T
H
P
Y
Site 32
Y355
T
F
F
Q
T
H
P
Y
F
R
V
L
L
E
E
Site 33
T366
L
L
E
E
G
S
A
T
V
P
R
L
A
E
R
Site 34
T376
R
L
A
E
R
L
T
T
E
L
I
M
H
I
Q
Site 35
S396
L
E
G
Q
I
R
E
S
H
Q
K
A
T
E
E
Site 36
S413
R
C
G
A
D
I
P
S
Q
E
A
D
K
M
F
Site 37
Y451
R
E
N
E
T
R
L
Y
N
K
I
R
E
D
F
Site 38
Y483
I
H
E
E
V
E
K
Y
E
K
Q
Y
R
G
K
Site 39
T548
E
F
F
N
L
N
Q
T
V
Q
S
T
I
E
D
Site 40
T552
L
N
Q
T
V
Q
S
T
I
E
D
I
K
V
K
Site 41
T602
E
I
F
N
P
L
G
T
P
S
Q
N
M
K
L
Site 42
S604
F
N
P
L
G
T
P
S
Q
N
M
K
L
N
S
Site 43
S611
S
Q
N
M
K
L
N
S
H
F
P
S
N
E
S
Site 44
S615
K
L
N
S
H
F
P
S
N
E
S
S
V
S
S
Site 45
S618
S
H
F
P
S
N
E
S
S
V
S
S
F
T
E
Site 46
S619
H
F
P
S
N
E
S
S
V
S
S
F
T
E
I
Site 47
S621
P
S
N
E
S
S
V
S
S
F
T
E
I
G
I
Site 48
S622
S
N
E
S
S
V
S
S
F
T
E
I
G
I
H
Site 49
Y633
I
G
I
H
L
N
A
Y
F
L
E
T
S
K
R
Site 50
T637
L
N
A
Y
F
L
E
T
S
K
R
L
A
N
Q
Site 51
S638
N
A
Y
F
L
E
T
S
K
R
L
A
N
Q
I
Site 52
S660
M
L
R
E
N
G
D
S
L
Q
K
A
M
M
Q
Site 53
Y675
I
L
Q
E
K
N
R
Y
S
W
L
L
Q
E
Q
Site 54
S676
L
Q
E
K
N
R
Y
S
W
L
L
Q
E
Q
S
Site 55
S683
S
W
L
L
Q
E
Q
S
E
T
A
T
K
R
R
Site 56
T685
L
L
Q
E
Q
S
E
T
A
T
K
R
R
I
L
Site 57
T687
Q
E
Q
S
E
T
A
T
K
R
R
I
L
K
E
Site 58
Y697
R
I
L
K
E
R
I
Y
R
L
T
Q
A
R
H
Site 59
T700
K
E
R
I
Y
R
L
T
Q
A
R
H
A
L
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation