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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MSH3
Full Name:
DNA mismatch repair protein Msh3
Alias:
Divergent upstream protein; DUC1; DUP; Mismatch repair 1; Mismatch repair protein 1; MRP1; MutS 3
Type:
DNA repair
Mass (Da):
127456
Number AA:
1137
UniProt ID:
P20585
International Prot ID:
IPI00329605
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032302
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030983
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0043570
GO:0006298
GO:0045910
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
R
R
K
P
A
S
G
G
L
A
A
S
S
Site 2
S14
A
S
G
G
L
A
A
S
S
S
A
P
A
R
Q
Site 3
S15
S
G
G
L
A
A
S
S
S
A
P
A
R
Q
A
Site 4
S25
P
A
R
Q
A
V
L
S
R
F
F
Q
S
T
G
Site 5
S30
V
L
S
R
F
F
Q
S
T
G
S
L
K
S
T
Site 6
T31
L
S
R
F
F
Q
S
T
G
S
L
K
S
T
S
Site 7
S33
R
F
F
Q
S
T
G
S
L
K
S
T
S
S
S
Site 8
S36
Q
S
T
G
S
L
K
S
T
S
S
S
T
G
A
Site 9
T37
S
T
G
S
L
K
S
T
S
S
S
T
G
A
A
Site 10
S38
T
G
S
L
K
S
T
S
S
S
T
G
A
A
D
Site 11
S39
G
S
L
K
S
T
S
S
S
T
G
A
A
D
Q
Site 12
S40
S
L
K
S
T
S
S
S
T
G
A
A
D
Q
V
Site 13
S111
V
Q
Q
K
E
G
G
S
D
L
G
M
S
G
N
Site 14
S116
G
G
S
D
L
G
M
S
G
N
S
E
P
K
K
Site 15
T127
E
P
K
K
C
L
R
T
R
N
V
S
K
S
L
Site 16
S131
C
L
R
T
R
N
V
S
K
S
L
E
K
L
K
Site 17
S133
R
T
R
N
V
S
K
S
L
E
K
L
K
E
F
Site 18
S144
L
K
E
F
C
C
D
S
A
L
P
Q
S
R
V
Site 19
S149
C
D
S
A
L
P
Q
S
R
V
Q
T
E
S
L
Site 20
T153
L
P
Q
S
R
V
Q
T
E
S
L
Q
E
R
F
Site 21
S155
Q
S
R
V
Q
T
E
S
L
Q
E
R
F
A
V
Site 22
S173
C
T
D
F
D
D
I
S
L
L
H
A
K
N
A
Site 23
S182
L
H
A
K
N
A
V
S
S
E
D
S
K
R
Q
Site 24
S186
N
A
V
S
S
E
D
S
K
R
Q
I
N
Q
K
Site 25
T196
Q
I
N
Q
K
D
T
T
L
F
D
L
S
Q
F
Site 26
S201
D
T
T
L
F
D
L
S
Q
F
G
S
S
N
T
Site 27
S205
F
D
L
S
Q
F
G
S
S
N
T
S
H
E
N
Site 28
S209
Q
F
G
S
S
N
T
S
H
E
N
L
Q
K
T
Site 29
T216
S
H
E
N
L
Q
K
T
A
S
K
S
A
N
K
Site 30
S218
E
N
L
Q
K
T
A
S
K
S
A
N
K
R
S
Site 31
S220
L
Q
K
T
A
S
K
S
A
N
K
R
S
K
S
Site 32
S225
S
K
S
A
N
K
R
S
K
S
I
Y
T
P
L
Site 33
S227
S
A
N
K
R
S
K
S
I
Y
T
P
L
E
L
Site 34
Y229
N
K
R
S
K
S
I
Y
T
P
L
E
L
Q
Y
Site 35
T230
K
R
S
K
S
I
Y
T
P
L
E
L
Q
Y
I
Site 36
Y236
Y
T
P
L
E
L
Q
Y
I
E
M
K
Q
Q
H
Site 37
Y256
C
V
E
C
G
Y
K
Y
R
F
F
G
E
D
A
Site 38
Y273
A
A
R
E
L
N
I
Y
C
H
L
D
H
N
F
Site 39
T282
H
L
D
H
N
F
M
T
A
S
I
P
T
H
R
Site 40
Y302
R
R
L
V
A
K
G
Y
K
V
G
V
V
K
Q
Site 41
S323
K
A
I
G
D
N
R
S
S
L
F
S
R
K
L
Site 42
S324
A
I
G
D
N
R
S
S
L
F
S
R
K
L
T
Site 43
S327
D
N
R
S
S
L
F
S
R
K
L
T
A
L
Y
Site 44
T331
S
L
F
S
R
K
L
T
A
L
Y
T
K
S
T
Site 45
Y334
S
R
K
L
T
A
L
Y
T
K
S
T
L
I
G
Site 46
T335
R
K
L
T
A
L
Y
T
K
S
T
L
I
G
E
Site 47
T338
T
A
L
Y
T
K
S
T
L
I
G
E
D
V
N
Site 48
Y367
M
T
D
T
S
T
S
Y
L
L
C
I
S
E
N
Site 49
S404
T
G
E
V
V
F
D
S
F
Q
D
S
A
S
R
Site 50
S408
V
F
D
S
F
Q
D
S
A
S
R
S
E
L
E
Site 51
S410
D
S
F
Q
D
S
A
S
R
S
E
L
E
T
R
Site 52
S412
F
Q
D
S
A
S
R
S
E
L
E
T
R
M
S
Site 53
T416
A
S
R
S
E
L
E
T
R
M
S
S
L
Q
P
Site 54
S419
S
E
L
E
T
R
M
S
S
L
Q
P
V
E
L
Site 55
S420
E
L
E
T
R
M
S
S
L
Q
P
V
E
L
L
Site 56
T444
E
A
L
I
H
R
A
T
S
V
S
V
Q
D
D
Site 57
S445
A
L
I
H
R
A
T
S
V
S
V
Q
D
D
R
Site 58
S447
I
H
R
A
T
S
V
S
V
Q
D
D
R
I
R
Site 59
Y462
V
E
R
M
D
N
I
Y
F
E
Y
S
H
A
F
Site 60
T480
T
E
F
Y
A
K
D
T
V
D
I
K
G
S
Q
Site 61
S520
F
N
L
E
K
M
L
S
K
P
E
N
F
K
Q
Site 62
T536
S
S
K
M
E
F
M
T
I
N
G
T
T
L
R
Site 63
T540
E
F
M
T
I
N
G
T
T
L
R
N
L
E
I
Site 64
T541
F
M
T
I
N
G
T
T
L
R
N
L
E
I
L
Site 65
T556
Q
N
Q
T
D
M
K
T
K
G
S
L
L
W
V
Site 66
T567
L
L
W
V
L
D
H
T
K
T
S
F
G
R
R
Site 67
T569
W
V
L
D
H
T
K
T
S
F
G
R
R
K
L
Site 68
S570
V
L
D
H
T
K
T
S
F
G
R
R
K
L
K
Site 69
T581
R
K
L
K
K
W
V
T
Q
P
L
L
K
L
R
Site 70
S598
N
A
R
L
D
A
V
S
E
V
L
H
S
E
S
Site 71
S603
A
V
S
E
V
L
H
S
E
S
S
V
F
G
Q
Site 72
S605
S
E
V
L
H
S
E
S
S
V
F
G
Q
I
E
Site 73
S606
E
V
L
H
S
E
S
S
V
F
G
Q
I
E
N
Site 74
Y629
E
R
G
L
C
S
I
Y
H
K
K
C
S
T
Q
Site 75
S650
K
T
L
Y
H
L
K
S
E
F
Q
A
I
I
P
Site 76
S680
L
E
I
P
E
L
L
S
P
V
E
H
Y
L
K
Site 77
T700
A
A
K
V
G
D
K
T
E
L
F
K
D
L
S
Site 78
S707
T
E
L
F
K
D
L
S
D
F
P
L
I
K
K
Site 79
S741
R
K
I
L
K
N
P
S
A
Q
Y
V
T
V
S
Site 80
Y744
L
K
N
P
S
A
Q
Y
V
T
V
S
G
Q
E
Site 81
S748
S
A
Q
Y
V
T
V
S
G
Q
E
F
M
I
E
Site 82
S773
T
D
W
V
K
V
G
S
T
K
A
V
S
R
F
Site 83
S782
K
A
V
S
R
F
H
S
P
F
I
V
E
N
Y
Site 84
Y846
K
V
A
K
Q
G
D
Y
C
R
P
T
V
Q
E
Site 85
T850
Q
G
D
Y
C
R
P
T
V
Q
E
E
R
K
I
Site 86
Y877
L
L
G
E
Q
D
Q
Y
V
P
N
N
T
D
L
Site 87
S885
V
P
N
N
T
D
L
S
E
D
S
E
R
V
M
Site 88
S888
N
T
D
L
S
E
D
S
E
R
V
M
I
I
T
Site 89
T895
S
E
R
V
M
I
I
T
G
P
N
M
G
G
K
Site 90
S903
G
P
N
M
G
G
K
S
S
Y
I
K
Q
V
A
Site 91
S904
P
N
M
G
G
K
S
S
Y
I
K
Q
V
A
L
Site 92
Y946
M
G
A
A
D
N
I
Y
K
G
R
S
T
F
M
Site 93
T951
N
I
Y
K
G
R
S
T
F
M
E
E
L
T
D
Site 94
T957
S
T
F
M
E
E
L
T
D
T
A
E
I
I
R
Site 95
T959
F
M
E
E
L
T
D
T
A
E
I
I
R
K
A
Site 96
T967
A
E
I
I
R
K
A
T
S
Q
S
L
V
I
L
Site 97
S968
E
I
I
R
K
A
T
S
Q
S
L
V
I
L
D
Site 98
T981
L
D
E
L
G
R
G
T
S
T
H
D
G
I
A
Site 99
S982
D
E
L
G
R
G
T
S
T
H
D
G
I
A
I
Site 100
Y1021
V
C
E
L
E
K
N
Y
S
H
Q
V
G
N
Y
Site 101
Y1028
Y
S
H
Q
V
G
N
Y
H
M
G
F
L
V
S
Site 102
S1035
Y
H
M
G
F
L
V
S
E
D
E
S
K
L
D
Site 103
S1039
F
L
V
S
E
D
E
S
K
L
D
P
G
A
A
Site 104
T1054
E
Q
V
P
D
F
V
T
F
L
Y
Q
I
T
R
Site 105
Y1068
R
G
I
A
A
R
S
Y
G
L
N
V
A
K
L
Site 106
S1090
L
K
K
A
A
H
K
S
K
E
L
E
G
L
I
Site 107
T1099
E
L
E
G
L
I
N
T
K
R
K
R
L
K
Y
Site 108
Y1106
T
K
R
K
R
L
K
Y
F
A
K
L
W
T
M
Site 109
T1131
E
E
F
N
M
E
E
T
Q
T
S
L
L
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation